Regulation Of Tissue Responses The Tweak Fn14 Pathway And Other Tnf Tnfr Superfamily Members That Activate Noncanonical Nfkb Signaling
DOWNLOAD eBooks
Download Regulation Of Tissue Responses The Tweak Fn14 Pathway And Other Tnf Tnfr Superfamily Members That Activate Noncanonical Nfkb Signaling PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Regulation Of Tissue Responses The Tweak Fn14 Pathway And Other Tnf Tnfr Superfamily Members That Activate Noncanonical Nfkb Signaling book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Regulation Of Tissue Responses The Tweak Fn14 Pathway And Other Tnf Tnfr Superfamily Members That Activate Noncanonical Nfkb Signaling
DOWNLOAD eBooks
Author : Linda C. Burkly
language : en
Publisher: Frontiers Media SA
Release Date : 2016-01-21
Regulation Of Tissue Responses The Tweak Fn14 Pathway And Other Tnf Tnfr Superfamily Members That Activate Noncanonical Nfkb Signaling written by Linda C. Burkly and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-21 with Electronic book categories.
The immune system mediates tissue responses under both physiological and pathological conditions, impacting the inflammatory, fibrogenic and regenerative components. In addition to various leukocyte subsets, it is now recognized that epithelial, endothelial and other non-hematopoietic tissue cell types actively contribute to the interplay shaping tissue responses. Further understanding the molecular pathways and mechanisms mediating these tissue responses is of great interest. In the past decade, TNF-like weak inducer of apoptosis (TWEAK) and its receptor, FGF-inducible molecule-14 (Fn14), members of the TNF/TNFR superfamily, have emerged as a prominent molecular axis regulating tissue responses. Generally leukocyte-derived, TWEAK signals through Fn14 which is highly induced in injured and diseased tissues on the surface of parenchymal, stromal and progenitor cells, thereby orchestrating a host of tissue-shaping responses, including inflammation, angiogenesis, cell proliferation or death, and the regulation of progenitor cells. Compelling preclinical results indicate that whereas transient TWEAK/Fn14 activation promotes productive tissue responses after acute injury, excessive or persistent TWEAK/Fn14 activation drives pathological tissue responses, leading to progressive damage and degeneration in target organs of injury, autoimmune and inflammatory diseases and cancer. Given that the highly inducible pattern of Fn14 expression is well conserved between mouse and man, the role of TWEAK/Fn14 in human disease is an area of intense investigation. Recent findings have also begun to shed light on how the TWEAK/Fn14 pathway fits into the immune network, interplaying with other well-established pathways, including TNFa, IL-17, IL-13 and TGFb, in regulating tissue responses. The noncanonical nuclear factor kB (NF?B) pathway plays a role in immunity and disease pathologies and appears to be activated by only a subset of TNF/ TNFR superfamily members. Of the various signaling pathways downstream of TWEAK/Fn14, particular attention has been placed on the noncanonical NF?B pathway given that given that TWEAK induces acute activation of canonical NF?B but prolonged activation of noncanonical pathway. Thus dovetailing of the TWEAK/Fn14 axis with noncanonical NF?B pathway activation may be a key mechanism underlying tissue responses. Also of great interest is a deeper understanding of where, when and how tissue responses are regulated by other TNF/ TNFR superfamily members that can signal through noncanonical NF?B. This Research Topic issue will cover: 1. TWEAK/Fn14 pathway biology, role in tissue responses, injury, and disease pathogenesis 2. Role of noncanonical NFkB signaling cascade in tissue responses 3. Translational studies of relevance of TWEAK/Fn14 and noncanonical NFkB in human disease 4. Other TNF superfamily members’ signaling through noncanonical NFkB in the regulation of tissue responses 5. Reviews and Perspectives on the above
Primary Immunodeficiency Diseases
DOWNLOAD eBooks
Author : Nima Rezaei
language : en
Publisher: Springer
Release Date : 2016-11-30
Primary Immunodeficiency Diseases written by Nima Rezaei and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-30 with Medical categories.
The number of diagnosed cases of primary immunodeficiency diseases (PIDs) – a group of inborn disorders of the immune system – is growing rapidly, but misdiagnosis or late diagnosis still occurs in a significant number of patients, with serious consequences. This is the second edition of a practical reference textbook on PIDs that has been widely welcomed by scientists and clinicians from around the world. The new edition has been extensively revised to reflect advances in knowledge and includes various PIDs not previously covered. For each disease, information is provided on definition, etiology, clinical manifestations, diagnosis, and management. This book will represent an ideal resource for specialists when engaging in diagnosis, clinical decision-making, and treatment planning. It will also prove invaluable for doctors in training and other physicians and nurses who wish to learn more about PIDs.
Trail Fas Ligand Tnf And Tlr3 In Cancer
DOWNLOAD eBooks
Author : Olivier Micheau
language : en
Publisher: Springer
Release Date : 2017-07-03
Trail Fas Ligand Tnf And Tlr3 In Cancer written by Olivier Micheau and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-07-03 with Medical categories.
This volume provides the current understanding of death receptor's/TLR3 signaling regulation in cancer. Death receptors, including TRAIL-R1, TRAIL-R2, Fas and TNF-RI, owing to their ability to trigger apoptosis and to contribute to the elimination of cancer cells by the immune system have been considered, to variable extent, as important therapeutic targets for cancer therapy. But an increasing body of evidence suggests that some of these receptors may also contribute to tumorigenesis, or that new players such as TLR3 may be targeted for cancer therapy due to their ability to behave like death receptors.
Advances In Tnf Family Research
DOWNLOAD eBooks
Author : David Wallach
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-12-09
Advances In Tnf Family Research written by David Wallach and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-12-09 with Medical categories.
The biennial TNF-family conferences have been held over the past 20 years, from the time that TNF was cloned. These meetings have followed the enormous progress in this field. Much is now known about the members of the TNF ligand and receptor families, their signaling proteins, mechanisms of action and cellular functions. This volume is the proceedings of the 12th TNF International Conference, held in April 2009. This conference focuses on the physiological, pathophysiological, and medical significance of these important regulators. Sessions at the meeting specifically address their involvement in immunity, development, apoptosis, autoimmunity, cancer, and infection, the normal function and pathology of the neuronal system, as well as major unresolved questions about their mechanisms of action.
D Type Cyclins And Cancer
DOWNLOAD eBooks
Author : Philip W. Hinds
language : en
Publisher: Humana
Release Date : 2017-10-18
D Type Cyclins And Cancer written by Philip W. Hinds and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-18 with Medical categories.
This volume provides an integrated account of our current understanding of the functions of D-type cyclins during development and tumorigenesis, with special emphasis on the kinase-independent functions of these proteins. The volume will provide a thorough review of the latest discoveries on the new functions and interacting partners of mammalian cyclin Ds crucial to explain their oncogenic and differentiation properties in different cellular contexts. The volume begins with a historical perspective of how D-type cyclins were first discovered and eventually cloned from cancer tissues, followed by an account on the canonical functions of cyclin Ds during the G1-S transition of the cell cycle. Several chapters will be devoted to review the functions of D-type cyclins as transcriptional regulators and the mechanisms through which these novel functions could impact the tumorigenic process. Also discussed is emerging evidence that points to a role of D-type cyclins, particularly cyclin D1, as a cytoplasmic regulator of various cellular functions. This property, in human cells at least, is traceable to certain splice isoforms with novel oncogenic implications. Finally, a chapter is devoted to recent efforts to revise the canonical view of the “retinoblastoma pathway” to incorporate new evidence that suggests that cyclin D1’s role in G1 is to singly-phosphorylate the retinoblastoma protein (pRb) for discrimination of target protein interactions. This work represents a significant departure from the view of cyclin D1 as a negative regulator of pRb and may have critical implications for understanding the function of antineoplastic agents that target the cyclin D1-associated kinases.
Tumor Invasion And Metastasis
DOWNLOAD eBooks
Author : L.A. Liotta
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Tumor Invasion And Metastasis written by L.A. Liotta and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The clinical significance of tumor spread has always been appreciated. Yet, in spite of the pioneering work and outstanding contributions of investigators such as D. Coman, H. Green, B. Fisher, S. Wood and I. Zeidman, studies on metastasis rarely achieved the popularity afforded to more esoteric areas of tumor biology. Tumor dissemination, occurring as it does in a responding host and being composed of a series of dynamic int~ractions, is a highly complex phenomenon. Few investigators were brave enough to attempt to unravel the mechanisms involved. Paradoxically, this very complexity may have contributed, in part, to the recent upsurge of interest in metastasis research. More and more researchers are becoming fascinated by the complexities of the cellular interactions involved in tumor spread. Accompanying this intellectual stimulation have been technological advances in related fields which allow the derivation of new model systems. The mechanisms of metastatic spread are increasingly amenable to both the reductionist and holistic approaches and it is the purpose of this volume to present many of these model systems while emphasizing the intricacy and complexity of the processes they mimic. We have attempted to emphasize two topics not previously covered in depth in previous books on metastases. These are in vitro models of invasion and in teractions of tumor cells with connective tissue.
25 Ways To Become Your Own Psychiatrist
DOWNLOAD eBooks
Author : Diego Carranza Tresoldi
language : en
Publisher:
Release Date : 2020-03-11
25 Ways To Become Your Own Psychiatrist written by Diego Carranza Tresoldi and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-11 with categories.
Neurobiology Of The Immune System
DOWNLOAD eBooks
Author : Angela Clow
language : en
Publisher: Elsevier
Release Date : 2003-01-08
Neurobiology Of The Immune System written by Angela Clow and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-01-08 with Medical categories.
Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. Provides solid scientific basis to our understanding of the associations between the brain and the immune system the importance of these connections Presents coherent development from cellular and molecular neuroimmune communication to social and health considerations, including psychological intervention Addresses the theory that there is a neurobiology of the immune system
Macrocycles In Drug Discovery
DOWNLOAD eBooks
Author : Jeremy I Levin
language : en
Publisher: Royal Society of Chemistry
Release Date : 2015
Macrocycles In Drug Discovery written by Jeremy I Levin and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Medical categories.
This book will review macrocycles in drug discovery, both those of natural origin and semi-synthetic derivatives of natural products, and those designed and synthesized based on principles of medicinal chemistry. A variety of macrocyclic natural products have become important drugs or have been identified as leads to marketed drugs. This text will discuss these compounds in the context of their broad chemotype as compounds composed of large rings. The medicinal chemistry of natural products is interesting in itself, but lessons learned from these compounds, in terms of the relationship between structure and desirable physicochemical properties, is now informing the design of fully synthetic drug candidates against a variety of targets. Furthermore, as more and more non-classical drug targets, such as protein-protein interactions, are pursued in the pharmaceutical industry, macrocyclic molecules are becoming increasingly important as they offer a way to provide drug-protein interactions that cover a larger surface area than traditional small molecules. An indication of this growing importance is the fact that several companies now provide libraries of macrocyclic molecules produced by proprietary chemical technology to use for lead generation. Providing a wide reaching review of this important area in a single volume, this book will be of interest to biochemists, pharmaceutical scientists and medicinal chemists working in industry or academia.
The Cancer Stem Cell Niche
DOWNLOAD eBooks
Author : Susie Nilsson
language : en
Publisher: Academic Press
Release Date : 2021-02-09
The Cancer Stem Cell Niche written by Susie Nilsson and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-09 with Science categories.
The Cancer Stem Cell Niche, Volume Five in the Advances in Stem Cells and their Niches series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Acute lymphoblastic leukemia and the bone marrow microenvironment, Stem cell niches in bone and their roles in cancer metastasis, The role of vasculature in cancer stem cell niches, The lung cancer stem cell niche, The prostate cancer stem cell niche: Genetic drivers and therapeutic approaches, Impact of prostate cancer stem cell niches on prostate cancer tumorigenesis and progression, The testicular cancer stem cell niche. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Advances in Stem Cells and their Niches series Includes the latest information on the Cancer Stem Cell Niche