Chantagear Um Milion Rio
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Translational Medicine
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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26
Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.
Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.
Violence Against Women
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Author : Pauline B. Bart
language : en
Publisher: SAGE
Release Date : 1993
Violence Against Women written by Pauline B. Bart and has been published by SAGE this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Family & Relationships categories.
Violence against women permeates our society at every level, in every setting. Murder, rape, intimidation, pornography, workplace harassment, incest are all part of a general belief built into the roots of patriarchal society: Women are proper targets of male violence. The chapters in this book, contributed by some of the most prolific contemporary writers on women's issues, explore this culture of violence and oppression, examining its ideological underpinnings and its structural supports in the social, political and legal systems that protect the violent by blaming the victim.
Open Veins Of Latin America
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Author : Eduardo Galeano
language : en
Publisher: NYU Press
Release Date : 1997
Open Veins Of Latin America written by Eduardo Galeano and has been published by NYU Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with History categories.
[In this book, the author's] analysis of the effects and causes of capitalist underdevelopment in Latin America present [an] account of ... Latin American history. [The author] shows how foreign companies reaped huge profits through their operations in Latin America. He explains the politics of the Latin American bourgeoisies and their subservience to foreign powers, and how they interacted to create increasingly unequal capitalist societies in Latin America.-Back cover.
The Age Of Unproductive Capital
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Author : Ladislau Dowbor
language : en
Publisher: Cambridge Scholars Publishing
Release Date : 2018-12-11
The Age Of Unproductive Capital written by Ladislau Dowbor and has been published by Cambridge Scholars Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-12-11 with Social Science categories.
This book offers a very direct and readable analysis of the main challenges facing our societies today, such as reducing inequality, protecting the planet, and in particular mobilizing our financial resources which linger in tax havens and feed speculation, instead of funding the sustainable development we need. It precisely considers the most important factors, including corporate governance, financialization, capturing political power, and the limits to adequate national economic policies in a world dominated by global finance. The book’s presentation of how sensible and productive policies are dismantled will be highly interesting for the international community, whether in the academic, corporate or government spheres.
Preclinical Safety Evaluation Of Biopharmaceuticals
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Author : Joy A. Cavagnaro
language : en
Publisher: John Wiley & Sons
Release Date : 2013-03-07
Preclinical Safety Evaluation Of Biopharmaceuticals written by Joy A. Cavagnaro and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-07 with Medical categories.
"The goal is to provide a comprehensive reference book for the preclinicaldiscovery and development scientist whose responsibilities span target identification, lead candidate selection, pharmacokinetics, pharmacology, and toxicology, and for regulatory scientists whose responsibilities include the evaluation of novel therapies." —From the Afterword by Anthony D. Dayan Proper preclinical safety evaluation can improve the predictive value, lessen the time and cost of launching new biopharmaceuticals, and speed potentially lifesaving drugs to market. This guide covers topics ranging from lead candidate selection to establishing proof of concept and toxicity testing to the selection of the first human doses. With chapters contributed by experts in their specific areas, Preclinical Safety Evaluation of Biopharmaceuticals: A Science-Based Approach to Facilitating Clinical Trials: Includes an overview of biopharmaceuticals with information on regulation and methods of production Discusses the principles of ICH S6 and their implementation in the U.S., Europe, and Japan Covers current practices in preclinical development and includes a comparison of safety assessments for small molecules with those for biopharmaceuticals Addresses all aspects of the preclinical evaluation process, including: the selection of relevant species; safety/toxicity endpoints; specific considerations based upon class; and practical considerations in the design, implementation, and analysis of biopharmaceuticals Covers transitioning from preclinical development to clinical trials This is a hands-on, straightforward reference for professionals involved in preclinical drug development, including scientists, toxicologists, project managers, consultants, and regulatory personnel.
Our Common Future
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Author :
language : en
Publisher:
Release Date : 1990
Our Common Future written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with Australia categories.
Funding Of Political Parties And Election Campaigns
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Author : Julie Ballington
language : en
Publisher:
Release Date : 2003
Funding Of Political Parties And Election Campaigns written by Julie Ballington and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Political Science categories.
This handbook provides a general description of the different models of political finance regulations and analyses the relationship between party funding and effective democracy. The most important part of the book is an extensive matrix on political finance laws and regulations for about 100 countries. Public funding regulations, ceilings on campaign expenditure, bans on foreign donations and enforcing an agency are some of the issues covered in the study. Includes regional studies and discusses how political funding can affect women and men differently, and the delicate issue of monitoring, control and enforcement of political finance laws.
Mining Capitalism
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Author : Stuart Kirsch
language : en
Publisher: Univ of California Press
Release Date : 2014-06-07
Mining Capitalism written by Stuart Kirsch and has been published by Univ of California Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-06-07 with Social Science categories.
Corporations are among the most powerful institutions of our time, but they are also responsible for a wide range of harmful social and environmental impacts. Consequently, political movements and nongovernmental organizations increasingly contest the risks that corporations pose to people and nature. Mining Capitalism examines the strategies through which corporations manage their relationships with these critics and adversaries. By focusing on the conflict over the Ok Tedi copper and gold mine in Papua New Guinea, Stuart Kirsch tells the story of a slow-moving environmental disaster and the international network of indigenous peoples, advocacy groups, and lawyers that sought to protect local rivers and rain forests. Along the way, he analyzes how corporations promote their interests by manipulating science and invoking the discourses of sustainability and social responsibility. Based on two decades of anthropological research, this book is comparative in scope, showing readers how similar dynamics operate in other industries around the world.
A Million Guilty Pleasures
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Author : C. L. Parker
language : en
Publisher: Bantam
Release Date : 2014-02-04
A Million Guilty Pleasures written by C. L. Parker and has been published by Bantam this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-02-04 with Fiction categories.
Two million dollars secured Noah Crawford the most enticing woman he has ever known. Initiating Delaine Talbot into a sensuous world of pleasure took them both to the brink—again and again. But when Noah discovers why the beautiful innocent sold her body to the highest bidder, he’s faced with the hardest thing he ever had to do: Set her free. Lanie can’t believe Noah would let her go. Doesn’t he know they share a bond deeper than sex—a connection too powerful to sever? Not even a treacherous enemy out to destroy Noah or the dark secret haunting the multimillionaire can keep them apart. But first Lanie has to show him that he belongs to her, even if it means risking everything for a love that can never be bought or sold. Praise for A Million Guilty Pleasures “[C. L.] Parker’s story shines with sexy shenanigans that steam up the pages.”—RT Book Reviews (4-1/2 stars) “The charm and passion that made the first book a success are back in spades here. . . . A great followup, and a fitting end to an amazing pair. Noah and Lanie are a raunchy, loving couple and so much fun to read about.”—Miss Boxy Frown “Million Dollar Duet has a sexy billionaire hero and quirky heroine. It is packed with steamy scenes, and as romantic as can be.”—Under the Covers A Million Guilty Pleasures is intended for mature audiences.
Tent Of Miracles
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Author : Jorge Amado
language : en
Publisher: Univ of Wisconsin Press
Release Date : 2003
Tent Of Miracles written by Jorge Amado and has been published by Univ of Wisconsin Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Fiction categories.
Explores the life of Pedro Archanjo, a mulatto man who spent his life fighting prejudice.