Brasil Versus Portugal Um Derby Ling Stico
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Translational Medicine
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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26
Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.
Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.
Non Wood Forest Products From Temperate Broad Leaved Trees
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Author : William M. Ciesla
language : en
Publisher: Food & Agriculture Org.
Release Date : 2002
Non Wood Forest Products From Temperate Broad Leaved Trees written by William M. Ciesla and has been published by Food & Agriculture Org. this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Technology & Engineering categories.
Temperate broadleaved trees grow in very different ecosystems in the northern and southern hemispheres, but are also found extensively in many tropical and subtropical mountain areas. A wide range of non-wood products are derived from temperate broadleaved trees, and their description is organized in this volume according to the part of the tree from which they are obtained (whole tree, foliage, flowers, etc.). This information is presented in order to raise awareness on, and assist in identifying, opportunities for the management and production of non-wood products from temperate broadleaved trees. The intended audience of this publication ranges from interest groups in the forest, agriculture and rural development sectors to conservation agencies in developed and developing countries.
Interventions For The Control Of Non Typhoidal Salmonella Spp In Beef And Pork
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Author : Food and Agriculture Organization of the United Nations
language : en
Publisher: Microbiological Risk Assessmen
Release Date : 2016
Interventions For The Control Of Non Typhoidal Salmonella Spp In Beef And Pork written by Food and Agriculture Organization of the United Nations and has been published by Microbiological Risk Assessmen this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with Business & Economics categories.
"Non-typhoidal Salmonella spp. are estimated to cause 93.8 million cases of acute gastroenteritis and 155,000 deaths globally each year, approximately 85% of which are estimated to be foodborne, establishing Salmonella as having a significant public health and economic impact on society. Pork products are among the top food-borne sources of Salmonella globally, while beef products have been implicated in several large outbreaks in recent years. Contamination of beef and pork with Salmonella can also have a negative impact on the agri-food and trade sectors due to costly recalls of products and by limiting market access. FAO and WHO have undertaken a systematic review of the available evidence on interventions to control Salmonella in beef and pork from primary production through processing. This information was then considered by an expert meeting which provided recommendations on efficacious interventions. This report presents the outcome of those deliberations as well as the review of studies on which the discussions were based, providing the reader with a wealth of up to date information on the currently available interventions for the control of Salmonella in beef and pork."--Publisher's description.
Mean Baby
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Author : Selma Blair
language : en
Publisher: Vintage
Release Date : 2022-05-17
Mean Baby written by Selma Blair and has been published by Vintage this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-17 with Biography & Autobiography categories.
NEW YORK TIMES BEST SELLER • Selma Blair has played many roles: Ingenue in Cruel Intentions. Preppy ice queen in Legally Blonde. Muse to Karl Lagerfeld. Advocate for the multiple sclerosis community. But before all of that, Selma was known best as … a mean baby. In a memoir that is as wildly funny as it is emotionally shattering, Blair tells the captivating story of growing up and finding her truth. "Blair is a rebel, an artist, and it turns out: a writer." —Glennon Doyle, Author of the #1 New York Times Bestseller Untamed and Founder of Together Rising The first story Selma Blair Beitner ever heard about herself is that she was a mean, mean baby. With her mouth pulled in a perpetual snarl and a head so furry it had to be rubbed to make way for her forehead, Selma spent years living up to her terrible reputation: biting her sisters, lying spontaneously, getting drunk from Passover wine at the age of seven, and behaving dramatically so that she would be the center of attention. Although Selma went on to become a celebrated Hollywood actress and model, she could never quite shake the periods of darkness that overtook her, the certainty that there was a great mystery at the heart of her life. She often felt like her arms might be on fire, a sensation not unlike electric shocks, and she secretly drank to escape. Over the course of this beautiful and, at times, devasting memoir, Selma lays bare her addiction to alcohol, her devotion to her brilliant and complicated mother, and the moments she flirted with death. There is brutal violence, passionate love, true friendship, the gift of motherhood, and, finally, the surprising salvation of a multiple sclerosis diagnosis. In a voice that is powerfully original, fiercely intelligent, and full of hard-won wisdom, Selma Blair’s Mean Baby is a deeply human memoir and a true literary achievement.
Marine Insects
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Author : Lanna Cheng
language : en
Publisher: North-Holland
Release Date : 1976
Marine Insects written by Lanna Cheng and has been published by North-Holland this book supported file pdf, txt, epub, kindle and other format this book has been release on 1976 with Nature categories.
This is the first exhaustive review of literature on marine insects, which are defined in this volume as those that spend at least part of their life in association with the marine environment. Not only are true insects, such as the Collembola and insect parasites of marine birds and mammals, considered, but also other kinds of intertidal air-breathing arthropods, notably spiders, scorpions, mites, centipedes and millipedes, which live and feed with, or even on, the insects of marine habitats. The chapters, written by leading authorities, are divided into two sections, the first treating primarily ecological aspects, the second dealing with major groups of insects in marine environments.
Catalogue Of Risks
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Author : Dirk Proske
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-07-24
Catalogue Of Risks written by Dirk Proske and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-07-24 with Technology & Engineering categories.
Since the German edition of this book, the topic of risk has experienced even greater attention, not only in the world of science but also in other fields, such as economics and politics. Therefore, many new publications have evolved. To keep with the idea of an encyclopedia for the topic of risk, this book has been completely reworked. Not only are many updated examples included in chapter “Risks and disasters” but also new chapters have been introduced, such as the chapter “Indetermination and risk”. This new chapter was developed since the question “Is it possible for risks to be completely eliminated, and if not why?” has become a major point of c- cern. Therefore, especially in this chapter, the focus of the book has - tended from a simple mathematical or engineering point of view to include much broader concepts. Here, not only aspects of system theory have to be considered, but also some general philosophical questions start to inf- ence the considerations of the topic of risk. The main goal of this edition, however, is not only the extension and revision of the book, but also the translation into the English language to allow more readers access to the ideas of the book. The author deeply hopes that the success the book made in the German edition continues and that readers experience a major gain from reading the book.
English One Tongue Many Voices
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Author : Jan Svartvik
language : en
Publisher: Springer
Release Date : 2016-01-19
English One Tongue Many Voices written by Jan Svartvik and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-19 with Language Arts & Disciplines categories.
This is the fully revised and expanded second edition of English - One Tongue, Many Voices, a book by three internationally distinguished English language scholars who tell the fascinating, improbable saga of English in time and space. Chapters trace the history of the language from its obscure beginnings over 1500 years ago as a collection of dialects spoken by marauding, illiterate tribes. They show how the geographical spread of the language in its increasing diversity has made English into an international language of unprecedented range and variety. The authors examine the present state of English as a global language and the problems, pressures and uncertainties of its future, online and offline. They argue that, in spite of the amazing variety and plurality of English, it remains a single language.
Data Analytics And Management
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Author : Ashish Khanna
language : en
Publisher: Springer Nature
Release Date : 2021-01-04
Data Analytics And Management written by Ashish Khanna and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-04 with Technology & Engineering categories.
This book includes original unpublished contributions presented at the International Conference on Data Analytics and Management (ICDAM 2020), held at Jan Wyzykowski University, Poland, during June 2020. The book covers the topics in data analytics, data management, big data, computational intelligence, and communication networks. The book presents innovative work by leading academics, researchers, and experts from industry which is useful for young researchers and students.
Methods In Computational Molecular Physics
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Author : Geerd H.F. Diercksen
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Methods In Computational Molecular Physics written by Geerd H.F. Diercksen and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
This NATO Advanced Study Institute was concerned with modern ab initio methods for the determination of the electronic structure of molecules. Recent years have seen considerable progress in computer technology and computer science and these developments have had a very significant influence on computational molecular physics. Progress in computer technology has led to increasingly larger and faster systems as well as powerful minicomputers. Simultaneous research in computer science has explored new methods for the optimal use of these resources. To a large extent develop ments in computer technology, computer science and computational molecular physics have been mutually dependent. The availability of new computational resources, particularly minicomputers and, more recently, vector processors, has stimulat'ed a great deal of research in molecular physics. Well established techniques have been reformulated to make more efficient use of the new computer technology and algorithms which were previously computationally intractable have now been successfully implemented. This research has given a new and exciting insight into molecular structure and molecular processes by enabling smaller systems to be studied in greater detail and larger systems to be studied for the first time.
Marine Biotoxins
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Author : Hans P. Egmond
language : en
Publisher: Food & Agriculture Org.
Release Date : 2004
Marine Biotoxins written by Hans P. Egmond and has been published by Food & Agriculture Org. this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Algal toxins categories.
This paper provides an extensive review of different aspects of five shellfish-poisoning syndromes (paralytic, diarrhoeic, amnesic, neurologic and azapiracid), as well as one fish-poisoning syndrome (ciguatera fish poisoning), and discusses in detail the causative toxins produced by marine organisms, chemical structures and analytical methods of the toxins, habitat and occurrence of the toxin-producing organisms, case studies and existing regulations. Based on this analysis, risk assessments are carried out for each of the toxins, and recommendations are elaborated to improve the management of these risks in order to reduce the harmful effect of these toxins on public health.