Exploring Spike Timing Dependent Plasticity

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Spike Timing Dependent Plasticity

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Author : Henry Markram
language : en
Publisher: Frontiers E-books
Release Date :

Spike Timing Dependent Plasticity written by Henry Markram and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.

Hebb's postulate provided a crucial framework to understand synaptic alterations underlying learning and memory. Hebb's theory proposed that neurons that fire together, also wire together, which provided the logical framework for the strengthening of synapses. Weakening of synapses was however addressed by "not being strengthened", and it was only later that the active decrease of synaptic strength was introduced through the discovery of long-term depression caused by low frequency stimulation of the presynaptic neuron. In 1994, it was found that the precise relative timing of pre and postynaptic spikes determined not only the magnitude, but also the direction of synaptic alterations when two neurons are active together. Neurons that fire together may therefore not necessarily wire together if the precise timing of the spikes involved are not tighly correlated. In the subsequent 15 years, Spike Timing Dependent Plasticity (STDP) has been found in multiple brain brain regions and in many different species. The size and shape of the time windows in which positive and negative changes can be made vary for different brain regions, but the core principle of spike timing dependent changes remain. A large number of theoretical studies have also been conducted during this period that explore the computational function of this driving principle and STDP algorithms have become the main learning algorithm when modeling neural networks. This Research Topic will bring together all the key experimental and theoretical research on STDP.

Neuroscience Exploring The Brain

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Author : Mark Bear
language : en
Publisher: Jones & Bartlett Learning
Release Date : 2025-07-11

Neuroscience Exploring The Brain written by Mark Bear and has been published by Jones & Bartlett Learning this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-07-11 with Medical categories.

Neuroscience: Exploring the Brain, Fifth Edition delivers a comprehensive, student-friendly introduction to the structure and function of the nervous system. Updated to reflect the latest research, this edition blends foundational science with engaging, real-world applications, making it ideal for introductory neuroscience or biological psychology courses across a wide range of departments, from psychology to allied health. With an approachable tone, expanded illustrations, and thoughtful pedagogy, this trusted text makes complex topics more accessible, even for students without a strong background in science.The Fifth Edition is distinguished by its clarity, adaptability, and practical relevance. It engages students through clear explanations, relatable scientific stories, and real-world connections, making complex material easier to grasp. Instructors also benefit from features that streamline course planning and support a variety of teaching and learning styles. Updated Content and Illustrations: Chapters reflect new neuroscience research, with improved visuals for improved clarity and engagement.Neuroscience and Medicine Boxes: Highlight the significance of material and connect concepts to real-world medical applications.Path of Discovery Boxes: Firsthand accounts from field experts and Nobel laureates that outline key discoveries and their broader impact.Brain Byte and Brain Food Boxes: Curiosity-sparking sidebars that offer fun facts or deeper dives into select topics to keep students engaged.Student-Focused Pedagogy: Each chapter includes learning objectives, review questions, and a glossary to reinforce understanding.Instructor Resources: Lecture slides, test questions, and chapter outlines that save instructors time and support effective course delivery. © 2026 | 975 pages

Neurorobotics Explores Machine Learning

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Author : Fei Chen
language : en
Publisher: Frontiers Media SA
Release Date : 2023-01-20

Neurorobotics Explores Machine Learning written by Fei Chen and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-20 with Science categories.

Exploring Spike Timing Dependent Plasticity

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Author : Rishidev Chaudhuri
language : en
Publisher:
Release Date : 2005

Exploring Spike Timing Dependent Plasticity written by Rishidev Chaudhuri and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Fokker-Planck equation categories.

Discovering The Human Connectome

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Author : Olaf Sporns
language : en
Publisher: MIT Press
Release Date : 2012-09-07

Discovering The Human Connectome written by Olaf Sporns and has been published by MIT Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-09-07 with Medical categories.

A pioneer in the field outlines new empirical and computational approaches to mapping the neural connections of the human brain. Crucial to understanding how the brain works is connectivity, and the centerpiece of brain connectivity is the connectome, a comprehensive description of how neurons and brain regions are connected. In this book, Olaf Sporns surveys current efforts to chart these connections—to map the human connectome. He argues that the nascent field of connectomics has already begun to influence the way many neuroscientists collect, analyze, and think about their data. Moreover, the idea of mapping the connections of the human brain in their entirety has captured the imaginations of researchers across several disciplines including human cognition, brain and mental disorders, and complex systems and networks. Discovering the Human Connectome offers the first comprehensive overview of current empirical and computational approaches in this rapidly developing field.

Fundamentals Of Computational Neuroscience

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Author : Thomas Trappenberg
language : en
Publisher: Oxford University Press (UK)
Release Date : 2010

Fundamentals Of Computational Neuroscience written by Thomas Trappenberg and has been published by Oxford University Press (UK) this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Mathematics categories.

The new edition of Fundamentals of Computational Neuroscience build on the success and strengths of the first edition. It introduces the theoretical foundations of neuroscience with a focus on the nature of information processing in the brain. The book covers the introduction and motivation of simplified models of neurons that are suitable for exploring information processing in large brain-like networks. Additionally, it introduces several fundamental networkarchitectures and discusses their relevance for information processing in the brain, giving some examples of models of higher-order cognitive functions to demonstrate the advanced insight that can begained with such studies.

Emergent Neural Computation From The Interaction Of Different Forms Of Plasticity

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Author : Cristina Savin
language : en
Publisher: Frontiers Media SA
Release Date : 2016-03-22

Emergent Neural Computation From The Interaction Of Different Forms Of Plasticity written by Cristina Savin and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-03-22 with Computational neuroscience categories.

From the propagation of neural activity through synapses, to the integration of signals in the dendritic arbor, and the processes determining action potential generation, virtually all aspects of neural processing are plastic. This plasticity underlies the remarkable versatility and robustness of cortical circuits: it enables the brain to learn regularities in its sensory inputs, to remember the past, and to recover function after injury. While much of the research into learning and memory has focused on forms of Hebbian plasticity at excitatory synapses (LTD/LTP, STDP), several other plasticity mechanisms have been characterized experimentally, including the plasticity of inhibitory circuits (Kullmann, 2012), synaptic scaling (Turrigiano, 2011) and intrinsic plasticity (Zhang and Linden, 2003). However, our current understanding of the computational roles of these plasticity mechanisms remains rudimentary at best. While traditionally they are assumed to serve a homeostatic purpose, counterbalancing the destabilizing effects of Hebbian learning, recent work suggests that they can have a profound impact on circuit function (Savin 2010, Vogels 2011, Keck 2012). Hence, theoretical investigation into the functional implications of these mechanisms may shed new light on the computational principles at work in neural circuits. This Research Topic of Frontiers in Computational Neuroscience aims to bring together recent advances in theoretical modeling of different plasticity mechanisms and of their contributions to circuit function. Topics of interest include the computational roles of plasticity of inhibitory circuitry, metaplasticity, synaptic scaling, intrinsic plasticity, plasticity within the dendritic arbor and in particular studies on the interplay between homeostatic and Hebbian plasticity, and their joint contribution to network function.

Fundamentals Of Computational Neuroscience

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Author : Thomas P. Trappenberg
language : en
Publisher: Oxford University Press
Release Date : 2023

Fundamentals Of Computational Neuroscience written by Thomas P. Trappenberg and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023 with Computers categories.

The new edition of Fundamentals of Computational Neuroscience build on the success and strengths of the previous editions. Completely redesigned and revised, it introduces the theoretical foundations of neuroscience with a focus on the nature of information processing in the brain.

Hippocampal Microcircuits

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Author : Vassilis Cutsuridis
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-02-01

Hippocampal Microcircuits written by Vassilis Cutsuridis and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-02-01 with Medical categories.

Rich in detail, Hippocampal Microcircuits: A Computational Modeler’s Resource Book provides succinct and focused reviews of experimental results. It is an unparalleled resource of data and methodology that will be invaluable to anyone wishing to develop computational models of the microcircuits of the hippocampus. The editors have divided the material into two thematic areas. Covering the subject’s experimental background, leading neuroscientists discuss the morphological, physiological and molecular characteristics as well as the connectivity and synaptic properties of the various cell types found in the hippocampus. Here, ensemble activity, related to behavior, on the part of morphologically identified neurons in anesthetized and freely moving animals, lead to insights into the functions of hippocampal areas. In the second section, on computational analysis, computational neuroscientists present models of hippocampal microcircuits at various levels of detail, including single-cell and network levels. A full chapter is devoted to the single-neuron and network simulation environments currently used by computational neuroscientists in developing their models. In addition to the above, the chapters also identify outstanding questions and areas in need of further clarification that will guide future research by computational neuroscientists.

Advances In Computational Neuroscience

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Author : Thomas Nowotny
language : en
Publisher: Frontiers Media SA
Release Date : 2022-02-23

Advances In Computational Neuroscience written by Thomas Nowotny and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-23 with Science categories.