Can Pathway Based Approaches Overcome The Problems Of Target Based Drug Discovery
DOWNLOAD
Download Can Pathway Based Approaches Overcome The Problems Of Target Based Drug Discovery PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Can Pathway Based Approaches Overcome The Problems Of Target Based Drug Discovery book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Surveying Antimicrobial Resistance Approaches Issues And Challenges To Overcome
DOWNLOAD
Author : Gilberto Igrejas
language : en
Publisher: Frontiers Media SA
Release Date : 2017-03-29
Surveying Antimicrobial Resistance Approaches Issues And Challenges To Overcome written by Gilberto Igrejas and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-29 with categories.
Why Antibiotic Resistance? The use of antibiotics in human and veterinary medicine may have consequences beyond their intended applications. The “One Health” concept recognizes that the health of humans is connected to the health of animals and the environment. Progress in molecular genetics is facilitating the rapid evaluation of the essentiality of these targets on a genomic scale. In 2015, a group of researchers established the International Conference on Antibiotic Resistance (IC2AR).The primary objective of this meeting is to bring together scientists involved in antibiotic resistance prevention and control. The IC2AR conducted its inaugural world congress in January 2015 at Caparica (Portugal). Antimicrobial resistance presents a significant challenge to scientists in the field of infectious diseases. The full knowledge of how antibiotics resistance is evolving and being transmitted between hosts in different ecosystems is taking on great importance. Necessary action includes research to define the scope of the problem including its various sources. This eBook comprises a series of original research and review articles dealing with the epidemiology of resistance in animal and zoonotic pathogens, mobile elements containing resistance genes, the omics of antimicrobial resistance, emerging antimicrobial resistance mechanisms, control of resistant infections, establishing antimicrobial use and resistance surveillance systems, and alternatives strategies to overcome the problem of antimicrobial resistance worldwide. Gilberto Igrejas, José Luis Capelo and Patrícia Poeta Scientific Committee of IC2AR, February 20th, 2017
Chemogenomics In Drug Discovery
DOWNLOAD
Author : Hugo Kubinyi
language : en
Publisher: John Wiley & Sons
Release Date : 2006-03-06
Chemogenomics In Drug Discovery written by Hugo Kubinyi and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-03-06 with Science categories.
Chemogenomics brings together the most powerful concepts in modern chemistry and biology, linking combinatorial chemistry with genomics and proteomics. This first reference devoted to the topic covers all stages of the early drug discovery process, from target selection to compound library and lead design. With the combined expertise of 20 research groups from academia and leading pharmaceutical companies, this is a must-have for every drug developer and medicinal chemist applying the powerful methods of chemogenomics to speed up the drug discovery process.
Discovery And Development Of Drugs For Neglected Diseases Chagas Disease Human African Trypanosomiasis And Leishmaniasis
DOWNLOAD
Author : Gildardo Rivera
language : en
Publisher: Frontiers Media SA
Release Date : 2021-12-20
Discovery And Development Of Drugs For Neglected Diseases Chagas Disease Human African Trypanosomiasis And Leishmaniasis written by Gildardo Rivera and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-20 with Science categories.
Innovative Approaches In Drug Discovery
DOWNLOAD
Author : Bhushan Patwardhan
language : en
Publisher: Academic Press
Release Date : 2016-10-03
Innovative Approaches In Drug Discovery written by Bhushan Patwardhan and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-03 with Medical categories.
Despite considerable technological advances, the pharmaceutical industry is experiencing a severe innovation deficit, especially in the discovery of new drugs. Innovative Approaches in Drug Discovery: Ethnopharmacology, Systems Biology and Holistic Targeting provides a critical review and analysis of health, disease and medicine, and explores possible reasons behind the present crisis in drug discovery. The authors illustrate the benefits of systems biology and pharmacogenomics approaches, and advocate the expansion from disease-centric discovery to person-centric therapeutics involving holistic, multi-target, whole systems approaches. This book lays a path for reigniting pharmaceutical innovation through a disciplined reemergence of pharmacognosy, embracing open innovation models and collaborative, trusted public-private partnerships. With unprecedented advances made in the development of biomedically-relevant tools and technologies, the need is great and the time is now for a renewed commitment towards expanding the repertoire of medicines. By incorporating real-life examples and state-of-the-art reviews, this book provides valuable insights into the discovery and development strategies for professionals, academicians, and students in the pharmaceutical sciences. - Analyzes the reasons behind historical drug failures to provide valuable insights on lessons learned - Uses current scientific research to promote learning from traditional knowledge systems and through the integration of traditional and western medicines - Discusses advances in technologies and systems biology to support the transition from formulation discovery to therapeutic discovery
Overcoming Obstacles In Drug Discovery And Development
DOWNLOAD
Author : Kan He
language : en
Publisher: Elsevier
Release Date : 2023-05-18
Overcoming Obstacles In Drug Discovery And Development written by Kan He and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-18 with Medical categories.
Overcoming Obstacles in Drug Discovery and Development uses real-world case studies to illustrate how critical thinking and problem solving skills are applied in the discovery and development of drugs. It also shows how developing critical thinking to overcome issues plays an essential role in the process. Modern drug discovery and development is a highly complex undertaking that requires scientific and professional expertise to be successful. After the identification of a molecular entity for treating a medical condition, challenges inevitably arise during the subsequent development to understand and characterize the biological profile; feedback from scientists is used to fine-tune the molecular entity to obtain an effective and safe product. In this process, the discovery team may identify unexpected safety issues and new medical disorders for treatment by the molecular entity. Invariably inherent in this complex undertaking are miscues, mistakes, and unexpected problems that can derail development and throw timetables into disarray, potentially leading to failure in the development of a medically useful drug. Addressing critical unexpected problems during development often requires scientists to utilize critical thinking and imaginative problem-solving skills. Overcoming Obstacles in Drug Discovery and Development will be essential to young scientists to help learn the skills to successfully face challenges, learn from mistakes, and further develop critical thinking skills. It will also be beneficial to experienced researchers who can learn from the case studies of successful and unsuccessful drug development. - Provides real-world case studies in drug discovery and the development of drugs - Illustrates the use of critical thinking and problem solving in approaching preclinical and clinical problems in drug discovery and development - Illustrates and analyses examples of successes and failures in drug discovery and development that have not previously been reported
Biochips As Pathways To Drug Discovery
DOWNLOAD
Author : Gary Hardiman
language : en
Publisher: CRC Press
Release Date : 2006-10-19
Biochips As Pathways To Drug Discovery written by Gary Hardiman and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-10-19 with Medical categories.
In the fiercely competitive pharmaceutical marketplace, your organization cannot afford to spend excess dollars developing drugs that will fail to get FDA approval or have profoundly poor characteristics. Biochips as Pathways to Drug Discovery takes a comprehensive look at how the industry faces these challenges, using new technologies such as bioc
Frontiers In The Pharmacological Manipulation Of Intracellular Camp Levels
DOWNLOAD
Author : George S. Baillie
language : en
Publisher: Frontiers Media SA
Release Date : 2016-04-08
Frontiers In The Pharmacological Manipulation Of Intracellular Camp Levels written by George S. Baillie and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-08 with Science (General) categories.
Cyclic adenosine monophosphate (cAMP) is a second messenger of paramount biological importance, involved in the regulation of a significant number of cellular functions through the cAMP-dependent intracellular signal transduction pathways. The aim of this "Frontiers in Pharmacology" Research Topic was to attract contributions that highlight emerging ideas in the cAMP field that: (i) describe its role in cellular function and homeostasis, (ii) present the current approaches to its pharmacological manipulation, and (iii) clarify its central role in the development of more targeted therapeutic approaches toward a spectrum of diseases. The present collection of articles highlights, in a representative (but certainly not exhaustive) way, the research activity and emerging concepts in the field, while it also reveals the therapeutic potential that targeted pharmacological manipulation of intracellular cAMP levels could exert on a number of pathological conditions.
Frontiers In Chemistry Editor S Pick 2022
DOWNLOAD
Author : Frontiers in Chemistry Editorial Office
language : en
Publisher: Frontiers Media SA
Release Date : 2022-09-06
Frontiers In Chemistry Editor S Pick 2022 written by Frontiers in Chemistry Editorial Office and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-06 with Science categories.
We are pleased to introduce the 2022 Frontiers in Chemistry: Editor’s Pick collection, showcasing articles stimulating interest in the field, carefully selected in collaboration with our Field Chief Editor, Prof. Steven Suib, of University of Connecticut. With this ebook we aim to highlight and disseminate important findings across the domains of chemistry research, capturing the multidisciplinary and inclusive approach our journal takes towards advancing the field of chemistry and supporting new technological breakthroughs that help humanity live healthier lives on a healthy planet. 2021 was a year which saw our highest journal impact factor yet, international community growth, and a record-breaking number of articles to choose from. We wish to elevate the contributions made by authors, encourage readership and innovation through our open-access philosophies, and thank our Editorial Board for their continued hard work and collaboration.
Quinone Based Compounds In Drug Discovery
DOWNLOAD
Author : Umar Ali Dar
language : en
Publisher: Elsevier
Release Date : 2024-10-25
Quinone Based Compounds In Drug Discovery written by Umar Ali Dar and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-10-25 with Medical categories.
Quinone-Based Compounds in Drug Discovery: Trends and Applications provides a comprehensive and up-to-date overview of the latest advances in the field of drug discovery using quinone-based materials. The book covers various aspects of quinone-based materials such as their synthesis, characterization, and applications in drug discovery, consolidating current research. It introduces quinones in the pharmacology context and then describes current developments in drugs for key diseases and conditions. Final chapters deal with the regulatory and commercial framework to take quinone-based drugs to the market.This book will benefit a wide range of readers, including researchers, scientists, and graduate students in the field of drug discovery. Chemists and biochemists will also benefit from the contents of this book. - Covers various aspects of quinone-based materials, including their synthesis, characterization, and applications in drug discovery - Includes specific chapters on antibiotic, neuroprotective, anticancer, antioxidant, and cardio protection through the action of quinones - Incorporates information on the regulatory, intellectual property, commercialization, and clinical development of quinone-based drugs
Frontiers In Anti Infective Drug Discovery Volume 8
DOWNLOAD
Author : Atta-ur-Rahman
language : en
Publisher: Bentham Science Publishers
Release Date : 2020-10-05
Frontiers In Anti Infective Drug Discovery Volume 8 written by Atta-ur-Rahman and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-05 with Medical categories.
This book series brings updated reviews to readers interested in advances in the development of anti-infective drug design and discovery. The scope of the book series covers a range of topics including rational drug design and drug discovery, medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. Frontiers in Anti-Infective Drug Discovery is a valuable resource for pharmaceutical scientists and post-graduate students seeking updated and critically important information for developing clinical trials and devising research plans in this field. The eighth volume of this series features 8 chapters that cover methods for antimicrobial drug discovery (with 2 chapters that focus on genomics) as well as updates on drug development against Helicobacter pylori and emerging coronaviruses, among other interesting topics: - Eradication of Helicobacter pylori Infection with Non-Bismuth Quadruple Concomitant Therapy - Drug Discovery Strategies Against Emerging Coronaviruses: A Global Threat - Opportunities Offered By Fragment-Based Drug Design in Antibiotic Development - Phage therapy as a Tool for Control of Foodborne Diseases: Advantages and Limitations - Subtractive Genomics Approaches: Towards Anti-Bacterial Drug Discovery - Recent Advances in the Discovery of Antimicrobials through Metagenomics - Phyto-Nano-Antimicrobials: Synthesis, Characterization, Discovery, and Advances - Aptamers as Anti-infective Agents.