Inflammation And Cancer
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Inflammation And Cancer
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Author : Bharat B. Aggarwal
language : en
Publisher: Springer
Release Date : 2014-05-12
Inflammation And Cancer written by Bharat B. Aggarwal and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-12 with Medical categories.
This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.
The Link Between Inflammation And Cancer
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Author : Angus G. Dalgleish
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-03-05
The Link Between Inflammation And Cancer written by Angus G. Dalgleish and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-03-05 with Medical categories.
A link between inflammation and cancer has been established many years ago, yet it is only recently that the potential significance of this connection has become apparent. Although several examples of chronic inflammatory conditions, often induced by persistent irritation and/or infection, developing into cancer have been known for some time, there has been a notable resistance to contemplate the possibility that this association may apply in a causative way to other cancers. Examples for such progression from chronic inflammation to cancer are colon carcinoma developing with increased frequency in patients with ulcerative colitis, and the increased incidence of bladder cancer in patients suffering from chronic Schistosoma infection. Inflammation and cancer have been recognized to be linked in another context for many years, i.e., with regards to pathologies resembling chronic lacerations or 'wounds that do not heal.' More recently, the immunology of wound healing has given us clues as to the mechanistic link between inflammation and cancer, in as much as wounds and chronic inflammation turn off local cell-mediated immune responses and switch on growth factor release as well the growth of new blood vessels - angiogenesis. Both of these are features of most types of tumours, which suggest that tumours may require an immunologically shielded milieu and a growth factor-rich environment.
Inflammation And Cancer
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Author : Takuji Tanaka
language : en
Publisher: MDPI
Release Date : 2018-06-27
Inflammation And Cancer written by Takuji Tanaka and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-27 with Electronic books categories.
This book is a printed edition of the Special Issue "Inflammation and Cancer" that was published in IJMS
Cancer And Inflammation
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Author : Derek J. Chadwick
language : en
Publisher: John Wiley & Sons
Release Date : 2004-06-25
Cancer And Inflammation written by Derek J. Chadwick and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-06-25 with Science categories.
Chronic inflammation predisposes to some forms of cancer and the host response to malignant disease shows several parallels with inflammation and wound healing. The cells involved in inflammation are detected in a range of common cancers, together with the inflammatory cytokines and members of the chemokine ligand/receptor systems. Neutralization or deletion of the gene for some inflammatory cytokines confers resistance to tumour induction and experimental metastasis. Over-expression of such cytokines in tumour cells may enhance malignant potential. Certain chemokines are likely to subvert antitumour immunity by favouring development of ineffective Type 2 responses. Tumour cells may even utilize chemokine receptors in homing to lymph nodes and other organs. Thus, the cells, cytokines and chemokines found in tumours are more likely to contribute to tumour growth, progression and immunosuppression than they are to mount an effective host antitumour response. This book draws together contributions from an international group of scientists and clinicians from diverse disciplines, ranging from epidemiology to immunology, cell biology, molecular oncology, molecular medicine and pharmacology to debate these and related issues. Topics covered include the epidemiological links between cancer and inflammation, the parallels between inflammation and cancer, the role of inflammation in cancer, inflammatory genes as risk factors for cancer initiation and progression, inflammation and cancer angiogenesis, and preventative and therapeutic strategies. Related Novartis Foundation symposia: 252 Generation and Effector Functions of Regulatory Lymphocytes Chair: Jean-François Bach 254 Immunoinformatics: Bioinformatic Strategies for Better Understanding of Immune Function Chair: Hans-Georg Rammensee
Inflammation And Cancer
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Author : Brendan J. Jenkins
language : en
Publisher: Springer Nature
Release Date : 2023-06-24
Inflammation And Cancer written by Brendan J. Jenkins and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-24 with Medical categories.
This second edition volume expands on the previous edition with an update on the broad spectrum of research models, techniques, and protocols used in laboratories by basic and clinical researchers. The chapters in this book are divided into two parts. Part One discusses the latest findings on the development and characterization of representative research models for chronic immune-based diseases and inflammation-associated cancers. Part Two covers biochemical, molecular, and cellular biological techniques that are commonly used to dissect the molecular mechanisms and cellular processes that drive the pathogenesis of certain disease states. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Inflammation and Cancer: Methods and Protocols, Second Edition is a valuable resource for those with a diverse range of laboratory-based experience, ranging from novice undergraduate students to established basic or clinical researchers who wish to diversify their existing portfolio of practical knowledge in the field.
Obesity Inflammation And Cancer
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Author : Andrew J. Dannenberg
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-05-21
Obesity Inflammation And Cancer written by Andrew J. Dannenberg and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-21 with Medical categories.
In addition to its metabolic and endocrinologic effects, obesity and adipose tissue have now been shown to be associated with low grade inflammation resulting in cellular and humoral inflammatory factors of which the latter may act by endocrine, paracrine and autocrine mechanisms. These inflammatory mediators have increasingly been suggested as contributing to the obesity link to carcinogenesis and cancer promotion. This volume of Energy Balance and Cancer will focus on recent developments and cutting edge research pointing to inflammation and inflammatory factors as key mediators of this linkage. The volume first provides information on inflammation as an important link between obesity and insulin resistance, which is in itself linked to promotion of cancer through hyperinsulinemia. The volume then covers some of the most important mechanisms by which obesity leads to inflammation, including the novel inflammasome concept, alterations in chromatin structure, circulating inflammatory factors, unique cellular interactions between adipocytes and macrophages and the direct link of dietary fat to inflammation and cancer. Overall, this volume will provide important insight to help understand how inflammation may help modulate the linkage between obesity and cancer and serve as a platform for developing future research in this area.
Cancer And Inflammation Mechanisms
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Author : Yusuke Hiraku
language : en
Publisher: John Wiley & Sons
Release Date : 2014-03-19
Cancer And Inflammation Mechanisms written by Yusuke Hiraku and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-03-19 with Science categories.
A new perspective on the link between inflammation andcancer Inflammation is the human body’s normal biologicalresponse to threats in the modern world, as well as a defenseagainst the harmful influence of pathogens, the environment, andpoor nutrition. But what happens when the inflammatory response istriggered repeatedly and sustained for long periods of time?Cancer and Inflammation Mechanisms: Chemical, Biological, andClinical Aspects discusses the mechanisms by which chronicinflammation can lead to cancer, the various causative agents, andpossible prevention methods. A compilation of the latest information coming out of thevarious fields of cancer research, this book provides a detailedlook at inflammation-related carcinogenesis from the perspective ofresearchers at the forefront of the field. It takes aninterdisciplinary approach to the topic, and provides comprehensiveinformation about the major factors at work in inflammation,cancer, and the intersection of the two conditions. Topicsinclude: A general overview of inflammation-related cancer The biochemistry of inflammation and its effects on DNA Molecular biology and the role of microRNA incarcinogenesis Specific causative agents including oncogenic viruses,asbestos, and nanomaterial Anti-inflammatories, nutraceuticals, and other preventativemeasures A deeper understanding of the mechanisms behindinflammation-related carcinogenesis can lead to better patientoutcomes by improving diagnostics and prevention, as well asaltering the approach to treatment. Cancer and InflammationMechanisms: Chemical, Biological, and Clinical Aspects providesthe knowledge base researchers need to push the field forward.
Inflammation Infection And Microbiome In Cancers
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Author : Jun Sun
language : en
Publisher: Springer Nature
Release Date : 2021-04-20
Inflammation Infection And Microbiome In Cancers written by Jun Sun and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-20 with Medical categories.
This book offers a summary and discussion of the advances of inflammation and infection in various cancers. The authors cover the classically known virus infections in cancer, novel roles of other pathogens (e.g. bacteria and fungi), as well as biomarkers for diagnosis and therapy. Further, the chapters highlight the progress of immune therapy, stem cells and the role of the microbiome in the pathophysiology of cancers. Readers will gain insights into complex microbial communities, that inhabit most external human surfaces and play a key role in health and disease. Perturbations of host-microbe interactions often lead to altered host responses that can promote cancer development. Thus, this book highlights emerging roles of the microbiome in pathogenesis of cancers and outcome of therapy. The focus is on mechanistic concepts that underlie the complex relationships between host and microbes. Approaches that can inhibit infection, suppress chronic inflammation and reverse the dysbiosis are discussed, as a means for restoring the balance between host and microbes. This comprehensive work will be beneficial to researchers and students interested in infectious diseases, microbiome, and cancer as well as clinicians and general physiologists.
Inflammation Aging And Cancer
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Author : Mahin Khatami
language : en
Publisher: Springer
Release Date : 2018-01-17
Inflammation Aging And Cancer written by Mahin Khatami and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-17 with Medical categories.
This book was prepared as extension of author’s accidental discoveries on experimental models of acute and chronic ocular inflammatory diseases that were established at the University of Pennsylvania in 1980’s. Analyses of original data suggest a series of first evidence for direct link between inflammation and developmental phases of immune dysfunction in multistep tumorigenesis and angiogenesis. The only evidence presented on initial events for interactions and synergies between activated host and recruiting cells toward tumorigenesis. Effective immunity was defined as balance between two highly regulated and biologically opposing arms, Yin and Yang of acute inflammation, an amazingly precise signal communications between immune and non-immune systems requiring differential bioenergetics. Unresolved inflammation is a common denominator mapping aging process and induction of ‘mild’, ‘moderate’ or ‘severe’ immune disorders including cancers. Our knowledge of the fascinating biology of immunity in health or chronic diseases is fragmentary, chaotic and confusing, particularly for cancer science. Lack of progress in curing majority of chronic diseases or cancer is primarily due to the fact that scientists work on isolated molecules/cells or topics that are funded and promoted by decision makers in medical/cancer establishment. Despite existence of over 25 million articles on cancer-related topics, cancer biology and cure remain mysteries to be solved. After a century of cancer research, the failure rates of therapies for solid tumors are 90% (+/-5). Current reductionist views on cancer science are irresponsible, shut-gun approaches and create chaos. Outcomes are loss of millions of precious lives and economic drain to society. Very little is known about initial events that disturb effective immunity whose function is to monitor and arrest growth of cancerous cells or defend against other external or internal hazardous agents that threaten body’s survival. The author demonstrates the serious need for systematic understanding of how immune disruptors and aging process would alter effective immunity. Outcomes of proposed orderly studies are expected to provide logical foundations for cost-effective strategies to promote immunity toward a healthier society. The policy makers and medical/cancer establishment are urged to return to the common sense that our Forefathers used to serve the public.
From Inflammation To Cancer
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Author : Chi Hin Cho
language : en
Publisher: World Scientific
Release Date : 2012-08-23
From Inflammation To Cancer written by Chi Hin Cho and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-08-23 with Medical categories.
Inflammation and cancer are two major disorders that cause huge concerns in our society. However, what one may not know is that both diseases are closely associated and, in particular, both occur in the gastrointestinal tract and liver. This book describes the mechanics of how inflammation can progress to cancer in these organs. The authors in this book comprehensively discuss the different biomarkers for early diagnosis, and current therapeutic treatments for these diseases. All of these would allow us to better understand the pathogenesis of both diseases. As such, this book provides comprehensive information concerning the interrelationship between inflammation and cancer in a cohesive manner, and the information derived would benefit not only basic scientists but also clinicians who are working in these fields. Contents:Inflammation and Cancer:General Introduction (Chung Wah Wu and Jun Yu)General Mechanisms of Inflammation (Liwei Lu and Min Yang)Genetic and Epigenetic Alterations in Inflammation-Related Cancers — General Mechanisms of Cancers (Yasuyuki Okamoto and Yutaka Kondo)From Inflammation to Cancer: The Molecular Basis (Hongchuan Jin)Models of Chronic Inflammation–Induced Cancers and Their Treatments:Advances in the Treatment of Helicobacter pylori Infection and Gastric Cancer (Guy D Eslick)Inflammatory Bowel Disease and Colorectal Cancer and Their Treatment (Crispin Corte and Rupert WL Leong)Hepatitis B and Hepatocellular Carcinoma and Their Treatment (Chi-Jen Chu, Teh-Ia Huo and Shou-Dong Lee)Hepatitis C and Hepatocellular Carcinoma: Implications for Pathogenesis and Treatment (Geoffrey C Farrell)Advances in the Interventional Therapies for Hepatocellular Carcinoma (Carmen Chi Min Cho, Joyce Wai Yi Hui and Simon Chun Ho Yu)Mediators in Chronic Inflammation and Cancers:Exploration of Cytokine Signaling in Clinical Management of Hepatocellular Carcinoma (Xuelian Zhao and Xin Wei Wang)Role of Nuclear Factor-κB Pathway in Gastrointestinal Inflammation and Cancer (Muthu K Shanmugam, Nadine Upton, Gautam Sethi and WS Fred Wong)Novel Mediators for Chronic Inflammation and Oncogenic Transformation: Tumor Necrosis Factor (TNF)-α (Naofumi Mukaida and Boryana K Popivanova)Peroxisome Proliferator Activated Receptor-γ (PPARγ): Roles in Chronic Inflammation and Intestinal Oncogenic Transformation (Ioannis A Voutsadakis)Proteinase-Activated Receptors (Hongying Wang)Molecular Markers of Cancers and Their Clinical Implications:Use of Tumor Markers in the Detection and Management of Patients with Colorectal Cancer (Michael J Duffy)Genetic Biomarkers for the Diagnosis and Prognosis of Hepatocellular Carcinoma (John M Luk, Angela M Liu, Kwong-Fai Wong and Ronnie T P Poon)Summary:Current Therapy and Future Perspectives for Inflammation-Associated Cancer (L Zhang and C H Cho) Readership: Both basic and clinical researchers in a variety of fields including cancer, gastroenterology, hepatology, pathology, pharmacology and radiology. Keywords:COX-2;Gastric Cancer;Colorectal Cancer;Gastrointestinal Tract;Hepatitis;Hepatocellular Carcinoma;Helicobacter Pylori;Inflammatory Bowel Disease;Nuclear Factor-κB;Peroxisome Proliferator Activated Receptor-γ;Tumor Markers;Tumor Necrosis Factor-αKey Features:Two important subjects described in a single publicationA diversified panel of contributors from Asia-Pacific, Europe and North America with different backgrounds including basic scientists and clinical practitioners