Clostridius Difficile
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Clostridioides Difficile
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Author : Henning Sommermeyer
language : en
Publisher: Springer Nature
Release Date : 2021-09-27
Clostridioides Difficile written by Henning Sommermeyer and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-27 with Medical categories.
The book provides a comprehensive overview of the current knowledge about Clostridioides (C.) difficile (formerly known as Clostridium difficile) and Clostridioides difficile infections (CDI). The diseases caused by C. difficile range from mild diarrhea to fulminant and in some cases fatal colitis. Historically, CDI was considered mainly as a hospital-acquired problem. Today, a significant portion of CDI is community acquired. Triggered by the introduction of new antibiotics, hypervirulent and multi-drug resistant strains of C. difficile (e.g., C. difficile ribotype R027) have emerged and spread across the globe. The volume covers the microbiology, pathophysiology, epidemiology, risk factors for CDI, diagnosis, clinical pictures, treatment and prophylaxis. It includes an extensive reference list that allows an easy navigation through the original research publications. Clostridioides difficile helps the reader gain a better understanding of C. difficile, the challenges that may arise and the available treatment options. Given its broad coverage and features, it will appeal to a wide readership, from gastroenterologists through general physicians, nurses, and other healthcare providers, to students.
Updates On Clostridium Difficile In Europe
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Author : Paola Mastrantonio
language : en
Publisher: Springer
Release Date : 2018-01-29
Updates On Clostridium Difficile In Europe written by Paola Mastrantonio and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-29 with Medical categories.
This book outlines the currently available clinical, epidemiological and experimental data on Clostridium difficile infection (CDI) with special emphasis on studies and results achieved in Europe. The incidence and severity of CDI has increased significantly over the last decade, and the book explains why C. difficile, recently reclassified as Clostridioides difficile, remains a significant challenge, also from economic perspective, to health care systems all over the world. The different reservoirs of this ubiquitous microorganism are reviewed as well as the different factors contributing to its virulence, such as toxins and biofilm formation. The rapid evolution of antibiotic resistance is clearly a concern and in a specific way can influence the CDI epidemiology. Additionally, new emerging strains and comparative genomics studies are discussed for their relevance from epidemiological and evolutionary point of view. The book also gives an overview on diagnostics, therapy and surveillance, all of which are still challenging. Therefore, a closer look is taken on the effect of probiotics as an alternative to antibiotics, for prevention and treatment of CDI. Fecal transplantation from healthy donors, passive immunotherapies and vaccines for patients with recurrences are also discussed in dedicated chapters. The book closes with a summary of the history and the achievements of the European Society of Clinical Microbiology and Infectious Diseases Study Group for Clostridium difficile (ESGCD) written by the current and past presidents of the Society. It is the aim of this book to raise awareness on CDI and to disseminate updated information on its prevention, diagnosis and treatment.
Clostridium Difficile
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Author : Shymaa Enany
language : en
Publisher: BoD – Books on Demand
Release Date : 2017-09-27
Clostridium Difficile written by Shymaa Enany and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-27 with Science categories.
Clostridium difficile bacteria could be found everywhere around us: in the air, water, and soil and in the feces of humans and animals. You can easily become infected with C. difficile if you touch contaminated clothing, sheets, or other objects and then touch your mouth. Many people have the bacteria in their intestines and never have any symptoms. Still, it can cause symptoms ranging from diarrhea to life-threatening inflammation of the colon. The chance of developing a C. difficile infection increases with the usage of high doses of antibiotics over a prolonged period; thus, it is most often spread in the healthcare facilities between workers, patients, and residents. Each year in the United States, almost a half million people get sick from C. difficile, and approximately 29,000 patients died within 30 days of its initial diagnosis. Nowadays, C. difficile infections have become more frequent, severe, and difficult to treat. Therefore, the early diagnosis and the suitable treatment have become a real demand. In this book, we present the experience of worldwide specialists on the diagnosis and the treatment of C. difficile infections along with its lights and shadows.
Clostridium Difficile Infection An Issue Of Infectious Disease Clinics Of North America
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Author : Mark H. Wilcox
language : en
Publisher: Elsevier Health Sciences
Release Date : 2015-04-07
Clostridium Difficile Infection An Issue Of Infectious Disease Clinics Of North America written by Mark H. Wilcox and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-07 with Medical categories.
This issue of Infectious Disease Clinics of North America, guest edited by Dr. Mark H. Wilcox, is devoted to Clostridium Difficile Infection. Articles in this issue include: Potential sources of C. difficile for human infection; Colonisation versus carriage of C. difficile; Diagnostic pitfalls in C. difficile infection; The epidemiology of C. difficile infection in and outside of healthcare institutions; What makes epidemic C. difficile strains epidemic?: Fact versus fiction; Environmental interventions to control C. difficile infection; The contribution of strains and hosts to outcomes in C. difficile infection; Treatment of C. difficile infection; Faecal microbiota transplantation for the management of C. difficile infection; The morbidity, mortality, and costs associated with C. difficile infection; The potential of probiotics to prevent C. difficile infection; The prospect for vaccines to prevent C. difficile infection; and Predictive value of models of C. difficile infection.
Kosystem Darm Special
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Author : Jean-Claude Rambaud
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-12-01
Kosystem Darm Special written by Jean-Claude Rambaud and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-01 with Medical categories.
Jean-Claude Rambaud The place occupied today in basic and clinical research by intestinal disease related to Clostridium difficile is such that it is hard to remember that this range of disorders was completely identified only in 1977-1978, even though pieces of the puzzle had been identified much earlier. A brief historical review of the discovery of the enteropathogenicity of C. difficile in man might thus be useful. The bacterium was described in 1935 in the stools of infants, using the name Bacillus difficilis [7]. Until 1977, the microorganism, renamed C. difficile, considered to be of endogenous origin, was isolated only in rare cases of abscess or infection, most often unrelated to the digestive tract. Its role in genito-urinary infections [6] was not confirmed. However, the frequency of infant healthy carriers was recognized from the outset [7, 13]. Pseudo-membranous colitis (PMC) was described in 1883 following a gastroenterostomy. Many cases of this condition were published subsequently before the antibiotic era, describing various risk factors [4]. However the disease began to flourish only with the increasingly wide use of antibiotics. Antibiotic associated PMC was first described as an enterocolitis, though with little pathological evidence. It was principally related to the use of chloramphenicol and tetracyclines and attributed to proliferation of Staphylococcus au reus [ 11], a concept strengthened by the spectacular therapeutic action of vancomycin.
Antibiotic Associated Diarrhoea And Colitis
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Author : S.P. Borriello
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Antibiotic Associated Diarrhoea And Colitis written by S.P. Borriello and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Antimicrobial-associated diarrhea is often caused by Clostridium difficile; this disease can best be diagnosed by detection of fecal cytotoxin in a tissue culture assay and, when therapy is indicated, can be effectively treated with orally administered vancomycin. The cause of disease in most cases of antimicrobial-associated diarrhea that do not involve C. difficile is not known; fortunately, this form of diarrhea 1S usually mild. Antimicrobial-associated diarrhea may also rarely involve s. aureus and certain enteric pathogens. 37 QHAPTER 4 Qf. TECTlON. ISOLATION Al:iQ. . . IQENTlFICATlON OF CLOSTRIDIUM PIFFICILE S.P. BORRIELLO and PAULINE HONOUR Introduction 38 Detection of Co dlfflcile in stools 38 Direct methods 38 Indirect methods 39 Isolation of Co djfficjle 40 Identification of Co difflcile 44 38 DETECTION ISOLATION AND IDENTIFICATION OF CLOSTRIDIUM DIFFICILE S.P. Borriello and Pauline Honour Introduction In view of the mounting evidence generated world wide in the last few years that firmly implicates £. difficile as the aetiological agent in both antibiotic and non-antibiotic associated pseudomembranous colitis (Larson ~ al., 1978, Bartlett ~ al., 1978a, George ~ al., 1978a), and also recent recognition of the fact that there may be a spectrum of gastrointestinal diseases associated with £. difficile infections (Borriello and Larson, 1981, Bolton ~ al., 1980, Brettle ~ al., 1982), an increasing number of laboratories are seeking to detect, isolate and identify £. difficile from clinical samples.
Clostridium Difficile
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Author : Rial D. Rolfe
language : en
Publisher: Elsevier
Release Date : 2013-10-22
Clostridium Difficile written by Rial D. Rolfe and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-22 with Medical categories.
Despite the tremendous progress made during the last few years in understanding the pathogenesis, epidemiology, diagnosis, and treatment of Clostridium difficile-associated intestinal disease, many extremely important and fundamental questions remain to be answered. The objectives of this book are to summarize the available information regarding Clostridium difficile and its role in intestinal disease and to serve as a basis for future investigations in this challenging area.Clostridium difficile: its role in Intestinal Disease. An excellent volume that should appeal not only to the devotee of C difficile but to all gastroenterologists and microbiologists, this will not languish on my library shelves like so many other books I have reviewed. It will be regularly thumbed. --R.H. George, consultant microbiologist, Children's Hospital, BirminghamClostridium difficile: Its Role in Intestinal disease. The book is well written and informative; it has a vast amount of information packed in it...this book would be a welcome addition to the researchers and clinicians interested in C difficile-associated intestinal diseases. --Edward Balish, University of Wisconsin Medical School
Clostridium Difficile Infection In Long Term Care Facilities
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Author : Teena Chopra
language : en
Publisher: Springer Nature
Release Date : 2019-11-14
Clostridium Difficile Infection In Long Term Care Facilities written by Teena Chopra and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-14 with Medical categories.
This book aims to fill knowledge gap among healthcare workers about Clostridium difficile (also known as C.difficile and CDI) among aging patients, especially those in long-term care facilities (LTCFs). Written by experts in infectious diseases and geriatric medicine, this book provides comprehensive information on all aspects of CDI pertaining to LTCF settings, including epidemiology, diagnosis, prevention, management and the unique challenges faced by LTCFs with regards to the CDI problem. The book begins by introducing the topic as it relates to aging patients before delving into the various aspects of CDI management. Topics include infection control and prevention, treatment of CDI, and the establishment of antibiotic stewardship programs to reduce inappropriate antibiotic use and reduce CDI rates. The book also features a chapter on probiotics for the prevention of CDI and new strategies to monitor environmental cleaning practices of CDI patient rooms that do not appear in any other resource. Clostridium Difficile Infection in Long-Term Care Facilities is an excellent resource for geriatricians, infectious diseases specialists, long-term care administrators, nurses, pharmacists, researchers, and all clinicians working with infections in long-term care settings.
Clostridium Difficile
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Author : K. Aktories
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-04-17
Clostridium Difficile written by K. Aktories and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-17 with Science categories.
Clostridium difficile has been recognized as the cause of a broad spectrum of enteric disease ranging from mild antibiotic-associated diarrhea to pseudomembranous colitis. This volume gives new insights into the microbiology, diagnostics and epidemiology of Clostridium difficile and describes recent strategies in treatment of diseases caused by this agent. Main parts of the volume are devoted to Clostridium difficile toxins A and B which are the major virulence factors. The molecular biology, biochemistry, pharmacology and cell biology of these toxins which are the prototypes of a new family of large clostridial cytotoxins is described in great detail. Clostridium difficile toxins act as glucosyltransferases to inactivate small GTP-binding proteins of the Rho family which are involved in regulation of the actin cytoskeleton, cell adhesion and various signaling processes.
Clostridium Difficile
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Author : Peter Mullany
language : en
Publisher: Humana
Release Date : 2010-06-08
Clostridium Difficile written by Peter Mullany and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-06-08 with Medical categories.
This book brings together the most recently developed methods for studying clostridium difficile, including techniques involving isolation, molecular typing, genomics, genetic manipulation, and the use of animal models.