O Regresso Da Hip Tese De Deus
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Translational Medicine
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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26
Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.
Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.
The Oracle Of Night
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Author : Sidarta Ribeiro
language : en
Publisher: Pantheon
Release Date : 2021-08-17
The Oracle Of Night written by Sidarta Ribeiro and has been published by Pantheon this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-17 with Science categories.
A groundbreaking history of the human mind told through our experience of dreams—from the earliest accounts to current scientific findings—and their essential role in the formation of who we are and the world we have made. "A resounding case for the mystery, beauty and cognitive importance of dreams." —The New York Times What is a dream? Why do we dream? How do our bodies and minds use them? These questions are the starting point for this unprecedented study of the role and significance of this phenomenon. An investigation on a grand scale, it encompasses literature, anthropology, religion, and science, articulating the essential place dreams occupy in human culture and how they functioned as the catalyst that compelled us to transform our earthly habitat into a human world. From the earliest cave paintings—where Sidarta Ribeiro locates a key to humankind’s first dreams and how they contributed to our capacity to perceive past and future and our ability to conceive of the existence of souls and spirits—to today’s cutting-edge scientific research, Ribeiro arrives at revolutionary conclusions about the role of dreams in human existence and evolution. He explores the advances that contemporary neuroscience, biochemistry, and psychology have made into the connections between sleep, dreams, and learning. He explains what dreams have taught us about the neural basis of memory and the transformation of memory in recall. And he makes clear that the earliest insight into dreams as oracular has been elucidated by contemporary research. Accessible, authoritative, and fascinating, The Oracle of Night gives us a wholly new way to understand this most basic of human experiences.
The Tyranny Of Science
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Author : Paul K. Feyerabend
language : en
Publisher: Polity
Release Date : 2011-05-06
The Tyranny Of Science written by Paul K. Feyerabend and has been published by Polity this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-05-06 with Social Science categories.
Paul Feyerabend is one of the greatest philosophers of science of the 20th century and his book Against Method is an international bestseller. In this new book he masterfully weaves together the main elements of his mature philosophy into a gripping tale: the story of the rise of rationalism in Ancient Greece that eventually led to the entrenchment of a mythical ‘scientific worldview’. In this wide-ranging and accessible book Feyerabend challenges some modern myths about science, including the myth that ‘science is successful’. He argues that some very basic assumptions about science are simply false and that substantial parts of scientific ideology were created on the basis of superficial generalizations that led to absurd misconceptions about the nature of human life. Far from solving the pressing problems of our age, such as war and poverty, scientific theorizing glorifies ephemeral generalities, at the cost of confronting the real particulars that make life meaningful. Objectivity and generality are based on abstraction, and as such, they come at a high price. For abstraction drives a wedge between our thoughts and our experience, resulting in the degeneration of both. Theoreticians, as opposed to practitioners, tend to impose a tyranny on the concepts they use, abstracting away from the subjective experience that makes life meaningful. Feyerabend concludes by arguing that practical experience is a better guide to reality than any theory, by itself, ever could be, and he stresses that there is no tyranny that cannot be resisted, even if it is exerted with the best possible intentions. Provocative and iconoclastic, The Tyranny of Science is one of Feyerabend’s last books and one of his best. It will be widely read by everyone interested in the role that science has played, and continues to play, in the shaping of the modern world.
Computer Supported Qualitative Research
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Author : António Pedro Costa
language : en
Publisher: Springer
Release Date : 2017-06-19
Computer Supported Qualitative Research written by António Pedro Costa and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-19 with Technology & Engineering categories.
This book includes a selection of the articles accepted for presentation and discussion at the second International Symposium on Qualitative Research (ISQR2017), held in Salamanca, Spain, July 12-14, 2017. ISQR2017 is part of the Iberian-American Congress on Qualitative Research (CIAIQ), and featured four main application fields (Education, Health, Social Sciences, and Engineering and Technology) and seven main subjects: Rationale and Paradigms of Qualitative Research; Systematization of approaches with Qualitative Studies; Qualitative and Mixed Methods Research; Data Analysis Types; Innovative Processes of Qualitative Data Analysis; Qualitative Research in Web Contexts; Qualitative Analysis with the Support of Specific Software. This book is a valuable resource for academics, researchers, teachers and students who need information on the above topics, as well as on the use of Computer Assisted Qualitative Data AnalysiS (CAQDAS).
The New Islamic Presence In Western Europe
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Author : Tomas Gerholm
language : en
Publisher: Burns & Oates
Release Date : 1988
The New Islamic Presence In Western Europe written by Tomas Gerholm and has been published by Burns & Oates this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988 with Civilization, Occidental categories.
Stems from a conference that took place in June 1986 and organized by the Centre for Research in International Migration and Ethnicity (CEIFO) at the University of Stockholm and the Royal Swedish Academy of Letters, History and Antiquities.
Post Colonial Drama
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Author : Helen Gilbert
language : en
Publisher: Routledge
Release Date : 2002-09-11
Post Colonial Drama written by Helen Gilbert and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-09-11 with Performing Arts categories.
Post-Colonial Drama is the first full-length study to address the ways in which performance has been instrumental in resisting the continuing effects of imperialism. It brings to bear the latest theoretical approaches from post-colonial and performance studies to a range of plays from Australia, Africa, Canada, New Zealand, the Caribbean and other former colonial regions. Some of the major topics discussed in Post-Colonial Drama include: * the interactions of post-colonial and performance theories * the post-colonial re-stagings of language and history * the specific enactments of ritual and carnival * the theatrical citations of the post-colonial body Post-Colonial Drama combines a rich intersection of theoretical approaches with close attention to a wide range of performance texts.
Age And Anthropological Theory
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Author : David I. Kertzer
language : en
Publisher: Ithaca, N.Y. : Cornell University Press
Release Date : 1984
Age And Anthropological Theory written by David I. Kertzer and has been published by Ithaca, N.Y. : Cornell University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1984 with Health & Fitness categories.
I Ve Always Kept A Unicorn
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Author : Mick Houghton
language : en
Publisher: Faber & Faber
Release Date : 2015-03-03
I Ve Always Kept A Unicorn written by Mick Houghton and has been published by Faber & Faber this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-03 with Biography & Autobiography categories.
I've Always Kept a Unicorn tells the story of Sandy Denny, one of the greatest British singers of her time and the first female singer-songwriter to produce a substantial and enduring body of original songs. Sandy Denny laid down the marker for folk-rock when she joined Fairport Convention in 1968, but her music went far beyond this during the seventies. After leaving Fairport she formed Fotheringay, whose influential eponymous album was released in 1970, before collaborating on a historic one-off recording with Led Zeppelin - the only other vocalist to record with Zeppelin in their entire career - and releasing four solo albums across the course of the decade. Her tragic and untimely death came in 1978. Sandy emerged from the folk scene of the sixties - a world of larger-than-life characters such as Alex Campbell, Jackson C. Frank, Anne Briggs and Australian singer Trevor Lucas, whom she married in 1973. Their story is at the core of Sandy's later life and work, and is told with the assistance of more than sixty of her friends, fellow musicians and contemporaries, one of whom, to paraphrase McCartney on Lennon, observed that she sang like an angel but was no angel.
Preclinical Safety Evaluation Of Biopharmaceuticals
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Author : Joy A. Cavagnaro
language : en
Publisher: John Wiley & Sons
Release Date : 2013-03-07
Preclinical Safety Evaluation Of Biopharmaceuticals written by Joy A. Cavagnaro and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-07 with Medical categories.
"The goal is to provide a comprehensive reference book for the preclinicaldiscovery and development scientist whose responsibilities span target identification, lead candidate selection, pharmacokinetics, pharmacology, and toxicology, and for regulatory scientists whose responsibilities include the evaluation of novel therapies." —From the Afterword by Anthony D. Dayan Proper preclinical safety evaluation can improve the predictive value, lessen the time and cost of launching new biopharmaceuticals, and speed potentially lifesaving drugs to market. This guide covers topics ranging from lead candidate selection to establishing proof of concept and toxicity testing to the selection of the first human doses. With chapters contributed by experts in their specific areas, Preclinical Safety Evaluation of Biopharmaceuticals: A Science-Based Approach to Facilitating Clinical Trials: Includes an overview of biopharmaceuticals with information on regulation and methods of production Discusses the principles of ICH S6 and their implementation in the U.S., Europe, and Japan Covers current practices in preclinical development and includes a comparison of safety assessments for small molecules with those for biopharmaceuticals Addresses all aspects of the preclinical evaluation process, including: the selection of relevant species; safety/toxicity endpoints; specific considerations based upon class; and practical considerations in the design, implementation, and analysis of biopharmaceuticals Covers transitioning from preclinical development to clinical trials This is a hands-on, straightforward reference for professionals involved in preclinical drug development, including scientists, toxicologists, project managers, consultants, and regulatory personnel.
Bernardi Siegfried Albini Tabulae Sceleti Et Musculorum Corporis Humani
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Author : BERNHARD SIEGFRIED. ALBINUS
language : en
Publisher: Gale Ecco, Print Editions
Release Date : 2018-04-23
Bernardi Siegfried Albini Tabulae Sceleti Et Musculorum Corporis Humani written by BERNHARD SIEGFRIED. ALBINUS and has been published by Gale Ecco, Print Editions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-04-23 with categories.
The 18th century was a wealth of knowledge, exploration and rapidly growing technology and expanding record-keeping made possible by advances in the printing press. In its determination to preserve the century of revolution, Gale initiated a revolution of its own: digitization of epic proportions to preserve these invaluable works in the largest archive of its kind. Now for the first time these high-quality digital copies of original 18th century manuscripts are available in print, making them highly accessible to libraries, undergraduate students, and independent scholars. Medical theory and practice of the 1700s developed rapidly, as is evidenced by the extensive collection, which includes descriptions of diseases, their conditions, and treatments. Books on science and technology, agriculture, military technology, natural philosophy, even cookbooks, are all contained here. ++++ The below data was compiled from various identification fields in the bibliographic record of this title. This data is provided as an additional tool in helping to insure edition identification: ++++ Cambridge University Library N049651 Londini: typis H. Woodfall. Impensis Johannis et Pauli Knapton, 1749. [94]p., XXV [i.e. 40] plates; 1°