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Mechanisms Of Axonal Regeneration After Central Nervous System Injury

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Mechanisms Of Neuronal Recovery In The Central Nervous System

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Author : Luis B. Tovar-y-Romo
language : en
Publisher: Frontiers Media SA
Release Date : 2021-10-13

Mechanisms Of Neuronal Recovery In The Central Nervous System written by Luis B. Tovar-y-Romo and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-13 with Science categories.

Mechanisms Of Axonal Regeneration In The Central Nervous System

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Author : Gunnar Heiko Dirk Poplawski
language : en
Publisher:
Release Date : 2014

Mechanisms Of Axonal Regeneration In The Central Nervous System written by Gunnar Heiko Dirk Poplawski and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with categories.

The regenerative capacity of central nervous system (CNS) axons after injury is severely impaired compared to axons of the peripheral nervous system (PNS). We hypothesized that mechanisms both intrinsic and extrinsic to the neuron influence the ability of CNS axons to regenerate. To investigate this hypothesis we explored two model systems. In the first model system, we identified a regeneration transcriptome in injured corticospinal motor neurons that is associated with enhanced central axon regeneration after spinal cord injury. The genetic mechanisms identified in this model include cAMP-Erk-CREB, Huntingtin, NFE2L2, ephrin and semaphorin signaling, and provide a dataset for potential therapeutic intervention to improve axonal regeneration in vivo after spinal cord injury. In the second model, we tested the hypothesis that glial cells of the peripheral nerve, Schwann cells, are an essential mechanism contributing to central axonal regeneration after "conditioning" lesions, wherein injury to the peripheral branch of a dorsal root ganglion sensory neuron enhances regeneration of the central branch of the sensory neuron. The gene encoding Low-density lipoprotein Receptor-related Protein-1 (LRP1) was conditionally deleted in Schwann cells, impairing the survival and function of Schwann cells after injury; animals with Schwann cell-specific deletion of LRP1 exhibited a significant reduction in axon regeneration in vitro and a trend towards central sensory axon regeneration after conditioning lesions, confirming that glial cells exhibit an essential but partial role in supporting axonal regeneration. Overall, these studies identify novel molecular and cellular mechanisms that influence central axon regeneration, and suggest therapeutic approaches to improve neural repair after CNS injury.

Mechanisms Of Axonal Regeneration After Central Nervous System Injury

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Author : Rita Juneja
language : en
Publisher:
Release Date : 2012

Mechanisms Of Axonal Regeneration After Central Nervous System Injury written by Rita Juneja and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Central nervous system categories.

Wiring The Nervous System Mechanisms Of Axonal And Dendritic Remodelling In Health And Disease

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Author : Tracy S. Tran
language : en
Publisher: CRC Press
Release Date : 2024-01-31

Wiring The Nervous System Mechanisms Of Axonal And Dendritic Remodelling In Health And Disease written by Tracy S. Tran and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-01-31 with Science categories.

This book examines recent key findings on the mechanisms of axonal and dendritic remodeling in different model organisms. Each chapter is contributed by a panel of experts in their respective subfields of neurosciences, to provide and discuss the latest discoveries ranging from neuronal morphogenesis during development, experience-dependent structural plasticity, to neuronal degeneration, regeneration, and pathologies in neurological disorders. The process of neuronal remodeling, specifically their axons and dendrites, is essential for the proper wiring of the nervous system during early development and continues during postnatal ages to shape the pattern of synaptic connections throughout the life of the organism, including humans. Over recent years, substantial progress has been made in our understanding of the cellular and molecular mechanisms that control neuronal remodeling. In addition, there is accumulating evidence demonstrating how the nervous system could remodel in response to injury and in pathological conditions. Topics discussed in the book include: Axonal degeneration during development and in pathological or disease conditions Neuronal morphogenesis (axons and dendrites) Experience-dependent structural plasticity to synaptogenesis Dendrite degeneration and regeneration

Advances In Cns Repair Regeneration And Neuroplasticity From Basic Mechanisms To Therapeutic Strategies

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Author : Shuxin Li
language : en
Publisher: Frontiers Media SA
Release Date : 2022-03-09

Advances In Cns Repair Regeneration And Neuroplasticity From Basic Mechanisms To Therapeutic Strategies written by Shuxin Li and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-09 with Science categories.