Cyclic Nucleotide Phosphodiesterases In The Central Nervous System
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Cyclic Nucleotide Phosphodiesterases In The Central Nervous System
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Author : Nicholas J. Brandon
language : en
Publisher: John Wiley & Sons
Release Date : 2014-03-07
Cyclic Nucleotide Phosphodiesterases In The Central Nervous System written by Nicholas J. Brandon and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-03-07 with Medical categories.
This book reviews advances in understanding phosphodiesteraseswithin the central nervous system and their therapeuticapplications. A range of expert authors from both academia andindustry describe these, then focus on the areas of greatestscientific and medical interest to provide more detailed coverage.Therapeutic and drug discovery applications are covered fordiseases including Alzheimer's, Parkinson's, schizophrenia,erectile dysfunction, and spinal cord injuries. There is also achapter on drug discovery tools such as in vitro assays and X-raystructures for medicinal chemistry studies.
Phosphodiesterases Cns Functions And Diseases
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Author : Han-Ting Zhang
language : en
Publisher: Springer
Release Date : 2017-09-26
Phosphodiesterases Cns Functions And Diseases written by Han-Ting Zhang and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-26 with Medical categories.
PDEs are a family of enzymes that catalyze the hydrolysis of intracellular cyclic nucleotides. They are implicated in a number of disorders and dysfunctions and PDE inhibitors have already proven to be effective therapies for erectile dysfunction, COPD, and psoriatic arthritis. This family of enzymes also plays a role in diseases and disorders of the CNS such as depression, anxiety, schizophrenia, and Alzheimer's Disease. Unfortunately no effective PDE inhibitors have been developed for the treatment of these diseases. The proposed book will be a comprehensive overview of the current state of basic and translational research on PDE inhibitors written by internationally recognized experts. Authors will also discuss potential PDE subtypes and splice variants in the hopes that this will spur more creative approaches to PDE targeting drugs.
Cyclic Nucleotides In The Nervous System
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Author : John Daly
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Cyclic Nucleotides In The Nervous System written by John Daly and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The elucidation of the cellular and molecular bases underlying the inte grated function of the central nervous system, both in disease and in health, must ultimately come from the combined efforts of scientists from many disciplines, including biology, chemistry, histology, pathology, physiology, pharmacology, and psychology. Communication between scientists from these various disciplines-vital to the advancement of our understanding of the function of the nervous system-has become more and more difficult in recent years. Both increasing specialization and the incredible increases in publications pertinent to brain research in a wide spectrum of journals, in symposium volumes, in monographs, in abstracts, and in reviews contrib ute to the problems of cross-communication and even of communication within a scientific discipline. Research on the significance of cyclic nucleo tides to the function of nervous systems is particularly illustrative of the communication problem. Since the initial publications by Sutherland, Rall, and Butcher in the late fifties and early sixties on high levels of adenylate cyclase, phosphodiesterases, and cyclic AMP in brain, the ensuing litera ture of this field has expanded exponentially. At the present time, from five to ten publications relevant to cyclic nucleotides and the nervous system appear each week. Indeed, these are minimal numbers based mainly on examination of literature titles and key index words. Many articles concerned with some aspect of central function contain, buried within their text, experiments with or related to cyclic nucleotides.
Cyclic Nucleotides In The Nervous System
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Author : George I. Drummond
language : en
Publisher: New York : Raven Press
Release Date : 1984
Cyclic Nucleotides In The Nervous System written by George I. Drummond and has been published by New York : Raven Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1984 with Cyclic nucleotides categories.
Phosphodiesterases
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Author :
language : en
Publisher:
Release Date : 2017
Phosphodiesterases written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with Nervous system categories.
PDEs are a family of enzymes that catalyze the hydrolysis of intracellular cyclic neucleotides. They are implicated in a number of disorders and dysfunctions and PDE inhibitors have already proven to be effective therapies for erectile dysfunction, COPD, and psoriatic arthiritis. This family of enzymes also plays a role in diseases and disorders of the CNS such as depression, anxiety, schizophrenia, and Alzheimer's Disease. Unfortunately no effective PDE inhibitors have been developed for the treatment of these diseases. The proposed book will be a comprehensive overview of the current state of basic and translational research on PDE inhibitors written by internationally recognized experts. Authors will also discuss potential PDE subtypes and splice variants in the hopes that this will spur more creative approaches to PDE targeting drugs.
Cyclic Nucleotide Signaling
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Author : Xiaodong C. Cheng
language : en
Publisher: CRC Press
Release Date : 2015
Cyclic Nucleotide Signaling written by Xiaodong C. Cheng and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Cellular signal transduction categories.
Cgmp Generators Effectors And Therapeutic Implications
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Author : Harald H. H. W. Schmidt
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-12-17
Cgmp Generators Effectors And Therapeutic Implications written by Harald H. H. W. Schmidt and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-12-17 with Science categories.
After the discovery of endogenous NO formation in the late '80s and the 1998 Nobel Prize in Physiology or Medicine, many researchers and physicians again became interested in the NO/sGC interaction and cGMP-dependent signaling. This book is an enthusiastic celebration of cyclic guanosine monophosphate (cGMP) and amply illustrates the importance of this field of science to patients and the way in which the field has evolved. It is exclusively devoted to this exciting and important signaling molecule, addressing all recent advances in understanding guanylate cyclase regulation, NO/sGC interactions, cGMP effector mechanisms and their pathophysiological and pharmacological implications. Particular attention will also be given to clinical applications of the novel cGMP-elevating drugs which are on the horizon, thus spanning the continuum from basic science to clinic.
Cyclic Nucleotide Signaling
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Author : XiaoDong Cheng
language : en
Publisher: CRC Press
Release Date : 2021-03-30
Cyclic Nucleotide Signaling written by XiaoDong Cheng and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-30 with Cellular signal transduction categories.
Showcasing the recent progresses of the field, Cyclic Nucleotide Signaling covers the major tools and methodologies used in various areas of research. The majority of the chapters are protocol oriented, with the goal of providing clear directions for laboratory use. Students and investigators new to the field will find this book particularly informative, as will scientists already actively researching nucleotide signaling.
Cyclic Nucleotide Phosphodiesterases In Health And Disease
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Author : Joseph A. Beavo
language : en
Publisher: CRC Press
Release Date : 2006-12-05
Cyclic Nucleotide Phosphodiesterases In Health And Disease written by Joseph A. Beavo and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-12-05 with Medical categories.
Since the last major compendium dedicated to cyclic nucleotide phosphodiesterases (PDEs) was published over 15 years ago, an enormous amount of progress has occurred in the field. There is great need for a centralized source for key information in this burgeoning and therapeutically important area of medical research. Cyclic Nucleotide Phosph
Cyclic Nucleotides
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Author : J. A. Nathanson
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Cyclic Nucleotides written by J. A. Nathanson and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The purpose of the present volume, the first of two on the pharmacology, biochemistry, and physiology of cyclic nucleotides, is to provide a comprehensive and up-to-date anthology on the nature and role of these important chemical regulators. Each of the chapters is the work of internationally known researchers who present a lucid and detailed review of their subject and not merely a single laboratory's viewpoint. The chapters emphasize critical assessments of the field rather than mere listings of experimental findings. By so doing, the contributors present the role of cyclic nucleotides in relationship to other intracellular regulators. Each chapter begins with a detailed summary to allow the reader to obtain a rapid overview of subsequent material. In addition, there are extensive bibliographies and a detailed subject index. Wherever pertinent, the chapters contain sections on drug mechanisms, physiological relevance, and disease processes. The Volume is divided into two sections, each beginning with an overview written by Professors T. W. RALL and P. GREENGARD, respectively. The first section focuses on the detailed pharmacology and chemistry of cyclic nucleotides, including their formation, degradation, measurement, and interaction with various modulatory agents, such as receptors and calcium. The second section is concerned with the biochemistry of protein phosphorylation, a process which appears to be one of the most important mechanisms for the intracellular expression of cyclic nucleotide action in eukaryotic cells.