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Gliomas Microenvironment New Drug Entities Mechanisms Of Action Molecular Biomarkers And Drug Delivery Strategies

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Author : Célia Cabral
language : en
Publisher: Frontiers Media SA
Release Date : 2024-07-26

Gliomas Microenvironment New Drug Entities Mechanisms Of Action Molecular Biomarkers And Drug Delivery Strategies written by Célia Cabral and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-26 with Science categories.

Gliomas are neoplasms originating in glial cells, the most malignant and frequent primary tumors of the Central Nervous System (CNS), representing approximately 40-50% of all intracranial tumors. Following the World Health Organization (WHO) guidelines, gliomas are classified into grades I-IV, regarding their malignancy degree. The latest report from WHO on CNS tumors considers that glioblastoma (GB), a grade IV adult-type diffuse glioma comprising isocitrate dehydrogenase (IDH)-wildtype tumors. Despite all efforts to improve patient survival and quality of life, the median survival remains lower due to the lack of effective diagnostic tools, poor prognosis, and limited therapeutic options. Regarding this, the design of novel treatment strategies is of the utmost importance. This can be by either the discovery of new medicines (for example synthetic compounds), repurposing known drugs or exploring novel strategies of drug delivery by nanotechnological platforms to improve treatment response and long-term survival of patients. Inter and intra-tumor heterogeneity mainly contribute to the poor prognosis and treatment efficacy. Therefore, exploiting tumor microenvironment (TME) and understanding GB’s cellular and molecular aspects are fundamental to developing more effective and better-tolerated personalized therapies. Thus, addressing physiological mechanisms involved in cancer development, progression and recurrence is crucial. Concerning this, our goal with this research topic is to share the latest advances in tumor-specific therapies for gliomas, especially GB, as well as to provide experimental validation of new bioactive molecules and their antitumor mechanism of action. Authors are invited to submit original research, review articles and systematic reviews covering, but not restricted to, the following topics: 1) Novel targeted therapies; 2) Mechanism of action and affected signaling pathways; 3) Repurposing drugs; 5) New chemical entities; 6) Pharmaceutical nanotechnology; 7) Drug delivery systems; 8) Preclinical and clinical studies of therapeutic molecules; 9) Potential molecular biomarkers to targeted therapies using proteomics or transcriptomics.

Polysaccharides

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Author : Severian Dumitriu
language : en
Publisher: CRC Press
Release Date : 2004-11-30

Polysaccharides written by Severian Dumitriu and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-11-30 with Medical categories.

Completely revised and expanded to reflect the latest advancements in the field, Polysaccharides: Structural Diversity and Functional Versatility, Second Edition outlines fundamental concepts in the structure, function, chemistry, and stability of polysaccharides and reveals new analytical techniques and applications currently impacting the cosmeti

Journal Of The National Cancer Institute

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Author :
language : en
Publisher:
Release Date : 2013

Journal Of The National Cancer Institute written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Cancer categories.

Carpenter

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Author :
language : en
Publisher:
Release Date : 1984

Carpenter written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1984 with Labor unions categories.

Identifying Novel Biomarkers In Bladder Cancer 2nd Edition

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Author : Thornsten Ecke
language : en
Publisher: Frontiers Media SA
Release Date : 2023-07-18

Identifying Novel Biomarkers In Bladder Cancer 2nd Edition written by Thornsten Ecke and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-18 with Science categories.

Bladder cancer is one of the most common urological diseases with a high mortality rate and poor prognosis. It is currently ranked as the 10th most common malignancy worldwide. The majority of bladder cancer patients have been found to be diagnosed with non-muscle invasive bladder cancer (NMIBC) and the remaining, are diagnosed with muscle-invasive bladder cancer (MIBC). Although there have been advances in the treatment and therapies provided for bladder cancer patients, the survival rate remains low, primarily due to recurrence and metastasis of the disease following treatment. Surgical treatment is currently the most common form including radical cystectomy which is the standard form of treatment combined with neoadjuvant chemotherapy. However, the 5-year overall survival rate is 50%. Therefore, further studies are required to understand the molecular mechanisms involved in the progression of bladder cancer and identify novel biomarkers to act as a diagnostic tool for patients. There have been many studies involving the detection of biomarkers in bladder cancer in addition to monitoring disease recurrence to understand the impact and predict potential outcomes. A variety of urine biomarkers have been developed to detect bladder cancer and prognostic risk stratification including mutational DNA and the levels of RNA expression. Circulating tumor cells have also been identified as a potential biomarker for bladder cancer patients. However, there are significant challenges as bladder cancer has demonstrated high levels of cellular and molecular heterogeneity and some markers do not have sufficient sensitivity for accurate detection. Therefore, further studies are required to continue to identify new novel biomarkers for bladder cancer. The aim of this Research Topic is to discuss novel biomarkers in bladder cancer and how it impacts the disease progression and the survival rate for bladder cancer patients.

Database Processing

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Author : David M. Kroenke
language : en
Publisher: Pearson Educación
Release Date : 2002

Database Processing written by David M. Kroenke and has been published by Pearson Educación this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Business & Economics categories.

for SATB, handbells, chimes, two trumpets, two trombones, and organ This sacred piece is suitable for holiday concerts or easter services. It begins with a brass fanfare with handbells and chimes and is answered by a choir of alleluias.

Architectural Isomerism And Inclusion Behavior Of Guanidinium Organosulfonates

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Author : Matthew John Horner
language : en
Publisher:
Release Date : 2005

Architectural Isomerism And Inclusion Behavior Of Guanidinium Organosulfonates written by Matthew John Horner and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with categories.

Human Drug Targets

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Author : Edward D. Zanders
language : en
Publisher: John Wiley & Sons
Release Date : 2015-11-09

Human Drug Targets written by Edward D. Zanders and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-11-09 with Science categories.

The identification of drug targets in a given disease has been central to pharmaceutical research from the latter half of the 20th century right up to the modern genomics era. Human Drug Targets provides an essential guide to one of the most important aspects of drug discovery – the identification of suitable protein and RNA targets prior to the creation of drug development candidates. The first part of the book consists of introductory chapters that provide the background to drug target discovery and highlight the way in which these targets have been organised into online databases. It also includes a user’s guide to the list of entries that forms the bulk of the book. Since this is not designed to be a compendium of drugs, the emphasis will be on the known (or speculated) biological role of the targets and not on the issues associated with pharmaceutical development. The objective is to provide just enough information to be informative and prompt further searches, while keeping the amount of text for each of the many entries to a minimum. Human Drug Targets will prove invaluable to those drug discovery professionals, in both industry and academia, who need to make some sense of the bewildering array of online information sources on current and potential human drug targets. As well as creating order out of a complex target landscape, the book will act as an ideas generator for potentially novel targets that might form the basis of future discovery projects.

Index Of Leases Of Manors And Lands In England Granted Since The Reformation Annis 4 And 5 Edw 6

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Author : Sir Thomas Phillipps
language : en
Publisher:
Release Date : 1832

Index Of Leases Of Manors And Lands In England Granted Since The Reformation Annis 4 And 5 Edw 6 written by Sir Thomas Phillipps and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1832 with Land titles categories.

Children S Garments

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Author : Claire Wargnier
language : en
Publisher: ESMOD
Release Date : 2021-08-13

Children S Garments written by Claire Wargnier and has been published by ESMOD this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-13 with Design categories.

Pattern drafting fashion book for children's wardrobe A pattern drafting manual for children’s ready-to-wear clothing that includes details on the overall shape of a child’s body from infancy to adolescence, as well as the procedures for development and transformation (volumes, sleeves, collars, details) + 10 added models of garments. ABOUT THE AUTHOR Claire Wargnier is a graduate of ESMOD, the world's oldest and most renowned fashion design school, where she was a pattern-drafting professor during thirty years. Her experience in the different sectors of the fashion industry have allowed her to adapt her teaching methods to the students' needs. She is also a consultant in the fashion industry, works and lives in Paris.