Actinobacteria A Source Of Biocatalytic Tools
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Actinobacteria A Source Of Biocatalytic Tools
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Author : Dirk Tischler
language : en
Publisher: Frontiers Media SA
Release Date : 2019-08-12
Actinobacteria A Source Of Biocatalytic Tools written by Dirk Tischler and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-12 with categories.
Actinobacteria (Actinomycetes) represent one of the largest and most diverse phyla among Bacteria. The remarkable diversity is displayed by various lifestyles, distinct morphologies, a wide spectrum of physiological and metabolic activities, as well as genetics. Interestingly, most Actinobacteria have a high GC-content (ranging from 51% to >70%) and belong to Gram-positive or Gram-variable type microbes. Many species are well known for large genomes which may be of linear style as in case of rhodococci or circular. Many of those harbor linear megaplasmids as a kind of genetic storage device. Frequently gene redundancy is reported and in most cases the evolutionary history or a functional role remains enigmatic. Nevertheless these large genomes and megaplasmids provide access to a number of potential (homologous) biocatalysts which await elucidation. Actinobacteria are well known for their biotechnological potential which is exemplarily described for amino acid producing Corynebacteria, secondary metabolite producing Streptomyces, pathogenic targets as Nocardia and Mycobacteria, carotenoid building Micrococcus strains, acid fermenting Propionibacteria, health and food related Bifidobacterium strains, rubber degrading Gordonia species, and organic pollutant degrading rhodococci among others. In many cases individual pathways or enzymes can be modified or recombinantly employed for biocatalysis. Even some genetic tools to work directly in those microbes have been successfully used as for example in Corynebacterium or in Rhodococcus species. During the last decade more and more genomes have been sequenced and made available for data mining and become accessible by state of the art genomic manipulation methods as minimal genomes, knock-out or artificial evolution. With respect to this large and ancient phylum many questions can be asked either from a scientific or industrial point of view. In order to provide some crystallization points we like to raise some examples as follows. How small can be an actinobacterial genome? What is the driving force to comprise large and repetitive genomes/megaplasmids? What is needed to generate an actinobacterial power house for industry? Can we annotate novel biocatalysts from scratch and improve functional annotation? What are common and different features with respect to other bacteria and/or fungi? How many novel antibiotics are hidden among Actinobacteria? Is there more potential among extremophile members or are they only specialized? Here especially the production of natural compounds is of high interest.
Bioprospecting And Biotechnology Of Extremophiles
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Author : Milko A. Jorquera
language : en
Publisher: Frontiers Media SA
Release Date : 2019-10-18
Bioprospecting And Biotechnology Of Extremophiles written by Milko A. Jorquera and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-18 with categories.
Natural Products From Actinomycetes
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Author : Ravishankar V. Rai
language : en
Publisher: Springer Nature
Release Date : 2022-04-15
Natural Products From Actinomycetes written by Ravishankar V. Rai and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-15 with Science categories.
This book provides in-depth information about the ecology, diversity and applications of Actinomycetes. The book is divided into two major parts. The first part discusses the diversity, chemical biology and ecology of Actinomycetes. It also covers the discovery of natural products from soil, endophytic and marine-derived Actinomycetes. It includes natural product discovery, chemical biology, new methods for discovering secondary metabolites, structure elucidation and biosynthetic research of natural products. The chapters in this part focus on the effects of biological and chemical elicitation at molecular level on secondary metabolism in Actinomycetes. The second part of the book discusses genomic and synthetic biology approaches in Actinomycetes drug discovery. This part includes chapters focused on the application of metabolic engineering to optimize natural product synthesis and the use of omics data in engineering of regulatory genes. It covers the advanced tools of synthetic biology and metabolic engineering including cluster assembly, CRISPR/Cas9 technologies, and chassis strain development for natural product overproduction in Actinomycetes. It describes the use of bioinformatics tools for reprogramming of biosynthetic pathways through polyketide synthase and non-ribosomal peptide synthetase engineering. These advanced genomic and molecular tools are expected to accelerate the discovery and development of new natural products from Actinomycetes with medicinal and other industrial applications. The book is useful to researchers and students in the field of microbiology, pharmaceutical sciences and drug discovery.
Whole Cell Biocatalysis
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Author : Sudheer D. V. N. Pamidimarri
language : en
Publisher: CRC Press
Release Date : 2024-06-28
Whole Cell Biocatalysis written by Sudheer D. V. N. Pamidimarri and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-28 with Science categories.
Whole-cell biocatalysis is a promising and emerging field of biological science that is mostly based on advancements in biosystems engineering for the production of useful products such as chemicals, fuels, and pharmaceuticals. It is a unique platform that provides an efficient catalytic system at affordable cost and with low maintenance. Recent studies have proven that whole-cell catalysis is very useful in conducting many complex and complicated chemical reactions that could be executed with greater ease and in an eco-friendly manner in ambient conditions with zero/minimal ecological effect. This has made whole-cell biocatalysis very popular and a center of significance in the field of modern biological catalysis. This new volume offers a comprehensive understanding of whole-cell biocatalysis, beginning with an introduction and an overview of relevant tools and techniques. It presents the basic as well as the advanced concepts of whole-cell biocatalysis, thus acting as a complete guide for the reader. It looks at the promising developments that have taken place in the past decade and discusses the application of computational tools, the use of metabolic flux systems, and the role of metabolic networks for the cell system development for whole-cell catalysis. The chapters explore whole-cell biocatalysis for the production of chemicals, of fuels, and for environmental restoration, with case studies and success stories that showcase new developments in the technology. This volume provides a valuable presentation of whole-cell biocatalysis for graduate students, faculty, industry professionals, and others working in biochemistry and bio-systems engineering.
Halophiles
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Author : Dinesh K Maheshwari
language : en
Publisher: Springer
Release Date : 2015-09-16
Halophiles written by Dinesh K Maheshwari and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-09-16 with Science categories.
The world of halophiles is quite diverse and their representatives in three domains of life i.e. archaea, bacteria and eukarya. They are found all over the small subunit rRNA based tree of life and these micro-organisms are adapted to salt concentration up to saturation hence able to grow at >300g/l Nacl concentration. Their metabolic diversity is high as well encompassing oxygenic and anoxygenic phototrophs, aerobic heterotrophs, denitrifiers, sulphate reducers, fermenters and methanogens. The proteins of halophiles are magnificently engineered to function in a milieu containing 2-5M salt that encodes genes represent a valuable repository and resource for reconstruction and visualizing processes of habitat selection and adaptive evolution. Search for new enzymes endowed with novel activities and enhanced stability continues to be desirable purpose for important commercial production of biotechnological significance. These poly extremophiles proved excellent source of enzymes and metabolites possessing inherent ability to function in extreme conditions of high salt, alkaline pH and facilitating catalysis for industrial application in food processing, industrial bioconversion, bioremediation etc. In fact, it has just begun to realize the great potential and true extent of diversity and suitable applications if explored them judiciously. This book highlights current applications and research on halophiles to provide a timely overview. Chapters are written by expert authors from around the world and include topics of varied importance which include their role to play in enzyme production, restoration of soil fertility and plant growth , antimicrobial and biocatalytic potential, biomolecules in nanotechnology and aspects of quorum sensing. The book is divided into three sections, dealing with biodiversity, biotechnology and sustainable exploitation of halophiles. This major new work represents a valuable source of information to all those scientists interested in microorganisms in general and extremophiles in particular with respect to their innovative products and applications.
Novel Enzyme And Whole Cell Biocatalysts
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Author : Anwar Sunna
language : en
Publisher: MDPI
Release Date : 2020-11-04
Novel Enzyme And Whole Cell Biocatalysts written by Anwar Sunna and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-04 with Science categories.
The concept of a circular economy relies on waste reduction, valorization, and recycling. Global trends for “green” synthesis of chemicals have positioned the field of enzyme technology and biocatalysis (multi-enzymes and whole-cells) as an alternative for the synthesis of more social- and environmentally-responsible bio-based chemicals. Recent advances in synthetic biology, computational tools, and metabolic engineering have supported the discovery of new enzymes and the rational design of whole-cell biocatalysts. In this book, we highlight these current advances in the field of biocatalysis, with special emphasis on novel enzymes and whole-cell biocatalysts for applications in several industrial biotechnological applications.
Actinobacteria
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Author : Loganathan Karthik
language : en
Publisher: Springer Nature
Release Date : 2022-01-29
Actinobacteria written by Loganathan Karthik and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-29 with Science categories.
This book summarizes the basics of actinobacteria, from microbiology to synthetic biology. It focuses on diversity, NRPS, sesquiterpenes, lantipeptide, bioinformatics apparatuses, cloning, CRISPR, reverse engineering, FDA supported medications, and marine actinobacteria. It also covers the latest trends in drug discovery from actinobacteria, and introduces several recently developed bioinformatics and synthetic biology tools to explore new antibiotics from actinobacteria. Many natural products such as polyketides, isoprenoids, phenazines, peptides, indolocarbarbazoles, sterols, and others have been isolated and characterized from actinobacteria. Some products are synthesized by the non-ribosomal peptide synthetases (NRPSs), polyketide synthases (PKSs), or other functional genes. Although genome sequencing has uncovered the differing qualities of these chemicals, recognizing new items and their biosynthetic pathways is still under examination. Cryptic metabolic pathways have been explored using molecular techniques or culture-dependent approaches. In recent years, researchers’ primary interest is to identify the specific conditions or agents that wake the cryptic antibiotics. Several bioinformatics and synthetic biology tools were developed to explore new antibiotics from actinobacteria. The book comprises 14 chapters with different aspects of application and utilization of actinomycetes from the microbiology; systems biology, pharmacology of natural products, bioinformatics, actinomycete and its diversity, CRISPR, artificial Intelligence, synthetic biology, metabolic engineering, expressional studies, and biosynthetic gene clusters. The book delivers useful information on actinomyces to researchers, novices in genome designing, specialists, clinicians, policymakers, and professionals.
Rhizosphere Engineering
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Author : Ramesh Chandra Dubey
language : en
Publisher: Academic Press
Release Date : 2022-02-15
Rhizosphere Engineering written by Ramesh Chandra Dubey and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-15 with Technology & Engineering categories.
Rhizosphere Engineering is a guide to applying environmentally sound agronomic practices to improve crop yield while also protecting soil resources. Focusing on the potential and positive impacts of appropriate practices, the book includes the use of beneficial microbes, nanotechnology and metagenomics. Developing and applying techniques that not only enhance yield, but also restore the quality of soil and water using beneficial microbes such as Bacillus, Pseudomonas, vesicular-arbuscular mycorrhiza (VAM) fungi and others are covered, along with new information on utilizing nanotechnology, quorum sensing and other technologies to further advance the science. Designed to fill the gap between research and application, this book is written for advanced students, researchers and those seeking real-world insights for improving agricultural production. - Explores the potential benefits of optimized rhizosphere - Includes metagenomics and their emerging importance - Presents insights into the use of biosurfactants
Recent Advances In Microbial Degradation
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Author : . Inamuddin
language : en
Publisher: Springer Nature
Release Date : 2021-07-07
Recent Advances In Microbial Degradation written by . Inamuddin and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-07 with Science categories.
Microbes play a major role in the degradation of various pollutants. Therefore, microbes find potential application in the area of energy and environmental technology. The book provides in-depth literature on the topics of environmental and industrial importance. It is compiled to explore the application of microbe used in the degradation of aflatoxin, polymers, biomass into fuel, disinfectants, food products, xenobiotic compounds, lipids, steroids, organic pollutants, proteins, oil waste, and wastewater pollutants. This book will be of interest to teachers, researchers, scientists, and capacity builders. Also, the book serves as additional reading material for undergraduate and graduate students of microbiology and environmental sciences. National and international remediation and restoration scientists, policymakers will also find this to be a useful read.
A Focus On Actinobacteria Diversity Distribution And Secondary Metabolites
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Author : Yu-Qin Zhang
language : en
Publisher: Frontiers Media SA
Release Date : 2022-05-27
A Focus On Actinobacteria Diversity Distribution And Secondary Metabolites written by Yu-Qin Zhang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-27 with Science categories.