Genotoxicity
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Genotoxicity
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Author : Marcelo Larramendy
language : en
Publisher: BoD – Books on Demand
Release Date : 2018-07-11
Genotoxicity written by Marcelo Larramendy and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-11 with Medical categories.
This book is designed to provide an overview of the different genotoxicants and their effects on living organisms, including humans. The contributions made by the specialists in this field of research are gratefully acknowledged. We hope that the information presented in this book will meet the expectations and needs of all those interested in the different aspects of the genotoxicity field. The publication of this book is of great importance to those scientists, pharmacologists, physicians and veterinarians, as well as engineers, teachers, graduate students and administrators of environmental programmes, who make use of these investigations to understand both the basic and applied genotoxic aspects of known and new xenobiotics, and to guide them in their future investigations.
Insight On Genotoxicity
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Author : Shiv Shankar Shukla
language : en
Publisher: CRC Press
Release Date : 2020-10-14
Insight On Genotoxicity written by Shiv Shankar Shukla and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-14 with Science categories.
Genetic toxicology is considered to be an important assessment tool as there is genetic impact of artificial chemicals. Insight on Genotoxicity discusses testing, mechanism, prediction, and bioindicator of genotoxicity taking into consideration recent advances in nano-engineered particles. Corollary of DNA dent is also discussed in detail taking into consideration the impact of ICH guidelines on genotoxicity testing, which is important for drug discovery innovation and development. Perspective review of genotoxicity evaluation in phytopharmaceuticals has been mentioned along with the prevention of genotoxicity in brief viewpoint. Salient Features Presents methods, standard protocols, and guidelines for genotoxicity testing Examines the impact of ICH Guidelines on genetic toxicity testing which is a regulatory requirement for drug discovery and development Defines appropriate strategies about advances in in vivo genotoxicity testing which have been listed along with progress and prospects Discusses advancement in the high-throughput approaches for genotoxicity testing Details computational prediction of genotoxicity with consideration of mutagenicity, chromosomal damage caused and strategies for computational prediction in drug development
Genotoxicity And Mutagenicity
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Author : Sonia Soloneski
language : en
Publisher: BoD – Books on Demand
Release Date : 2021
Genotoxicity And Mutagenicity written by Sonia Soloneski and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with categories.
This edited book, "Genotoxicity and Mutagenicity - Mechanisms and Test Methods", aims to present the latest developments from different fields, highlighting the detrimental influence that mutagenic and genotoxic agents inflict on DNA and how antimutagenic and anticarcinogenic modulators are able to reduce the negative impact of such toxic agents on living species.
Genotoxicity
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Author : Andor Kocsis
language : en
Publisher: Nova Science Publishers
Release Date : 2009
Genotoxicity written by Andor Kocsis and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with DNA adducts categories.
This book looks at genotoxicity which is a deleterious action on cell genetic material affecting its integrity. Genotoxic substances are known to be potentially mutagenic or carcinogenic, specifically those capable of causing genetic mutation and of contributing to the development of tumours. In humans, DNA damage or genotoxicity may be caused by exposure to outside agents like radiation, pesticides, combustion of hydrocarbon products as well as antineoplastic drugs. DNA damage could also come from inside of the body, determined mainly by excessive free radical production generated by some disease process. The importance then, is to identify the genotoxity and try to protect the body, which may be as simple as removing the source of exposure or providing protection against such agents. This new important book gathers the latest research from around the globe in this dynamic field of study.
Genotoxicity Advances In Research And Applications
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Author : Chibuisi Gideon Alimba
language : en
Publisher:
Release Date : 2023-12-14
Genotoxicity Advances In Research And Applications written by Chibuisi Gideon Alimba and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-12-14 with categories.
The Induction of genotoxic effects on prokaryote and eukaryotes' genetic materials is a crucial step in the initiation of cancer and genotoxic disease syndromes. Cancer risk assessment and other genetic disease syndromes required the application of genotoxicity biomarkers. Several genotoxicity assays have been developed and applied to assess the potentials for xenobiotics to induce DNA damage. In the edited book: "Genotoxicity: Advances in Research and Applications", the applications of genotoxicity biomarkers were used to monitor heat-induced genotoxic agents in the reproductive system. Genotoxicity assays were applied in the assessment of genomic instability induced by environmental xenobiotics (including cement dust and pesticides) that humans and biota are exposed to in occupational settings and the environment. Advances in the application of genotoxicity include the use of in silico techniques to predict the genotoxic potentials of xenobiotics including pharmaceuticals which are increasingly being accumulated in the environment. Renounced authors in the field of genotoxicity have made comprehensive contributions to achieve the quality of the book contents.
Genotoxicity Assessment
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Author : Alok Dhawan
language : en
Publisher: Humana
Release Date : 2020-09-02
Genotoxicity Assessment written by Alok Dhawan and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-02 with Medical categories.
This current edition explores new tests for genotoxicity testing, along with other well-known techniques. This will further help in our understanding of the genotoxic effects of chemicals. The book has different sections dealing with various assays for gene mutation, chromosomal abnormalities, primary DNA damage, etc. It also delves into plant models, animals and their alternates, as well as in silico approaches for genetic toxicology. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Genotoxicity Assessment: Methods and Protocols, Second Edition serves as a highly useful and ready resource for research students and scientists working in regulatory toxicology as well as biomedical, biochemical, and pharmaceutical sciences.
Genotoxicity And Carcinogenicity Testing Of Pharmaceuticals
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Author : Michael J. Graziano
language : en
Publisher: Springer
Release Date : 2015-11-02
Genotoxicity And Carcinogenicity Testing Of Pharmaceuticals written by Michael J. Graziano and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-11-02 with Medical categories.
This book provides an overview of the nonclinical testing strategies that are used to asses and de-risk the genotoxicity and carcinogenicity properties of human pharmaceuticals. It includes a review of relevant ICH guidelines, numerous case studies where follow-up studies were conducted to further investigate positive findings, and practical considerations for the use of alternative and emerging tests. With contributions from recognized experts in the pharmaceutical industry and health authorities, this volume presents a balanced view on the interpretation and application of genotoxicity and carcinogenicity regulatory guidances. Genotoxicity and Carcinogenicity Testing of Pharmaceuticals is a valuable resource for scientists, regulators, and consultants that are engaged in the conduct, reporting, and review of nonclinical studies. This book will also help academicians better understand and appreciate the complexity of the regulations and breadth of toxicology research that are necessary to support the development and marketing of new drugs.
Induced Genotoxicity And Oxidative Stress In Plants
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Author : Zeba Khan
language : en
Publisher: Springer Nature
Release Date : 2021-08-03
Induced Genotoxicity And Oxidative Stress In Plants written by Zeba Khan and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-03 with Science categories.
This book focuses on the effects of genotoxic agents causing oxidative stress in plants. The book explores different kind of chemicals which induces genotoxicity, their mechanism of action and effects on plant health. Impacts at the physiological and molecular levels are discussed. The book is of interest to teachers, researchers and plant scientists. Also the book serves as additional reading material for undergraduate and graduate students of agriculture, forestry, ecology, soil science, and environmental sciences. National and international agricultural scientists will also find this to be a useful read.
From Basic Research To New Tools And Challenges For The Genotoxicity Testing Of Nanomaterials
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Author : Valérie Fessard
language : en
Publisher: MDPI
Release Date : 2021-03-24
From Basic Research To New Tools And Challenges For The Genotoxicity Testing Of Nanomaterials written by Valérie Fessard and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-24 with Medical categories.
This Special Issue presents studies on the genotoxicity of nanomaterials. Although nanomaterials provide multiple benefits in a wide range of applications, challenges remain in addressing strong concerns about their risks to the environment and human health. As a result of inconsistencies among published results and diverging conclusions, the understanding of nanomaterial exposure and toxicity remains unclear. Determining whether these materials cause DNA damage—the first step in carcinogenesis—must be a priority in testing. In this book, readers will find recent publications on the genotoxic response to a broad range of nanomaterials, the impact of physico-chemical characteristics, safe-by-design and new developed tools.
Genotoxicity And Dna Repair
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Author : L. María Sierra
language : en
Publisher: Humana Press
Release Date : 2014-08-22
Genotoxicity And Dna Repair written by L. María Sierra and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-08-22 with Medical categories.
Genotoxicity and DNA Repair: A Practical Approach provides a key reference for determining how to analyze the genotoxic activity of molecules or materials and, at the same time, serves as a useful tool for researchers in the Environmental Mutagenesis and DNA Repair fields. Focused on genotoxicity assays recommended by the “OECD guidelines for the testing of chemicals”, this volume also covers other useful assays, such as some gene mutation assays, the comet assay in different species and applications, and the SMART assays of Drosophila. For all the assays, the book presents brief theoretical introductions to the topics and updated standard and modified step-by-step protocols to perform them. Special emphasis is placed on the analysis of nanoparticles, including an integrative approach analysis. The DNA Repair section includes several assays that provide information on repair activity in vitro and in vivo, as well as recent applications to study DNA repair in humans, cell cultures, and animal models. As a volume in the Methods in Pharmacology and Toxicology series, the chapters contain the kind of detail and key implementation advice that ensures reproducible results in the lab. Authoritative and invaluable, Genotoxicity and DNA Repair: A Practical Approach aims to aid scientists in their pursuit of forwarding this vital field of study.