Les Eph M Res

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Biological Mechanisms And The Advancing Approaches To Overcoming Cancer Drug Resistance

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Author : Andrew Freywald
language : en
Publisher: Academic Press
Release Date : 2020-11-17

Biological Mechanisms And The Advancing Approaches To Overcoming Cancer Drug Resistance written by Andrew Freywald and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-17 with Science categories.

Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance, Volume 12, discusses new approaches that are being undertaken to counteract tumor plasticity, understand and tackle the interactions with the microenvironment, and disrupt the rewiring of malignant cells or bypass biological mechanism of resistance by using targeted radionuclide therapies. This book provides a unique opportunity to the reader to understand the fundamental causes of drug resistance and how different approaches are applied. It is a one-stop-shop to understand why it is so difficult to treat cancer, and why only a very few patients respond to therapy and a significant portion develop resistance. Despite a rapid development of more effective anti-cancer drugs and combination therapies, cancer remains the leading cause of lethality in the developed world. The main reason for this is the ability of heterogeneous subpopulations of tumor cells interacting with constantly evolving tumor microenvironment to resist elimination and eventually, trigger cancer relapse. In this book, experts review current concepts explaining molecular and biological mechanisms of cancer drug resistance and discussing advancing approaches for overcoming these therapeutic challenges. Provides the most updated knowledge on the mechanisms of cancer drug resistance and the emerging therapeutic approaches reviewed by experts in the field Brings detailed analyses of most important recently reported developments related to drug resistance and their relevance to overcoming it in cancer patients Discusses in-depth molecular mechanisms and novel concepts of cancer resistance to conventional and advanced therapies

U S Army Register

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Author : United States. Adjutant-General's Office
language : en
Publisher:
Release Date : 1957

U S Army Register written by United States. Adjutant-General's Office and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1957 with categories.

Le Guide Musical

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Author :
language : en
Publisher:
Release Date : 1886

Le Guide Musical written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1886 with categories.

Vetus Latina Verzeichnis Der Sigel F R Handschriften Und Kirchenschriftsteller Von B Fischer 1949

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Author :
language : un
Publisher:
Release Date : 1949

Vetus Latina Verzeichnis Der Sigel F R Handschriften Und Kirchenschriftsteller Von B Fischer 1949 written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1949 with Bible categories.

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Author :
language : en
Publisher: Brill Archive
Release Date :

written by and has been published by Brill Archive this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.

Christian Prophecy

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Author : Niels Christian Hvidt
language : en
Publisher: Oxford University Press
Release Date : 2007-04-19

Christian Prophecy written by Niels Christian Hvidt and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-04-19 with Religion categories.

Throughout the Hebrew Bible, God guides and saves his people through the words of his prophets. When the prophets are silenced, the people easily lose their way. What happened after the incarnation, death and resurrection of Christ? Did God fall silent? The dominant position in Christian theology is that prophecy did indeed cease at some point in the past -if not with the Old Testament prophets, then with John the Baptist, with Jesus, with the last apostle, or with the closure of the canon of the New Testament. Nevertheless, throughout the history of Christianity there have always been acclaimed saints and mystics -most of them women-who displayed prophetic traits. In recent years, the charismatic revival in both Protestant and Catholic circles has once again raised the question of the place and function of prophecy in Christianity. Scholarly theological attitudes toward Christian prophecy range from modest recognition to contempt. Mainstream systematic theology, both Protestant and Catholic, has mostly marginalized or ignored the gift of prophecy. In this book, however, Niels Christian Hvidt argues that prophecy has persisted in Christianity as an inherent and continuous feature in the life of the church. Prophecy never died, he argues, but rather proved its dynamism by mutating to meet new historical conditions. He presents a comprehensive history of prophecy from ancient Israel to the present and closely examines the development of the theological discourse that surrounds it. Throughout, though, there is always an awareness of the critical discernment required when evaluating the charism of prophecy. The debate about prophecy, Hvidt shows, leads to some profound insights about the very nature of Christianity and the church. For example, some have argued that Christianity is a perfect state and that all that is required for salvation is acceptance of its doctrines. Others have emphasized how God continues to intervene and guide his people onto the right path as the full implementation of God's salvation in Christ is still far away. This is the position that Hvidt forcefully and persuasively defends and develops in this ambitious and important work.

The History And Genealogies Of Ancient Windsor Connecticut

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Author : Henry Reed Stiles
language : en
Publisher:
Release Date : 1893

The History And Genealogies Of Ancient Windsor Connecticut written by Henry Reed Stiles and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1893 with Bloomfield (Conn. : Town) categories.

Intestinal Stem Cell Niche

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Author :
language : en
Publisher: Academic Press
Release Date : 2018-04-24

Intestinal Stem Cell Niche written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-04-24 with Science categories.

Advances in Stem Cells and Their Niches addresses stem cells during development, homeostasis, and disease/injury of the respective organs, presenting new developments in the field, including new data on disease and clinical applications. Video content illustrates such areas as protocols, transplantation techniques, and work with mice. Explores not only reviews of research, but also shares methods, protocols, and transplantation techniques Contains video content to illustrate such areas as protocols, transplantation techniques, and work with mice Each volume concentrates on one organ, making this a unique publication

Improving The Therapeutic Ratio In Head And Neck Cancer

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Author :
language : en
Publisher: Academic Press
Release Date : 2019-10-04

Improving The Therapeutic Ratio In Head And Neck Cancer written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-04 with Science categories.

Improving the Therapeutic Ratio in Head and Neck Cancer provides a complete review of current approaches to modulating therapeutic sensitivity in head and neck cancer. It presents a broad background of current approaches and by highlighting the potential for clinical translational, introduces a roadmap for how to move promising preclinical findings into the clinic. The book discusses topics such as immunotherapy and molecularly targeted therapies in head and neck cancer, PI3k/mTOR pathway, autophagy inhibition to sensitize HNC to radiation and chemotherapy, TAM and Eph/Ephrin family proteins and metabolic reprogramming to modulate therapeutic sensitivity. Additionally, it details approaches to improve the response to immunotherapy, and Chk1/2 inhibition in radiation and cetuximab resistance. This book is a valuable source to head and neck cancer researchers and advanced students, and to those studying specific approaches in other model systems and disease sites. Provides key scientific background for clinicians when developing novel clinical trials and important examples for basic scientists of the types of work required to move a concept from the lab to the clinic Presents consistent pathway diagrams in each chapter, thus making it easier to understand complicated pathways Includes chapter summaries of the critical next steps needed to move studies from their current state into practice changing clinical data

Translational Immunotherapy Of Brain Tumors

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Author : John H. Sampson
language : en
Publisher: Academic Press
Release Date : 2017-02-06

Translational Immunotherapy Of Brain Tumors written by John H. Sampson and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-02-06 with Science categories.

Translational Immunotherapy of Brain Tumors gives researchers and practitioners an up-to-date and comprehensive overview of the field. Chapters include adoptive immunotherapy, immunosuppression, CAR therapy of brain tumors, and dendritic cell therapy for brain tumors. Very few agents have been shown to be efficacious in the treatment of malignant gliomas. Recently, there have been a number of studies demonstrating the potential success of immunotherapy for brain tumors. Immunotherapeutics are becoming the most frequent drugs to be used in cancer therapy. These new breakthroughs, now approved by the FDA, are a part of multiple phase III international trials and ongoing research in malignant glioma, meaning that the information in this cutting-edge book will be of great importance to practitioners and researchers alike. Comprehensive overview, providing an update on immunology, translational immunotherapy, and clinical trials relating to malignant gliomas Edited by a prominent neurosurgeon with contributions by leading researchers in the field Ideal resource for researchers and practitioners interested in learning about mechanisms that use the immune system to treat brain tumors