As J Ias Da Coroa

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Translational Medicine

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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26

Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.

Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.

Coroa Da Meia Noite Trono De Vidro 2

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Author : Sarah J. Maas
language : pt-BR
Publisher: Editorial Presença
Release Date :

Coroa Da Meia Noite Trono De Vidro 2 written by Sarah J. Maas and has been published by Editorial Presença this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.

The Voyage Of Fran Ois Pyrard Of Laval To The East Indies The Maldives The Moluccas And Brazil

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Author : François Pyrard
language : en
Publisher:
Release Date : 1888

The Voyage Of Fran Ois Pyrard Of Laval To The East Indies The Maldives The Moluccas And Brazil written by François Pyrard and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1888 with East Indies categories.

Emmanuelis Alvarez Pegas Commentaria Ad Ordinationes Regni Portugalliae

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Author : Manuel Álvares Pêgas
language : la
Publisher:
Release Date : 1691

Emmanuelis Alvarez Pegas Commentaria Ad Ordinationes Regni Portugalliae written by Manuel Álvares Pêgas and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1691 with categories.

Financial Reporting And Global Capital Markets

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Author : Kees Camfferman
language : en
Publisher: OUP Oxford
Release Date : 2007-03-08

Financial Reporting And Global Capital Markets written by Kees Camfferman and has been published by OUP Oxford this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-03-08 with Business & Economics categories.

A detailed and scholarly historical study of the International Accounting Standards Committee (IASC), which prepared the way for the International Accounting Standards Board (IASB). The IASB holds the dominant influence over the financial reporting of thousands of listed companies in the European Union as well as in many other countries.

Latin American Coral Reefs

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Author : J. Cortés
language : en
Publisher: Elsevier
Release Date : 2003-04-25

Latin American Coral Reefs written by J. Cortés and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-04-25 with Science categories.

Approx.508 pages

Dami O De Gois

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Author : Elisabeth Feist Hirsch
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Dami O De Gois written by Elisabeth Feist Hirsch and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with History categories.

Scholars have given relatively little attention to sixteenth-century Portuguese humanism, although Portugal's vital influence on the humanistic thirst for learning has been readily acknowledged. Through her heroic explorations of distant lands and dangerous sea routes, Portugal infected many humanists with the excitement of discovery, none more than Damiao de Gois, Portuguese student of history. Gois, although generally little known, was - in his life and finally as a victim of the Inquisition in Portugal - thoroughly representative of the course of sixteenth-century Erasmian humanism in Portugal; in addition he deserves recognition in his own right as a contributor to modern historiography. Portugal's explorations and the atmosphere of passion for discovery that prevailed in Lisbon had as strong an influence on Gois during his early years as that of the school of Erasmus, the "prince of humanists" who was eventually to become his personal friend and guide. Gois's two great chronicles of the Portuguese kings John II and Ma nuel I culminated a life spent as diplomat, composer, art collector, articulate pleader for religious tolerance, and scrupulous student of history. A factual report of Gois's life - in the main outlines accurate but not complete - exists in Portuguese, and a short resume of his life has been published in English, but so far no full study has been available in any language.

The Last Empire

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Author : Stewart Lloyd-Jones
language : en
Publisher: Intellect Books
Release Date : 2003

The Last Empire written by Stewart Lloyd-Jones and has been published by Intellect Books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with History categories.

This book is the result of a conference organised by the Contemporary Portuguese Political History Research Centre (CPHRC) and the University of Dundee that took place during September 2000. The purpose of this conference, and the resulting book, was to bring together various experts in the field to analyse and debate the process of Portuguese decolonisation, which was then 25 years old, and the effects of this on the Portuguese themselves. For over one century, the Portuguese state had defined its foreign policy on the basis of its vast empire – this was the root of its 'Atlanticist' vision. The outbreak of war of liberation in its African territories, which were prompted by the new international support for self determination in colonised territories, was a serious threat that undermined the very foundations of the Portuguese state. This book examines the nature of this threat, how the Portuguese state initially attempted to overcome it by force, and how new pressures within Portuguese society were given space to emerge as a consequence of the colonial wars. This is the first book that takes a multidisciplinary look at both the causes and the consequences of Portuguese decolonisation – and is the only one that places the loss of Portugal's Eastern Empire in the context of the loss of its African Empire. Furthermore, it is the only English language book that relates the process of Portuguese decolonisation with the search for a new Portuguese vision of its place in the world. This book is intended for anyone who is interested in regime change, decolonisation, political revolutions and the growth and development of the European Union. It will also be useful for those who are interested in contemporary developments in civil society and state ideologies. Given that a large part of the book is dedicated to the process of change in the various countries of the former Portuguese Empire, it will also be of interest to students of Africa. It will be useful to those who study decolonisation processes within the other former European Empires, as it provides comparative detail. The book will be most useful to academic researchers and students of comparative politics and area studies.

Sapiens

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Author : Yuval Noah Harari
language : en
Publisher: Random House
Release Date : 2014-09-04

Sapiens written by Yuval Noah Harari and has been published by Random House this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-04 with History categories.

'Interesting and provocative... It gives you a sense of how briefly we've been on this Earth' Barack Obama What makes us brilliant? What makes us deadly? What makes us Sapiens? One of the world's preeminent historians and thinkers, Yuval Noah Harari challenges everything we know about being human. Earth is 4.5 billion years old. In just a fraction of that time, one species among countless others has conquered it: us. In this bold and provocative book, Yuval Noah Harari explores who we are, how we got here and where we're going. **ONE OF THE GUARDIAN'S 100 BEST BOOKS OF THE 21st CENTURY** PRAISE FOR SAPIENS: 'Jaw-dropping from the first word to the last... It may be the best book I've ever read' Chris Evans 'Startling... It changes the way you look at the world' Simon Mayo 'I would recommend Sapiens to anyone who's interested in the history and future of our species' Bill Gates

The Amazonian Caboclo And The A A Palm

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Author : Eduardo S. Brondízio
language : en
Publisher: Debolsillo
Release Date : 2008

The Amazonian Caboclo And The A A Palm written by Eduardo S. Brondízio and has been published by Debolsillo this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Technology & Engineering categories.