Lignes Directrices Pour Les Essais De Produits Chimiques Section 4 Effets Sur La Sant Essai N 421 Essai De D Pistage De La Toxicit Pour La Reproduction Et Le D Veloppement
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Essai N 421 Essai De D Pistage De La Toxicit Pour La Reproduction Et Le D Veloppement
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Author : OECD
language : fr
Publisher: OECD Publishing
Release Date : 1995-07-27
Essai N 421 Essai De D Pistage De La Toxicit Pour La Reproduction Et Le D Veloppement written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-07-27 with categories.
La substance d’essai est administrée en dose graduée à plusieurs groupes de mâles et de femelles. Les mâles doivent être traités pendant un minimum de quatre semaines. Les femelles doivent être traitées tout au long de l’étude, soit ...
Recommendations On The Transport Of Dangerous Goods Model
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Author :
language : en
Publisher:
Release Date :
Recommendations On The Transport Of Dangerous Goods Model written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Application Of Systematic Review Methods In An Overall Strategy For Evaluating Low Dose Toxicity From Endocrine Active Chemicals
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Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2017-08-14
Application Of Systematic Review Methods In An Overall Strategy For Evaluating Low Dose Toxicity From Endocrine Active Chemicals written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-14 with Science categories.
To safeguard public health, the US Environmental Protection Agency (EPA) must keep abreast of new scientific information and emerging technologies so that it can apply them to regulatory decision-making. For decades the agency has dealt with questions about what animal-testing data to use to make predictions about human health hazards, how to perform dose-response extrapolations, how to identify and protect susceptible subpopulations, and how to address uncertainties. As alternatives to traditional toxicity testing have emerged, the agency has been faced with additional questions about how to incorporate data from such tests into its chemical assessments and whether such tests can replace some traditional testing methods. Endocrine active chemicals (EACs) have raised concerns that traditional toxicity-testing protocols might be inadequate to identify all potential hazards to human health because they have the ability to modulate normal hormone function, and small alterations in hormone concentrations, particularly during sensitive life stages, can have lasting and significant effects. To address concerns about potential human health effects from EACs at low doses, this report develops a strategy to evaluate the evidence for such low-dose effects.
Guidelines For Canadian Drinking Water Quality
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Author :
language : en
Publisher:
Release Date : 2023
Guidelines For Canadian Drinking Water Quality written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023 with Drinking water categories.
"Malathion is a registered insecticide and acaricide used on a wide variety of sites including agricultural and non-agricultural sites. In 2018 (the most recent year for which data are available), over 25 000 kg of malathion was sold in Canada. Malathion may be released into surface water or soil as runoff from the application site. Malathion is not usually found in drinking water sources in Canada. Low levels of malathion have been found in several Canadian provinces. The maximum reported concentrations are well below the MAC. Malathion is rarely detected in foods"--Executive summary.
Exposure Science In The 21st Century
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 2012-10-28
Exposure Science In The 21st Century written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-10-28 with Nature categories.
From the use of personal products to our consumption of food, water, and air, people are exposed to a wide array of agents each day-many with the potential to affect health. Exposure Science in the 21st Century: A Vision and A Strategy investigates the contact of humans or other organisms with those agents (that is, chemical, physical, and biologic stressors) and their fate in living systems. The concept of exposure science has been instrumental in helping us understand how stressors affect human and ecosystem health, and in efforts to prevent or reduce contact with harmful stressors. In this way exposure science has played an integral role in many areas of environmental health, and can help meet growing needs in environmental regulation, urban and ecosystem planning, and disaster management. Exposure Science in the 21st Century: A Vision and A Strategy explains that there are increasing demands for exposure science information, for example to meet needs for data on the thousands of chemicals introduced into the market each year, and to better understand the health effects of prolonged low-level exposure to stressors. Recent advances in tools and technologies-including sensor systems, analytic methods, molecular technologies, computational tools, and bioinformatics-have provided the potential for more accurate and comprehensive exposure science data than ever before. This report also provides a roadmap to take advantage of the technologic innovations and strategic collaborations to move exposure science into the future.
A Systems Biology Approach To Advancing Adverse Outcome Pathways For Risk Assessment
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Author : Natàlia Garcia-Reyero
language : en
Publisher: Springer
Release Date : 2018-02-24
A Systems Biology Approach To Advancing Adverse Outcome Pathways For Risk Assessment written by Natàlia Garcia-Reyero and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02-24 with Science categories.
Social pressure to minimize the use of animal testing, the ever-increasing concern on animal welfare, and the need for more human-relevant and more predictive toxicity tests are some of the drivers for new approaches to chemical screening. This book focuses on The Adverse Outcome Pathway, an analytical construct that describes a sequential chain of causally linked events at different levels of biological organization that lead to an adverse health or ecotoxicological effect. While past efforts have focused on toxicological pathway-based vision for human and ecological health assessment relying on in vitro systems and predictive models, The Adverse Outcome Pathway framework provides a simplified and structured way to organize toxicological information. Within the book, a systems biology approach supplies the tools to infer, link, and quantify the molecular initiating events and the key events and key event relationships leading to adverse outcomes. The advancement of these tools is crucial for the successful implementation of AOPs for regulatory purposes.
Environmental Effects Of Transgenic Plants
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 2002-02-22
Environmental Effects Of Transgenic Plants written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-02-22 with Technology & Engineering categories.
Transgenic crops offer the promise of increased agricultural productivity and better quality foods. But they also raise the specter of harmful environmental effects. In this new book, a panel of experts examines: • Similarities and differences between crops developed by conventional and transgenic methods • Potential for commercialized transgenic crops to change both agricultural and nonagricultural landscapes • How well the U.S. government is regulating transgenic crops to avoid any negative effects. Environmental Effects of Transgenic Plants provides a wealth of information about transgenic processes, previous experience with the introduction of novel crops, principles of risk assessment and management, the science behind current regulatory schemes, issues in monitoring transgenic products already on the market, and more. The book discusses public involvementâ€"and public confidenceâ€"in biotechnology regulation. And it looks to the future, exploring the potential of genetic engineering and the prospects for environmental effects.
Investing Against Evidence
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Author : Marope, P.T.M.
language : en
Publisher: UNESCO Publishing
Release Date : 2015-08-17
Investing Against Evidence written by Marope, P.T.M. and has been published by UNESCO Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-08-17 with Education categories.
Per And Polyfluorinated Substances In The Nordic Countries
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Author : Stefan Posner
language : en
Publisher: Nordic Council of Ministers
Release Date : 2013-06-19
Per And Polyfluorinated Substances In The Nordic Countries written by Stefan Posner and has been published by Nordic Council of Ministers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-19 with Science categories.
This Tema Nord report presents a study based on open information and custom market research to review the most common perfluorinated substances (PFC) with less focus on PFOS and PFOA. The study includes three major parts:1) Identification of relevant per-and polyfluorinated substances and their use in various industrial sectors in the Nordic market by interviews with major players and database information; 2) Emissions to and occurence in the Nordic environment of the substances described in 1); 3) A summary of knowledge of the toxic effects on humans and the environment of substances prioritized in 2); There is a lack of physical chemical data, analystical reference substances, human and environmental occurrence and toxicology data, as well as market information regarding PFCs other than PFOA and PFOS and the current legislation cannot enforce disclosure of specific PFC substance information.
Europe S Environment
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Author : European Environment Agency
language : en
Publisher:
Release Date : 1998
Europe S Environment written by European Environment Agency and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Environmental monitoring categories.