Meu Corpo Fant Stico
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Translational Medicine
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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26
Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.
Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.
Change Your Schedule Change Your Life
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Author : Dr. Suhas Kshirsagar
language : en
Publisher: HarperCollins
Release Date : 2018-01-30
Change Your Schedule Change Your Life written by Dr. Suhas Kshirsagar and has been published by HarperCollins this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-30 with Health & Fitness categories.
An eye-opening handbook from a leading Ayurvedic physician that blends cutting-edge science on "clock genes" with ancient eastern wisdom to help us understand how to harness the power of chronobiology to effortlessly lose weight, sleep better, exercise stronger, reduce stress, and boost our wellbeing. "It’s not you, it’s your schedule." Does it sound like magic? It’s not. We’ve all heard of circadian rhythms—those biological processes that give us jet lag and make us night owls or early birds. But few of us know just how profoundly these diurnal patterns affect our overall health. Bad habits like skipping meals, squeezing in workouts when it’s convenient, working late into the night to maximize productivity and then trying to "catch up" on sleep during the weekend disrupt our natural cycles. A growing body of research on chronobiology reveals just how sensitive the human body is to these rhythms all the way down to the genetic level. Our "clock genes" control more than we realize, and small changes can make the difference between battling our bodies, and effortlessly managing weight, sleep, stress, inflammation, and more. Marrying ancient Ayurvedic wisdom with the latest scientific research, Dr. Suhas Kshirsagar’s holistic step-by-step 30-day plan gives you the tools—and the schedule—you need to transform your life. With diagnostic quizzes to determine your specific mind-body type, you will learn to adapt you schedule for effortless wellness for life.
Conversations With Friends
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Author : Sally Rooney
language : en
Publisher: Faber & Faber
Release Date : 2017-05-25
Conversations With Friends written by Sally Rooney and has been published by Faber & Faber this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-25 with Fiction categories.
** Pre-order Sally Rooney's new novel Intermezzo now ** 'A nuanced, page-turning portrait.' Zadie Smith 'Brilliant.' Marian Keyes 'A sharp, darkly funny comment on modern relationships.' Sunday Telegraph The critically-acclaimed debut novel from the globally bestselling author of Normal People and Beautiful World, Where Are You. Frances is twenty-one years old, cool-headed and observant. At night she performs spoken word with her best friend Bobbi, who used to be her girlfriend. When they are befriended by Melissa, a well-known journalist who is married to Nick, an actor, they enter a world of beautiful houses, raucous dinner parties and holidays in Provence, beginning a complex ménage-à-quatre. But when Frances and Nick get unexpectedly closer, Frances is forced to honestly confront her own vulnerabilities for the first time.
The Danish Girl
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Author : David Ebershoff
language : en
Publisher: Hachette UK
Release Date : 2015-05-28
The Danish Girl written by David Ebershoff and has been published by Hachette UK this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-05-28 with Fiction categories.
Now a major motion picture starring Eddie Redmayne and Oscar-winning Alicia Vikander 'An enthralling read' THE TIMES 'Heartbreaking and unforgettable, it is a complete triumph' BOSTON GLOBE 'Beautifully written. It is absolutely engrossing' SUNDAY EXPRESS Loosely inspired by a true story, this tender portrait of marriage asks: What do you do when the person you love has to change? It starts with a question, a simple favour asked by a wife of her husband while both are painting in their studio, setting off a transformation neither can anticipate. Uniting fact and fiction into an original romantic vision, The Danish Girl eloquently portrays the unique intimacy that defines every marriage and the remarkable story of Lili Elbe, a pioneer in transgender history, and the woman torn between loyalty to her marriage and her own ambitions and desires. The Danish Girl is an evocative and deeply moving novel about one of the most passionate and unusual love stories of the 20th century.
The Chase Of The Golden Meteor
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Author : Jules Verne
language : en
Publisher: U of Nebraska Press
Release Date : 1998
The Chase Of The Golden Meteor written by Jules Verne and has been published by U of Nebraska Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Fiction categories.
The announcement that a solid gold asteroid has fallen to earth creates a worldwide sensation. The discovery of this falling golden meteor and the race to find it form the core of this exciting tale from the grandfather of science fiction, Jules Verne. 23 illustrations.
The Chandler Legacies
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Author : Abdi Nazemian
language : en
Publisher: HarperCollins
Release Date : 2022-02-15
The Chandler Legacies written by Abdi Nazemian and has been published by HarperCollins this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-15 with Young Adult Fiction categories.
From the Stonewall Honor–winning author of Like a Love Story comes a revelatory novel about the enclosed world of privilege and silence at an elite boarding school and the unlikely group of friends who dare to challenge the status quo through their writing. Perfect for fans of E. Lockhart, Kathleen Glasgow, and Jandy Nelson, with crossover appeal for readers of Donna Tartt’s The Secret History and Curtis Sittenfeld’s Prep. Beth Kramer is a “townie” who returns to her sophomore year after having endured a year of tension with her roommate, Sarah. But Sarah Brunson knows there’s more to that story. Amanda Priya “Spence” Spencer is the privileged daughter of NYC elites, who is reeling from the realization that her family name shielded her from the same fate as Sarah. Ramin Golafshar arrives at Chandler as a transfer student to escape the dangers of being gay in Iran, only to suffer brutal hazing under the guise of tradition in the boys’ dorms. And Freddy Bello is the senior who’s no longer sure of his future but knows he has to stand up to his friends after what happened to Ramin. At Chandler, the elite boarding school, these five teens are brought together in the Circle, a coveted writing group where life-changing friendships are born—and secrets are revealed. Their professor tells them to write their truths. But is the truth enough to change the long-standing culture of abuse at Chandler? And can their friendship survive the fallout?
The Earth My Butt And Other Big Round Things
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Author : Carolyn Mackler
language : en
Publisher: Bloomsbury Publishing
Release Date : 2018-04-05
The Earth My Butt And Other Big Round Things written by Carolyn Mackler and has been published by Bloomsbury Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-04-05 with Young Adult Fiction categories.
Fifteen-year-old Virginia feels like a fat, awkward outsider in her perfect family, especially next to her golden-boy big brother Byron. She's got a lot to deal with – her weight, her best friend moving away, the mean girls at school – not to mention a boy who seems to like her! To survive, she decides to follow the 'Fat Girl Code of Conduct' to make herself acceptable, unnoticed ... invisible. It seems to be working until something unthinkable happens and, before her eyes, Virginia's flawless family begins to fall apart. As her world spins out of orbit, Virginia realises that breaking the Fat Girl Code might be the only way to create a life that belongs to her. Carolyn Mackler's acclaimed book has been updated for a new audience and is as relevant, funny and full of heart as it was when it was first published fifteen years ago.
Counting Heads
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Author : David Marusek
language : en
Publisher: Macmillan
Release Date : 2007-10-16
Counting Heads written by David Marusek and has been published by Macmillan this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-10-16 with Fiction categories.
Counting Heads is David Marusek's extraordinary launch as an SF novelist: The year is 2134, and the Information Age has given rise to the Boutique Economy in which mass production and mass consumption are rendered obsolete. Life extension therapies have increased the human lifespan by centuries. Loyal mentars (artificial intelligences) and robots do most of society's work. The Boutique Economy has made redundant ninety-nine percent of the world's fifteen billion human inhabitants. The world would be a much better place if they all simply went away. Eleanor K. Starke, one of the world's leading citizens is assassinated, and her daughter, Ellen, is mortally wounded. Only Ellen, the heir to her mother's financial empire, is capable of saving Earth from complete domination plotted by the cynical, selfish, immortal rich, that is if she survives. Her cryonically frozen head is in the hands of her family's enemies. A ragtag ensemble of unlikely heroes join forces to rescue Ellen's head, all for their own purposes. Counting Heads arrives as a science fiction novel like a bolt of electricity, galvanizing readers with an entirely new vision of the future. At the Publisher's request, this title is being sold without Digital Rights Management Software (DRM) applied.
My Year Of Rest And Relaxation
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Author : Ottessa Moshfegh
language : en
Publisher: Penguin
Release Date : 2018-07-10
My Year Of Rest And Relaxation written by Ottessa Moshfegh and has been published by Penguin this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-10 with Fiction categories.
From one of our boldest, most celebrated new literary voices, a novel about a young woman's efforts to duck the ills of the world by embarking on an extended hibernation with the help of one of the worst psychiatrists in the annals of literature and the battery of medicines she prescribes Our narrator should be happy, shouldn't she? She's young, thin, pretty, a recent Columbia graduate, works an easy job at a hip art gallery, lives in an apartment on the Upper East Side of Manhattan paid for, like the rest of her needs, by her inheritance. But there is a dark and vacuous hole in her heart, and it isn't just the loss of her parents, or the way her Wall Street boyfriend treats her, or her sadomasochistic relationship with her best friend, Reva. It's the year 2000 in a city aglitter with wealth and possibility; what could be so terribly wrong? My Year of Rest and Relaxation is a powerful answer to that question. Through the story of a year spent under the influence of a truly mad combination of drugs designed to heal our heroine from her alienation from this world, Moshfegh shows us how reasonable, even necessary, alienation can be. Both tender and blackly funny, merciless and compassionate, it is a showcase for the gifts of one of our major writers working at the height of her powers.
Winning The Story Wars
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Author : Jonah Sachs
language : en
Publisher: Harvard Business Press
Release Date : 2012-06-19
Winning The Story Wars written by Jonah Sachs and has been published by Harvard Business Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-06-19 with Business & Economics categories.
Trying to get your message heard? Build an iconic brand? Welcome to the battlefield. The story wars are all around us. They are the struggle to be heard in a world of media noise and clamor. Today, most brand messages and mass appeals for causes are drowned out before they even reach us. But a few consistently break through the din, using the only tool that has ever moved minds and changed behavior—great stories. With insights from mythology, advertising history, evolutionary biology, and psychology, viral storyteller and advertising expert Jonah Sachs takes readers into a fascinating world of seemingly insurmountable challenges and enormous opportunity. You’ll discover how: • Social media tools are driving a return to the oral tradition, in which stories that matter rise above the fray • Marketers have become today’s mythmakers, providing society with explanation, meaning, and ritual • Memorable stories based on timeless themes build legions of eager evangelists • Marketers and audiences can work together to create deeper meaning and stronger partnerships in building a better world • Brands like Old Spice, The Story of Stuff, Nike, the Tea Party, and Occupy Wall Street created and sustained massive viral buzz Winning the Story Wars is a call to arms for business communicators to cast aside broken traditions and join a revolution to build the iconic brands of the future. It puts marketers in the role of heroes with a chance to transform not just their craft but the enterprises they represent. After all, success in the story wars doesn’t come just from telling great stories, but from learning to live them.