Drugs For The Treatment Of Parkinson S Disease
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Drugs For The Treatment Of Parkinson S Disease
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Author : Donald B. Calne
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Drugs For The Treatment Of Parkinson S Disease written by Donald B. Calne and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
With contributions by numerous experts
Drugs For The Treatment Of Parkinson S Disease
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Author : Donald B. Calne
language : en
Publisher: Springer
Release Date : 1989-06-26
Drugs For The Treatment Of Parkinson S Disease written by Donald B. Calne and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989-06-26 with Medical categories.
With contributions by numerous experts
The New Parkinson S Disease Treatment Book
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Author : J. Eric Ahlskog, ,
language : en
Publisher: Oxford University Press, USA
Release Date : 2015
The New Parkinson S Disease Treatment Book written by J. Eric Ahlskog, , and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Health & Fitness categories.
As many as one million Americans, including Michael J. Fox and Muhammad Ali, suffer from Parkinson's Disease. Now, a leader in the fight against Parkinson's, Dr. J. Eric Ahlskog of the Mayo Clinic, has revised and updated his definitive guide for patients and their families. Dr. Ahlskog offers a crystal-clear, nuts-and-bolts approach to the treatment of PD, distilled from more than 30 years of experience as a clinician and researcher. His goal is to educate patients so that they can better team with their doctors to do battle with the disease, streamlining the decision-making process and enhancing their treatment. To do this, Dr. Ahlskog offers a gold mine of information: How do I know if I have PD? What kinds of tests can I take? What medications slow the progress of the disease? What if medications don't help my tremor? What kinds of movement problems may develop later? How can I cope with insomnia and daytime sleepiness, dizziness and depression, memory problems, paranoia, and delusions? Indeed, the book covers virtually every topic related to Parkinson's, from sexual impotence and skin rashes, to the role of nutrition, exercise, and physical therapy. In addition, Dr. Ahlskog discusses brain surgery (though he urges that patients only consider this as a last resort) and such experimental therapies as stem cell transplantation and gene therapy. There are also lists of support and advocacy groups and Web sites that focus on Parkinson's. The ultimate guide to symptoms and treatment, this thoroughly updated Second Edition is the first place patients should turn for reliable, easy-to-grasp information on Parkinson's disease.
Principles Of Treatment In Parkinson S Disease
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Author : Anthony Henry Vernon Schapira
language : en
Publisher: Elsevier Health Sciences
Release Date : 2005-01-01
Principles Of Treatment In Parkinson S Disease written by Anthony Henry Vernon Schapira and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-01-01 with Medical categories.
This succinct volume offers an up-to-date review and comparison of the treatment options available for Parkinson's disease, and provides evidence-based recommendations on appropriate treatments for specific cases. Offers expert guidance on the best treatment options from authorities in the field. Delivers expert guidance on drug therapies, physical therapies, and surgical interventions. Discusses conditions such as depression ? hallucinations ? cognition ? and sleep disorders. Explores neuroprotection in Parkinson's disease. Provides insights into future therapies.
Fast Facts Treatment Optimization Of Motor Fluctuations In Parkinson S Disease
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Author : Fabrizio Stocchi
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2019-06-07
Fast Facts Treatment Optimization Of Motor Fluctuations In Parkinson S Disease written by Fabrizio Stocchi and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-07 with Medical categories.
Although dopaminergic medication is the most effective treatment for patients with Parkinson’s disease (PD), its long-term use is associated with debilitating motor fluctuations. Patients may not spontaneously seek assistance when fluctuations develop, so strategies need to be put in place to identify and alleviate motor dysfunction. This concise resource will increase readers’ awareness of: • the different types of motor fluctuation, why they occur and how to recognize them • the drugs that can be added to levodopa to reduce fluctuations • advanced and emerging therapies that will help to improve outcomes. No two patients with PD are alike in their disease progression or response to treatment. This 'Fast Facts' title provides the information healthcare professionals need to provide effective individualized care that will improve their patients’ quality of life.
Levodopa Pharmacokinetics From Stomach To Brain
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Author : Maria Nord
language : sv
Publisher: Linköping University Electronic Press
Release Date : 2019-01-07
Levodopa Pharmacokinetics From Stomach To Brain written by Maria Nord and has been published by Linköping University Electronic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-07 with categories.
Parkinson’s disease (PD) is one of the most common neurodegenerative disorders and it is caused by a loss of dopamine (DA) producing neurons in the basal ganglia in the brain. The PD patient suffers from motor symptoms such as tremor, bradykinesia and rigidity and treatment with levodopa (LD), the precursor of DA, has positive effects on these symptoms. Several factors affect the availability of orally given LD. Gastric emptying (GE) is one factor and it has been shown to be delayed in PD patients resulting in impaired levodopa uptake. Different enzymes metabolize LD on its way from the gut to the brain resulting in less LD available in the brain and more side effects from the metabolites. By adding dopa decarboxylase inhibitors (carbidopa or benserazide) or COMT-inhibitors (e.g. entacapone) the bioavailability of LD increases significantly and more LD can pass the blood-brain-barrier and be converted to DA in the brain. It has been considered of importance to avoid high levodopa peaks in the brain because this seems to induce changes in postsynaptic dopaminergic neurons causing disabling motor complications in PD patients. More continuously given LD, e.g. duodenal or intravenous (IV) infusions, has been shown to improve these motor complications. Deep brain stimulation of the subthalamic nucleus (STN DBS) has also been proven to improve motor complications and to make it possible to reduce the LD dosage in PD patients. In this doctoral thesis the main purpose is to study the pharmacokinetics of LD in patients with PD and motor complications; in blood and subcutaneous tissue and study the effect of GE and PD stage on LD uptake and the effect of continuously given LD (CDS) on LD uptake and GE; in blood and cerebrospinal fluid (CSF) when adding the peripheral enzyme inhibitors entacapone and carbidopa to LD infusion IV; in brain during STN DBSand during oral or IV LD treatment. To conclude, LD uptake is more favorable in PD patients with less severe disease and GE is delayed in PD patients. No obvious relation between LD uptake and GE or between GE and PD stage is seen and CDS decreases the LD levels. Entacapone increases the maximal concentration of LD in blood and CSF. This is more evident with additional carbidopa and important to consider in avoiding high LD peaks in brain during PD treatment. LD in brain increases during both oral and IV LD treatment and the DA levels follows LD well indicating that PD patients still have capacity to metabolize LD to DA despite probable pronounced nigral degeneration. STN DBS seems to increase putaminal DA levels and together with IV LD treatment also increases LD in brain possibly explaining why it is possible to decrease LD medication after STN DBS surgery. Parkinsons sjukdom (PS) är en av de vanligaste s.k. neurodegenerativasjukdomarna och orsakas av förlust av dopamin(DA)producerande nervceller i hjärnan. Detta orsakar motoriska symptom såsom skakningar, stelhet och förlångsammade rörelser. Levodopa (LD) är ett ämne, som kan omvandlas till DA i hjärnan och ge symptomlindring och det är oftast förstahandsval vid behandling av patienter med PS. Flera faktorer påverkar tillgängligheten av LD, bl.a. den hastighet som magsäcken tömmer sig med och denna verkar förlångsammad hos personer med PS vilket ger sämre tillgänglighet av LD i blodet och därmed i hjärnan. LD bryts även ner i hög grad av olika enzym ute i kroppen vilket leder till mindre mängd LD som hamnar i hjärnan och till fler nedbrytningsprodukter som orsakar biverkningar. Tillägg av enzymhämmare leder till ökad mängd LD som kan nå hjärnan och omvandlas till DA. Det anses viktigt att undvika höga toppar av LD i hjärnan då dessa verkar bidra till utvecklandet av besvärliga motoriska komplikationer hos patienter med PS. Om LD ges mer kontinuerligt, exempelvis som en kontinuerlig infusion in i tarmen eller i blodet, så minskar dessa motoriska komplikationer. Inopererande av stimulatorer i vissa delar av hjärnan (DBS) har också visat sig minska dessa motoriska komplikationer och även resultera i att man kan minska LD-dosen. Huvudsyftet med den här avhandlingen är att studera LD hos patienter med PS; i blod och fettvävnad då LD ges i tablettform och se om det finns något samband med LD-upptag och hastigheten på magsäckstömningen (MT) och om kontinuerligt given LD påverkar LD-upptaget eller MT; i blod och i ryggmärgsvätska då enzymhämmarna entakapon och karbidopa tillsätts LD; i hjärna vid behandling med DBS och då LD ges både som tablett och som infusion i blodet. Sammanfattningsvis kan vi se att LD-upptaget är mer gynnsamt hos patienter med PS i tidigare skede av sjukdomens komplikationsfas. MT är förlångsammad hos patienter med PS och det är inget tydligt samband mellan LD-upptag och MT eller mellan MT och sjukdomsgrad. Kontinuerligt given LD minskar LDnivåerna. Enzymhämmaren entakapon ökar den maximala koncentrationen av LD i blod och ryggmärgsvätska och effekten är mer tydlig vid tillägg av karbidopa vilket är viktigt att ta i beaktande vid behandling av PS för att undvika höga toppar av LD i hjärnan. LD ökar i hjärnan då man behandlar med LD i tablettform och som infusion i blodet och DA-nivåerna i hjärnan följer LD väl vilket visar på att patienter med PS fortfarande kan omvandla LD till DA trots trolig uttalad brist av de DA-producerande nervcellerna i hjärnan. DBS verkar öka DA i vissa områden i hjärnan och tillsammans med LD-infusion i blodet verkar det även öka LD i hjärnan och det kan förklara varför man kan sänka LDdosen efter DBS-operation.
Parkinson S Disease
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Author : Dr. Stewart A. Factor, DO
language : en
Publisher: Demos Medical Publishing
Release Date : 2007-12-15
Parkinson S Disease written by Dr. Stewart A. Factor, DO and has been published by Demos Medical Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-12-15 with Medical categories.
Parkinson's disease (PD) is the second most common neurodegenerative disease in the world. Still the only major text on the subject, the completely revised and updated second edition of Parkinson's Disease: Diagnosis and Clinical Management comes at a time when specialists have made important advances in our understanding of the etiology, pathogenesis, investigation, and management of Parkinson's disease. The book includes 23 completely new chapters, and has updated information on: Genetics Pathology Biomarkers Pathogenesis Impulse control disorders in Parkinson's disease Updated outcome measures Complementary and alternative medicine for the treatment of Parkinson's disease Together the chapters form a comprehensive review of the many issues facing PD physicians today. Lucid and easily readable from beginning to end, each chapter may also stand on its own as a scholarly review of the individual subject. Each one is concisely written and heavily referenced for this purpose. The second edition of Parkinson's Disease: Diagnosis and Clinical Management provides a state-of-the-art review of where we've been, where we are now, and where we are going in treating this disease.
Diagnosis And Management Of Parkinson S Disease
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Author : Cheryl H. Waters
language : en
Publisher: Professional Communications
Release Date : 2008-11
Diagnosis And Management Of Parkinson S Disease written by Cheryl H. Waters and has been published by Professional Communications this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-11 with Medical categories.
Provides the clinician with the concepts involved in effective management of Parkinson's disease. The diagnosis of PD is reviewed, as well as differential diagnosis. Pharmacologic management is the main focus of the book with detailed information on the efficacy of available drug therapies. Management of complications of PD and their therapy and surgical treatment options are reviewed.
Non Motor Symptoms Of Parkinson S Disease
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Author : K. Ray Chaudhuri
language : en
Publisher: Oxford University Press, USA
Release Date : 2014
Non Motor Symptoms Of Parkinson S Disease written by K. Ray Chaudhuri and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with Medical categories.
Patients with Parkinson's disease (PD) are known to suffer from motor symptoms of the disease, but they also experience non-motor symptoms (NMS) that are often present before diagnosis or that inevitably emerge with disease progression. The motor symptoms of Parkinson's disease have been extensively researched, and effective clinical tools for their assessment and treatment have been developed and are readily available. In contrast, researchers have only recently begun to focus on the NMS of Parkinson's Disease, which are poorly recognized and inadequately treated by clinicians. The NMS of PD have a significant impact on patient quality of life and mortality and include neuropsychiatric, sleep-related, autonomic, gastrointestinal, and sensory symptoms. While some NMS can be improved with currently available treatments, others may be more refractory and will require research into novel (non-dopaminergic) drug therapies for the future. Edited by members of the UK Parkinson's Disease Non-Motor Group (PD-NMG) and with contributions from international experts, this new edition summarizes the current understanding of NMS symptoms in Parkinson's disease and points the way towards future research.
Ldn For Parkinson S Disease
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Author : Robert Rodgers, PhD
language : en
Publisher: Parkinsons Recovery
Release Date : 2014-02-10
Ldn For Parkinson S Disease written by Robert Rodgers, PhD and has been published by Parkinsons Recovery this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-02-10 with Health & Fitness categories.
LDN (Low Dose Naltrexone) is a proven-safe (by the FDA in 50mg doses!) off-label prescription drug which has gained a great deal of attention over the past few months due to its remarkable disease modifying effects of controlling and reversing symptoms of Parkinson's Disease. Lexie is one person who has experienced a reversal of most of her Parkinsons Disease symptoms over the past 5 years. She was officially diagnosed with Parkinsons disease in 2008 (although her non-motor symptoms began 20 years earlier). In this question and answer format with Robert Rodgers, PhD from Parkinsons Recovery, Lexie offers detailed information about her experience with taking LDN. She has been able to titrate off her daily use of traditional PD medications, while controlling and reversing most of her own PD symptoms, thanks to LDN. Many doctors are not familiar with LDN as a treatment for Parkinson's symptoms. It is a prescription medication, so a prescription from a doctor is necessary. Lexie offers suggestions about how to discuss a request for a LDN prescription from your doctor and offers specific suggestions about where to get LDN once a prescription is in hand. This interview was originally published in Pioneers of Recovery, a series of stories by people who succeeded in reversing their Parkinson's symptoms using one modality or another. Lexie's story of recovery centers on the use of LDN which has been so beneficial to her own recovery from Parkinsons Disease.