N Akt
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Nakt Akt
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Author : Willy Zielke
language : en
Publisher:
Release Date : 1952
Nakt Akt written by Willy Zielke and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1952 with categories.
Synthesis And Characterization Of N Pentylaminophenoxazine Akt Inhibitors In Cancer Cells
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Author : Parimala B. Hanumesh
language : en
Publisher:
Release Date : 2007
Synthesis And Characterization Of N Pentylaminophenoxazine Akt Inhibitors In Cancer Cells written by Parimala B. Hanumesh and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Antineoplastic agents categories.
Bulletin
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Author : Maharashtra (India). Sales Tax Dept
language : en
Publisher:
Release Date : 1964
Bulletin written by Maharashtra (India). Sales Tax Dept and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1964 with Sales tax categories.
Includes legislation.
The Illustrated National Pronouncing Dictionary Of The English Language On The Basis Of Webster Worcester Walker Johnson With An Appendix Etc
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Author : Dictionaries. [English.]
language : en
Publisher:
Release Date : 1869
The Illustrated National Pronouncing Dictionary Of The English Language On The Basis Of Webster Worcester Walker Johnson With An Appendix Etc written by Dictionaries. [English.] and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1869 with English language categories.
A Manual Of Scientific Terms
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Author : James Stormonth
language : en
Publisher:
Release Date : 1885
A Manual Of Scientific Terms written by James Stormonth and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1885 with Science categories.
Ampk And Akt Differentially Regulate The Upr In Acute Lymphoblastic Leukemia
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Author : Jeffim N Kuznetsov
language : en
Publisher:
Release Date : 2012
Ampk And Akt Differentially Regulate The Upr In Acute Lymphoblastic Leukemia written by Jeffim N Kuznetsov and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with categories.
Acute Lymphoblastic Leukemia (ALL) is the most common hematological malignancy and the main cause of cancer-related death in children. Current chemotherapy treatments based mainly on antifolate regimens have lead to high cure rates ([almost equal to]80%), however event-free survival (EFS) for children and adults diagnosed with chemotherapy resistant phenotypes of ALL or after the relapse, continues to be dismal (EFS ∼10-20%). High-risk chemotherapy treatment based on intensification strategies and/or the use of stem cell transplantation have led to marginal improvements with limited impact on cure rates of resistant/refractory or relapsed ALL phenotypes. Our studies attempted to discover highly effective treatment strategies for ALL by targeting novel molecular pathways with existing agents that represent a backbone of current effective chemotherapeutic regimens for ALL. Our findings for the first time demonstrated that ALL exhibited sensitivity to reactive oxygen species (ROS) -induced endoplasmic reticulum (ER) stress and the unfolded protein response (UPR)-mediated cell death. These findings suggest a novel use for methotrexate (MTX), the backbone of current antifolate-based ALL chemotherapy, in combination with exogenous 5-aminoimidazole- 4-carboxamide-1-beta-4-ribofuranoside (AICAr) as part of the treatment intensification to target ER stress/UPR signaling in ALL. The sensitivity of ALL cell lines and primary patient cells to ER stress-induced cytotoxicity was further confirmed by using the glycolytic inhibitor 2-deoxy-D-glucose (2-DG) in ALL cell models. We found that 2-DG induced significant cell death under normoxia in Bp-ALL and T-ALL cells. This finding makes ALL one of the few tumor cell lines that exhibit sensitivity to glycolytic inhibitor 2-DG under normoxia. Using D-mannose, a sugar essential for N-linked glycosylation, our laboratory has postulated that 2-DG inhibits N-linked glycosylation and interferes with glycan-dependent folding and quality control of nascent ER proteins, which leads to ER stress-induced cytotoxicity in ALL. Our data also demonstrate for the first time that Akt and AMP-activated protein kinase (AMPK) differentially modulate the UPR function in ALL and determine the cellular responses (survival vs. death) depending on a type of ER stress-causing chemotherapeutic injury. In the case of AICAr plus MTX treatment we postulate that AMPK blocks the induction of the proapoptotic UPR signaling caused by the accumulation of ROS and the prolonged ER stress. In that case, Akt, a cellular antagonist of AMPK, plays a paradoxical proapoptotic role. However, in the case of 2- DG treatment, the effects of AMPK and Akt on cell cytotoxicity are reversed. We postulate that it is AMPK-mediated inhibition of the pro-survival glucose regulated protein 78 (GRP78)-regulated UPR signaling that synergistically potentiates apoptosis in ALL via induction of proteotoxicity. Our data underscore the complexity of the interactions within these pathways, and suggests that the contextual relationship between these signaling proteins and cross-talk with related pathways are critical determinants of cellular responses and fate in ALL cells.
Equations Of State For Solids In Geophysics And Ceramic Science
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Author : Orson Anderson
language : en
Publisher: Oxford University Press
Release Date : 1995-01-12
Equations Of State For Solids In Geophysics And Ceramic Science written by Orson Anderson and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-01-12 with Science categories.
Written by a renowned expert in the field, this book is the most comprehensive treatment available on the applications of equations of state (EoS) in geophysics and materials science, a topic of fundamental importance to those studying the physics and chemistry of the Earth. Part one offers comprehensive treatments of thermal properties associated with EoS, thermodynamic and statistical mechanical backgrounds, and thermoelastic properties. Definitions of the physical properties needed for the EoS are provided as well. Part two discusses the isothermal pressure-volume relationship. The ab initio approach--EoS based upon quantum mechanics fundamentals using numerical methods--is utilized to clearly represent and analyze the measured data. Part three offers an advanced treatment of thermal properties at high temperature, and includes discussions of thermal pressure, shocked solids, and EoS applications to materials science topics such as melting and thermodynamic function. Advanced students, researchers, and professionals in geophysics, ceramics science, solid state physics, and geochemistry will want to read this book.
The Illustrated National Pronouncing Dictionary Of The English Language
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Author : English language
language : en
Publisher:
Release Date : 1869
The Illustrated National Pronouncing Dictionary Of The English Language written by English language and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1869 with categories.
Natural Language Processing And Information Systems
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Author : Mokrane Bouzeghoub
language : en
Publisher: Springer
Release Date : 2003-06-29
Natural Language Processing And Information Systems written by Mokrane Bouzeghoub and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-06-29 with Computers categories.
This book includes the papers presented at the fifth International Conference on Application of Natural Language to Information Systems (NLDB 2000) which was held in Versailles (France) on June 28-30. Following NLDB95 in Versailles, NLDB96 i n Amsterdam, NLDB97 i n Vancouver, and NLDB99 i n Klagenfurt, NLDB 2000 was a forum for exchanging new research results and trends on the benefits of integrating Natural Language resources in Information System Engineering. Since the first NLDB workshop in 1995 it has become apparent that each aspect of an information system life cycle may be improved by natural language techniques: database design (specification, validation, conflict resolution), database query languages, and application programming that use new software engineering research (natural language program specifications). As information systems are now evolving into the communication area, the term databases should be considered in the broader sense of information and communication systems. The main new trend in NLDB 2000 is related to the WEB wave: WEB querying, WEB answering, and information retrieval. Among 47 papers submitted from 18 countries, the program committee selected 29 papers to be presented during the conference. Besides these regular papers, two invited talks (given by Pr. Reind P. van de Riet and Pr. Maurice Gross), and a set of posters and demonstrations are also included in these proceedings.
The New Excelsior Dictionary
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Author :
language : en
Publisher:
Release Date : 1887
The New Excelsior Dictionary written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1887 with English language categories.