Gregorio Garc A Segura
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Translational Medicine
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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26
Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.
Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.
Authoritarianism And The Elite Origins Of Democracy
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Author : Michael Albertus
language : en
Publisher: Cambridge University Press
Release Date : 2018-02
Authoritarianism And The Elite Origins Of Democracy written by Michael Albertus and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02 with Political Science categories.
Provides an innovative theory of regime transitions and outcomes, and tests it using extensive evidence between 1800 and today.
New Policies For Mandatory Defined Contribution Pensions
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Author : Gregorio Impavido
language : en
Publisher: World Bank Publications
Release Date : 2010-06-04
New Policies For Mandatory Defined Contribution Pensions written by Gregorio Impavido and has been published by World Bank Publications this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-06-04 with Business & Economics categories.
Mandatory defined contribution pension markets are present in a growing number of countries around the world. But despite their popularity, policymakers continue to struggle with two key policy concerns. On the one hand, a number of design shortcomings encourages pension firms to charge high administrative fees. On the other hand, the global crisis that started in 2007 has reignited the debate on whether pension participants bear excessive investment risk. Both are valid policy concerns as their incidence can imply higher than expected levels of poverty among old age individuals. Both concerns have the same root problem---the limited capacity of individuals to choose what is best for them. This, in turn, stems from a combination of inadequate financial education, bounded rationality and the use of simplistic 'rules of thumb' that produce systematic biases in the decision making process of individuals. While improving financial education is an obvious avenue to pursue, this book is more concerned with design features that can exploit these systematic biases to protect consumers from themselves. 'New Policies for Mandatory Defined Contribution Pensions: Industrial Organization Models and Investment Products' (i) discusses the main implications for the functioning of mandatory defined contribution pensions of consumers inability to make rational choices; (ii) describes how jurisdictions have tried to address these problems through ad hoc policy interventions; and (iii) proposes new policy directions in the areas of industrial organization models and investment products to address these concerns more effectively. Written for practitioners and researchers around the world, this book provides access to new thinking on mandatory defined contribution pension systems and it makes an important contribution to the on-going policy debate on how to best structure mandatory defined contribution pillars.
Handbook For Translators Of Spanish Historical Documents
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Author : Juan Villasana Haggard
language : en
Publisher: Рипол Классик
Release Date : 1969
Handbook For Translators Of Spanish Historical Documents written by Juan Villasana Haggard and has been published by Рипол Классик this book supported file pdf, txt, epub, kindle and other format this book has been release on 1969 with History categories.
3rd Symposium Of Ubiquitous Computing And Ambient Intelligence 2008
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Author : Juan Manuel Corchado Rodríguez
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-09-16
3rd Symposium Of Ubiquitous Computing And Ambient Intelligence 2008 written by Juan Manuel Corchado Rodríguez and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-09-16 with Computers categories.
The Symposium on Ubiquitous Computing and Ambient Intelligence (UCAmI) began as a workshop held in 2003 in San Sebastián (Spain) under the Spanish Artificial Intelligence Conference. This event gathered 32 attendees and 18 papers were p- sented. The second edition, already as a Symposium, took place in Granada (Spain) under the first Spanish Computer Science Conference (CEDI). Later, in 2006, a s- ond workshop was celebrated in Ciudad Real and, in 2007; the second Symposium was organized in Zaragoza by the CEDI conference. Now we continue to work on the organization of this event in Salamanca, a beautiful Spanish city. The European Community and the Sixth and Seventh Framework Programs - courage researchers to explore the generic scope of the AmI vision. In fact, some researchers have a crucial role in this vision. Emile Aarts from Philips describes - bient Intelligence as "the integration of technology into our environment, so that p- ple can freely and interactively utilize it". This idea agrees with the proposal of Mark Weiser regarding the Ubiquitous Computing paradigm.
The History Of America
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Author : William Robertson
language : en
Publisher:
Release Date : 1822
The History Of America written by William Robertson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1822 with America categories.
One Hundred Years Of Solitude
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Author : Gabriel García Márquez
language : en
Publisher: Blackstone Publishing
Release Date : 2022-10-11
One Hundred Years Of Solitude written by Gabriel García Márquez and has been published by Blackstone Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-11 with Fiction categories.
One of the twentieth century’s enduring works, One Hundred Years of Solitude is a widely beloved and acclaimed novel known throughout the world and the ultimate achievement in a Nobel Prize–winning career. The novel tells the story of the rise and fall of the mythical town of Macondo through the history of the Buendía family. Rich and brilliant, it is a chronicle of life, death, and the tragicomedy of humankind. In the beautiful, ridiculous, and tawdry story of the Buendía family, one sees all of humanity, just as in the history, myths, growth, and decay of Macondo, one sees all of Latin America. Love and lust, war and revolution, riches and poverty, youth and senility, the variety of life, the endlessness of death, the search for peace and truth—these universal themes dominate the novel. Alternately reverential and comical, One Hundred Years of Solitude weaves the political, personal, and spiritual to bring a new consciousness to storytelling. Translated into dozens of languages, this stunning work is no less than an account of the history of the human race.
The Works Of William Robertson D D
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Author : William Robertson
language : en
Publisher:
Release Date : 1821
The Works Of William Robertson D D written by William Robertson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1821 with History categories.
Cacti
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Author : Park S. Nobel
language : en
Publisher: Univ of California Press
Release Date : 2002-07-10
Cacti written by Park S. Nobel and has been published by Univ of California Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-07-10 with Nature categories.
"There is nothing in the world like this book. It should be in every library and on the bookshelves of all those interested in cacti. The book will be an important resource for plant physiology, agronomy, and horticulture classes at both the undergraduate and graduate level."—Bruce Smith, Brigham Young University "Cacti: Biology and Uses is a landmark publication of one of the world's most unique group of plants. Park Nobel, a leading authority on succulent plants, has assembled a collection of contributions that spans a wide range of issues extending from basic systematics, anatomy, physiology and ecology to considerations of conservation and human uses of this diverse group of plants. This nicely-produced and well-illustrated volume provides a resource that will be of great use to a wide range of scientists, practitioners, and enthusiasts of this plant group."—Harold Mooney, Paul S. Achilles Professor of Environmental Biology, Stanford University
Multilingualism And The Periphery
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Author : Sari Pietikainen
language : en
Publisher: Oxford University Press, USA
Release Date : 2013-03-07
Multilingualism And The Periphery written by Sari Pietikainen and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-07 with Education categories.
This edited volume explores the ways in which core-periphery dynamics shape multilingualism.