Peixe El Trico 02
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Translational Medicine
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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26
Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.
Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.
The Birds Of Angola
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Author : William Richard John Dean
language : en
Publisher:
Release Date : 2000
The Birds Of Angola written by William Richard John Dean and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Birds categories.
Asylums
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Author : Erving Goffman
language : en
Publisher: Routledge
Release Date : 2017-09-08
Asylums written by Erving Goffman and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-08 with Social Science categories.
A total institution is defined by Goffman as a place of residence and work where a large number of like-situated, individuals, cut off from the wider society for an appreciable period of time, together lead an enclosed, formally administered round of life. Prisons serve as a clear example, providing we appreciate that what is prison-like about prisons is found in institutions whose members have broken no laws. This volume deals with total institutions in general and, mental hospitals, in particular. The main focus is, on the world of the inmate, not the world of the staff. A chief concern is to develop a sociological version of the structure of the self. Each of the essays in this book were intended to focus on the same issue--the inmate's situation in an institutional context. Each chapter approaches the central issue from a different vantage point, each introduction drawing upon a different source in sociology and having little direct relation to the other chapters. This method of presenting material may be irksome, but it allows the reader to pursue the main theme of each paper analytically and comparatively past the point that would be allowable in chapters of an integrated book. If sociological concepts are to be treated with affection, each must be traced back to where it best applies, followed from there wherever it seems to lead, and pressed to disclose the rest of its family.
Age And Gender Considerations In Psychiatric Diagnosis
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Author : William E. Narrow
language : en
Publisher: American Psychiatric Pub
Release Date : 2008-05-20
Age And Gender Considerations In Psychiatric Diagnosis written by William E. Narrow and has been published by American Psychiatric Pub this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-05-20 with Medical categories.
Written to help identify major gaps in our knowledge of how gender and age affect psychiatric diagnoses and to stimulate much-needed research to fill these gaps, Age and Gender Considerations in Psychiatric Diagnosis serves as both a valuable short-term source for the DSM-V Task Force and its disorder-specific workgroups, and a long-term guide for future studies that will contribute to revised psychiatric classifications in these three areas. Here, 47 experts present findings in three areas of psychiatric research that historically have been neglected but rightfully have received increasing attention in recent years and thus are worthy of investigation into their clinical features, etiology, and course: 1. Significant gender differences in prevalence, symptom profiles, and risk factors for mental disorders, including neurodevelopmental, neurophysiological, and environmental factors for men and women that cut across diagnostic categories-for example, the critical importance of gender in how psychiatric illness develops and presents; DSM's approach to gender to date; and relevant research findings and gaps in the epidemiology, etiology, and pathophysiology of disorders and the gender-related expression of psychopathology, including the controversial and complex question of whether DSM should have different diagnostic criteria for men and women. 2. Mental disorders in infancy and early childhood, including diagnosis and measurement of psychopathology; PTSD and social and cognitive factors related to the experience of stress; reactive attachment disorder (unique in part because of its specificity to early childhood); mood and anxiety disorders and difficulties in diagnosis; sleep disorders, including two new disorders, Night-Waking Dysomnia and Sleep-Onset Dysomnia; feeding disorders, including the need to address overeating and overfeeding (especially given the alleged U.S. epidemic of obesity); early childhood manifestations of behavior disorders; and early symptoms and diagnosis of autism. 3. Mental disorders in the elderly, such as dementia and depression, once considered normal consequences of aging but now understood to represent mental disorders, including the need to identify specific brain structure abnormalities, biomarkers, and the many contributing biological, psychosocial, and environmental factors of mental illness in late life and to understand their roles in the elderly to better diagnose and monitor disease progression. Written for clinicians and researchers alike, this thought-provoking compendium contributes critical information that helps enhance our understanding of the causes of mental disorders, develop effective preventive and treatment interventions, and inform future editions of DSM and ICD.
Biology Of Semiarid Tropical Fish
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Author : José Rosa Gomes
language : en
Publisher: Nova Science Publishers
Release Date : 2014
Biology Of Semiarid Tropical Fish written by José Rosa Gomes and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with Arid regions categories.
Brazil is home to equatorial, tropical, semi-arid, highland tropical, and subtropical climatic regions. The semiarid region of Northeastern Brazil, considered an area of drought polygon, has distinctive scrub vegetation referred to as Caatinga that covers over 10% of the Brazilian territory with approximately twenty million inhabitants. The Caatinga is considered one of the 37 Wilderness Areas of the World, and it plays an important role in the maintenance of regional macro-ecological processes, as well as indirectly supporting regions with biodiversity and endemism. The Brazilian semiarid region is also home to Neotropical fish species that occur in diversified aquatic ecosystems, exhibiting different strategies to survive and reproduce. In this scenario of fantastic diversity there exists an intensive and yet insufficiently known interaction of environmental factors and fish communities. To fully understand this it is necessary to know the details about how it works. For completed book description please visit our website at the link below.
Calculo Volume 2
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Author : James Stewart
language : pt
Publisher:
Release Date : 2017-03-09
Calculo Volume 2 written by James Stewart and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-09 with categories.
Cálculo foi escrito originalmente na forma de um curso. Sempre dando ênfase à compre- ensão dos conceitos, James Stewart inicia a obra oferecendo uma visão geral do assunto para, em seguida, apresentá-lo em detalhes, por meio da formulação de problemas, exercícios, tabelas e gráfi cos. A obra está dividida em dois volumes: Vol. 1 ? capítulos 1 a 8 e Vol. 2 ? capítulos 9 a 17. Esta edição de Cálculo traz diversas inovações em relação à edição anterior: dados de exemplos e exercícios foram atualizados, novos exemplos foram incluídos, algumas resoluções de exemplos foram ampliadas e mais de 20% de exercícios em cada capítulo são novos. Assim como na edição anterior, a obra apresenta exercícios graduados, com progressão cuidadosamente planejada dos conceitos básicos até problemas complexos e desafiadores. Neste volume: equações diferenciais, equações paramétricas e coordenadas polares, sequências e séries infinitas, vetores e a geometria do espaço, funções vetoriais, derivadas parciais, integrais múltiplas, cálculo vetorial, equações diferenciais de segunda ordem.
Nutrient Requirements Of Dogs And Cats
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 2006-07-01
Nutrient Requirements Of Dogs And Cats written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-07-01 with Technology & Engineering categories.
Updating recommendations last made by the National Research Council in the mid-1980s, this report provides nutrient recommendations based on physical activity and stage in life, major factors that influence nutrient needs. It looks at how nutrients are metabolized in the bodies of dogs and cats, indications of nutrient deficiency, and diseases related to poor nutrition. The report provides a valuable resource for industry professionals formulating diets, scientists setting research agendas, government officials developing regulations for pet food labeling, and as a university textbook for dog and cat nutrition. It can also guide pet owners feeding decisions for their pets with information on specific nutrient needs, characteristics of different types of pet foods, and factors to consider when feeding cats and dogs.
The Ethics Of Biomedical Research
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Author : Baruch A. Brody
language : en
Publisher: Oxford University Press, USA
Release Date : 1998
The Ethics Of Biomedical Research written by Baruch A. Brody and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Medical categories.
Examines the many ethical issues related to biomedical research, including the use of animals in research, research on human subjects, clinical trials, international research ethics policies, and other related topics.
List Of Shipowners Managers Managing Agents
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Author :
language : en
Publisher:
Release Date : 1999
List Of Shipowners Managers Managing Agents written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Ship registers categories.
The Double Life Of Fidel Castro
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Author : Juan Reinaldo Sánchez
language : en
Publisher: Macmillan + ORM
Release Date : 2015-05-12
The Double Life Of Fidel Castro written by Juan Reinaldo Sánchez and has been published by Macmillan + ORM this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-05-12 with Biography & Autobiography categories.
In The Double Life of Fidel Castro, one of Castro's soldiers of 17 years breaks his silence and shares his memoir of years of service, and eventual imprisonment and torture for displeasing the notorious dictator, and his dramatic escape from Cuba. Responsible for protecting the Lider maximo for two decades, Juan Reinaldo Sánchez was party to his secret life – because everything around Castro was hidden. From the ghost town in which guerrillas from several continents were trained, to his immense personal fortune – including a huge property portfolio, a secret paradise island, and seizure of public money – as well as his relationship with his family and his nine children from five different partners. Sanchez's tell-all expose reveals countless state secrets and the many sides of the Cuban monarch: genius war leader in Nicaragua and Angola, paranoid autocrat at home, master spy, Machiavellian diplomat, and accomplice to drug traffickers. This extraordinary testimony makes us re-examine everything we thought we knew about the Cuban story and Fidel Castro Ruz.