Cr Tica De La Tontuna Aplicada

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Translational Medicine

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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26

Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.

Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.

Temas De Ling Stica Aplicada

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Author : Jorge Fernández-Barrientos Martín
language : es
Publisher:
Release Date : 1995

Temas De Ling Stica Aplicada written by Jorge Fernández-Barrientos Martín and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with Education categories.

Mathematical Statistics With Applications In R

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Author : Kandethody M. Ramachandran
language : en
Publisher: Elsevier
Release Date : 2014-09-14

Mathematical Statistics With Applications In R written by Kandethody M. Ramachandran and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-14 with Mathematics categories.

Mathematical Statistics with Applications in R, Second Edition, offers a modern calculus-based theoretical introduction to mathematical statistics and applications. The book covers many modern statistical computational and simulation concepts that are not covered in other texts, such as the Jackknife, bootstrap methods, the EM algorithms, and Markov chain Monte Carlo (MCMC) methods such as the Metropolis algorithm, Metropolis-Hastings algorithm and the Gibbs sampler. By combining the discussion on the theory of statistics with a wealth of real-world applications, the book helps students to approach statistical problem solving in a logical manner.This book provides a step-by-step procedure to solve real problems, making the topic more accessible. It includes goodness of fit methods to identify the probability distribution that characterizes the probabilistic behavior or a given set of data. Exercises as well as practical, real-world chapter projects are included, and each chapter has an optional section on using Minitab, SPSS and SAS commands. The text also boasts a wide array of coverage of ANOVA, nonparametric, MCMC, Bayesian and empirical methods; solutions to selected problems; data sets; and an image bank for students.Advanced undergraduate and graduate students taking a one or two semester mathematical statistics course will find this book extremely useful in their studies. Step-by-step procedure to solve real problems, making the topic more accessible Exercises blend theory and modern applications Practical, real-world chapter projects Provides an optional section in each chapter on using Minitab, SPSS and SAS commands Wide array of coverage of ANOVA, Nonparametric, MCMC, Bayesian and empirical methods

Escritura Y Sociedad

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Author : Virginia Zavala
language : es
Publisher: Universidad del Pacifico
Release Date : 2004

Escritura Y Sociedad written by Virginia Zavala and has been published by Universidad del Pacifico this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Ethnology categories.

Daniel Goleman Omnibus

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Author : Daniel Goleman
language : en
Publisher: Bloomsbury Publishing
Release Date : 2004

Daniel Goleman Omnibus written by Daniel Goleman and has been published by Bloomsbury Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Emotional intelligence categories.

Emotional Intelligence Does IQ define our destiny? Daniel Goleman argues that our view of human intelligence is far too narrow, and that our emotions play a major role in thought, decision making and individual success. Self-awareness, impulse control, persistence, motivation, empathy and social deftness are all qualities that mark people who excel: whose relationships flourish, who are stars in the workplace. With new insights into the brain architecture underlying emotion and rationality, Goleman shows precisely how emotional intelligence can be nurtured and strengthened in all of us. Working with Emotional Intelligence Do you want to be more successful at work? Do you want to improve your chances of promotion? Do you want to get on better with your colleagues? Daniel Goleman draws on unparalleled access to business leaders around the world and the thorough research that is his trademark. He demonstrates that emotional intelligence at work matters twice as much as cognitive abilities such as IQ or technical expertise in this inspiring sequel.

Leaving College

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Author : Vincent Tinto
language : en
Publisher: University of Chicago Press
Release Date : 2012-04-27

Leaving College written by Vincent Tinto and has been published by University of Chicago Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-04-27 with Education categories.

In this 1994 classic work on student retention, Vincent Tinto synthesizes far-ranging research on student attrition and on actions institutions can and should take to reduce it. The key to effective retention, Tinto demonstrates, is in a strong commitment to quality education and the building of a strong sense of inclusive educational and social community on campus. He applies his theory of student departure to the experiences of minority, adult, and graduate students, and to the situation facing commuting institutions and two-year colleges. Especially critical to Tinto’s model is the central importance of the classroom experience and the role of multiple college communities.

Using Research To Improve Teaching

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Author : Janet Gail Donald
language : en
Publisher:
Release Date : 1985

Using Research To Improve Teaching written by Janet Gail Donald and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1985 with Education categories.

Pedagogy Of Freedom

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Author : Paulo Freire
language : en
Publisher: Rowman & Littlefield Publishers
Release Date : 2000-12-13

Pedagogy Of Freedom written by Paulo Freire and has been published by Rowman & Littlefield Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-12-13 with Education categories.

This book displays the striking creativity and profound insight that characterized Freire's work to the very end of his life-an uplifting and provocative exploration not only for educators, but also for all that learn and live.

Papers On Syntax

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Author : Z. Harris
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Papers On Syntax written by Z. Harris and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Language Arts & Disciplines categories.

The selection of papers reprinted here traces the development of syntax from structural linguistics through transformational linguistics to operator gram mar. These three are not opposing views or independent assumptions about language. Rather, they are successive stages of investigation into the word combinations which constitue the sentences of a language in contrast to those which do not. Throughout, the goal has been to find the systemati cities of these combinations, and then to obtain each sentence in a uniform way from its parts. In structural analysis, the parts were words (simple or complex, belonging to particular classes) or particular sequences of these. In transformational analysis, it is found that the parts of a sentence are elementary sentences, whose parts in turn are simple words of particular classes. The relation between these two analyses is seen in the existence of an intermediate stage between the two, presented in paper 4, From Morpheme to Utterance. A further intermediate stage is presented in the writer's String Analysis of Sentence Structure, Papers on Formal Linguistics I, Mouton, The Hague 1962 (though it was developed after transformations, as a syntactic rep resentation for computational analysis). Generalization of both of these analyses leads to operator grammar, in which each sentence is derived in a uniform way as a partial ordering of the originally simple words which enter into it: Each step (least upper bound) of the partial ordering (of a word requiring another) forms a sentence which is a component of the sentence being analyzed.

Feminist Philosophy Of Technology

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Author : Janina Loh
language : en
Publisher: J.B. Metzler
Release Date : 2020-01-30

Feminist Philosophy Of Technology written by Janina Loh and has been published by J.B. Metzler this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-30 with Philosophy categories.

There has been little attention to feminism and gender issues in mainstream philosophy of technology and vice versa. Since the beginning of the so-called »second wave feminism« (in the middle of the 20th century), there has been a growing awareness of the urgency of a critical reflection of technology and science within feminist discourse. But feminist thinkers have not consistently interpreted technology and science as emancipative and liberating for the feminist movement. Because technological development is mostly embedded in social, political, and economic systems that are patriarchally hierarchized, many feminists criticized the structures of dominance, marginalization and oppression inherent in numerous technologies. Therefore, the question of defining and ascribing responsibility in technics and science is essential for this anthology – regarding for instance the technological transformation of labor, the life in the information society, and the relationship between humans and machines.