Iarc Scientific Publications
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Tumour Site Concordance And Mechanisms Of Carcinogenesis
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Author : Robert A. Baan
language : en
Publisher: International Agency for Research on Cancer
Release Date : 2019-05-22
Tumour Site Concordance And Mechanisms Of Carcinogenesis written by Robert A. Baan and has been published by International Agency for Research on Cancer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-22 with Medical categories.
This Scientific Publication reviews the information on cancer sites and mechanistic events for the more than 100 agents classified in Group 1 (carcinogenic to humans) by the IARC Monographs Program. This category of agents is diverse and includes chemicals and chemical mixtures; occupations; metals, dusts, and fibres; radiation; viruses and other biological agents; personal habits; and pharmaceuticals. For the Group 1 agents, there were cross-cutting questions about the relevance to humans of certain cancer sites or mechanistic pathways in animals. This publication is based on a systematic identification and comparison of the cancer sites observed in humans and those observed in experimental animals, and a compilation of mechanistic events for agents known to cause cancer in humans. Relevant information was analyzed on all the agents classified in Group 1 in Monographs up to and including Volume 109, most of which are reviewed in Volume 100A-F. A database of tumor sites seen in humans and animals was used to examine the degree of concordance by use of an anatomically based tumor classification scheme. The analysis of mechanistic aspects of the IARC Group 1 agents focused on 10 key characteristics of human carcinogens developed during the course of this work. Genotoxicity was the most prevalent mechanistic characteristic, consistent with the process of carcinogenesis necessarily involving genomic changes. The IARC concordance database represents a useful source of information for comparing animal and human data with respect to the tumors caused in different species. The results of the mechanistic analysis can provide a basis for future efforts to categorize mechanistic data for carcinogens through a systematic review process. These reviews and analyses were discussed during a two-part Workshop on Tumour Site Concordance and Mechanisms of Carcinogenesis convened by IARC. This Scientific Publication is the report of that Workshop and of subsequent work by the participants, both individually and collectively. This publication also presents a statement of consensus among the Workshop participants, which summarizes the main findings and their implications for human cancer risk assessment.
Cancer Registration
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Author : Ole Møller Jensen
language : en
Publisher: IARC
Release Date : 1991
Cancer Registration written by Ole Møller Jensen and has been published by IARC this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Medical categories.
Data obtained by population based cancer registries have a pivotal role in cancer control. Now also available in Spanish and French, this volume, which contains 15 authored chapters and four useful appendices, remains a standard reference for those planning to establish new cancer registries and those keen to adopt recognized methodologies. Information is given on the techniques required to collect, store, analyse and interpret data.
Molecular Epidemiology
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Author : Paul A. Schulte
language : en
Publisher: Academic Press
Release Date : 2012-12-02
Molecular Epidemiology written by Paul A. Schulte and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.
This book will serve as a primer for both laboratory and field scientists who are shaping the emerging field of molecular epidemiology. Molecular epidemiology utilizes the same paradigm as traditional epidemiology but uses biological markers to identify exposure, disease or susceptibility. Schulte and Perera present the epidemiologic methods pertinent to biological markers. The book is also designed to enumerate the considerations necessary for valid field research and provide a resource on the salient and subtle features of biological indicators.
The Use Of Short And Medium Term Tests For Carcinogens And Data On Genetic Effects In Carcinogenic Hazard Evaluation
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Author : D. McGregor
language : en
Publisher: Oxford University Press, USA
Release Date : 1999
The Use Of Short And Medium Term Tests For Carcinogens And Data On Genetic Effects In Carcinogenic Hazard Evaluation written by D. McGregor and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Medical categories.
Lifetime assays for carcinogenicity in experimental animals, together with data on genetic and related effects on a variety of organisms, have long been the foundation for predictions of carcinogenic hazard to human beings. Recent scientific advances have provided new assays and novel test systems that are beginning to supplement, and in the future may even replace, the well-established tests that have been widely used for the last four decades. This publication reviews the evidence that justifies the use of lesions that precede histologically defined malignancy as endpoints to predict carcinogenicity. It evaluates the utility of non-mammalian species and of genetically engineered rodents as subjects for carcinogenicity tests and mutations in cancer-related genes in human and experimental animal tumours as 'footprints' of environmental carcinogens. It evaluates the use of established and novel assays for genetic toxicity in the prediction of carcinogenicity. Finally it formulates recommendations on the use of such data in the process of evaluation of carcinogenic hazards by the IARC Monographs on the Evaluation of Carcinogenic Risks to Humans.
Cancer
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Author : L. Tomatis
language : en
Publisher: Oxford University Press, USA
Release Date : 1990
Cancer written by L. Tomatis and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with Cancer categories.
The question regarding the preventability of cancer is one of great interest and debate. This text presents evidence on the subject, by describing the occurrence of, and variations in, the different forms of cancer. It gives details of risk factors and estimates possible prevention.
Iarc Scientific Publications
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Author :
language : en
Publisher:
Release Date : 1987
Iarc Scientific Publications written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987 with Cancer categories.
Mechanisms Of Carcinogenesis In Risk Identification
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Author : Harri Vainio
language : en
Publisher: Oxford University Press, USA
Release Date : 1992
Mechanisms Of Carcinogenesis In Risk Identification written by Harri Vainio and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Cancer categories.
This volume includes the background documents and the recommendations of a group of experts convened to discuss the contributions of epidemiological and experimental studies to our understanding of the mechanisms of carcinogenesis and the extent to which
Epidemiology Of Childhood Cancer
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Author : Julian Little
language : en
Publisher: Oxford University Press, USA
Release Date : 1999
Epidemiology Of Childhood Cancer written by Julian Little and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Cancer categories.
Cancer is the second commonest cause of death, after accidents, among children in developed countries, while in developing countries, improvements in the control of communicable diseases and the occurrence of premature delivery may lead to the emergence of cancer in children as a greater public health problem than in the past. The rationale for considering childhood cancers separately from cancers in adults in that there are differences in the sites of occurrence, in the histological appearance and in their clinical behavior. This book reviews the epidemiology of specific types of childhood cancer to mid-1997. The scale of the problem is first reviewed in a major compilation of data on the descriptive epidemiology of childhood cancer, then separate chapters describe studies of the different postulated causal factors and summarize what can be concluded from them.
Species Differences In Thyroid Kidney And Urinary Bladder Carcinogenesis
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Author : Charles C. Capen
language : en
Publisher: Oxford University Press, USA
Release Date : 1999
Species Differences In Thyroid Kidney And Urinary Bladder Carcinogenesis written by Charles C. Capen and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Bladder categories.
An IARC workshop held in Lyon, Nov. 3-7, 1997.
The Design And Analysis Of Cohort Studies
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Author : Norman E. Breslow
language : en
Publisher:
Release Date : 1987
The Design And Analysis Of Cohort Studies written by Norman E. Breslow and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987 with Cancer categories.