Jh D N Mukadm
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Innovations For Next Generation Antibody Drug Conjugates
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Author : Marc Damelin
language : en
Publisher: Springer
Release Date : 2018-05-29
Innovations For Next Generation Antibody Drug Conjugates written by Marc Damelin and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-29 with Medical categories.
Antibody-drug conjugates (ADCs) stand at the verge of a transformation. Scores of clinical programs have yielded only a few regulatory approvals, but a wave of technological innovation now empowers us to overcome past technical challenges. This volume focuses on the next generation of ADCs and the innovations that will enable them. The book inspires the future by integrating the field’s history with novel strategies and cutting-edge technologies. While the book primarily addresses ADCs for solid tumors, the last chapter explores the emerging interest in using ADCs to treat other diseases. The therapeutic rationale of ADCs is strong: to direct small molecules to the desired site of action (and away from normal tissues) by conjugation to antibodies or other targeting moieties. However, the combination of small and large molecules imposes deep complexity to lead optimization, pharmacokinetics, toxicology, analytics and manufacturing. The field has made significant advances in all of these areas by improving target selection, ADC design, manufacturing methods and clinical strategies. These innovations will inspire and educate scientists who are designing next-generation ADCs with the potential to transform the lives of patients.
Applied Affective Computing
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Author : Leimin Tian
language : en
Publisher: Morgan & Claypool
Release Date : 2022-02-04
Applied Affective Computing written by Leimin Tian and has been published by Morgan & Claypool this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-04 with Computers categories.
Affective computing is a nascent field situated at the intersection of artificial intelligence with social and behavioral science. It studies how human emotions are perceived and expressed, which then informs the design of intelligent agents and systems that can either mimic this behavior to improve their intelligence or incorporate such knowledge to effectively understand and communicate with their human collaborators. Affective computing research has recently seen significant advances and is making a critical transformation from exploratory studies to real-world applications in the emerging research area known as applied affective computing. This book offers readers an overview of the state-of-the-art and emerging themes in affective computing, including a comprehensive review of the existing approaches to affective computing systems and social signal processing. It provides in-depth case studies of applied affective computing in various domains, such as social robotics and mental well-being. It also addresses ethical concerns related to affective computing and how to prevent misuse of the technology in research and applications. Further, this book identifies future directions for the field and summarizes a set of guidelines for developing next-generation affective computing systems that are effective, safe, and human-centered. For researchers and practitioners new to affective computing, this book will serve as an introduction to the field to help them in identifying new research topics or developing novel applications. For more experienced researchers and practitioners, the discussions in this book provide guidance for adopting a human-centered design and development approach to advance affective computing.
White Dwarfs
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Author : Domitilla de Martino
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
White Dwarfs written by Domitilla de Martino and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Proceedings of the NATO Advanced Research Workshop, held in Naples, Italy, 24-28 June 2002
Neuropsychological Assessments Of Dementia In Down Syndrome And Intellectual Disabilities
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Author : Vee P. Prasher
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-04-29
Neuropsychological Assessments Of Dementia In Down Syndrome And Intellectual Disabilities written by Vee P. Prasher and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-04-29 with Medical categories.
This book reviews important neuropsychological measures currently used in the assessment of dementia by the principal clinicians and researchers associated with the test, offering practical guidance on each test along with an analysis of its limitations.
Very Low Mass Stars And Brown Dwarfs
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Author : Rafael Rebolo
language : en
Publisher: Cambridge University Press
Release Date : 2000-11-27
Very Low Mass Stars And Brown Dwarfs written by Rafael Rebolo and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-11-27 with Science categories.
This volume provides a state-of-the-art review of our current knowledge of brown dwarfs and very low-mass stars. The hunt for and study of these elusive objects is currently one of the most dynamic areas of research in astronomy for two reasons. Brown dwarfs bridge the gap between stars and planets, and they may constitute an important part of the 'dark matter' of the Universe. This volume presents review articles from a team of international authorities who gathered at a conference in La Palma to assess the spectacular progress that has been made in this field in the last few years.
Neurovascular Neuropsychology
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Author : Joanne Festa
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-06-12
Neurovascular Neuropsychology written by Joanne Festa and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-06-12 with Medical categories.
Neurovascular diseases and conditions, and their associated risk factors, represent a significant cause of cognitive disability in the United States and throughout the world. In the USA alone there are 750,000 new strokes each year, representing the number one cause of disability in the country. Hypertension, found in approximately 50 million Americans, has been shown to be associated with alterations of cognitive function, even in the absence of stroke and dementia. Recent studies of neurovascular disease have now revealed that neuropsychological function may be a more sensitive measure of brain integrity than coordination, motor or sensory function and correlates will with functional outcome measures. Neurovascular Neuropsychology focuses on focal and diffuse neurovascular disease in addition to systemic conditions in which cognition and behavior have been uniquely associated with different pathologic states. With an increasing number of patients being treated by healthcare professionals, Neurovascular Neuropsychology will prove to be a strong reference to consult in regards to neuropsychological syndromes.
Cognitive Stimulation Therapy For Dementia
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Author : Lauren A. Yates
language : en
Publisher: Routledge
Release Date : 2017-09-11
Cognitive Stimulation Therapy For Dementia written by Lauren A. Yates and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-11 with Psychology categories.
Cognitive Stimulation Therapy (CST) has made a huge global, clinical impact since its inception, and this landmark book is the first to draw all the published research together in one place. Edited by experts in the intervention, including members of the workgroup who initially developed the therapy, Cognitive Stimulation Therapy for Dementia features contributions from authors across the globe, providing a broad overview of the entire research programme. The book demonstrates how CST can significantly improve cognition and quality of life for people with dementia, and offers insight on the theory and mechanisms of change, as well as discussion of the practical implementation of CST in a range of clinical settings. Drawing from several research studies, the book also includes a section on culturally adapting and translating CST, with case studies from countries such as Japan, New Zealand and Sub-Saharan Africa. Cognitive Stimulation Therapy for Dementia will be essential reading for academics, researchers and postgraduate students involved in the study of dementia, gerontology and cognitive rehabilitation. It will also be of interest to health professionals, including psychologists, psychiatrists, occupational therapists, nurses and social workers.
Medical Biosensors For Point Of Care Poc Applications
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Author : Roger Narayan
language : en
Publisher: Woodhead Publishing
Release Date : 2016-08-21
Medical Biosensors For Point Of Care Poc Applications written by Roger Narayan and has been published by Woodhead Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-21 with Medical categories.
Medical Biosensors for Point of Care (POC) Applications discusses advances in this important and emerging field which has the potential to transform patient diagnosis and care. Part 1 covers the fundamentals of medical biosensors for point-of-care applications. Chapters in part 2 go on to look at materials and fabrication of medical biosensors while the next part looks at different technologies and operational techniques. The final set of chapters provide an overview of the current applications of this technology. Traditionally medical diagnostics have been dependent on sophisticated technologies which only trained professionals were able to operate. Recent research has focused on creating point-of-care diagnostic tools. These biosensors are miniaturised, portable, and are designed to be used at the point-of-care by untrained individuals, providing real-time and remote health monitoring. Provides essential knowledge for designers and manufacturers of biosensors for point-of-care applications Provides comprehensive coverage of the fundamentals, materials, technologies, and applications of medical biosensors for point-of-care applications Includes contributions from leading international researchers with extensive experience in developing medical biosensors Discusses advances in this important and emerging field which has the potential to transform patient diagnosis and care
Cumulated Index Medicus
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Author :
language : en
Publisher:
Release Date : 1988
Cumulated Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988 with Medicine categories.
The Oxford Handbook Of Affective Computing
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Author : Rafael A. Calvo
language : en
Publisher: Oxford Library of Psychology
Release Date : 2015
The Oxford Handbook Of Affective Computing written by Rafael A. Calvo and has been published by Oxford Library of Psychology this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Computers categories.
"The Oxford Handbook of Affective Computing is a definitive reference in the burgeoning field of affective computing (AC), a multidisciplinary field encompassing computer science, engineering, psychology, education, neuroscience, and other disciplines. AC research explores how affective factors influence interactions between humans and technology, how affect sensing and affect generation techniques can inform our understanding of human affect, and on the design, implementation, and evaluation of systems involving affect at their core. The volume features 41 chapters and is divided into five sections: history and theory, detection, generation, methodologies, and applications. Section 1 begins with the making of AC and a historical review of the science of emotion. The following chapters discuss the theoretical underpinnings of AC from an interdisciplinary viewpoint. Section 2 examines affect detection or recognition, a commonly investigated area. Section 3 focuses on aspects of affect generation, including the synthesis of emotion and its expression via facial features, speech, postures, and gestures. Cultural issues are also discussed. Section 4 focuses on methodological issues in AC research, including data collection techniques, multimodal affect databases, formats for the representation of emotion, crowdsourcing techniques, machine learning approaches, affect elicitation techniques, useful AC tools, and ethical issues. Finally, Section 5 highlights applications of AC in such domains as formal and informal learning, games, robotics, virtual reality, autism research, health care, cyberpsychology, music, deception, reflective writing, and cyberpsychology. This compendium will prove suitable for use as a textbook and serve as a valuable resource for everyone with an interest in AC."--