Ltp
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Long Term Potentiation And Directed Forgetting
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Author : Diyani Anne De Silva
language : en
Publisher:
Release Date : 2014
Long Term Potentiation And Directed Forgetting written by Diyani Anne De Silva and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with Memory categories.
The current experiment aimed to investigate if visual Long Term Potentiation (LTP) is associated with the cognitive process of forgetting. In order to do this, a paradigm to induce LTP through visual tetanisation was interleaved with an item method directed forgetting paradigm. This allowed investigation of possible relationships between LTP and behavioral measures of memory, such as successful remembering, intentional forgetting, and normal forgetting. Relationships between LTP and other electrophysiological correlates of memory such as the Old/New effect were also examined. Results showed no correlation between LTP and forgetting. However, significant relationships were found between LTP and forget cued words that were remembered, and foil words reported as remembered. Significant relationships were also found between LTP and the amplitude of the P600 when participants successfully recognised remember cued words. Results also showed a directed forgetting effect. Therefore it can be seen that LTP correlated with behavioral as well as ERP correlates of memory, in terms of remembering. Results also implied that forgetting is not simply a passive process, but is an active and adaptive aspect of memory.
The Involvement Of The Nicotinic Acetylcholine System In Early Ltp Consolidation
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Author : Bryan Galvez
language : en
Publisher:
Release Date : 2015
The Involvement Of The Nicotinic Acetylcholine System In Early Ltp Consolidation written by Bryan Galvez and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with categories.
Long-term potentiation (LTP) shows memory-like consolidation and thus becomes increasingly stable over time. LTP quickly becomes resistant to disruption by non-LTD-inducing paradigms such as low frequency stimulation (LFS). However, it is known that nicotine application during LFS uniquely depotentiates consolidated LTP. Here, we investigated how nicotine allows LFS to disrupt stabilized LTP. We found that selective removal of hippocampal cholinergic inputs allowed for depotentiation of consolidated LTP in the absence of nicotine, implying that nicotine depotentiates consolidated LTP by preventing endogenous ACh signaling. Moreover, that [alpha] nicotinic acetylcholine receptor (nAChR) antagonists mimicked the effect of nicotine, indicating that nicotine's effect occurs through [alpha] nAChR desensitization. Furthermore, nicotine-induced depotentiation does not involve long-term depression mechanisms and requires the activation of GluN2A-containing NMDARs. We further examined whether nicotine-induced depotentiation involves the reversal of LTP mechanisms. Phosphorylation of Ser-831 on the GluA1 subunit of AMPARs increases single-channel conductance. LTP causes increased phosphorylation of Ser-831. This phosphorylation remained unchanged after nicotine-facilitated depotentiation. LTP involves the insertion of new AMPARs into the synapse; additionally, the internalization of AMPARs is associated with dephosphorylation of Ser-845 on GluA1 and caspase-3 activity. Nicotine-induced depotentiation occurred without dephosphorylation of the Ser-845 site and in the presence of a caspase-3 inhibitor. LTP is also accompanied by increased filamentous actin (F-actin) and spine enlargement. Nicotine-induced depotentiation was prevented by jasplakinolide, which stabilizes F-actin, suggesting that nicotine depotentiates consolidated LTP by destabilizing F-actin. Our results demonstrate a new role of nicotinic cholinergic system for protecting potentiated synapses from depotentiation via the interaction of [alpha] nAChR- and GluN2A-NMDAR-mediated signaling for modulating actin destabilization.
Cortical Plasticity
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Author : Sam Fazeli
language : en
Publisher: Garland Science
Release Date : 2020-08-18
Cortical Plasticity written by Sam Fazeli and has been published by Garland Science this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-18 with Science categories.
This book provides an insight into the rapidly growing field of cortical plasticity. It brings together diverse experimental approaches to the study of activity-dependent changes in neuronal connections, as exemplified by long-term potentiation (LTP) and long-term depression (LTD).
Neuronal Mechanisms Of Memory Formation
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Author : Christian Hölscher
language : en
Publisher: Cambridge University Press
Release Date : 2001
Neuronal Mechanisms Of Memory Formation written by Christian Hölscher and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Medical categories.
Long-term potentiation (LTP) is by far the most dominant model for neuronal changes that might encode memory. LTP is an elegant concept that meets many criteria set up by theoreticians long before the model's discovery, and it also fits anatomical data of learning-dependent synapse changes. Since the discovery of LTP, the question has remained about how closely LTP produced in vitro by artificial stimulation of neurons actually models putative learning-induced synaptic changes. A number of recent investigations have tried to correlate synaptic changes observed after learning with changes produced by artificial stimulation of neurons. These studies have failed to find a correlation between the two forms of synaptic plasticity. In this book, an international group of neurobiologists and psychologists discuss their latest ideas and data. The results of experiments using electrophysiological techniques in vitro are discussed and compared with the results of in vivo experiments. Learning experiments are also discussed. Theoretical models such as the Hebb theory of synaptic changes during learning are compared to different models that do not predict upregulation of synaptic transmission. A wide approach is taken, and research and models in different brain areas such as the neocortex and the basal brain are discussed.
Long Term Potentiation
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Author : Tim V. P. Bliss
language : en
Publisher:
Release Date : 2004
Long Term Potentiation written by Tim V. P. Bliss and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Medical categories.
In the thirty years since its discovery by Terje Lomo and Tim Bliss, Long Term Potentiation (LTP) has become one of the most extensively studied topics in contemporary neuroscience. In LTP the strength of synapses between neurons is potentiated following brief but intense activation. LTP is thought to play a central role in learning and memory, though the exact nature of its role is less clear. In spite of years of research, there are many questions about LTP regarding its functional relevance that remain unanswered - for example, is it a model of memory formation, or is the actual neural mechanism used by the brain to store information?This volume presents a state of the art account of LTP. It begins with lively accounts, by the scientists most closely involved, of the discovery of LTP and of the experiments that established its basic properties and induction mechanisms. Later contributions contain reviews and new research that cover the range of molecular, cellular, physiological and behavioural approaches to the study of LTP. Provocative, accessible, and authoritative, this book makes it clear why LTP continues in equal measure to puzzle and beguile neuroscientists today.Advance praise for Long Term Potentiation: 'This book provides a definitive overview of the development of ideas about synaptic plasticity and about the wide range of current research in this fascinating field.' Colin Blakemore, University of OxfordReadership: Neuroscientists from postgraduate level upwards
Ltp Publications
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Author :
language : en
Publisher:
Release Date : 1975
Ltp Publications written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1975 with Library administration categories.
Signaling Cascades Underlying Two Different Forms Of Ltp In Hippocampus
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Author :
language : en
Publisher:
Release Date : 1999
Signaling Cascades Underlying Two Different Forms Of Ltp In Hippocampus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with categories.
Removal And Reinstatement Of A Memory With Ltd And Ltp
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Author : Rocky Garrett Fox
language : en
Publisher:
Release Date : 2014
Removal And Reinstatement Of A Memory With Ltd And Ltp written by Rocky Garrett Fox and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with categories.
It has been long believed that long-term potentiation (LTP) and long-term depression (LTD) are the primary mechanisms for encoding memory. However, causal evidence of this has thus far been elusive. Here we demonstrate a causal relationship between these mechanisms of plasticity and associative fear memory in rats. Using optogenetic targeting of auditory inputs to the lateral amygdala, an associative memory can be formed through light stimulation paired with foot-shock. Following this conditioning, fear memory can be activated through light stimulation as demonstrated by freezing and avoidance of a strongly rewarding task. LTD induction through low frequency stimulus leads to removal of this memory, demonstrated by continued reward task activity during light stimulation. Subsequent LTP induction through high frequency stimulation leads to restoration of the memory, as shown by restored freezing and award task avoidance during light stimulation. Using this simple series of experiments we have demonstrated the removal and reinstatement of a memory using LTD and LTP, thus demonstrating a causal relationship between these synaptic processes and memory.
Concise Learning And Memory
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Author :
language : en
Publisher: Academic Press
Release Date : 2010-05-25
Concise Learning And Memory written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-05-25 with Psychology categories.
The study of learning and memory is a central topic in neuroscience and psychology. Many of the basic research findings are directly applicable in the treatment of diseases and aging phenomena, and have found their way into educational theory and praxis. Concise Learning and Memory represents the best 30 chapters from Learning and Memory: A comprehensive reference (Academic Press March 2008), the most comprehensive source of information about learning and memory ever assembled, selected by one of the most respective scientists in the field, John H. Byrne. This concise version provides a truly authoritative collection of overview articles representing fundamental reviews of our knowledge of this central cognitive function of animal brains. It will be an affordable and accessible reference for scientists and students in all areas of neuroscience and psychology. There is no other single-volume reference with such authority and comprehensive coverage and depth currently available. Represents an authoritative selection of the fundamental chapters from the most comprehensive source of information about learning and memory ever assembled, Learning and Memory - A comprehensive reference (Academic Press Mar 2008) Representing outstanding scholarship, each chapter is written by a leader in the field and an expert in the topic area All topics represent the most up to date research Full color throughout, heavily illustrated Priced to provide an affordable reference to individuals and workgroups
Does Ltp Have The Properties That Make It An Ideal Synaptic Mechanism For Memory Storage
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Author : Sharon Laing
language : en
Publisher:
Release Date : 1995
Does Ltp Have The Properties That Make It An Ideal Synaptic Mechanism For Memory Storage written by Sharon Laing and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with categories.