Estruturas Sint Ticas
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Translational Medicine
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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26
Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.
Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.
Computational Processing Of The Portuguese Language
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Author : Nuno J. Mamede
language : en
Publisher: Springer Science & Business Media
Release Date : 2003-06-18
Computational Processing Of The Portuguese Language written by Nuno J. Mamede and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-06-18 with Education categories.
The refereed proceedings of the 6th International Workshop on Computational Processing of the Portuguese Language, PROPOR 2003, held in Faro, Portugal, in June 2003. The 24 revised full papers and 17 revised short papers presented were carefully reviewed and selected from 64 submissions. The papers are organized in topical sections on speech analysis and recognition; speech synthesis; pragmatics, discourse, semantics, syntax, and the lexicon; tools, resources, and applications; dialogue systems; summarization and information extraction; and evaluation.
Biology Ecology And Management Of Aquatic Plants
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Author : Joseph Caffrey
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-04-17
Biology Ecology And Management Of Aquatic Plants written by Joseph Caffrey and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-17 with Science categories.
There is a growing need for appropriate management of aquatic plants in rivers and canals, lakes and reservoirs, and drainage channels and urban waterways. This management must be based on a sound knowledge of the ecology of freshwater plants, their distribution and the different forms of control available including chemical and physical, and biological and biomanipulation. This series of papers from over 20 different countries was generated from the tenth in the highly successful series of European Weed Research Society symposia on aquatic plant management, this being the tenth. It provides a valuable insight into the complexities involved in managing aquatic systems, discusses state-of-the-art control techniques and deals with patterns of regrowth and recovery post-management. Careful consideration is given to the use of chemicals, a practice which has come under scrutiny in recent years. Underpinning the development of such control techniques is a growing body of knowledge relating to the biology and ecology of water plants. The authorship of the papers represents the collective wisdom of leading scientists and experts from fisheries agencies, river authorities, nature conservation agencies, the agrochemical industry and both governmental and non-governmental organisations.
Matem Ticas 4 Eso 14 Estad Stica Bidimensional
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Author : JosŽ Rodolfo Das L—pez
language : es
Publisher: Lulu.com
Release Date : 2018-07-13
Matem Ticas 4 Eso 14 Estad Stica Bidimensional written by JosŽ Rodolfo Das L—pez and has been published by Lulu.com this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-13 with categories.
Cuaderno de ejercicios para matem+ticas de 41/4 de ESO relacionados con el tema de estad'stica descriptiva bidimensional. Cuenta con una introducci-n te-rica con ejemplos en cada apartado y soluciones al final del cuaderno de todos los ejercicios
Paisagens In Ternas
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Author : Rosa Ignez
language : pt-BR
Publisher:
Release Date : 1973
Paisagens In Ternas written by Rosa Ignez and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1973 with Application software categories.
Oecd Public Integrity Handbook
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2020-05-20
Oecd Public Integrity Handbook written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-20 with categories.
The OECD Public Integrity Handbook provides guidance to government, business and civil society on implementing the OECD Recommendation on Public Integrity. The Handbook clarifies what the Recommendation’s thirteen principles mean in practice and identifies challenges in implementing them.
72 Frequently Asked Questions About Participatory Budgeting
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Author : Global Campaign on Urban Governance
language : en
Publisher: UN-HABITAT
Release Date : 2004
72 Frequently Asked Questions About Participatory Budgeting written by Global Campaign on Urban Governance and has been published by UN-HABITAT this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Local budgets categories.
An Lisis De Estructuras
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Author : Jacques Heyman
language : es
Publisher: Reverte
Release Date : 2004
An Lisis De Estructuras written by Jacques Heyman and has been published by Reverte this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Architecture categories.
Los libros sobre historia de la teoría de las estructuras son escasos y se centran exclusivamente en el desarrollo de la teoría elástica. El presente libro acomete, por primera vez, la tarea de dar una visión completa, incluyendo el cálculo plástico, del desarrollo de la teoría de estructuras. El autor elige los episodios centrales y los estudia en detalle con un extraordinario rigor y claridad.
Panoan Languages And Linguistics
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Author : David William Fleck
language : en
Publisher:
Release Date : 2013
Panoan Languages And Linguistics written by David William Fleck and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Amazon River Region categories.
This monographic study of the Panoan family will serve as an invaluable handbook for both Panoanists seeking a broader perspective and scholars who require an introduction to the family. A new classification encompassing all the extant and extinct Panoan languages and dialects, an evaluation of proposed relations to other language families, a detailed history of Panoan linguistics, a typological overview of the phonology and grammar, and a description of ethnolinguistic features in the family combine to provide a complete picture of Panoan languages and linguistics. An index with the synonyms and spelling variants of all the language names and ethnonyms that are or have been claimed to be Panoan will allow for obscure references in the literature to be quickly resolved.
Teor A Historia Y Restauraci N De Estructuras De F Brica
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Author : Jacques Heyman
language : es
Publisher: Reverte
Release Date : 2007
Teor A Historia Y Restauraci N De Estructuras De F Brica written by Jacques Heyman and has been published by Reverte this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Architecture categories.
Este libro recopila, por vez primera, los ensayos del profesor Heyman sobre el funcionamiento de las estructuras de fábrica. Corresponde al profesor Heyman el mérito de haber "traducido" las teorías y teoremas del análisis límite a las fábricas. Esto supone, sin pérdida de rigor, una simplificación importante del aparato teórico pero, sobre todo, permite una compresión cualitativa ( y cuantitativa) del funcionamiento de estas construcciones. Así, es posible entender por qué las catedrales góticas tienen arbotantes, cuál es la función de los nervios de las bóvedas de crucería o cómo se comportan los puentes de piedra. Aún más, permite explicar la enorme estabilidad de las antiguas fábricas (el Panteón de Roma lleva en pie casi dos milenios sin reparaciones de importancia; Santa Sofía soporta desde el siglo VI sismos de importancia; los puentes romanos transportan cargas muy superiores a las de su época, etc.). Además, el análisis límite de las fábricas, permite interpretar correctamente y sin alarmismos la presencia, inevitable en estas construcciones, de grietas. Éstas no son, necesariamente, signos de ruina; simplemente expresan la naturaleza del material y la adaptación del edificio a los pequeños movimientos del entorno. En resumen, el libro es un "manual" de las estructuras de fábrica y mejorará el conocimiento sobre nuestro patrimonio construido.
