Inventario Cient Fico Tecnol Gico Nacional
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Translational Medicine
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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26
Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.
Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.
Multiple Criteria Decision Analysis
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Author : Valerie Belton
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Multiple Criteria Decision Analysis written by Valerie Belton and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Business & Economics categories.
The field of multiple criteria decision analysis (MCDA), also termed multiple criteria decision aid, or multiple criteria decision making (MCDM), has developed rapidly over the past quarter century and in the process a number of divergent schools of thought have emerged. This can make it difficult for a new entrant into the field to develop a comprehensive appreciation of the range of tools and approaches which are available to assist decision makers in dealing with the ever-present difficulties of seeking compromise or consensus between conflicting inter ests and goals, i.e. the "multiple criteria". The diversity of philosophies and models makes it equally difficult for potential users of MCDA, i.e. management scientists and/or decision makers facing problems involving conflicting goals, to gain a clear understanding of which methodologies are appropriate to their particular context. Our intention in writing this book has been to provide a compre hensive yet widely accessible overview of the main streams of thought within MCDA. We aim to provide readers with sufficient awareness of the underlying philosophies and theories, understanding of the practi cal details of the methods, and insight into practice to enable them to implement any of the approaches in an informed manner. As the title of the book indicates, our emphasis is on developing an integrated view of MCDA, which we perceive to incorporate both integration of differ ent schools of thought within MCDA, and integration of MCDA with broader management theory, science and practice.
Medicine And International Relations In The Caribbean
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Author : Rodrigo Fernos
language : en
Publisher: iUniverse
Release Date : 2006-02
Medicine And International Relations In The Caribbean written by Rodrigo Fernos and has been published by iUniverse this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-02 with History categories.
Medicine has long framed race relations in the Caribbean-that basin where African and European cultures have met from the beginning of the Colonial Period to the twentieth century. Whether Sir Hans Sloane, founder of the British Museum and President of the Royal Society of London, who as a physician wrote about African medical beliefs and practices, or Dr. Leonard Wood, military physician who served as military governor to Cuba, medicine and its practitioners have played a key role in the perception of the African Other. The book is a collection of essays treating the subject from various points of views. While it may perhaps not surprise the reader that colonial physicians often failed to acknowledge the same failings in their own Western medicine as that criticized of African practices, the medical view found later in the period lacked that biting racism of an earlier era.
World Anthropologies
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Author : Gustavo Lins Ribeiro
language : en
Publisher: Routledge
Release Date : 2020-07-13
World Anthropologies written by Gustavo Lins Ribeiro and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-13 with Social Science categories.
Since its inception, anthropology's authority has been based on the assumption that it is a unified discipline emanating from the West. In an age of heightened globalization, anthropologists have failed to discuss consistently the current status of their practice and its mutations across the globe. World Anthropologies is the first book to provoke this conversation from various regions of the world in order to assess the diversity of relations between regional or national anthropologies and a contested, power-laden Western discourse. Can a planetary anthropology cope with both the 'provincial cosmopolitanism' of alternative anthropologies and the 'metropolitan provincialism' of hegemonic schools? How might the resulting 'world anthropologies' challenge the current panorama in which certain allegedly national anthropological traditions have more paradigmatic weight - and hence more power - than others? Critically examining the international dissemination of anthropology within and across national power fields, contributors address these questions and provide the outline for a veritable world anthropologies project.
The United Nations World Water Development Report 2017
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Author : WWAP
language : en
Publisher: UNESCO Publishing
Release Date : 2017-03-15
The United Nations World Water Development Report 2017 written by WWAP and has been published by UNESCO Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-15 with Education categories.
The United Nations World Water Assessment Programme (WWAP) is hosted and led by UNESCO. WWAP brings together the work of 31 UN-Water Members and 38 Partners to publish The United Nations World Water Development Report, (WWDR) series. The annual World Water Development Reports focus on strategic water issues. UN-Water Members and Partners, all experts in their respective fields, contribute the latest findings on a specific theme. The 2017 edition of the World Water Development Report focuses on 'Wastewater' and seeks to inform decision-makers, inside and outside the water community, about the importance of managing wastewater as an undervalued and sustainable source of water, energy, nutrients and other recoverable by-products, rather than something to be disposed of or a nuisance to be ignored. The report's title - Wastewater: The Untapped Resource - reflects the critical role that wastewater is poised to play in the context of a circular economy, whereby economic development is balanced with the protection of natural resources and environmental sustainability, and where a cleaner and more sustainable economy has a positive effect on the water quality. Improved wastewater management is not only critical to achieving the Sustainable Development Goal on clean water and sanitation (SDG 6), but also to other goals of the 2030 Agenda for Sustainable Development.
Preclinical Safety Evaluation Of Biopharmaceuticals
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Author : Joy A. Cavagnaro
language : en
Publisher: John Wiley & Sons
Release Date : 2013-03-07
Preclinical Safety Evaluation Of Biopharmaceuticals written by Joy A. Cavagnaro and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-07 with Medical categories.
"The goal is to provide a comprehensive reference book for the preclinicaldiscovery and development scientist whose responsibilities span target identification, lead candidate selection, pharmacokinetics, pharmacology, and toxicology, and for regulatory scientists whose responsibilities include the evaluation of novel therapies." —From the Afterword by Anthony D. Dayan Proper preclinical safety evaluation can improve the predictive value, lessen the time and cost of launching new biopharmaceuticals, and speed potentially lifesaving drugs to market. This guide covers topics ranging from lead candidate selection to establishing proof of concept and toxicity testing to the selection of the first human doses. With chapters contributed by experts in their specific areas, Preclinical Safety Evaluation of Biopharmaceuticals: A Science-Based Approach to Facilitating Clinical Trials: Includes an overview of biopharmaceuticals with information on regulation and methods of production Discusses the principles of ICH S6 and their implementation in the U.S., Europe, and Japan Covers current practices in preclinical development and includes a comparison of safety assessments for small molecules with those for biopharmaceuticals Addresses all aspects of the preclinical evaluation process, including: the selection of relevant species; safety/toxicity endpoints; specific considerations based upon class; and practical considerations in the design, implementation, and analysis of biopharmaceuticals Covers transitioning from preclinical development to clinical trials This is a hands-on, straightforward reference for professionals involved in preclinical drug development, including scientists, toxicologists, project managers, consultants, and regulatory personnel.
Production And Operations Management
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Author : Norman Gaither
language : en
Publisher:
Release Date : 1984
Production And Operations Management written by Norman Gaither and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1984 with Business & Economics categories.
The Lean Startup
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Author : Eric Ries
language : en
Publisher: Crown Currency
Release Date : 2011-09-13
The Lean Startup written by Eric Ries and has been published by Crown Currency this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-13 with Business & Economics categories.
Most startups fail. But many of those failures are preventable. The Lean Startup is a new approach being adopted across the globe, changing the way companies are built and new products are launched. Eric Ries defines a startup as an organization dedicated to creating something new under conditions of extreme uncertainty. This is just as true for one person in a garage or a group of seasoned professionals in a Fortune 500 boardroom. What they have in common is a mission to penetrate that fog of uncertainty to discover a successful path to a sustainable business. The Lean Startup approach fosters companies that are both more capital efficient and that leverage human creativity more effectively. Inspired by lessons from lean manufacturing, it relies on “validated learning,” rapid scientific experimentation, as well as a number of counter-intuitive practices that shorten product development cycles, measure actual progress without resorting to vanity metrics, and learn what customers really want. It enables a company to shift directions with agility, altering plans inch by inch, minute by minute. Rather than wasting time creating elaborate business plans, The Lean Startup offers entrepreneurs—in companies of all sizes—a way to test their vision continuously, to adapt and adjust before it’s too late. Ries provides a scientific approach to creating and managing successful startups in a age when companies need to innovate more than ever.
The Power Of Habit
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Author : Charles Duhigg
language : en
Publisher: Random House
Release Date : 2012-02-28
The Power Of Habit written by Charles Duhigg and has been published by Random House this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-02-28 with Business & Economics categories.
NEW YORK TIMES BESTSELLER • This instant classic explores how we can change our lives by changing our habits. NAMED ONE OF THE BEST BOOKS OF THE YEAR BY The Wall Street Journal • Financial Times In The Power of Habit, award-winning business reporter Charles Duhigg takes us to the thrilling edge of scientific discoveries that explain why habits exist and how they can be changed. Distilling vast amounts of information into engrossing narratives that take us from the boardrooms of Procter & Gamble to the sidelines of the NFL to the front lines of the civil rights movement, Duhigg presents a whole new understanding of human nature and its potential. At its core, The Power of Habit contains an exhilarating argument: The key to exercising regularly, losing weight, being more productive, and achieving success is understanding how habits work. As Duhigg shows, by harnessing this new science, we can transform our businesses, our communities, and our lives. With a new Afterword by the author “Sharp, provocative, and useful.”—Jim Collins “Few [books] become essential manuals for business and living. The Power of Habit is an exception. Charles Duhigg not only explains how habits are formed but how to kick bad ones and hang on to the good.”—Financial Times “A flat-out great read.”—David Allen, bestselling author of Getting Things Done: The Art of Stress-Free Productivity “You’ll never look at yourself, your organization, or your world quite the same way.”—Daniel H. Pink, bestselling author of Drive and A Whole New Mind “Entertaining . . . enjoyable . . . fascinating . . . a serious look at the science of habit formation and change.”—The New York Times Book Review
The Doubtful Strait El Estrecho Dudoso
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Author : Ernesto Cardenal
language : en
Publisher: Indiana University Press
Release Date : 1995-02-22
The Doubtful Strait El Estrecho Dudoso written by Ernesto Cardenal and has been published by Indiana University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-02-22 with Literary Criticism categories.
"... very well translated... Cardenal merits praise for presenting, on such an ambitious scale, a passionate alternative history of the Spanish encounter with Central America." --Booklist "Combining hsitory with poetry, Cardenal exposes the violence, treachery, injustice, and exploitation that are so much a part of Central America and Mexico's] past and present." --World Literature Today "Explore this dense, beautiful poem and you will be rewarded with riches that 'delight and hurt not'." --Nicaragua Update "... a remarkable text.... El estrecho dudoso is a masterful and compelling poetic account of early colonial Central America, and the translation is likewise masterful." --Colonial Latin American Historical Review In this book-length poem, Nicaraguan priest and revolutionary Ernesto Cardenal tells the story of the Spanish conquest of Central America from the "discovery" of the American continent to recent historical events. A remarkable achievement and an engrossing narrative, the poem is published here in both Spanish and English.