Bem Vindo A Solit Rios
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Translational Medicine
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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26
Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.
Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.
Veja Rio
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Author :
language : pt-BR
Publisher:
Release Date : 2002
Veja Rio written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with categories.
This Side Of Brightness
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Author : Colum McCann
language : en
Publisher: A&C Black
Release Date : 2013-08-01
This Side Of Brightness written by Colum McCann and has been published by A&C Black this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-08-01 with Fiction categories.
By the author of Let the Great World Spin, this critically acclaimed novel delves deep into the underbelly of New York 'Vivid, potent, beautifully measured, and sustained by astonishingly deft description' Maggie O'Farrell 'A dazzling blend of menace and heartbreak' New York Times Book Review ___________________________ At the turn of the twentieth century, Nathan Walker comes to New York City to take the most dangerous job in the country: digging the tunnel far beneath the Hudson that will carry trains from Brooklyn to Manhattan. In the bowels of the riverbed, the workers - black, white, Irish and Italian - dig together, the darkness erasing all differences. But above ground, the men keep their distance until a dramatic accident on a bitter winter's day welds a bond between Walker and his fellow workers that will both bless and curse three generations. Almost ninety years later, a homeless man nicknamed Treefrog stumbles on the same tunnels and sets about creating a home amongst the drug addicts, alcoholics, prostitutes and petty criminals that comprise the forgotten homeless community.
Bookdown
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Author : Yihui Xie
language : en
Publisher: CRC Press
Release Date : 2016-12-12
Bookdown written by Yihui Xie and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-12 with Mathematics categories.
bookdown: Authoring Books and Technical Documents with R Markdown presents a much easier way to write books and technical publications than traditional tools such as LaTeX and Word. The bookdown package inherits the simplicity of syntax and flexibility for data analysis from R Markdown, and extends R Markdown for technical writing, so that you can make better use of document elements such as figures, tables, equations, theorems, citations, and references. Similar to LaTeX, you can number and cross-reference these elements with bookdown. Your document can even include live examples so readers can interact with them while reading the book. The book can be rendered to multiple output formats, including LaTeX/PDF, HTML, EPUB, and Word, thus making it easy to put your documents online. The style and theme of these output formats can be customized. We used books and R primarily for examples in this book, but bookdown is not only for books or R. Most features introduced in this book also apply to other types of publications: journal papers, reports, dissertations, course handouts, study notes, and even novels. You do not have to use R, either. Other choices of computing languages include Python, C, C++, SQL, Bash, Stan, JavaScript, and so on, although R is best supported. You can also leave out computing, for example, to write a fiction. This book itself is an example of publishing with bookdown and R Markdown, and its source is fully available on GitHub.
Torrent Of Portyngale
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Author : Erich Adam
language : en
Publisher:
Release Date : 1887
Torrent Of Portyngale written by Erich Adam and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1887 with English poetry categories.
Data Science From Scratch
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Author : Joel Grus
language : en
Publisher: "O'Reilly Media, Inc."
Release Date : 2015-04-14
Data Science From Scratch written by Joel Grus and has been published by "O'Reilly Media, Inc." this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-14 with Computers categories.
Data science libraries, frameworks, modules, and toolkits are great for doing data science, but they’re also a good way to dive into the discipline without actually understanding data science. In this book, you’ll learn how many of the most fundamental data science tools and algorithms work by implementing them from scratch. If you have an aptitude for mathematics and some programming skills, author Joel Grus will help you get comfortable with the math and statistics at the core of data science, and with hacking skills you need to get started as a data scientist. Today’s messy glut of data holds answers to questions no one’s even thought to ask. This book provides you with the know-how to dig those answers out. Get a crash course in Python Learn the basics of linear algebra, statistics, and probability—and understand how and when they're used in data science Collect, explore, clean, munge, and manipulate data Dive into the fundamentals of machine learning Implement models such as k-nearest Neighbors, Naive Bayes, linear and logistic regression, decision trees, neural networks, and clustering Explore recommender systems, natural language processing, network analysis, MapReduce, and databases
Special Topics In Multimedia Iot And Web Technologies
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Author : Valter Roesler
language : en
Publisher: Springer Nature
Release Date : 2020-03-02
Special Topics In Multimedia Iot And Web Technologies written by Valter Roesler and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-02 with Computers categories.
This book presents a set of recent advances that involve the areas of multimedia, IoT, and web technologies. These advances incorporate aspects of clouds, artificial intelligence, data analysis, user experience, and games. In this context, the work will bring the reader the opportunity to understand new possibilities of use and research in these areas. We think that this book is suitable for students (postgraduates and undergraduates) and lecturers on these specific topics. Professionals can also benefit from the book since some chapters work with practical aspects relevant to the industry.
Pedagogy Of The Oppressed
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Author : Paulo Freire
language : en
Publisher:
Release Date : 1972
Pedagogy Of The Oppressed written by Paulo Freire and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1972 with Education categories.
The Power Of Habit
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Author : Charles Duhigg
language : en
Publisher: Random House
Release Date : 2012-02-28
The Power Of Habit written by Charles Duhigg and has been published by Random House this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-02-28 with Business & Economics categories.
NEW YORK TIMES BESTSELLER • This instant classic explores how we can change our lives by changing our habits. NAMED ONE OF THE BEST BOOKS OF THE YEAR BY The Wall Street Journal • Financial Times In The Power of Habit, award-winning business reporter Charles Duhigg takes us to the thrilling edge of scientific discoveries that explain why habits exist and how they can be changed. Distilling vast amounts of information into engrossing narratives that take us from the boardrooms of Procter & Gamble to the sidelines of the NFL to the front lines of the civil rights movement, Duhigg presents a whole new understanding of human nature and its potential. At its core, The Power of Habit contains an exhilarating argument: The key to exercising regularly, losing weight, being more productive, and achieving success is understanding how habits work. As Duhigg shows, by harnessing this new science, we can transform our businesses, our communities, and our lives. With a new Afterword by the author “Sharp, provocative, and useful.”—Jim Collins “Few [books] become essential manuals for business and living. The Power of Habit is an exception. Charles Duhigg not only explains how habits are formed but how to kick bad ones and hang on to the good.”—Financial Times “A flat-out great read.”—David Allen, bestselling author of Getting Things Done: The Art of Stress-Free Productivity “You’ll never look at yourself, your organization, or your world quite the same way.”—Daniel H. Pink, bestselling author of Drive and A Whole New Mind “Entertaining . . . enjoyable . . . fascinating . . . a serious look at the science of habit formation and change.”—The New York Times Book Review
Casa Grande E Senzala
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Author : Gilberto Freyre
language : en
Publisher: Univ of California Press
Release Date : 1986
Casa Grande E Senzala written by Gilberto Freyre and has been published by Univ of California Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986 with History categories.