Ilargi Harria
DOWNLOAD
Download Ilargi Harria PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Ilargi Harria book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Lasso Peptides
DOWNLOAD
Author : Yanyan Li
language : en
Publisher: Springer
Release Date : 2014-10-21
Lasso Peptides written by Yanyan Li and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-21 with Medical categories.
Lasso peptides form a growing family of fascinating ribosomally-synthesized and post-translationally modified peptides produced by bacteria. They contain 15 to 24 residues and share a unique interlocked topology that involves an N-terminal 7 to 9-residue macrolactam ring where the C-terminal tail is threaded and irreversibly trapped. The ring results from the condensation of the N-terminal amino group with a side-chain carboxylate of a glutamate at position 8 or 9, or an aspartate at position 7, 8 or 9. The trapping of the tail involves bulky amino acids located in the tail below and above the ring and/or disulfide bridges connecting the ring and the tail. Lasso peptides are subdivided into three subtypes depending on the absence (class II) or presence of one (class III) or two (class I) disulfide bridges. The lasso topology results in highly compact structures that give to lasso peptides an extraordinary stability towards both protease degradation and denaturing conditions. Lasso peptides are generally receptor antagonists, enzyme inhibitors and/or antibacterial or antiviral (anti-HIV) agents. The lasso scaffold and the associated biological activities shown by lasso peptides on different key targets make them promising molecules with high therapeutic potential. Their application in drug design has been exemplified by the development of an integrin antagonist based on a lasso peptide scaffold. The biosynthesis machinery of lasso peptides is therefore of high biotechnological interest, especially since such highly compact and stable structures have to date revealed inaccessible by peptide synthesis. Lasso peptides are produced from a linear precursor LasA, which undergoes a maturation process involving several steps, in particular cleavage of the leader peptide and cyclization. The post-translational modifications are ensured by a dedicated enzymatic machinery, which is composed of an ATP-dependent cysteine protease (LasB) and a lactam synthetase (LasC) that form an enzymatic complex called lasso synthetase. Microcin J25, produced by Escherichia coli AY25, is the archetype of lasso peptides and the most extensively studied. To date only around forty lasso peptides have been isolated, but genome mining approaches have revealed that they are widely distributed among Proteobacteria and Actinobacteria, particularly in Streptomyces, making available a rich resource of novel lasso peptides and enzyme machineries towards lasso topologies.
Hard X Ray Photoelectron Spectroscopy Haxpes
DOWNLOAD
Author : Joseph Woicik
language : en
Publisher: Springer
Release Date : 2015-12-26
Hard X Ray Photoelectron Spectroscopy Haxpes written by Joseph Woicik and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-12-26 with Science categories.
This book provides the first complete and up-to-date summary of the state of the art in HAXPES and motivates readers to harness its powerful capabilities in their own research. The chapters are written by experts. They include historical work, modern instrumentation, theory and applications. This book spans from physics to chemistry and materials science and engineering. In consideration of the rapid development of the technique, several chapters include highlights illustrating future opportunities as well.
Medium Of Instruction Policies
DOWNLOAD
Author : James W. Tollefson
language : en
Publisher: Routledge
Release Date : 2003-10-03
Medium Of Instruction Policies written by James W. Tollefson and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-10-03 with Education categories.
Medium of instruction policies in education have considerable impact not only on the school performance of students and the daily work of teachers, but also on various forms of social and economic (in)equality. In many multiethnic and multilingual countries, the choice of a language for the medium of instruction in state educational systems raises a fundamental and complex educational question: what combination of instruction in students' native language(s) and in a second language of wider communication will ensure that students gain both effective subject-content education, as well as the second-language skills necessary for higher education and employment? Beyond this educational issue of choice of language(s) of instruction, medium of instruction policies are also linked to a range of important sociopolitical issues, including globalization, migration, labor policy, elite competition, and the distribution of economic resources and political power. The contributors to this volume examine the tension between the educational agendas and other social and political agendas underlying medium of instruction policies in different countries around the world, and unravel the connections between these policies and the related, critically important educational, social, political, and economic issues. Medium of Instruction Policies: Which Agenda? Whose Agenda? is intended for scholars and specialists in education, language policy, sociolinguistics, applied linguistics, and language teaching, and is intended for use in graduate and advanced undergraduate courses on language education and language policy.
Basque And Romance
DOWNLOAD
Author : Ane Berro
language : en
Publisher: BRILL
Release Date : 2019-05-07
Basque And Romance written by Ane Berro and has been published by BRILL this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-07 with Language Arts & Disciplines categories.
Aligning Grammars: Basque and Romance offers a theoretically-informed in-depth description of several linguistic structures of Basque and surrounding Romance languages. Its goal is to shed some light on the linguistic systems of these languages and their interactions.
Pediatric Gastroenterology E Book
DOWNLOAD
Author : Chris A. Liacouras
language : en
Publisher: Elsevier Health Sciences
Release Date : 2007-11-22
Pediatric Gastroenterology E Book written by Chris A. Liacouras and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-22 with Medical categories.
This volume in the Requisites in Pediatrics series offers expert guidance in the assessment and treatment of gastroenterological disorders commonly encountered in clinical practice. It delivers all the information you need in the proven "high-yield" Requisites format - equipping you to master the material quickly. Perfect for quick review and exam preparation, this is one resource you'll consult over and over again! Follows a logical, consistent chapter format to facilitate quick and easy reference. Offers abundant tables that present differential diagnoses, lab values / radiologic studies, treatment / therapy recommendations, and guidance on when to refer to a specialist. Presents thought-provoking clinical scenarios to help you determine the best course of action in situations where there are controversies concerning the standard of care. Features a wealth of illustrations that make details clearer. Includes highlighted boxes that emphasize relevant case studies · key points of each section · current controversies · and other important information.
Tombs Temples And Their Orientations
DOWNLOAD
Author : Michael A. Hoskin
language : en
Publisher:
Release Date : 2001
Tombs Temples And Their Orientations written by Michael A. Hoskin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with History categories.
This study of archaeoastronomy looks at more than 2,500 communal tombs and sanctuaries from around the Mediterranean. After a brief discussion of Hoskin's aims and the methodology for his fieldwork, individual chapters focus on evidence from particular regions: Malta, Gozo, the Balearics, Iberia, southern France, Corsica and Sardinia, Sicily and Pantelleria, Tunisia, Algeria and Morocco. The author concludes that in most of these regions the monuments faced sunrise, or more generally the sun when it was rising or climbing in the sky. Along the Mediterranean coast of France, however, there is a reverse sunset custom; in North Africa tombs faced downhill and in a Minoan cemetery on Crete all the tombs faced moonrise and look towards a mountain on whose peak was a sanctuary probably sacred to a lunar god. 264p, b/w figs and photos throughout, tables (Ocarina Books 2001) ` adorned with dozens of beautiful photographs, technical diagrams, and an extraordinary Corpus Mensurarum.....a living masterpiece in the field of archaeoastronomy ' - Juan Antonio Belmonte, Instituto de Astroficia de Canarias `
Young Children S Thinking About Biological World
DOWNLOAD
Author : Giyoo Hatano
language : en
Publisher: Psychology Press
Release Date : 2013-04-15
Young Children S Thinking About Biological World written by Giyoo Hatano and has been published by Psychology Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-15 with Psychology categories.
Presents research on the topic of young children's naive biology, examining such theoretical issues as processes, conditions and mechanisms in conceptual development using the development of biological understanding as the target case.
Mood Disorders
DOWNLOAD
Author : Sudhakar Selvaraj
language : en
Publisher: Cambridge University Press
Release Date : 2021-01-07
Mood Disorders written by Sudhakar Selvaraj and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-07 with Medical categories.
Offering up-to-date information on brain imaging in mood disorders, this book is an invaluable resource for mental health professionals.
American Monstrosity
DOWNLOAD
Author : Nathan J. Robinson
language : en
Publisher:
Release Date : 2020
American Monstrosity written by Nathan J. Robinson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with Businessmen categories.
Hanshu Volume 95 The Southwest Peoples Two Yues And Chaoxian Translation With Commentary
DOWNLOAD
Author : Amies, Alex
language : en
Publisher: chinesenotes
Release Date : 2019-12-31
Hanshu Volume 95 The Southwest Peoples Two Yues And Chaoxian Translation With Commentary written by Amies, Alex and has been published by chinesenotes this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-31 with History categories.
A new translation of Volume 95 of the Hanshu, also known as the Book of Han, is provided along with commentary on the text and discussion. The present translation is given with aligned Chinese source text. Volume 95 is a 傳 zhuan ‘biography’ describing the 西南夷 Southwest peoples of present-day Sichuan, Yunnan, and Guizhou; 兩粵 two Yues, Nanyue of present-day Guangdong, Guangxi, and Vietnam and Minyue of present-day Fujian, Jiangsu, and adjacent areas; and 朝鮮 Chaoxian in the Korean peninsula. A discussion of how the text relates to trade, transportation, and cultural exchange in Panyu, in the area of present-day Guangzhou, as the capital of Nanyue and administrative center of the Nanhai commandery is also given.