Erro M Dico E A Lei
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Translational Medicine
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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26
Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.
Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.
Sacred Heart
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Author : Liz Suburbia
language : en
Publisher: Fantagraphics Books
Release Date : 2015-09-02
Sacred Heart written by Liz Suburbia and has been published by Fantagraphics Books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-09-02 with Comics & Graphic Novels categories.
The children of U.S. small-town Alexandria are just trying to live like normal teens until their parents’ promised return from a mysterious, four-year religious pilgrimage, and Ben Schiller is no exception. She’s just trying to take care of her sister, keep faith that her parents will come back, and get through her teen years as painlessly as possible. But her relationship with her best friend is changing, her younger sister is hiding a dark secret, and a terrible tragedy is coming for them all.
A Gen Tica E A Lei
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Author : Francisco M. Salzano
language : pt-BR
Publisher:
Release Date : 1983
A Gen Tica E A Lei written by Francisco M. Salzano and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1983 with Human genetics categories.
Intorno All Abuso Il Maltrattamento Familiare Tra Terapia E Controllo
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Author : Juan L. Linares
language : it
Publisher: Armando Editore
Release Date : 2007
Intorno All Abuso Il Maltrattamento Familiare Tra Terapia E Controllo written by Juan L. Linares and has been published by Armando Editore this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Family & Relationships categories.
Il maltrattamento familiare costituisce una tematica di dolorosa attualità. Intorno ad essa si scatenano polemiche, si espongono modelli teorici e strategie d'intervento. La lettura del presente volume fornirà ai professionisti della salute mentale, dei servizi sociali e a tutti coloro che operano in questo ambito, utili chiavi di lettura per affrontare il maltrattamento familiare come un fenomeno "umano" che va esaminato da un punto di vista terapeutico nel contesto in cui si produce, ossia il tessuto delle relazioni familiari.
Down To You
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Author : M. Leighton
language : en
Publisher: Penguin
Release Date : 2013-02-12
Down To You written by M. Leighton and has been published by Penguin this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-02-12 with Fiction categories.
One girl. Twin brothers. An uncommon triangle. When college student Olivia Townsend returned home to help her father run his business, she never imagined a complication like Cash and Nash Davenport—twin brothers different in so many ways but with one thing in common: an uncontrollable desire for Olivia. Cash is dangerous, sexy, and bad to the bone—a man whose kisses make Olivia forget she is playing with fire. Nash is successful, reliable and intensely passionate—and already taken. But all it takes is one soft stroke to make Olivia forget he belongs to someone else. However, Olivia is in for a surprise. These boys have a secret that should make her run away as far and as fast as she can. If only it wasn’t too late. A sensual game between three players has begun, and it’s about to spin deliriously out of control. Includes a teaser for The Wild Ones
Direito Administrativo Sancionat Rio Um Problema E Muitos Desafios
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Author : Isabel Celeste M. Fonseca
language : pt-BR
Publisher: Leya
Release Date : 2023-05-31
Direito Administrativo Sancionat Rio Um Problema E Muitos Desafios written by Isabel Celeste M. Fonseca and has been published by Leya this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-31 with Law categories.
A aplicação de sanções pelas entidades administrativas no exercício da função administrativa e, em particular, os temas das multas, dos processos disciplinares, o princípio da legalidade em matéria do exercício do poder administrativo punitivo, o princípio da taxatividade das sanções, o levantamento de autos, a apreensão de bens e aplicação de coimas, o direito de defesa do arguido e o controlo da medida da sanção disciplinar não são temas que vulgarmente sejam tratados a par, em conjunto, no mesmo lugar. Este livro reúne diversos estudos realizados no Mestrado em Direito Administrativo, visando dar resposta a muitos desafios que os temas enunciados continuam a suscitar aos respetivos aplicadores e à ciência do direito. Numa altura em que se conhece a deliberação da CNPD que aplica uma sanção ao Município de Lisboa, no montante de 1,2 milhões de euros, pelo envio indevido de dados pessoais para embaixadas de países estrangeiros, ganha importância o estudo sistematizado do direito administrativo sancionatório, do substantivo, do procedimental e do processual, pela ciência do direito administrativo.
The Membranes
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Author : Chi Ta-wei
language : en
Publisher: Columbia University Press
Release Date : 2021-06-01
The Membranes written by Chi Ta-wei and has been published by Columbia University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-01 with Fiction categories.
It is the late twenty-first century, and Momo is the most celebrated dermal care technician in all of T City. Humanity has migrated to domes at the bottom of the sea to escape devastating climate change. The world is dominated by powerful media conglomerates and runs on exploited cyborg labor. Momo prefers to keep to herself, and anyway she’s too busy for other relationships: her clients include some of the city’s best-known media personalities. But after meeting her estranged mother, she begins to explore her true identity, a journey that leads to questioning the bounds of gender, memory, self, and reality. First published in Taiwan in 1995, The Membranes is a classic of queer speculative fiction in Chinese. Chi Ta-wei weaves dystopian tropes—heirloom animals, radiation-proof combat drones, sinister surveillance technologies—into a sensitive portrait of one young woman’s quest for self-understanding. Predicting everything from fitness tracking to social media saturation, this visionary and sublime novel stands out for its queer and trans themes. The Membranes reveals the diversity and originality of contemporary speculative fiction in Chinese, exploring gender and sexuality, technological domination, and regimes of capital, all while applying an unflinching self-reflexivity to the reader’s own role. Ari Larissa Heinrich’s translation brings Chi’s hybrid punk sensibility to all readers interested in books that test the limits of where speculative fiction can go.
Orlando Furioso
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Author : L. Ariosto
language : en
Publisher:
Release Date : 1834
Orlando Furioso written by L. Ariosto and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1834 with categories.
Disarm
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Author : June Gray
language : en
Publisher: Penguin
Release Date : 2013-05-28
Disarm written by June Gray and has been published by Penguin this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-28 with Fiction categories.
PART ONE OF JUNE GRAY'S DISARM SERIES Even the deepest secrets always find a way to surface... Twenty-six-year-old Elsie Sherman has had a crush on her brother's best friend, Henry Logan, since she was twelve years old. Unfortunately, Henry has only ever treated her like a younger sister, stepping into her brother's shoes after he was killed in action. That is, until one night, when one dance ignites a sensual fire between the two, leaving Elsie aroused and confused. Is she allowed to lust after her surrogate big brother who also happens to be her roommate? But Henry, an Air Force officer, has been harboring two secrets—one will bring them together and the other will tear them apart—and it is up to Elsie to decide if their relationship is worth fighting for. Don't miss Besiege, part two of the Disarm series!
My Last Kiss
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Author : Bethany Neal
language : en
Publisher: Farrar, Straus and Giroux (BYR)
Release Date : 2014-06-10
My Last Kiss written by Bethany Neal and has been published by Farrar, Straus and Giroux (BYR) this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-06-10 with Young Adult Fiction categories.
What if your last kiss was with the wrong boy?In Bethany Neal's My Last Kiss, Cassidy Haines remembers her first kiss vividly. It was on the old covered bridge the summer before her freshman year with her boyfriend of three years, Ethan Keys. But her last kiss—the one she shared with someone at her seventeenth birthday party the night she died—is a blur. Now, Cassidy is trapped in the living world, not only mourning the loss of her human body, but left with the grim suspicion that her untimely death wasn't a suicide as everyone assumes. She can't remember anything from the weeks leading up to her birthday and she's worried that she may have betrayed her boyfriend. If Cassidy is to uncover the truth about that fateful night and make amends with the only boy she'll ever love, she must face her past and all the decisions she made—good and bad—that led to her last kiss.