Akt

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Pi3k And Akt Isoforms In Immunity

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Author : Margarita Dominguez-Villar
language : en
Publisher: Springer Nature
Release Date : 2022-10-15

Pi3k And Akt Isoforms In Immunity written by Margarita Dominguez-Villar and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-15 with Medical categories.

This book provides an essential overview of the role of phosphoinositide-3-phosphate kinase (PI3K) isoforms in modulating the function of immune system cells and their involvement in disease. PI3K is a family of kinases involved in basic cellular processes such as proliferation, migration and cell death. Recent work has highlighted the multiple roles of PI3K classes and subunits and their involvement in the immune response to the body’s own and foreign antigens and diseases such as cancer and autoimmunity. This book offers a detailed introduction to the biology of the three PI3K classes, followed by an extensive discussion of the diverse roles of AKT and PI3K isoforms in immune cells. Based on this knowledge, it subsequently explains in more detail how specific isoforms are connected to immune-mediated diseases. The book concludes by highlighting the latest advances in the production of isoform-specific inhibitors and their use in various human diseases. This book is intended as a reference guide for students and researchers interested in the multifaceted aspects of PI3K biology.

Rcgp Akt

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Author : Julian Hick
language : en
Publisher: CRC Press
Release Date : 2014-09-05

Rcgp Akt written by Julian Hick and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-05 with Medical categories.

This book has been specifically designed to help GP trainees pass the compulsory AKT examination. Each topic has been skilfully refined to correlate directly with primary care and the RCGP curriculum, revealing how and why critical appraisal and evidence based medicine are essential for good medical practice throughout a career as an independent, k

Oncogenic Pi3kt Akt Mtor Pathway Alterations Ros Homeostasis Targeted Cancer Therapy And Drug Resistance

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Author : Rozangela Curi Pedrosa
language : en
Publisher: Frontiers Media SA
Release Date : 2024-02-23

Oncogenic Pi3kt Akt Mtor Pathway Alterations Ros Homeostasis Targeted Cancer Therapy And Drug Resistance written by Rozangela Curi Pedrosa and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-02-23 with Medical categories.

The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway is an important signaling route that regulates several cell functions. PI3K/AKT/mTOR pathway is a crossroad of cell death and survival, playing a pivotal role in multiple interconnected cell signaling mechanisms implicated in cell metabolism, growth and proliferation, apoptosis, and angiogenesis. Disruptions in the Akt‑regulated pathways and alterations in PTEN expression are associated to Reactive oxygen species (ROS) homeostasis and different types of cancer. Genomic studies have shown that activating mutations in oncogenes as well as inactivating mutations in tumor suppressor genes are present across a variety of malignancies, including constitutive activation of the PI3K/AKT/mTOR pathway. The regulation of the Akt signaling pathway renders multiple challenges and valuable therapeutic targets. The discovery process of Akt, PDK1 and mTOR synthetic and natural products as inhibitors or immune checkpoint inhibitors using various strategies, could led to the identification of small molecule inhibitors with great selectivity, low side‑effects and also low toxicity regarding drug development.

Pkb Akt Kinase Localization And Role In Stemness Maintenance In Cancer

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Author : Mayur Vilas Jain
language : en
Publisher: Linköping University Electronic Press
Release Date : 2016-04-27

Pkb Akt Kinase Localization And Role In Stemness Maintenance In Cancer written by Mayur Vilas Jain and has been published by Linköping University Electronic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-27 with categories.

Cancer incidence rates have increased over the last decade. Currently available therapies are only moderately effective in targeting cancer cells. Established cancer treatment protocols fail to eliminate populations of cancer stem cells (CSCs), which develop resistance against the chemotherapeutic drugs and lead to cancer recurrence. Therefore, understanding the mechanisms by which CSCs resist drugs and identifying molecular markers are both necessary to further improve prognosis and to develop new treatment strategies. Increased protein kinase B/Akt1 gene expression and/or activity have been found increased in majority of cancer types. Akt1 is a key player in PI3K-AktmTOR pathway that is vital for cell survival, proliferation, migration, invasion, metastasis, angiogenesis and apoptosis. In this study, we investigated a series of novel markers to improve the characterization of CSCs, with particular focus the roles of Akt in CSC maintenance and the regulatory role of micro-RNA (miR) in cancer cells. While utilizing in breast cancer cells as models, we found that luminescent conjugated oligothiophenes (LCOs), p-HTMI and p-HTAA have the potential to differentially stain various subpopulations of cancer cells, presumably also CSCs among breast cancer cells. However, further studies are needed to confirm these results. Additionally, when we investigated the effect of Akt intracellular compartmentalization on CSC development, the results revealed that nuclear Akt enhances CSC proliferation (ALDH +/High CD44+/High/CD24-/Low) and clonogenicity, which was counter examined and confirmed by using the Aktspecific inibitor triciribine. Furthermore, while investigating the impact of Akt on miR regulation in cancer cells, we found that Akt overexpression decreased.

Isocucurbitacin B Inhibits Glioma Growth Through Pi3k Akt Pathways And Increases Glioma Sensitivity To Tmz By Inhibiting Hsa Mir 1286a

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Author : Mingyu Han
language : en
Publisher: OAE Publishing Inc.
Release Date : 2024-05-08

Isocucurbitacin B Inhibits Glioma Growth Through Pi3k Akt Pathways And Increases Glioma Sensitivity To Tmz By Inhibiting Hsa Mir 1286a written by Mingyu Han and has been published by OAE Publishing Inc. this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-08 with Medical categories.

Aim: Glioma accounts for 81% of all cancers of the nervous system cancers and presents one of the most drug-resistant malignancies, resulting in a relatively high mortality rate. Despite extensive efforts, the complete treatment options for glioma remain elusive. The effect of isocucurbitacin B (isocuB), a natural compound extracted from melon pedicels, on glioma has not been investigated. This study aims to investigate the inhibitory effect of isocuB on glioma and elucidate its underlying mechanisms, with the objective of developing it as a potential therapeutic agent for glioma. Methods: We used network pharmacology and bioinformatics analysis to predict potential targets and associated pathways of isocuB in glioma. Subsequently, the inhibitory effect of isocuB on glioma and its related mechanisms were assessed through Counting Kit-8 (CCK-8), wound healing, transwell, Western blot (WB), reverse transcription-quantitative polymerase chain reaction (RT-qPCR), and other in vitro experiments, alongside tumor formation experiments in nude mice. Results: Based on this investigation, it suggested that isocuB might inhibit the growth of gliomas through the PI3K-AKT and MAPK pathways. Additionally, we proposed that isocuB may enhance glioma drug sensitivity to temozolomide (TMZ) via modulation of hsa-mir-1286a. The CCK-8 assay revealed that isocuB exhibited inhibitory effects on U251 and U87 proliferation and outperformed TMZ. Wound healing and transwell experiments showed that isocuB inhibited the invasion and migration of U251 cells by suppressing the activity of MMP-2/9, N-cadherin, and Vimentin. The tunnel and flow cytometry (FCM) assays revealed that isocuB induced cell apoptosis through inhibition of BCL-2. Subsequently, we conducted RT-qPCR and WB experiments, which revealed that PI3K/AKT and MAPK pathways might be involved in the mechanism of the inhibition isocuB on glioma. Additionally, isocuB promoted the sensitivity of glioma U251 to TMZ by inhibiting hsa-mir-1286a. Furthermore, we constructed TMZ-resistant U251 strains and demonstrated effective inhibition by isocuB against these resistant strains. Finally, we confirmed that isocuB can inhibit tumor growth in vivo through experiments on tumors in nude mice. Conclusion: IsocuB may protect against glioma by acting on the PI3K/AKT and MAPK pathways and promote the sensitivity of glioma U251 to TMZ by inhibiting hsa-mir-1286a.

Re Akt Reconstruction Re Enactment Re Reporting

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Author :
language : en
Publisher: Domenico Quaranta
Release Date : 2009

Re Akt Reconstruction Re Enactment Re Reporting written by and has been published by Domenico Quaranta this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Art categories.

Cellular And Molecular Roles Of The Akt Protein Kinase In Breast Carcinomas

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Author : Anne B. Vojtek
language : en
Publisher:
Release Date : 1999

Cellular And Molecular Roles Of The Akt Protein Kinase In Breast Carcinomas written by Anne B. Vojtek and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with categories.

Akt is a serine/threonine kinase that has been implicated in the initiation and/or progression of breast cancers. In order to gain an understanding of how Akt promotes malignant transformation, we identified proteins that are regulated by phosphorylation by Akt, including a POU domain family transcription factor and the B-Raf serine/threonine kinase. Whereas Akt may upregulate gene expression through phosphorylation of the POU domain transcription factor, Akt negatively regulates B-Raf activity in vitro and in vivo by phosphorylating two residues in the amino-terminal regulatory domain of B-raf.

Notes For The Mrcgp

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Author : Keith Palmer
language : en
Publisher: John Wiley & Sons
Release Date : 2009-12-21

Notes For The Mrcgp written by Keith Palmer and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-12-21 with Medical categories.

Notes for the MRCGP This classic book has been providing help for candidates of the MRCGP exam for over 20 years. Now fully updated for UK trained doctors wishing to obtain a Certificate of Completion of Training in General Practice, this new edition covers all three required components of the integrated assessment programme. It provides sample questions for the Applied Knowledge Test (AKT), practice cases for Clinical Skill Assessment (CSA) and a guide to Workplace Based Assessment (WPBA). The chapters follow the 16 sections of the RCGP curriculum and include summaries of the current evidence base with clinical guidelines, examination tips, revision tactics, and advice on where to get support – but not just at the crucial time of exams – it includes invaluable information for GPs starting their first year in practice and helps provide the “life skills” needed to be a GP, including topics relevant for the rest of a GP’s career and their “continuing professional development” – appraisal, revalidation, managing change, teamwork, burnout, and other areas of self care.

Applied Knowledge Test For The New Mrcgp

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Author : Nuzhet A-Ali
language : en
Publisher: Scion Publishing
Release Date : 2010

Applied Knowledge Test For The New Mrcgp written by Nuzhet A-Ali and has been published by Scion Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Family medicine categories.

This book helps candidates pass the AKT (Applied Knowledge Test) paper in the new MRCGP. It features nearly 400 questions using all the formats featured in the AKT exam to provide the reader with the ideal exam preparation. Importantly, detailed answers are also given, complete with references to guide readers to the supporting evidence. This new edition features even more questions in every format: a total of 300 extended matching and single best answer questions over 50 algorithm completion questions including management of coeliac disease, symptoms and signs suggestive of chronic heart failure, and management of the unconscious adult over 30 picture questions, with all photographs presented in full colour "

Apoptosome

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Author : Francesco Cecconi
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-12-01

Apoptosome written by Francesco Cecconi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-12-01 with Medical categories.

"Apoptosome" is the first book that presents a concise synthesis of recent developments in the understanding of how the activation of the cell death cascade is handled by a cytosolic signalling platform known as the apoptosome. The book also discusses how insights into the regulation of apoptosome may be exploited for designing new drugs aimed at interfere with a plethora of pathogenetic processes involved in human diseases. The authors emphasize novel translational approaches that are rapidly moving from the laboratory bench top to the patient's bedside for the future treatment of diseases associated with apoptosis. This book will be a valuable resource for researchers investigating the role of apoptosome-dependent cell death in cancer and other diseases, for researchers investigating the molecular mechanism of chemotherapeutic agents and drug-resistance and for physicians using chemotherapeutic agents. Additionally, this book will be an important educational source for PhD students and MD students specializing in molecular and cell biology, and to anybody interested in science, medicine, as well as in recent developments of the ideas and concepts of the molecular biology of programmed cell death.