88 Segredos Dos Milion Rios
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Translational Medicine
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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26
Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.
Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.
The One And Only Sparkella
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Author : Channing Tatum
language : en
Publisher: Feiwel & Friends
Release Date : 2021-05-04
The One And Only Sparkella written by Channing Tatum and has been published by Feiwel & Friends this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-04 with Juvenile Fiction categories.
An Instant #1 New York Times Bestseller! A Publishers Weekly Bestseller! Leading actor, producer and director Channing Tatum's picture book debut, The One and Only Sparkella is a charming ode to self-esteem and the love between a father and daughter—illustrated by Kim Barnes. Ella is excited for her first day at a new school. Glimmering pencil case? Check! Shimmering backpack? Check! Glittery ribbons in her hair? Check! She can't wait to meet the other kids and share her sparkly personality. But her first day doesn't go quite as planned: Her new classmates don't like her disco-ball shoes, her PB&J-with-sprinkles sandwich, or her rainbow-y unicorn painting. Ella decides to try to be less sparkly at school the next day so the other kids won't make fun of her. But with a little help from her dad, she soon learns the importance of just being herself, no matter what other people say.
Slave And Citizen
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Author : Frank Tannenbaum
language : en
Publisher: Vintage
Release Date : 2012-08-29
Slave And Citizen written by Frank Tannenbaum and has been published by Vintage this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-08-29 with Social Science categories.
Slave & Citizen deals with one of the most intriguing problems presented by the development of the New World: the contrast between the legal and social positions of the Negro in the United States and in Latin America. It is well-known that in Brazil and in the Caribbean area, Negroes do not suffer legal or even major social disabilities on account of color, and that a long history of acceptance and miscegenation has erased the sharp line between white and colored. Professor Tannenbaum, one of our leading authorities on Latin America, asks why there has been such a sharp distinction between the United States and the other parts of the New World into which Negroes were originally brought as slaves. In the legal structure of the United States, the Negro slave became property. There has been little experience with Negro slaves in England, and the ancient and medieval traditions affecting slavery had died out. As property, the slave was without rights to marriage, to children, to the product of his work, or to freedom. In the Iberian peninsula, on the other hand, Negro slaves were common, and the laws affecting them were well developed. Therefore, in the colonies of Spain and Portugal, while the slave was the lowest person in the social order, he was still a human being, with some rights, and some means by which he might achieve freedom. Only the United States made a radical split with the tradition in which all men, even slaves, had certain inalienable rights.
River Algae
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Author : Orlando Necchi JR
language : en
Publisher: Springer
Release Date : 2016-06-02
River Algae written by Orlando Necchi JR and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-06-02 with Technology & Engineering categories.
The content is focused on benthic communities showing how they play an in important role in the river ecosystems. Provides also information on taxonomy of river-inhabiting algal groups, including phylogeny, distribution, collection, preservation and description of the most representative genera of algae in river benthic algal communities. The book also approaches the ecology of river algae not to mention the ecological factors influencing abundance, distribution and diversity of river benthic algal communities and their use as bio-indicators, providing an up-to-date information on taxonomy, ecology, methodology and uses, and a great source of research to everyone interested in freshwater algae, limnology, water quality assessment and biodiversity in river ecosystems.
Fruit The Art Of Pastry
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Author : Cedric Ramadier
language : en
Publisher: Ducasse Books
Release Date : 2019-03-19
Fruit The Art Of Pastry written by Cedric Ramadier and has been published by Ducasse Books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-19 with Cooking categories.
C dric Grolet is simply the most talented pastry chef of his generation--he was named World's Best Pastry Chef in 2018. Food & Wine called his work "the apotheosis of confectionary creation." He fashions trompe l'oeil pieces that appear to be the most perfect, sparkling fruit but are, once cut, revealed to be exquisite pastries with surprising fillings. They are absolutely unforgettable, both to look at and, of course, to eat. This lush cookbook presents Grolet's fruit-based haute-couture pastries like works of art. The chef explains his techniques and his search for authentic tastes and offers a peek into his boundless imagination--he begins the creation of each dessert by drawing. With 130 recipes featuring 45 fruits--citrus, berries, wild and exotic fruits, and even nuts--every pastry lover will want Fruit, for inspiration and to admire the edible sculptures made by this award-winning star of French pastry making.
Has Latin American Inequality Changed Direction
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Author : Luis Bértola
language : en
Publisher: Springer
Release Date : 2017-01-25
Has Latin American Inequality Changed Direction written by Luis Bértola and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-25 with Business & Economics categories.
This book is open access under a CC BY 4.0 license. This book brings together a range of ideas and theories to arrive at a deeper understanding of inequality in Latin America and its complex realities. To so, it addresses questions such as: What are the origins of inequality in Latin America? How can we create societies that are more equal in terms of income distribution, gender equality and opportunities? How can we remedy the social divide that is making Latin America one of the most unequal regions on earth? What are the roles played by market forces, institutions and ideology in terms of inequality? In this book, a group of global experts gathered by the Institute for the Integration of Latin America and the Caribbean (INTAL), part of the Inter-American Development Bank (IDB), show readers how various types of inequality, such as economical, educational, racial and gender inequality have been practiced in countries like Brazil, Bolivia, Chile, Mexico and many others through the centuries. Presenting new ideas, new evidence, and new methods, the book subsequently analyzes how to move forward with second-generation reforms that lay the foundations for more egalitarian societies. As such, it offers a valuable and insightful guide for development economists, historians and Latin American specialists alike, as well as students, educators, policymakers and all citizens with an interest in development, inequality and the Latin American region.
Migratory Fishes Of South America
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Author : Joachim Carolsfeld
language : en
Publisher: IDRC
Release Date : 2003
Migratory Fishes Of South America written by Joachim Carolsfeld and has been published by IDRC this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Nature categories.
Roraima
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Author : John Hemming
language : en
Publisher:
Release Date : 1990
Roraima written by John Hemming and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with History categories.
The Atlantic Forest
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Author : Marcia C. M. Marques
language : en
Publisher: Springer Nature
Release Date : 2021-01-13
The Atlantic Forest written by Marcia C. M. Marques and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-13 with Science categories.
The Atlantic Forest is one of the 36 hotspots for biodiversity conservation worldwide. It is a unique, large biome (more than 3000 km in latitude; 2500 in longitude), marked by high biodiversity, high degree of endemic species and, at the same time, extremely threatened. Approximately 70% of the Brazilian population lives in the area of this biome, which makes the conflict between biodiversity conservation and the sustainability of the human population a relevant issue. This book aims to cover: 1) the historical characterization and geographic variation of the biome; 2) the distribution of the diversity of some relevant taxa; 3) the main threats to biodiversity, and 4) possible opportunities to ensure the biodiversity conservation, and the economic and social sustainability. Also, it is hoped that this book can be useful for those involved in the development of public policies aimed at the conservation of this important global biome.
The African Film Industry
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Author : UNESCO
language : en
Publisher: UNESCO Publishing
Release Date : 2021-10-01
The African Film Industry written by UNESCO and has been published by UNESCO Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-01 with Political Science categories.
The production and distribution of film and audiovisual works is one of the most dynamic growth sectors in the world. Thanks to digital technologies, production has been growing rapidly in Africa in recent years. For the first time, a complete mapping of the film and audiovisual industry in 54 States of the African continent is available, including quantitative and qualitative data and an analysis of their strengths and weaknesses at the continental and regional levels.The report proposes strategic recommendations for the development of the film and audiovisual sectors in Africa and invites policymakers, professional organizations, firms, filmmakers and artists to implement them in a concerted manner.