Patrim Nios Subterr Neos Em Bras Lia

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Translational Medicine

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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26

Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.

Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.

The Mediterranean In The Ancient World

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Author : Fernand Braudel
language : en
Publisher: Penguin UK
Release Date : 2002-04-25

The Mediterranean In The Ancient World written by Fernand Braudel and has been published by Penguin UK this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-04-25 with History categories.

This general reader's history of the ancient mediterranean combines a thorough grasp of the scholarship of the day with an great historian's gift for imaginative reconstruction and inspired analogy. Extensive notes allow the reader to appreciate thestate of scholarship at the time of writing, the scale and breadth of Braudel's learning and the points where orthodoxy has changed, sometimes vindicating Braudel, sometimes proving him wrong. Above all the book offers us the chance to situate Braudel's mediterranean, born of a lifetime's love and knowledge, more clearly in the climates of the sea's history.

Unesco General History Of Africa Vol I Abridged Edition

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Author : Jacqueline Ki-Zerbo
language : en
Publisher: Univ of California Press
Release Date : 1990

Unesco General History Of Africa Vol I Abridged Edition written by Jacqueline Ki-Zerbo and has been published by Univ of California Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with History categories.

"This volume covers the period from the end of the Neolithic era to the beginning of the seventh century of our era. This lengthy period includes the civilization of Ancient Egypt, the history of Nubia, Ethiopia, North Africa and the Sahara, as well as of the other regions of the continent and its islands."--Publisher's description

Reclaiming Heritage

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Author : Ferdinand de Jong
language : en
Publisher: Routledge
Release Date : 2016-06-03

Reclaiming Heritage written by Ferdinand de Jong and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-06-03 with Social Science categories.

Struggles over the meaning of the past are common in postcolonial states. State cultural heritage programs build monuments to reinforce in nation building efforts—often supported by international organizations and tourist dollars. These efforts often ignore the other, often more troubling memories preserved by local communities—markers of colonial oppression, cultural genocide, and ethnic identity. Yet, as the contributors to this volume note, questions of memory, heritage, identity and conservation are interwoven at the local, ethnic, national and global level and cannot be easily disentangled. In a fascinating series of cases from West Africa, anthropologists, archaeologists and art historians show how memory and heritage play out in a variety of postcolonial contexts. Settings range from televised ritual performances in Mali to monument conservation in Djenne and slavery memorials in Ghana.

Roots Of Brazil

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Author : Sérgio Buarque de Holanda
language : en
Publisher: University of Notre Dame Pess
Release Date : 2012-10-15

Roots Of Brazil written by Sérgio Buarque de Holanda and has been published by University of Notre Dame Pess this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-10-15 with History categories.

Sérgio Buarque de Holanda's Roots of Brazil is one of the iconic books on Brazilian history, society, and culture. Originally published in 1936, it appears here for the first time in an English language translation with a foreword, "Why Read Roots of Brazil Today?" by Pedro Meira Monteiro, one of the world's leading experts on Buarque de Holanda. Roots of Brazil focuses on the multiple cultural influences that forged twentieth-century Brazil, especially those of the Portuguese, the Spanish, other European colonists, Native Americans, and Africans. Buarque de Holanda argues that all of these originary influences were transformed into a unique Brazilian culture and society—a "transition zone." The book presents an understanding of why and how European culture flourished in a large, tropical environment that was totally foreign to its traditions, and the manner and consequences of this development. Buarque de Holanda uses Max Weber’s typological criteria to establish pairs of "ideal types" as a means of stressing particular characteristics of Brazilians, while also trying to understand and explain the local historical process. Along with other early twentieth-century works such as The Masters and the Slaves by Gilberto Freyre and The Colonial Background of Modern Brazil by Caio Prado Júnior, Roots of Brazil set the parameters of Brazilian historiography for a generation and continues to offer keys to understanding the complex history of Brazil. Roots of Brazil has been published in Italian, Spanish, Japanese, Chinese, German, and French. This long-awaited English translation will interest students and scholars of Portuguese, Brazilian, and Latin American history, culture, literature, and postcolonial studies.

The Fairy Faith In Celtic Countries

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Author : Walter Yeeling Evans-Wentz
language : en
Publisher: Createspace Independent Publishing Platform
Release Date : 1911

The Fairy Faith In Celtic Countries written by Walter Yeeling Evans-Wentz and has been published by Createspace Independent Publishing Platform this book supported file pdf, txt, epub, kindle and other format this book has been release on 1911 with Fiction categories.

In this study, which is first of all a folk-lore study, we pursue principally an anthropo-psychological method of interpreting the Celtic belief in fairies, though we do not hesitate now and then to call in the aid of philology; and we make good use of the evidence offered by mythologies, religions, metaphysics, and physical sciences.

Mammals Of South America Volume 2

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Author : James L. Patton
language : en
Publisher: University of Chicago Press
Release Date : 2015-03-09

Mammals Of South America Volume 2 written by James L. Patton and has been published by University of Chicago Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-09 with Science categories.

The second installment in a planned three-volume series, this book provides the first substantive review of South American rodents published in over fifty years. Increases in the reach of field research and the variety of field survey methods, the introduction of bioinformatics, and the explosion of molecular-based genetic methodologies have all contributed to the revision of many phylogenetic relationships and to a doubling of the recognized diversity of South American rodents. The largest and most diverse mammalian order on Earth—and an increasingly threatened one—Rodentia is also of great ecological importance, and Rodents is both a timely and exhaustive reference on these ubiquitous creatures. From spiny mice and guinea pigs to the oversized capybara, this book covers all native rodents of South America, the continental islands of Trinidad and Tobago, and the Caribbean Netherlands off the Venezuelan coast. It includes identification keys and descriptions of all genera and species; comments on distribution; maps of localities; discussions of subspecies; and summaries of natural, taxonomic, and nomenclatural history. Rodents also contains a detailed list of cited literature and a separate gazetteer based on confirmed identifications from museum vouchers and the published literature.

Unesco General History Of Africa Vol Iii Abridged Edition

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Author : Unesco. International Scientific Committee for the Drafting of a General History of Africa
language : en
Publisher: Univ of California Press
Release Date : 1992-11-03

Unesco General History Of Africa Vol Iii Abridged Edition written by Unesco. International Scientific Committee for the Drafting of a General History of Africa and has been published by Univ of California Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-11-03 with History categories.

"The book first places Africa in the context of world history at the opening of the seventh century, before examining the general impact of Islamic penetration, the continuing expansion of the Bantu-speaking peoples, and the growth of civilizations in the Sudanic zones of West Africa"--Back cover.

Casa Grande E Senzala

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Author : Gilberto Freyre
language : en
Publisher: Univ of California Press
Release Date : 1986

Casa Grande E Senzala written by Gilberto Freyre and has been published by Univ of California Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986 with History categories.

Age And Sex In The Social Structure Of The United States

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Author : Talcott Parsons
language : en
Publisher: Irvington Pub
Release Date : 1993-08-01

Age And Sex In The Social Structure Of The United States written by Talcott Parsons and has been published by Irvington Pub this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-08-01 with categories.