The Molecular Basis Of Immune Cell Function
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The Molecular Basis Of Immune Cell Function
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Author : J. Gordin Kaplan
language : en
Publisher: Amsterdam ; New York : Elsevier/North-Holland Biomedical Press ; New York : sole distributors for the USA and Canada, Elsevier North Holland
Release Date : 1979
The Molecular Basis Of Immune Cell Function written by J. Gordin Kaplan and has been published by Amsterdam ; New York : Elsevier/North-Holland Biomedical Press ; New York : sole distributors for the USA and Canada, Elsevier North Holland this book supported file pdf, txt, epub, kindle and other format this book has been release on 1979 with Medical categories.
The Molecular Basis Of Immune Cell Function
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Author : J. Gordin Kaplan
language : en
Publisher:
Release Date : 1979
The Molecular Basis Of Immune Cell Function written by J. Gordin Kaplan and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1979 with Cell physiology categories.
The Molecular Basis Of Immune Cell Function
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Author :
language : en
Publisher:
Release Date : 1979
The Molecular Basis Of Immune Cell Function written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1979 with categories.
Hematology Basic Principles And Practice E Book
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Author : Leslie E. Silberstein
language : en
Publisher: Elsevier Health Sciences
Release Date : 2017-06-14
Hematology Basic Principles And Practice E Book written by Leslie E. Silberstein and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-14 with Medical categories.
Get the expert guidance you need to offer your patients the best possible outcomes with Hematology: Basic Principles and Practice, 7th Edition. This thoroughly up-to-date text contains both unparalleled scientific content and must-know clinical guidance, so you can enhance your problem-solving skills and make optimal use of the newest diagnostic techniques and therapeutic options in this fast-changing field. Delivers state-of-the-art information and guidance from editors and global contributors who are at the forefront of their respective subspecialty areas Features sweeping content updates throughout, including basic science research which serves as a foundation for modern hematology, recent advances in stem cell transplantation, clinical advances in the treatment of each of the hematologic malignancies, immune checkpoint inhibitors, molecular diagnostics, transfusion medicine, and much more Includes several new chapters including Epigenetics and Epigenomics, Stem Cell Model of Hematologic Diseases, Multiple Myeloma, IND Enabling Processes for Cell-Based Therapies, and Immune Checkpoint Blockade in Hematologic Malignancies New Virtual Microscope with the ability to zoom in on high-quality digital hematopathology slides and frequent content updates accessible anywhere, any time on your favorite digital device Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, Q&As, and references from the book on a variety of devices Delivers state-of-the-art information and guidance from editors and global contributors who are at the forefront of their respective subspecialty areas. Features sweeping content updates throughout, including basic science research which serves as a foundation for modern hematology, recent advances in stem cell transplantation, clinical advances in the treatment of each of the hematologic malignancies, immune checkpoint inhibitors, molecular diagnostics, transfusion medicine, and much more. Includes several new chapters including Epigenetics and Epigenomics, Stem Cell Model of Hematologic Diseases, Multiple Myeloma, IND Enabling Processes for Cell-Based Therapies, and Immune Checkpoint Blockade in Hematologic Malignancies. New Virtual Microscope with the ability to zoom in on high-quality digital hematopathology slides and frequent content updates accessible anywhere, any time on your favorite digital device. Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, Q&As, and references from the book on a variety of devices.
Regulation Of Immune System Cell Functions By Protein Kinase C
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Author : Noah Isakov
language : en
Publisher: Frontiers E-books
Release Date : 2014-11-11
Regulation Of Immune System Cell Functions By Protein Kinase C written by Noah Isakov and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-11 with Immunologic diseases. Allergy categories.
Members of the protein kinase C (PKC) family of Ser/Thr kinases are encoded by nine distinct but closely related genes, which give rise to more than 12 different protein isoforms via a mechanism of alternative RNA splicing. Most PKC proteins are ubiquitously expressed and participate in a plethora of functions in most cell types. A majority of PKC isoforms is also expressed in cells of the immune system in which they are involved in signal transduction downstream of a range of surface receptors, including the antigen receptors on T and B lymphocytes. PKC proteins are central to signal initiation and propagation, and to the regulation of processes leading to immune cell proliferation, differentiation, homing and survival. As a result, PKC proteins directly impact on the quality and quantity of immune responses and indirectly on the host resistance to pathogens and tendency to develop immune deficiencies and autoimmune diseases. A significant progress was made in recent years in understanding the regulation of PKC enzymes, their mechanism of action and their role in determining immunocyte behavior This volume reviews the most significant contributions made in the field of immune cell regulation by PKC enzymes. Several manuscripts are devoted to the role of distinct PKC isoforms in the regulation of selected immunocyte responses. Additional manuscripts review more general mechanisms of regulation of PKC enzymes, either by post-translational modifications, such as phosphorylation or controlled proteolysis, or by interaction with different binding proteins that may alter the conformation, activity and subcellular location of PKC. Both types of mechanisms can introduce conformational changes in the molecule, which may affect its ability to interact with cofactors, ATP, or substrates. This topic will be followed by a discussion on the positive and negative impact of individual PKC isoforms on cell cycle regulation. A second section of this volume concentrates on selected topics relevant to role of the novel PKC isoform, PKC-theta, in T lymphocyte function. PKC-theta plays important and some non-redundant roles in T cell activation and is a key isoform that recruits to the immunological synapse - the surface membrane area in T cells that comes in direct contact with antigen presenting cells. The immunological synapse is formed in T cells within seconds following the engagement of the TCR by a peptide-bound MHC molecule on the surface of antigen-presenting cells. It serves as a platform for receptors, adaptor proteins, and effector molecules, which assemble into multimolecular activation complexes required for signal transduction. The unique ability of PKC-theta to activate the NF-kB, AP-1 and NF-AT transcription factors is well established, and recent studies contributed essential information on the mechanisms involved in the recruitment of PKC-theta to the center of the immunological synapse and the nature of its substrates and the role of their phosphorylated forms in signal transduction. Additional review manuscripts will describe the unique behavior of PKC-theta in regulatory T cells and its role in the regulation of other cell populations, including those of the innate immune response. This volume brings together leading experts from different disciplines that review the most recent discoveries and offer new perspectives on the contributions of PKC isoforms to biochemical processes and signaling events in different immune cell populations and their impact on the overall host immune response.
Genetic And Epigenetic Foundations Molecular Basis And Mechanistic Pathways Of Chronic Inflammation Driven Tumorigenesis
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Author : Jeff Radwell
language : en
Publisher: Black Mill Publishing
Release Date : 2025-01-29
Genetic And Epigenetic Foundations Molecular Basis And Mechanistic Pathways Of Chronic Inflammation Driven Tumorigenesis written by Jeff Radwell and has been published by Black Mill Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-01-29 with Medical categories.
Chronic inflammation is a silent yet powerful driver of cancer, altering genetic and epigenetic landscapes to promote tumor progression, immune evasion, and therapy resistance. This comprehensive volume unpacks the intricate molecular mechanisms linking inflammation and oncogenesis, from oxidative DNA damage to epigenetic modifications that rewire cellular fate. Examining key pathways such as NF-κB, STAT3, and TGF-β, this text provides a rigorous yet accessible analysis of inflammation-driven tumorigenesis. With a focus on genetic mutations, histone modifications, and therapeutic targets, it bridges fundamental research with clinical implications, offering insights into novel intervention strategies.
Heat Shock Proteins Potent Mediators Of Inflammation And Immunity
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Author : Alexzander A.A. Asea
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-09-05
Heat Shock Proteins Potent Mediators Of Inflammation And Immunity written by Alexzander A.A. Asea and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-09-05 with Medical categories.
Heat Shock Proteins: Potent Mediators of Inflammation and Immunity currently provides the most up-to-date review on new mechanisms and provides exciting insights into how heat shock proteins modulates the hosts immune response. Written by leaders in the field of heat shock protein immunobiology, the chapters systematically and in a step wise fashion takes the reader through the fascinating sequence of events by which heat shock proteins activate immune responses and provides answers as to its biological significance to the host. From the early stages of binding and receptors-mediated signalling, to new paradigms by which heat shock proteins are released into the circulation, to antigen processing and presentation, and finally to the immune response itself this book is a must read for graduate and postgraduates in the field of Biology (plant and mammal), Biochemistry (pro- and eukaryotic), Immunology, Microbiology, Exercise Medicine, Physiology, Inflammatory diseases, Autoimmunity, Pharmacology and Pathology.
Biomedical Index To Phs Supported Research Pt A Subject Access A H
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Author :
language : en
Publisher:
Release Date : 1992
Biomedical Index To Phs Supported Research Pt A Subject Access A H written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Medicine categories.
Biomedical Index To Phs Supported Research
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Author :
language : en
Publisher:
Release Date : 1987
Biomedical Index To Phs Supported Research written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987 with Medicine categories.
Middleton S Allergy Principles And Practice E Book
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Author : N. Franklin Adkinson Jr.
language : en
Publisher: Elsevier Health Sciences
Release Date : 2008-11-27
Middleton S Allergy Principles And Practice E Book written by N. Franklin Adkinson Jr. and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-11-27 with Medical categories.
This best-selling resource has a worldwide reputation as the leader in its field. Focusing on human immunology and biology, while also reporting on scientific experimentation and advancement, it provides comprehensive coverage of state-of-the-art basic science as well as authoritative guidance on the practical aspects of day-to-day diagnosis and management. This new edition includes 700 full-color illustrations and a new, more accessible format to make finding information a snap for the busy practitioner. And this Expert Consult Edition offers online access to the complete contents of the 2-volume set, fully searchable, and much more. Includes a glossary of allergy and immunology for quick and easy reference. Contains keypoints and clinical pearls highlighted to find important information quickly. links to useful online resources both for you and for your patients. Offers contributions from hundreds of international authorities for world-class expertise in overcoming any clinical challenge. Contains 400 new illustrations, 700 in all, to better illustrate complex immunology. Covers the very latest in the field, including hot topics such as food allergy and immunotherapy. Includes the latest guidelines from The National Asthma Education and Prevention Program (NAEPP). Utilizes a new, more user-friendly full-color format for easier reference. Includes online access to the entire contents of the book, fully searchable, with links to MEDLINE abstracts for all of the references.