Portugal Leg Timo Na Hora Da Verdade

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Translational Medicine

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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26

Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.

Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.

A Nation Upon The Ocean Sea

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Author : Daviken Studnicki-Gizbert
language : en
Publisher: Oxford University Press
Release Date : 2007-01-04

A Nation Upon The Ocean Sea written by Daviken Studnicki-Gizbert and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-01-04 with History categories.

With the opening of sea routes in the fifteenth century, groups of men and women left Portugal to establish themselves across the ports and cities of the Atlantic or Ocean sea. They were refugees and migrants, traders and mariners, Jews , Catholics, and the Marranos of mixed Judaic-Catholic culture. They formed a diasporic community known by contemporaries as the Portuguese Nation. By the early seventeenth century, this nation without a state had created a remarkable trading network that spanned the Atlantic, reached into the Indian Ocean and Asia, and generated millions of pesos that were used to bankroll the Spanish empire. A Nation Upon the Ocean Sea traces the story of the Portuguese Nation from its emergence in the late fifteenth century to its fragmentation in the middle of the seventeenth and situates it in relation to the parallel expansion and crisis of Spanish imperial dominion in the Atlantic. Against the backdrop of this relationship, the book reconstitutes the rich inner life of a community based on movement, maritime trade, and cultural hybridity. We are introduced to mariners and traders in such disparate places as Lima, Seville and Amsterdam, their day-to-day interactions and understandings, their houses and domestic relations, their private reflections and public arguments. This finaly-textured account reveals how the Portuguese Nation created a cohesive and meaningful community despite the mobility and dispersion of its members; how its forms of sociability fed into the development of robust transatlantic commercial networks; and how the day-to-day experience of trade was translated into the sphere of Spanish imperial politics of commercial reform based on religious-ethnic toleration and the liberalization of trade. A microhistory, A Nation Upon the Ocean Sea contributes to our understanding of the broader histories of capitalism, empire, and diaspora in the early Atlantic.

Harry Styles Adore You

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Author : Carolyn McHugh
language : en
Publisher:
Release Date : 2021-10

Harry Styles Adore You written by Carolyn McHugh and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10 with categories.

Harry Styles is an English singer, songwriter, and actor. His musical career began in 2010 as a solo contestant on the British music competition series The X Factor. Following his elimination early on, he was brought back to join the boy band One Direction, which went on to become one of the best- selling boy bands of all time. Styles released his self-titled debut solo album through Columbia Records in 2017. It debuted at number one in the UK and the US, and became one of the world's top-ten best-selling albums of the year. Its lead single, "Sign of the Times", topped the UK Singles Chart. Styles' second album, Fine Line (2019), debuted a top the US Billboard 200 with the biggest first-week sales by an English male artist in history, and was listed among Rolling Stone's "500 Greatest Albums of All Time. Throughout his career, Styles has earned several accolades, including a Brit Award, a Grammy, an American Music Award, two ARIA Music Awards, and a Billboard Music Award.

Peace And War

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Author : Raymond Aron
language : en
Publisher: Transaction Publishers
Release Date : 2003

Peace And War written by Raymond Aron and has been published by Transaction Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Political Science categories.

Peace and War by Raymond Aron is one of the greatest books ever written on international relations. Aron's starting point is the state of nature that exists between nations, a condition that differs essentially from the civil state that holds within political communities. Ever keeping this brute fact about the life of nations in mind and ranging widely over political history and many disciplines, Aron develops the essential analytical tools to enable us to think clearly about the stakes and possibilities of international relations. In his first section, “Theory,” Aron shows that, while international relations can be mapped, and probabilities discerned, no closed, global “science” of international relations is anything more than a mirage. In the second part, “Sociology,” Aron studies the many ways various subpolitical forces influence foreign policy. He emphasizes that no rigorous determinism is at work: politics—and thus the need for prudent statesmanship—are inescapable in international relations. In part three, “History,” Aron offers a magisterial survey of the twentieth century. He looks at key developments that have had an impact on foreign policy and the emergence of what he calls “universal history,” which brings far-flung peoples into regular contact for the first time. In a final section, “Praxeology,” Aron articulates a normative theory of international relations that rejects both the bleak vision of the Machiavellians, who hold that any means are legitimate, and the naiveté of the idealists, who think foreign policy can be overcome. This new edition of Peace and War includes an informative introduction by Daniel J. Mahoney and Brian C. Anderson, situating Aron's thought in a new post-Cold War context, and evaluating his contribution to the study of politics and international relations.

Women Business And The Law 2020

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Author : World Bank Group
language : en
Publisher: World Bank Publications
Release Date : 2020-04-24

Women Business And The Law 2020 written by World Bank Group and has been published by World Bank Publications this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-24 with Law categories.

The World Bank Group’s Women, Business and the Law examines laws and regulations affecting women’s prospects as entrepreneurs and employees across 190 economies. Its goal is to inform policy discussions on how to remove legal restrictions on women and promote research on how to improve women’s economic inclusion.

Mozambique

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Author : J. Cabrita
language : en
Publisher: Springer
Release Date : 2001-01-19

Mozambique written by J. Cabrita and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-01-19 with Political Science categories.

Mozambique's civil war was inevitable given the tradition of conflict that has always characterized Frelimo, first as an independence movement, and then as a ruling party. Without disregarding the role played by both Rhodesia and South Africa in the war - in fact providing new and detailed information about it - Cabrita guides the reader through Frelimo's early days and gives a clear understanding of the pattern of internal dissent, persecution and physical elimination of members and opponents that remained the organization's hallmark.

On The Origins Of Global History

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Author : Sanjay Subrahmanyam
language : en
Publisher: Collège de France
Release Date : 2016-03-17

On The Origins Of Global History written by Sanjay Subrahmanyam and has been published by Collège de France this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-03-17 with History categories.

How does one think of history on a world scale? Should one turn to the intellectuals of the past or the historians of the present? Universal history as it was practised from Antiquity started to change from the sixteenth century in varied contexts, from East Asia to Spanish America. Applying his extensive knowledge of archives across the world and his command of languages and historiographic traditions of Asia, Europe and the Americas, Sanjay Subrahmanyam considers the history of networks and exchanges of goods, myths and ideologies from a new perspective. He works outside traditional geopolitical frameworks based on the nation-state model, to present global history as a field defined and redefined by “connected histories”.

Through The Brazilian Wilderness

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Author : Theodore Roosevelt
language : en
Publisher:
Release Date : 2017-06-05

Through The Brazilian Wilderness written by Theodore Roosevelt and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-05 with Travel categories.

In 1914, with the well-wishes of the Brazilian government, Theodore Roosevelt, ex-president of the United States; his son, Kermit; and Colonel Rondon travel to South America on a quest to course the River of Doubt. While in Brazil, Theodore is also tasked with a “zoogeographic reconnaissance” of the local wilderness for the archives of the Natural History Museum of New York. In addition to the perils of the incredibly difficult and dangerous terrain, the river was nicknamed “The River of Death” as a testament to its ferocious rapids. Covering a previously undocumented area of South America, this expedition would be a momentous undertaking and fraught with danger. The expedition, officially named Expedicรฃo Scientific Roosevelt-Rondon, was not without incident; men were lost, a cannibalistic tribe tracked the group, and at one point Roosevelt contracted flesh-eating bacteria. In the end though, the Roosevelt-Rondon expedition was a success, and the River of Doubt was renamed the Rio Roosevelt in his honor. Written by a city-born boy who grew up to be a true explorer and leader, Roosevelt's Through the Brazilian Wilderness is a unique and important part of history, and it is indicative of the ex-president's true wanderlust and bravery. Candid black-and-white photos from the expedition fill the pages, adding further dimensions to this remarkable journey. Through the Brazilian Wilderness is an engaging must-read for historians, Roosevelt fans, and modern-day explorers alike.

Expert One On One J2ee Development Without Ejb

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Author : Rod Johnson
language : en
Publisher: John Wiley & Sons
Release Date : 2004-06-14

Expert One On One J2ee Development Without Ejb written by Rod Johnson and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-06-14 with Computers categories.

What is this book about? Expert One-on-One J2EE Development without EJB shows Java developers and architects how to build robust J2EE applications without having to use Enterprise JavaBeans (EJB). This practical, code-intensive guide provides best practices for using simpler and more effective methods and tools, including JavaServer pages, servlets, and lightweight frameworks. What does this book cover? The book begins by examining the limits of EJB technology — what it does well and not so well. Then the authors guide you through alternatives to EJB that you can use to create higher quality applications faster and at lower cost — both agile methods as well as new classes of tools that have evolved over the past few years. They then dive into the details, showing solutions based on the lightweight framework they pioneered on SourceForge — one of the most innovative open source communities. They demonstrate how to leverage practical techniques and tools, including the popular open source Spring Framework and Hibernate. This book also guides you through productive solutions to core problems, such as transaction management, persistence, remoting, and Web tier design. You will examine how these alternatives affect testing, performance, and scalability, and discover how lightweight architectures can slash time and effort on many projects. What will you learn from this book? Here are some details on what you'll find in this book: How to find the simplest and most maintainable architecture for your application Effective transaction management without EJB How to solve common problems in enterprise software development using AOP and Inversion of Control Web tier design and the place of the Web tier in a well-designed J2EE application Effective data access techniques for J2EE applications with JDBC, Hibernate, and JDO How to leverage open source products to improve productivity and reduce custom coding How to design for optimal performance and scalability

Preclinical Safety Evaluation Of Biopharmaceuticals

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Author : Joy A. Cavagnaro
language : en
Publisher: John Wiley & Sons
Release Date : 2013-03-07

Preclinical Safety Evaluation Of Biopharmaceuticals written by Joy A. Cavagnaro and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-07 with Medical categories.

"The goal is to provide a comprehensive reference book for the preclinicaldiscovery and development scientist whose responsibilities span target identification, lead candidate selection, pharmacokinetics, pharmacology, and toxicology, and for regulatory scientists whose responsibilities include the evaluation of novel therapies." —From the Afterword by Anthony D. Dayan Proper preclinical safety evaluation can improve the predictive value, lessen the time and cost of launching new biopharmaceuticals, and speed potentially lifesaving drugs to market. This guide covers topics ranging from lead candidate selection to establishing proof of concept and toxicity testing to the selection of the first human doses. With chapters contributed by experts in their specific areas, Preclinical Safety Evaluation of Biopharmaceuticals: A Science-Based Approach to Facilitating Clinical Trials: Includes an overview of biopharmaceuticals with information on regulation and methods of production Discusses the principles of ICH S6 and their implementation in the U.S., Europe, and Japan Covers current practices in preclinical development and includes a comparison of safety assessments for small molecules with those for biopharmaceuticals Addresses all aspects of the preclinical evaluation process, including: the selection of relevant species; safety/toxicity endpoints; specific considerations based upon class; and practical considerations in the design, implementation, and analysis of biopharmaceuticals Covers transitioning from preclinical development to clinical trials This is a hands-on, straightforward reference for professionals involved in preclinical drug development, including scientists, toxicologists, project managers, consultants, and regulatory personnel.