Dogm Tica Cat Lica
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Translational Medicine
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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26
Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.
Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.
Transcendental Magic Its Doctrine And Ritual
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Author : Éliphas Lévi
language : en
Publisher: e-artnow
Release Date : 2022-01-24
Transcendental Magic Its Doctrine And Ritual written by Éliphas Lévi and has been published by e-artnow this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-24 with Body, Mind & Spirit categories.
This book is the first treatise on magic by Éliphas Lévi and one of his fundamental works. In this book, he criticizes magic as a collection of methods and rituals. Instead, he says magic is a universal power and attribute of a man, an eternal religion that existed before Christianity and other religions. According to his theory, proper magic as an attribute of a human is a combination of psychic force, will, and imagination. He calls the ordinary miracles attributed to unnecessary magic exaggerations. Yet, the access to the true magic is constricted only to a narrow circle of selected people, or Magi. Those who go through the initiation to Magi acquire force to alter human wills. His works became quickly popular, as their publication coincided with the interest in magic and occultism in the second half of the 19th and the beginning of the 20th century. It also greatly influenced the magic of the Hermetic Order of the Golden Dawn. Also, in this text, Éliphas Lévi, for the first time, pointed out that a pentagram or five-pointed star with one point down and two points up represents evil, while a pentagram with one end up and two points down represent the good.
Thoughts On Grammaticalization
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Author : Christian Lehmann
language : en
Publisher: BoD – Books on Demand
Release Date : 2024-05-23
Thoughts On Grammaticalization written by Christian Lehmann and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-23 with Language Arts & Disciplines categories.
"Thoughts on grammaticalization" was first published in a working-paper version in 1982 and became very influential immediately, even though it was properly published only in 1995. Despite its modest title, the book can be read as an advanced introduction to grammaticalization, though its conception is very original. The present edition contains a number of corrections of the 1995 edition. After a short review of the history of research, the work introduces and delimits the concepts related to grammaticalization. It then provides extensive exemplification of grammaticalization phenomena in diverse languages, ordered by grammatical domains such as the verbal, pronominal and nominal sphere and clause level relations. The final chapter presents a theory of grammaticalization which is based on the autonomy of the linguistic sign with respect to the paradigmatic and syntagmatic axes. This is the basis of the structural parameters that constitute grammaticalization. They are operationalized to the point of rendering degrees of grammaticalization measurable.
Connecting Lives And Learning
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Author : Brenton Prosser
language : en
Publisher: Wakefield Press
Release Date : 2010
Connecting Lives And Learning written by Brenton Prosser and has been published by Wakefield Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Education categories.
CONNECTING LIVES AND LEARNING is a project dedicated to connecting learning to student lives, connecting teachers with the latest middle years research, and better connecting primary and secondary schools to keep students at school longer. Based in Adelaide's lower socio-economic northern urban fringe, the project helps teachers use students' everyday experience and expertise to develop new ways of teaching and learning that involve students in intellectually challenging tasks. This book tells the stories of real teachers, in real classrooms, making real attempts for change, and not always succeeding. It is a book about teachers making a difference in difficult times and tough places. But most importantly, this book reaffirms that being an educator is inherently about adopting socially just practices, building community capacity and contributing to a more socially sustainable world.
Panoan Languages And Linguistics
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Author : David William Fleck
language : en
Publisher:
Release Date : 2013
Panoan Languages And Linguistics written by David William Fleck and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Amazon River Region categories.
This monographic study of the Panoan family will serve as an invaluable handbook for both Panoanists seeking a broader perspective and scholars who require an introduction to the family. A new classification encompassing all the extant and extinct Panoan languages and dialects, an evaluation of proposed relations to other language families, a detailed history of Panoan linguistics, a typological overview of the phonology and grammar, and a description of ethnolinguistic features in the family combine to provide a complete picture of Panoan languages and linguistics. An index with the synonyms and spelling variants of all the language names and ethnonyms that are or have been claimed to be Panoan will allow for obscure references in the literature to be quickly resolved.
Constraint Grammar
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Author : Fred Karlsson
language : en
Publisher: Walter de Gruyter
Release Date : 2011-08-30
Constraint Grammar written by Fred Karlsson and has been published by Walter de Gruyter this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-08-30 with Language Arts & Disciplines categories.
Cat Wars
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Author : Peter P. Marra
language : en
Publisher: Princeton University Press
Release Date : 2016-09-20
Cat Wars written by Peter P. Marra and has been published by Princeton University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-20 with Science categories.
Why our cats are a danger to species diversity and human health In 1894, a lighthouse keeper named David Lyall arrived on Stephens Island off New Zealand with a cat named Tibbles. In just over a year, the Stephens Island Wren, a rare bird endemic to the island, was rendered extinct. Mounting scientific evidence confirms what many conservationists have suspected for some time—that in the United States alone, free-ranging cats are killing birds and other animals by the billions. Equally alarming are the little-known but potentially devastating public health consequences of rabies and parasitic Toxoplasma passing from cats to humans at rising rates. Cat Wars tells the story of the threats free-ranging cats pose to biodiversity and public health throughout the world, and sheds new light on the controversies surrounding the management of the explosion of these cat populations. This compelling book traces the historical and cultural ties between humans and cats from early domestication to the current boom in pet ownership, along the way accessibly explaining the science of extinction, population modeling, and feline diseases. It charts the developments that have led to our present impasse—from Stan Temple's breakthrough studies on cat predation in Wisconsin to cat-eradication programs underway in Australia today. It describes how a small but vocal minority of cat advocates has campaigned successfully for no action in much the same way that special interest groups have stymied attempts to curtail smoking and climate change. Cat Wars paints a revealing picture of a complex global problem—and proposes solutions that foresee a time when wildlife and humans are no longer vulnerable to the impacts of free-ranging cats.
Handbook For Translators Of Spanish Historical Documents
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Author : Juan Villasana Haggard
language : en
Publisher: Рипол Классик
Release Date : 1969
Handbook For Translators Of Spanish Historical Documents written by Juan Villasana Haggard and has been published by Рипол Классик this book supported file pdf, txt, epub, kindle and other format this book has been release on 1969 with History categories.
The Background Of The Rebellion Of An Lu Shan
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Author : Edwin G. Pulleyblank
language : en
Publisher: Greenwood Publishing Group
Release Date : 1955
The Background Of The Rebellion Of An Lu Shan written by Edwin G. Pulleyblank and has been published by Greenwood Publishing Group this book supported file pdf, txt, epub, kindle and other format this book has been release on 1955 with History categories.
This volume deals with the events which prepared the way for the rebellion of the frontier general An Lu-Shan, which weakened the T'ang dynasty (712-756 A.D.) so that it gradually collapsed into a number of independent states in the Five Dynasties period.
Essay Writing
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Author : MunLing Shields
language : en
Publisher: SAGE
Release Date : 2010-02-16
Essay Writing written by MunLing Shields and has been published by SAGE this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-02-16 with Social Science categories.
Essay Writing is a student guide with a mission: to enable students to write better essays and get the grades they deserve by demystifying the essay-writing process. MunLing Shields places essay writing within the larger university experience for students. In a clear and easy to understand way the author guides the reader through the process of writing successful university essays by looking at essay writing in the context of academic communication, academic culture and different learning styles and approaches. This book: Helps students study more independently and learn more meaningfully to write better essays Offers invaluable insights into the way tutors see essays Explains why essays are set, and how to understand the rationale behind them Demonstrates how best to approach answering the question. This highly accessible book offers practical, in-depth guidance on each of the stages of the essay writing process - planning, drafting and editing - and relates them to the important sub-skills of information-gathering, reading academic texts, how to get the most out of lectures, referencing and citations, and fluency and appropriateness of style and language. ′An excellent guide for students new to writing essays at university′ - David Ellicott, Senior Lecturer in Youth Justice and Youth Studies, Nottingham Trent University SAGE Study Skills are essential study guides for students of all levels. From how to write great essays and succeeding at university, to writing your undergraduate dissertation and doing postgraduate research, SAGE Study Skills help you get the best from your time at university. Visit the SAGE Study Skills hub for tips, quizzes and videos on study success!