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Regulatory T Cells And Clinical Application
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Author : Shuiping Jiang
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-12-14
Regulatory T Cells And Clinical Application written by Shuiping Jiang and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-12-14 with Medical categories.
Covering one of the hottest topics in immunology today, this book provides a comprehensive view of all types of regulatory T cells described so far in the literature. The book will have broad appeal to both researchers and clinicians.
T Cell Activation By Cd1 And Lipid Antigens
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Author : Branch D. Moody
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-05-10
T Cell Activation By Cd1 And Lipid Antigens written by Branch D. Moody and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-05-10 with Medical categories.
There is increasing evidence that the CD1 system has been conserved throughout mammalian evolution and is capable of presenting structurally diverse diacyglycerol, sphingolipid, polyisoprenol and lipopeptide antigens. This volume provides a comprehensive discussion of these basic aspects of CD1 biology and summarizes the most recent research into the role of CD1 in infectious, autoimmune, allergic and neoplastic disease.
Clinical And Basic Immunodermatology
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Author : Anthony Gaspari
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-11-05
Clinical And Basic Immunodermatology written by Anthony Gaspari and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-11-05 with Medical categories.
Dermatologists are being asked to understand the pathophysiology of a number of immune-mediated skin diseases. In addition, a number of new products have appeared on the market during the past decade which requires an understanding of the mechanisms of action of these drugs. Dermatologists, however, have no easily understood book to which they can refer to regarding the disease or the drug.
Basic Immunology And Its Clinical Application
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Author : Mitsuru Matsumoto
language : en
Publisher: Springer Nature
Release Date :
Basic Immunology And Its Clinical Application written by Mitsuru Matsumoto and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Cd1 And Mr1 Restricted T Cells In Antimicrobial Immunity
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Author : S.M. Mansour Haeryfar
language : en
Publisher: Frontiers Media SA
Release Date : 2016-01-21
Cd1 And Mr1 Restricted T Cells In Antimicrobial Immunity written by S.M. Mansour Haeryfar and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-21 with Cytology categories.
Cell-mediated immunity to extracellular and intracellular microbes has been traditionally linked to CD4+ and CD8+ T cells that recognize pathogen-derived peptides in the context of major histocompatibility complex (MHC) class II and class I molecules, respectively. Recent progress in our understanding of early host defense mechanisms has brought ‘unconventional’, innate-like T cells into the spotlight. These are a heterogeneous population of non-MHC-restricted T cells that exhibit ‘memory-like’ properties and mount emergency responses to infection. They may directly detect and destroy infected cells, but are best known for their ability to regulate downstream effector cells including but not limited to conventional T cells. Innate-like T cells include among others CD1-restricted natural killer T (NKT) cells and MR1-restricted mucosa-associated invariant T (MAIT) cells. NKT cells recognize lipid antigens, and MAIT cells were recently demonstrated to respond to microbe-derived vitamin B metabolites. However, much remains to be learned about the antigen specificity range of these cells, their activation mode and their true potentials in immunotherapeutic applications. Like in many other areas of biology, uncertainties and controversies surrounding these cells and some of the experimental models, techniques and reagents employed to study them have brought about excitement and sometimes hot debates. This Special Topic was launched to provide updated reviews on protective and/or pathogenic roles of NKT and MAIT cells during infection. Leading experts discuss current controversies, pressing questions and the challenges that lie ahead for the advancement of this intriguing and rapidly evolving area of immunology. Unlike MHC, CD1 and MR1 display very limited polymorphism. Therefore, NKT and MAIT cells may be considered attractive targets for various diseases in diverse human populations. The potential benefits of NKT cell- and MAIT cell-based vaccination and treatment strategies in infectious diseases is an important subject that is also covered in this Topic.
Inflammation Stem Cells And Wound Healing In Skin Aging
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Author : Ji Li
language : en
Publisher: Frontiers Media SA
Release Date : 2022-11-16
Inflammation Stem Cells And Wound Healing In Skin Aging written by Ji Li and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-16 with Science categories.
Role Of Cd1 And Mr1 Restricted T Cells In Immunity And Disease
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Author : Kazuya Iwabuchi
language : en
Publisher: Frontiers Media SA
Release Date : 2019-10-18
Role Of Cd1 And Mr1 Restricted T Cells In Immunity And Disease written by Kazuya Iwabuchi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-18 with categories.
CD1 and MR1 are major histocompatibility complex (MHC) class I-related proteins that bind and present non-peptide antigens to subsets of T cells with specialized functions. CD1 proteins typically present lipid antigens to CD1-restricted T cells, whereas MR1 presents vitamin B-based ligands and a variety of drugs and drug-like molecules to MR1-restricted T cells. The CD1 family of antigen presenting molecules has been divided into two groups: Group 1 contains CD1a, CD1b and CD1c, and Group 2 contains CD1d. Additionally, CD1e is expressed intracellularly and is involved in the loading of lipid antigens onto Group 1 CD1 proteins. Humans express both Groups 1 and 2 CD1 proteins, whereas mice only express CD1d. Group 1 CD1 proteins present lipid antigens to T cells that generally express diverse T cell receptors (TCRs) and exhibit adaptive-like functions, whereas CD1d presents lipid antigens to subsets of T cells that express either diverse or highly restricted TCRs and exhibit innate-like functions. CD1d-restricted T cells are called natural killer T (NKT) cells, which includes Type I or invariant NKT (iNKT) cells expressing semi-invariant TCRs, and Type II NKT cells expressing more diverse TCRs. CD1-restricted T cells have been implicated in a wide variety of diseases, including cancer, infections, and autoimmune, inflammatory and metabolic diseases. Additionally, NKT cells have been targeted for immunotherapy of disease with ligands such as α-galactosylceramide for iNKT cells, or sulfatide for Type II NKT cells. Like iNKT cells, MR1-restricted T cells express semi-invariant TCRs and display innate-like functions. MR1-restricted T cells, also called mucosal-associated invariant T (MAIT) cells, have been implicated in immune responses against a variety of pathogens such as Mycobacterium tuberculosis, Pseudomonas aeruginosa, Helicobacter pylori, hepatitis C virus and influenza virus. Moreover, these cells contribute to autoimmune and inflammatory diseases, including colitis, rheumatoid arthritis, psoriasis, lupus, and diabetes.
Nkt Cells In Cancer Immunotherapy 2nd Edition
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Author : Tonya J. Webb
language : en
Publisher: Frontiers Media SA
Release Date : 2020-11-20
Nkt Cells In Cancer Immunotherapy 2nd Edition written by Tonya J. Webb and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-20 with Science categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Molecular Autoimmunity
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Author : Moncef Zouali
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-04-07
Molecular Autoimmunity written by Moncef Zouali and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-04-07 with Medical categories.
2004 marks the 100th anniversary of the first description of the autoimmune disease paroxysmal cold hemoglobinuria, a rare hemolytic disorder, by Julius Donath and Karl Landsteiner. After a century of research, the list of autoimmune diseases has become impressive. With a prevalence of approximately 5% of the world-wide population, these chronic, debilitating conditions affect almost every major organ of the body and, for reasons that remain unclear, are much more prevalent in woman than in men. Despite our rapidly expanding knowledge of the cellular and molecular pathways that govern a normal immune response, deciphering the precise etiology of autoimmune diseases remains an important challenge. Over the last few years, our understanding of the pathogenesis of autoimmune diseases has improved rapidly, leading to the emergence of elegant immunointervention strategies. Molecular Autoimmunity illustrates how cutting-edge research is continuing to advance our understanding of autoimmune disease mechanisms and identifies novel therapeutic targets that provide a hope for effective future treatments. This volume contains a selected number of exciting advances in unraveling autoimmune reactions, and the resulting new armory of experimental immunotherapies that may lead to new ways of controlling autoimmune reactions.
Encyclopedia Of Immunobiology
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Author :
language : en
Publisher: Academic Press
Release Date : 2016-04-27
Encyclopedia Of Immunobiology written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-27 with Medical categories.
Encyclopedia of Immunobiology, Five Volume Set provides the largest integrated source of immunological knowledge currently available. It consists of broad ranging, validated summaries on all of the major topics in the field as written by a team of leading experts. The large number of topics covered is relevant to a wide range of scientists working on experimental and clinical immunology, microbiology, biochemistry, genetics, veterinary science, physiology, and hematology. The book is built in thematic sections that allow readers to rapidly navigate around related content. Specific sections focus on basic, applied, and clinical immunology. The structure of each section helps readers from a range of backgrounds gain important understanding of the subject. Contains tables, pictures, and multimedia features that enhance the learning process In-depth coverage allows readers from a range of backgrounds to benefit from the material Provides handy cross-referencing between articles to improve readability, including easy access from portable devices