L Ltima Causa Perduda
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Translational Medicine
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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26
Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.
Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.
The Lost Honor Of Katharina Blum
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Author : Heinrich Böll
language : en
Publisher: McGraw-Hill Companies
Release Date : 1975
The Lost Honor Of Katharina Blum written by Heinrich Böll and has been published by McGraw-Hill Companies this book supported file pdf, txt, epub, kindle and other format this book has been release on 1975 with Fiction categories.
A young woman's association with a hunted man makes her the target of a journalist determined to grab headlines by portraying her as an evil woman. As the attacks on her escalate and she becomes the victim of anonymous threats, Katharina sees only one way out of her nightmare.
Vita
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Author : Melania G. Mazzucco
language : en
Publisher: Farrar, Straus and Giroux
Release Date : 2005-09-15
Vita written by Melania G. Mazzucco and has been published by Farrar, Straus and Giroux this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-09-15 with Fiction categories.
In April 1903, the steamship Republic spills more than two thousand immigrants onto Ellis Island. Among them are Diamante, age twelve, and Vita, nine, sent by their poor families in southern Italy to make their way in America. Amid the chaos and splendor of New York, the misery and criminality of Little Italy, and the shady tenants of Vita's father's decrepit Prince Street boarding house, Diamante and Vita struggle to survive, to create a new life, and to become American. From journeys west in search of work to journeys back to Italy in search of their roots, to Vita's son's encounter with his mother's home town while serving as an army captain in World War II, Vita touches on every aspect of the heartbreaking and inspiring immigrant story. The award-winning Italian author Melania G. Mazzucco weaves her own family history into a great American novel of the immigrant experience. A sweeping tale of discovery, love, and loss, Vita is a passionate blend of biography and autobiography, of fantasy and fiction.
Muslims In Spain 1492 1814
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Author : Eloy Martín Corrales
language : en
Publisher: Mediterranean Reconfigurations
Release Date : 2020-12
Muslims In Spain 1492 1814 written by Eloy Martín Corrales and has been published by Mediterranean Reconfigurations this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12 with History categories.
"In Muslims in Spain, 1492-1814: Living and Negotiating in the Land of the Infidel, Eloy Martín-Corrales surveys Hispano-Muslim relations from the late fifteenth to the eighteenth centuries, a period of chronic hostilities. Nonetheless there were thousands of Muslims in Spain during this time: ambassadors, exiles, merchants, converts, and travelers. Their negotiating strategies and the necessary support they found on both shores of the Mediterranean prove that relations between Spaniards and Muslims were based on reasons of state and a pragmatism that generated intense ties, both political and economic. These increased enormously after the peace treaties that Spain signed with Muslim countries between 1767 and 1791"--
L Ocell Negre
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Author : Xavi D. Manu
language : ca
Publisher: Letrame Grupo Editorial
Release Date : 2021-09-23
L Ocell Negre written by Xavi D. Manu and has been published by Letrame Grupo Editorial this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-23 with Fiction categories.
L'Aleix Arimany viu presoner dels fantasmes del seu passat. Captiu d'una Barcelona hostil, és un inadaptat sense rumb en un món estrany i fosc. La Júlia, la seva amiga de la infància i veu de la consciència, amb prou feines el pot mantenir lluny del seu propi pensament, no acaba de trobar l'espurna necessària que empenyi al seu company de pis a tornar a brillar amb llum pròpia. El dia més inesperat però, l'Aleix coneixerà a la misteriosa Janet, qui farà tremolar la seva realitat. Una amistat forçada pel destí que l'arrossegarà a sortir de la seva zona de confort. Un quadre misteriós, un rebel sense causa, una dama de la nit i una nena òrfena es creuaran enmig d'una aventura frenètica, personatges repudiats pel món buscant la tan anhelada llibertat. Una història que no us deixarà indiferents: somnis i esperances, que xocaran contra un mur de mentides, crims i traïcions. Esteu disposats a seguir l'Aleix en el seu viatge? Esteu preparats, per emprendre el vol?
Preclinical Safety Evaluation Of Biopharmaceuticals
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Author : Joy A. Cavagnaro
language : en
Publisher: John Wiley & Sons
Release Date : 2013-03-07
Preclinical Safety Evaluation Of Biopharmaceuticals written by Joy A. Cavagnaro and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-07 with Medical categories.
"The goal is to provide a comprehensive reference book for the preclinicaldiscovery and development scientist whose responsibilities span target identification, lead candidate selection, pharmacokinetics, pharmacology, and toxicology, and for regulatory scientists whose responsibilities include the evaluation of novel therapies." —From the Afterword by Anthony D. Dayan Proper preclinical safety evaluation can improve the predictive value, lessen the time and cost of launching new biopharmaceuticals, and speed potentially lifesaving drugs to market. This guide covers topics ranging from lead candidate selection to establishing proof of concept and toxicity testing to the selection of the first human doses. With chapters contributed by experts in their specific areas, Preclinical Safety Evaluation of Biopharmaceuticals: A Science-Based Approach to Facilitating Clinical Trials: Includes an overview of biopharmaceuticals with information on regulation and methods of production Discusses the principles of ICH S6 and their implementation in the U.S., Europe, and Japan Covers current practices in preclinical development and includes a comparison of safety assessments for small molecules with those for biopharmaceuticals Addresses all aspects of the preclinical evaluation process, including: the selection of relevant species; safety/toxicity endpoints; specific considerations based upon class; and practical considerations in the design, implementation, and analysis of biopharmaceuticals Covers transitioning from preclinical development to clinical trials This is a hands-on, straightforward reference for professionals involved in preclinical drug development, including scientists, toxicologists, project managers, consultants, and regulatory personnel.
The Book Of Disquiet
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Author : Fernando Pessoa
language : en
Publisher: Serpent's Tail
Release Date : 2017-08-17
The Book Of Disquiet written by Fernando Pessoa and has been published by Serpent's Tail this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-17 with Fiction categories.
The Book of Disquiet is one of the great literary works of the twentieth century. Written over the course of Fernando Pessoa's life, it was first published in 1982, pieced together from the thousands of individual manuscript pages left behind by Pessoa after his death in 1935. Now this fragmentary modernist masterpiece appears in a major new edition that unites Margaret Jull Costa's celebrated translation with the most complete version of the text ever produced. It is presented here, for the first time in English, by order of original composition, and accompanied by facsimiles of the original manuscript. Narrated principally by an assistant bookkeeper named Bernardo Soares - an alias of sorts for Pessoa himself - The Book of Disquiet is 'the autobiobraphy of someone who never existed', a mosaic of dreams, of hope and despair; a hymn to the streets and cafs of 1930s Lisbon, and an extraordinary record of the inner life of one of the century's most important writers. This new edition represents the most complete vision of Pessoa's genius.
Portugal E Os Estrangeiros
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Author : Manoel Bernardes Branco
language : en
Publisher:
Release Date : 1879
Portugal E Os Estrangeiros written by Manoel Bernardes Branco and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1879 with Portugal categories.
The Psychology Of The Child
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Author : Jean Piaget
language : en
Publisher: Hachette UK
Release Date : 2019-04-23
The Psychology Of The Child written by Jean Piaget and has been published by Hachette UK this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-04-23 with Psychology categories.
The definite account of psychologist Jean Piaget's work Jean Piaget's influence on psychology has been profound. His pathbreaking investigations and theories of cognitive development have set child psychology moving in entirely new directions. His bold speculations have provided the inspiration for the work of others. His studies have been the subject of many books and countless articles. And, significantly, his influence has spread to other disciplines and is having an ever-growing impact on the general culture at large. Here Jean Piaget, with the assistance of his long-time collaborator Bäel Inhelder, offers a definitive presentation of the developmental psychology he has elaborated over the last forty years. This comprehensive synthesis traces each stage of the child's cognitive development, over the entire period of childhood, from infancy to adolescence.
Hist Ria De Fraga Segle Xvii Ii
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Author : Félix Otero Carrasco
language : ca
Publisher: IEBC
Release Date : 1994
Hist Ria De Fraga Segle Xvii Ii written by Félix Otero Carrasco and has been published by IEBC this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Juvenile Nonfiction categories.