Mulheres Escritoras S V Speras Da Morte
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Translational Medicine
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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26
Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.
Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.
Pixologic Zbrush 4r7
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Author : Prof Sham Tickoo Purdue Univ
language : en
Publisher:
Release Date : 2016-01-04
Pixologic Zbrush 4r7 written by Prof Sham Tickoo Purdue Univ and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-04 with categories.
Pixologic ZBrush 4R7: A Comprehensive Guide textbook covers all features of ZBrush 4R7 in a simple, lucid, and comprehensive manner. The ZBrush 4R7 book gives in-depth details of the concepts and explains the usage and functions of the most commonly used tools of ZBrush. In this edition, new feature such as, ZModeler, NanoMesh, and KeyShot renderer have been added. This tool is used to re-create a new polygonal mesh with a controlled flow of polygonal structure for a model. The ZBrush 4R7 book will unleash your creativity and imagination by helping you create realistic 3D models. ZBrush 4R7 book caters to the needs of both the novice and advanced users of ZBrush 4R7 and is ideally suited for learning at your convenience and at your pace.
Preventing Reading Difficulties In Young Children
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 1998-07-22
Preventing Reading Difficulties In Young Children written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-07-22 with Education categories.
While most children learn to read fairly well, there remain many young Americans whose futures are imperiled because they do not read well enough to meet the demands of our competitive, technology-driven society. This book explores the problem within the context of social, historical, cultural, and biological factors. Recommendations address the identification of groups of children at risk, effective instruction for the preschool and early grades, effective approaches to dialects and bilingualism, the importance of these findings for the professional development of teachers, and gaps that remain in our understanding of how children learn to read. Implications for parents, teachers, schools, communities, the media, and government at all levels are discussed. The book examines the epidemiology of reading problems and introduces the concepts used by experts in the field. In a clear and readable narrative, word identification, comprehension, and other processes in normal reading development are discussed. Against the background of normal progress, Preventing Reading Difficulties in Young Children examines factors that put children at risk of poor reading. It explores in detail how literacy can be fostered from birth through kindergarten and the primary grades, including evaluation of philosophies, systems, and materials commonly used to teach reading.
Women Family And Ritual In Renaissance Italy
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Author : Christiane Klapisch-Zuber
language : en
Publisher: University of Chicago Press
Release Date : 1987-06-15
Women Family And Ritual In Renaissance Italy written by Christiane Klapisch-Zuber and has been published by University of Chicago Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987-06-15 with History categories.
English translations of the author's most important articles.
Nutrient Requirements Of Dogs And Cats
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 2006-07-01
Nutrient Requirements Of Dogs And Cats written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-07-01 with Technology & Engineering categories.
Updating recommendations last made by the National Research Council in the mid-1980s, this report provides nutrient recommendations based on physical activity and stage in life, major factors that influence nutrient needs. It looks at how nutrients are metabolized in the bodies of dogs and cats, indications of nutrient deficiency, and diseases related to poor nutrition. The report provides a valuable resource for industry professionals formulating diets, scientists setting research agendas, government officials developing regulations for pet food labeling, and as a university textbook for dog and cat nutrition. It can also guide pet owners feeding decisions for their pets with information on specific nutrient needs, characteristics of different types of pet foods, and factors to consider when feeding cats and dogs.
Critical Limb Ischemia
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Author : Robert S. Dieter
language : en
Publisher: Springer
Release Date : 2016-10-26
Critical Limb Ischemia written by Robert S. Dieter and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-26 with Medical categories.
This book provides a comprehensive overview of acute and chronic critical limb ischemia (CLI). Loss of an extremity, or a portion thereof, is not necessarily a life-ending process, but it is a debilitating experience whether involvement is of the upper or lower extremity. It reviews the epidemiology, pathophysiology, etiology, physical examination, imaging modalities, diagnosis, and treatment of limb ischemia. It investigates the most frequent as well as the more unusual etiological processes that may lead to the most dreaded concern of patients and families: amputation. The therapeutics of CLI has been significantly advanced through the multidisciplinary approach to the patient and disease, a focus that is explored in detail throughout the book. Surgical and endovascular treatment guidelines as well as medical therapy, wound healing, and long-term care are discussed. Featuring an extensive illustration program, Critical Limb Ischemia: Acute and Chronic, is a valuable resource for vascular and endovascular surgeons, vascular medicine specialists, interventional radiologists, and cardiologists.
Nightmare Japan
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Author : Jay McRoy
language : en
Publisher: BRILL
Release Date : 2008-01-01
Nightmare Japan written by Jay McRoy and has been published by BRILL this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-01-01 with Social Science categories.
Over the last two decades, Japanese filmmakers have produced some of the most important and innovative works of cinematic horror. At once visually arresting, philosophically complex, and politically charged, films by directors like Tsukamoto Shinya (Tetsuo: The Iron Man [1988] and Tetsuo II: Body Hammer [1992]), Sato Hisayasu (Muscle [1988] and Naked Blood [1995]) Kurosawa Kiyoshi (Cure [1997], Séance [2000], and Kaïro [2001]), Nakata Hideo (Ringu [1998], Ringu II [1999], and Dark Water [2002]), and Miike Takashi (Audition [1999] and Ichi the Killer [2001]) continually revisit and redefine the horror genre in both its Japanese and global contexts. In the process, these and other directors of contemporary Japanese horror film consistently contribute exciting and important new visions, from postmodern reworkings of traditional avenging spirit narratives to groundbreaking works of cinematic terror that position depictions of radical or ‘monstrous’ alterity/hybridity as metaphors for larger socio-political concerns, including shifting gender roles, reconsiderations of the importance of the extended family as a social institution, and reconceptualisations of the very notion of cultural and national boundaries.
Aesopic Conversations
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Author : Leslie Kurke
language : en
Publisher: Princeton University Press
Release Date : 2010-10-25
Aesopic Conversations written by Leslie Kurke and has been published by Princeton University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-10-25 with Literary Criticism categories.
Examining the figure of Aesop and the traditions surrounding him, Aesopic Conversations offers a portrait of what Greek popular culture might have looked like in the ancient world. What has survived from the literary record of antiquity is almost entirely the product of an elite of birth, wealth, and education, limiting our access to a fuller range of voices from the ancient past. This book, however, explores the anonymous Life of Aesop and offers a different set of perspectives. Leslie Kurke argues that the traditions surrounding this strange text, when read with and against the works of Greek high culture, allow us to reconstruct an ongoing conversation of "great" and "little" traditions spanning centuries. Evidence going back to the fifth century BCE suggests that Aesop participated in the practices of nonphilosophical wisdom (sophia) while challenging it from below, and Kurke traces Aesop's double relation to this wisdom tradition. She also looks at the hidden influence of Aesop in early Greek mimetic or narrative prose writings, focusing particularly on the Socratic dialogues of Plato and the Histories of Herodotus. Challenging conventional accounts of the invention of Greek prose and recognizing the problematic sociopolitics of humble prose fable, Kurke provides a new approach to the beginnings of prose narrative and what would ultimately become the novel. Delving into Aesop, his adventures, and his crafting of fables, Aesopic Conversations shows how this low, noncanonical figure was--unexpectedly--central to the construction of ancient Greek literature. Some images inside the book are unavailable due to digital copyright restrictions.
Mind S World
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Author : Alexander M. Schlutz
language : en
Publisher: University of Washington Press
Release Date : 2010-05-01
Mind S World written by Alexander M. Schlutz and has been published by University of Washington Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-05-01 with Literary Criticism categories.
Winner of the 2009 International Conference on Romanticism's Jean-Pierre Barricelli Award for the best book in Romanticism studies As the mental faculty that mediates between self and world, mind and body, the senses and the intellect, imagination is indispensable for modern models of subjectivity. From René Descartes's Meditations to the aesthetic and philosophical systems of the Romantic period, to think about the subject necessarily means to address the problem of imagination. In close readings of Descartes, Kant, Fichte, Hardenberg (Novalis) and Coleridge, and with a sustained return to the origins of the discourse about imagination in Greek antiquity, Alexander Schlutz demonstrates that neither the unity of the subject itself, nor the unity of the philosophical systems that are based on it, can be conceptualized without recourse to imagination. Yet, philosophers like Descartes and Kant must deny imagination any such foundational role because of its dangerous connection to the body, the senses and the unruly passions, which threatens the desired autonomy of the rational subject. The modern subject is simultaneously dependent upon and constructed in opposition to imagination, and the resulting ambivalence about the faculty is one of the fundamental conditions of modern models of subjectivity. Schlutz's readings of the Romantic poet-philosophers Coleridge and Hardenberg highlight that also their texts are not free of fears about the faculty's disruptive potential and its connection to the body. While imagination is now openly enlisted to produce the aesthetic unity of subjectivity, it still threatens to unravel and destroy a subject that needs to keep the body and its desires at bay in order to secure its rational and moral autonomy. The dark abyss of a self not in control of its thoughts, feelings, and desires is not overcome by the philosophical glorification of the subject's powers of imagination.
Women Poets In Ancient Greece And Rome
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Author : Ellen Greene
language : en
Publisher: University of Oklahoma Press
Release Date : 2005
Women Poets In Ancient Greece And Rome written by Ellen Greene and has been published by University of Oklahoma Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Literary Collections categories.
Although Greek society was largely male-dominated, it gave rise to a strong tradition of female authorship. Women poets of ancient Greece and Rome have long fascinated readers, even though much of their poetry survives only in fragmentary form. This pathbreaking volume is the first collection of essays to examine virtually all surviving poetry by Greek and Roman women. It elevates the status of the poems by demonstrating their depth and artistry. Edited and with an introduction by Ellen Greene, the volume covers a broad time span, beginning with Sappho (ca. 630 b.c.e.) in archaic Greece and extending to Sulpicia (first century B.C.E.) in Augustan Rome. In their analyses, the contributors situate the female poets in an established male tradition, but they also reveal their distinctly “feminine” perspectives. Despite relying on literary convention, the female poets often defy cultural norms, speaking in their own voices and transcending their positions as objects of derision in male-authored texts. In their innovative reworkings of established forms, women poets of ancient Greece and Rome are not mere imitators but creators of a distinct and original body of work.