Bel M Transforma Es Na Ordem Urbana

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Translational Medicine

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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26

Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.

Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.

The Cristal Experiment

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Author : Armando Navarro
language : en
Publisher: Univ of Wisconsin Press
Release Date : 1998-07-15

The Cristal Experiment written by Armando Navarro and has been published by Univ of Wisconsin Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-07-15 with Political Science categories.

Amidst the turbulence and militancy of the 1960s and early 1970s, the Mexicano population of the dusty agricultural town of Crystal City, Texas (Cristal in Spanish), staged two electoral revolts, each time winning control of the city council and school board. The landmark city council victory in 1963 was a first for Mexican Americans in South Texas, and Cristal—the “spinach capital of the world”—became for a time the political capital of the Chicano Movement. In The Cristal Experiment, Armando Navarro presents the most comprehensive examination to date of the rise of the Chicano political movement in Cristal, its successes and conflicts (both internal and external), and its eventual decline. He looks particularly at the larger and more successful “Second Revolt” in 1970 and its aftermath up to 1981, examining the political, economic, educational, and social changes for Mexicanos that resulted. Drawing upon nearly 100 interviews, a wealth of secondary materials, and his own experiences as a political organizer in the Chicano Movement, Navarro offers a shrewd and insightful analysis not only of the events in Cristal, but also of the workings of local politics generally, the politics of community control, and the factors inherent in the American political system that lead to the self-destruction of political movements. As both a political scientist and an organizer, he outlines important lessons to be learned from what happened in Cristal and to the Chicano Movement.

From Manual Workers To Wage Laborers

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Author : Robert Castel
language : en
Publisher: Routledge
Release Date : 2017-07-05

From Manual Workers To Wage Laborers written by Robert Castel and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-07-05 with Political Science categories.

In this monumental book, sociologist Robert Castel reconstructs the history of what he calls "the social question," or the ways in which both labor and social welfare have been organized from the Middle Ages onward to contemporary industrial society. Throughout, the author identifies two constants bearing directly on the question of who is entitled to relief and who can be excluded: the degree of embeddedness in any given community and the ability to work. Along this dual axis the author locates virtually the entire history of social welfare in early-modern and contemporary Europe.This work is a systematic defense of the meaningfulness of the category of "the social," written in the tradition of Foucault, Durkheim, and Marx. Castel imaginatively builds on Durkheim's insight into the essentially social basis of work and welfare. Castel populates his sociological framework with vivid characterizations of the transient lives of the "disaffiliated": those colorful itinerants whose very existence proved such a threat to the social fabric of early-modern Europe. Not surprisingly, he discovers that the cruel and punitive measures often directed against these marginal figures are deeply implicated in the techniques and institutions of power and social control.The author also treats the flipside of the problem of social assistance: namely, matters of work and wage-labor. Castel brilliantly reveals how the seemingly objective line of demarcation between able-bodied beggars?those who are capable of work but who chose not to do so?and those who are truly disabled becomes stretched in modernity to make room for the category of the "working poor." It is the novel crisis posed by those masses of population who are unable to maintain themselves by their labor alone that most deeply challenges modern societies and forges recognizably modern policies of social assistance.The author's gloss on the social question also offers us valuable perspectives on contempo

Discipline And Punish

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Author : Michel Foucault
language : en
Publisher: Vintage
Release Date : 2012-04-18

Discipline And Punish written by Michel Foucault and has been published by Vintage this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-04-18 with Social Science categories.

A brilliant work from the most influential philosopher since Sartre. In this indispensable work, a brilliant thinker suggests that such vaunted reforms as the abolition of torture and the emergence of the modern penitentiary have merely shifted the focus of punishment from the prisoner's body to his soul.

Transforming Technology

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Author : Andrew Feenberg
language : en
Publisher: Oxford University Press
Release Date : 2002-02-06

Transforming Technology written by Andrew Feenberg and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-02-06 with Political Science categories.

Thoroughly revised, this new edition of Critical Theory of Technology rethinks the relationships between technology, rationality, and democracy, arguing that the degradation of labor--as well as of many environmental, educational, and political systems--is rooted in the social values that preside over technological development. It contains materials on political theory, but the emphasis has shifted to reflect a growing interest in the fields of technology and cultural studies.

Garden Cities Of To Morrow

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Author : Ebenezer Howard
language : en
Publisher: Routledge
Release Date : 2013-01-11

Garden Cities Of To Morrow written by Ebenezer Howard and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-01-11 with Science categories.

Originally published in 1898 as To-Morrow: A peaceful path to reform, "the book", writes F.J. Osborn "holds a unique place in town planning literature, is cited in all planning bibliographies, stands on the shelves of the more important libraries, and is alluded to in most books on planning; yet most of the popular writers on planning do not seem to have read it - or if they have read it, to remember what it says." The book led directly to two experiments in town-founding that by imitation, and imitation of imitation, have had a profound influence on practical urban development throughout the world. The book was responsible for the introduction of the term Garden City in numbers of languages - Cite-Jardin, Gartenstadt, Ciudad-jardin, Tuinstad - and set into motion ideas that have helped transform the scientific and political outlook on town structure and town growth. With urban renewal and the development of suburban communities as features of the contemoprary American scene, Garden cities of To-Morrow becomes "must" reading. In the words of Lewis Mumford: "This is not merely a book for Technicians: above all it is a book for citizens, for the people whose actively expressed needs, desires and interests should guide the planner and administrator at every turn." This book was first published in it's current form in 1965.

History And Memory

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Author : Jacques Le Goff
language : en
Publisher: Columbia University Press
Release Date : 1992

History And Memory written by Jacques Le Goff and has been published by Columbia University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with History categories.

In this brillant meditation on conceptions of history, Le Goff traces the evolution of the historian's craft. Examining real and imagined oppositions between past and present, ancient and modern, oral and written history, History and Memory reveals the strands of continuity that have characterized historiography from ancient Mesopotamia to modern Europe.

Globalization

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Author : Zygmunt Bauman
language : en
Publisher: John Wiley & Sons
Release Date : 2013-05-28

Globalization written by Zygmunt Bauman and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-28 with Political Science categories.

'Globalization' is a word that is currently much in use. This book is an attempt to show that there is far more to globalization than its surface manifestations. Unpacking the social roots and social consequences of globalizing processes, this book disperses some of the mist that surrounds the term. Alongside the emerging planetary dimensions of business, finance, trade and information flow, a 'localizing', space-fixing process is set in motion. What appears as globalization for some, means localization for many others; signalling new freedom for some, globalizing processes appear as uninvited and cruel fate for many others. Freedom to move, a scarce and unequally distributed commodity, quickly becomes the main stratifying factor of our times. Neo-tribal and fundamentalist tendencies are as legitimate offspring of globalization as the widely acclaimed 'hybridization' of top culture - the culture at the globalized top. A particular reason to worry is the progressive breakdown in communication between the increasingly global and extra- territorial elites and ever more 'localized' majority. The bulk of the population, the 'new middle class', bears the brunt of these problems, and suffers uncertainty, anxiety and fear as a result. This book is a major contribution to the unfolding debate about globalization, and as such will be of interest to students and professionals in sociology, human geography and cultural issues.

Worlds Of Work

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Author : Daniel B. Cornfield
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Worlds Of Work written by Daniel B. Cornfield and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Social Science categories.

The advent of transnational economic production and market integration compels sociologists of work to look beyond traditional national boundaries and build an international sociology of work in order to effectively address the human, scientific, and practical challenges posed by global economic transnationalism. The purpose of this volume is to promote transnational dialogue about the sociology of work and help build a truly international discipline in this field.

Conversations With Zygmunt Bauman

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Author : Zygmunt Bauman
language : en
Publisher: John Wiley & Sons
Release Date : 2013-05-31

Conversations With Zygmunt Bauman written by Zygmunt Bauman and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-31 with Social Science categories.

Zygmunt Bauman is one of the leading figures in contemporary social thought. His work ranges across issues of ethics, culture and politics. It never forgets that social thought ought to help men and women make sense of their lives and aspire towards something different. His books and essays always focus on the here and now: violence and moral indifference, globalization, consumerism, politics and individualization. They cast a sharp eye on the panaceas of ‘there is no alternative'; the embrace of community and the fads of the ‘counselling boom'; through which men and women are told that they can achieve biographical solutions to what are, in fact, systemic problems. In this new book, Zygmunt Bauman and Keith Tester engage in five accessible conversations that uncover and explore the assumptions and commitments underpinning Bauman's ground-breaking social thought. The conversations show how those commitments have influenced Bauman's analyses of modernity, postmodernity and ‘liquid modernity'. The book ranges widely, from autobiographical reflection through to pointers for the understanding and future of Bauman's social thought. The conversations illustrate the moral substance of Bauman's refusal to accept that the world cannot be made different. They show why social thought is a human necessity. Conversations with Zygmunt Bauman is a book which will offer fresh insight into Bauman's work for those who are familiar with it, and provide an engaging and helpful entry point for those who are new to it.