Cenas De Pol Tica Expl Cita
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Translational Medicine
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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26
Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.
Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.
The Phantom Image
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Author : Patrick R. Crowley
language : en
Publisher: University of Chicago Press
Release Date : 2019-12-10
The Phantom Image written by Patrick R. Crowley and has been published by University of Chicago Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-10 with Art categories.
Drawing from a rich corpus of art works, including sarcophagi, tomb paintings, and floor mosaics, Patrick R. Crowley investigates how something as insubstantial as a ghost could be made visible through the material grit of stone and paint. In this fresh and wide-ranging study, he uses the figure of the ghost to offer a new understanding of the status of the image in Roman art and visual culture. Tracing the shifting practices and debates in antiquity about the nature of vision and representation, Crowley shows how images of ghosts make visible structures of beholding and strategies of depiction. Yet the figure of the ghost simultaneously contributes to a broader conceptual history that accounts for how modalities of belief emerged and developed in antiquity. Neither illustrations of ancient beliefs in ghosts nor depictions of afterlife, these images show us something about the visual event of seeing itself. The Phantom Image offers essential insight into ancient art, visual culture, and the history of the image.
In Defiance Of Painting
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Author : Christine Poggi
language : en
Publisher: Yale University Press
Release Date : 1992-01-01
In Defiance Of Painting written by Christine Poggi and has been published by Yale University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-01-01 with Art categories.
The invention of collage by Picasso and Braque in 1912 proved to be a dramatic turning point in the development of Cubism and Futurism and ultimately one of the most significant innovations in twentieth-century art. Collage has traditionally been viewed as a new expression of modernism, one allied with modernism's search for purity of means, anti-illusionism, unity, and autonomy of form. This book - the first comprehensive study of collage and its relation to modernism - challenges this view. Christine Poggi argues that collage did not become a new language of modernism but a new language with which to critique modernism. She focuses on the ways Cubist collage - and the Futurist multimedia work that was inspired by it - undermined prevailing notions of material and stylistic unity, subverted the role of the frame and pictorial ground, and brought the languages of high and low culture into a new relationship of exchange.
Failure Of A Revolution Germany 1918 1919
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Author : Sebastian Haffner
language : en
Publisher: Plunkett Lake Press
Release Date : 2019-08-16
Failure Of A Revolution Germany 1918 1919 written by Sebastian Haffner and has been published by Plunkett Lake Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-16 with History categories.
The masterfully told story of what happened in Germany following its defeat in the first world war: the Kaiser’s exit from the stage, the sailors’ mutiny, the spreading of the revolution and its betrayal by its own chosen socialist leaders. Haffner recounts the murder of Karl Liebknecht and of Rosa Luxemburg — and the deliberate creation of those relentless counter-revolutionary forces that became the nightmare of the Third Reich. More than a brilliant historical study: it has vital lessons for our own day. “Haffner’s history of the revolution is unrivalled — tight, precise, passionately rational, brilliantly formulated.” — Profil/Wien “No-one else has described and analysed the events of 1918/19 that were decisive for the century as well and as convincingly as Sebastian Haffner.” — Tagespiegel “For Haffner, the revolution was a social-democratic revolution. That it was nevertheless ultimately suppressed bloodily by social-democratic politicians confirms Haffner’s suspicion that this was a case of betrayal.” — Norddeutscher Rundfunk(North German Radio) “Haffner’s book is one of the few that breaks open previously locked doors and shines a light on dark corners of our past.” — Kölner Stadt-Anzeiger “Sebastian Haffner’s brilliant intellect clarifies contrasts and similarities in situations, motivations and deeds and describes lucidly and dramatically the main lines of the complex developments from September 1918 to January 1919.” — Dieter Wunderlich “Those who know Haffner’s method of making the writing of history an inspection of the past motivated by the present, will appreciate this book.” — zitty/Berlin
Presidentialism And Democracy In Latin America
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Author : Scott Mainwaring
language : en
Publisher: Cambridge University Press
Release Date : 1997-05-13
Presidentialism And Democracy In Latin America written by Scott Mainwaring and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-05-13 with Biography & Autobiography categories.
Addressing the current debate regarding the liabilities and merits of presidential government, this work asks: does presidentialism make it less likely that democratic governments will be able to manage political conflict, as many prominent scholars have argued? With the unprecedented wave of transitions to democracy since the 1970s, this question has been hotly contested in political and intellectual circles all over the globe. The contributors to this volume examine variations among different presidential systems and sceptically view claims that presidentialism has added significantly to the problems of democratic governance and stability. The contributors argue that presidential systems vary in important ways, mostly according to the constitutional powers accorded to the president to affect legislation and the degree to which presidents parties control legislative majorities.
The Oxford Handbook Of Migration Crises
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Author : Dr. Cecilia Menjívar
language : en
Publisher: Oxford University Press
Release Date : 2019-01-16
The Oxford Handbook Of Migration Crises written by Dr. Cecilia Menjívar and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-16 with Social Science categories.
The objective of The Oxford Handbook of Migration Crises is to deconstruct, question, and redefine through a critical lens what is commonly understood as "migration crises." The volume covers a wide range of historical, economic, social, political, and environmental conditions that generate migration crises around the globe. At the same time, it illuminates how the media and public officials play a major role in framing migratory flows as crises. The volume brings together an exceptional group of scholars from around the world to critically examine migration crises and to revisit the notion of crisis through the context in which permanent and non-permanent migration flows occur. The Oxford Handbook of Migration Crises offers an understanding of individuals in societies, socio-economic structures, and group processes. Focusing on migrants' departures and arrivals in all continents, this comprehensive handbook explores the social dynamics of migration crises, with an emphasis on factors that propel these flows as well as the actors that play a role in classifying them and in addressing them. The volume is organized into nine sections. The first section provides a historical overview of the link between migration and crises. The second looks at how migration crises are constructed, while the third section contextualizes the causes and effects of protracted conflicts in producing crises. The fourth focuses on the role of climate and the environment in generating migration crises, while the fifth section examines these migratory flows in migration corridors and transit countries. The sixth section looks at policy responses to migratory flows, The last three sections look at the role media and visual culture, gender, and immigrant incorporation play in migration crises.
A Simple Matter Of Salt
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Author : Renate Lellep Fernandez
language : en
Publisher: Univ of California Press
Release Date : 2024-06-21
A Simple Matter Of Salt written by Renate Lellep Fernandez and has been published by Univ of California Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-21 with Medical categories.
Why do certain easily preventable diseases persist in the modern world? Renate Lellep Fernandez sheds light on this paradox by investigating the high incidence of iodine deficiency disease (IDD) among mountain villagers in northern Spain. Just as the mystery of non-prevention leads the author far beyond the confines of a single place, so are the experiences of these villagers rich in lessons for biocultural anthropology and public health in many contexts. The symptoms of iodine deficiency include not only the disfiguring goiters associated with the disease but also a catalog of more serious and even fatal complications. The burden of caring for victims of IDD has taxed the resources of this Spanish village beyond reason. Yet even though its people were—and are—eager for good health and quick to take advantage of modern medical treatment, which has long been available, until very recently they failed to learn that iodized salt prevents the disease. A Simple Matter of Salt unveils the social and political obstacles that have impeded the successful dissemination of preventive knowledge. Here are valuable implications for the prevention of other endemic diseases on a global scale. This title is part of UC Press's Voices Revived program, which commemorates University of California Press’s mission to seek out and cultivate the brightest minds and give them voice, reach, and impact. Drawing on a backlist dating to 1893, Voices Revived makes high-quality, peer-reviewed scholarship accessible once again using print-on-demand technology. This title was originally published in 1990.
Lonely Planet Rome
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Author : Lonely Planet
language : en
Publisher: Lonely Planet
Release Date : 2018-01-01
Lonely Planet Rome written by Lonely Planet and has been published by Lonely Planet this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-01 with Travel categories.
Lonely Planet Rome is your passport to the most relevant, up-to-date advice on what to see and skip, and what hidden discoveries await you. Channel your inner gladiator at the Colosseum, spend hours wandering the vast Vatican Museums, or toss a coin and make a wish at Trevi Fountain; all with your trusted travel companion.
Biology
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Author : Teresa Audesirk
language : en
Publisher: Pearson
Release Date : 2011
Biology written by Teresa Audesirk and has been published by Pearson this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Biologie categories.
Includes 45 case studies and essays under the topics: Earth watch; Health watch; A closer look at ...; Scientific inquiry; Links to everyday life.
Empire In Transition
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Author : Alfred Hower
language : pt
Publisher: University Press of Florida
Release Date : 2018-02-20
Empire In Transition written by Alfred Hower and has been published by University Press of Florida this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02-20 with History categories.
The books in the Florida and the Caribbean Open Books Series demonstrate the University Press of Florida’s long history of publishing Latin American and Caribbean studies titles that connect in and through Florida, highlighting the connections between the Sunshine State and its neighboring islands. Books in this series show how early explorers found and settled Florida and the Caribbean. They tell the tales of early pioneers, both foreign and domestic. They examine topics critical to the area such as travel, migration, economic opportunity, and tourism. They look at the growth of Florida and the Caribbean and the attendant pressures on the environment, culture, urban development, and the movement of peoples, both forced and voluntary. The Florida and the Caribbean Open Books Series gathers the rich data available in these architectural, archaeological, cultural, and historical works, as well as the travelogues and naturalists’ sketches of the area in prior to the twentieth century, making it accessible for scholars and the general public alike. The Florida and the Caribbean Open Books Series is made possible through a grant from the National Endowment for the Humanities and the Andrew W. Mellon Foundation, under the Humanities Open Books program.