Quando A M Sica Entra Em Cena

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Translational Medicine

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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26

Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.

Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.

Dracula

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Author : Bram Stoker
language : en
Publisher: Random House Books for Young Readers
Release Date : 1982-04-12

Dracula written by Bram Stoker and has been published by Random House Books for Young Readers this book supported file pdf, txt, epub, kindle and other format this book has been release on 1982-04-12 with Juvenile Fiction categories.

String garlic by the window and hang a cross around your neck! The most powerful vampire of all time returns in our Stepping Stone Classic adaption of the original tale by Bran Stoker. Follow Johnathan Harker, Mina Harker, and Dr. Abraham van Helsing as they discover the true nature of evil. Their battle to destroy Count Dracula takes them from the crags of his castle to the streets of London... and back again.

Brutal Vision

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Author : Karl Schoonover
language : en
Publisher: U of Minnesota Press
Release Date : 2012

Brutal Vision written by Karl Schoonover and has been published by U of Minnesota Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Art categories.

How spectacular visions of physical suffering in post–World War II Italian neorealist films redefined moviegoing as a form of political action

Preclinical Safety Evaluation Of Biopharmaceuticals

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Author : Joy A. Cavagnaro
language : en
Publisher: John Wiley & Sons
Release Date : 2013-03-07

Preclinical Safety Evaluation Of Biopharmaceuticals written by Joy A. Cavagnaro and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-07 with Medical categories.

"The goal is to provide a comprehensive reference book for the preclinicaldiscovery and development scientist whose responsibilities span target identification, lead candidate selection, pharmacokinetics, pharmacology, and toxicology, and for regulatory scientists whose responsibilities include the evaluation of novel therapies." —From the Afterword by Anthony D. Dayan Proper preclinical safety evaluation can improve the predictive value, lessen the time and cost of launching new biopharmaceuticals, and speed potentially lifesaving drugs to market. This guide covers topics ranging from lead candidate selection to establishing proof of concept and toxicity testing to the selection of the first human doses. With chapters contributed by experts in their specific areas, Preclinical Safety Evaluation of Biopharmaceuticals: A Science-Based Approach to Facilitating Clinical Trials: Includes an overview of biopharmaceuticals with information on regulation and methods of production Discusses the principles of ICH S6 and their implementation in the U.S., Europe, and Japan Covers current practices in preclinical development and includes a comparison of safety assessments for small molecules with those for biopharmaceuticals Addresses all aspects of the preclinical evaluation process, including: the selection of relevant species; safety/toxicity endpoints; specific considerations based upon class; and practical considerations in the design, implementation, and analysis of biopharmaceuticals Covers transitioning from preclinical development to clinical trials This is a hands-on, straightforward reference for professionals involved in preclinical drug development, including scientists, toxicologists, project managers, consultants, and regulatory personnel.

Le Tre Costituzioni Pacifiste

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Author : Mario G. Losano
language : en
Publisher:
Release Date : 2020

Le Tre Costituzioni Pacifiste written by Mario G. Losano and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.

The three defeated Axis powers - Japan, Italy and Germany - incorporated a prohibition on wars of aggression into their democratic constitutions. This book covers the years of the Nuremberg and Tokyo Trials and the constituent assemblies of 1947- 49 through to current debates on the adaptation of the pacifi st articles in line with new “humanitarian” wars. Aspects relating to the birth of the three countries' constitutions are treated in great detail in three appendices.

Heidegger And The Essence Of Man

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Author : Michel Haar
language : en
Publisher: SUNY Press
Release Date : 1993-01-01

Heidegger And The Essence Of Man written by Michel Haar and has been published by SUNY Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-01-01 with Philosophy categories.

Michel Haar argues that Heidegger went too far in transferring all traditional properties of man to being. Haar examines what is left, after this displacement, not only of human identity, but perhaps more importantly, of nature, life, embodiment - of the flesh of human existence. This sensitive yet critical reading of Heidegger raises such issues in relation to questions of language, technology, human freedom, and history. In doing so, it provides a compelling argument for the need to rethink what it means to be human.

Peace And War

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Author : Raymond Aron
language : en
Publisher: Transaction Publishers
Release Date : 2003

Peace And War written by Raymond Aron and has been published by Transaction Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Political Science categories.

Peace and War by Raymond Aron is one of the greatest books ever written on international relations. Aron's starting point is the state of nature that exists between nations, a condition that differs essentially from the civil state that holds within political communities. Ever keeping this brute fact about the life of nations in mind and ranging widely over political history and many disciplines, Aron develops the essential analytical tools to enable us to think clearly about the stakes and possibilities of international relations. In his first section, “Theory,” Aron shows that, while international relations can be mapped, and probabilities discerned, no closed, global “science” of international relations is anything more than a mirage. In the second part, “Sociology,” Aron studies the many ways various subpolitical forces influence foreign policy. He emphasizes that no rigorous determinism is at work: politics—and thus the need for prudent statesmanship—are inescapable in international relations. In part three, “History,” Aron offers a magisterial survey of the twentieth century. He looks at key developments that have had an impact on foreign policy and the emergence of what he calls “universal history,” which brings far-flung peoples into regular contact for the first time. In a final section, “Praxeology,” Aron articulates a normative theory of international relations that rejects both the bleak vision of the Machiavellians, who hold that any means are legitimate, and the naiveté of the idealists, who think foreign policy can be overcome. This new edition of Peace and War includes an informative introduction by Daniel J. Mahoney and Brian C. Anderson, situating Aron's thought in a new post-Cold War context, and evaluating his contribution to the study of politics and international relations.

Understanding Digital Humanities

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Author : D. Berry
language : en
Publisher: Springer
Release Date : 2012-02-07

Understanding Digital Humanities written by D. Berry and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-02-07 with Computers categories.

Confronting the digital revolution in academia, this book examines the application of new computational techniques and visualisation technologies in the Arts & Humanities. Uniting differing perspectives, leading and emerging scholars discuss the theoretical and practical challenges that computation raises for these disciplines.

The Time Of Music

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Author : Jonathan D. Kramer
language : en
Publisher: MacMillan Publishing Company
Release Date : 1988

The Time Of Music written by Jonathan D. Kramer and has been published by MacMillan Publishing Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988 with Music categories.

Italian Neorealism And Global Cinema

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Author : Laura E. Ruberto
language : en
Publisher: Wayne State University Press
Release Date : 2007

Italian Neorealism And Global Cinema written by Laura E. Ruberto and has been published by Wayne State University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Literary Criticism categories.

This volume addresses the influence of Italian neorealist films on world cinema well beyond the post-World War II period associated with the movement. Despite its lack of organization and relatively short life span, the Italian neorealist movement deeply influenced directors and film traditions around the world. This collection examines the impact of Italian neorealism beyond the period of 1945-52, the years conventionally connected to the movement, and beyond the postwar Italian film industry where the movement originated. Providing a refreshing aesthetic and ideological contrast to mainstream Hollywood films, neorealist filmmakers demonstrated not only how an engaging narrative technique could be brought to bear upon social issues but also how cinema could shape and redefine national identity. The fourteen essays in Italian Neorealism and Global Cinema consider films from Italy, India, Brazil, Africa, the Czech Republic, postwar Germany, Hong Kong, the United States, France, Belgium, Colombia, and Great Britain. Each essay explores neorealism's complex relationship to a different national film tradition, style, or historical period, illustrating the profound impact of neorealism and the ways it continues to complicate the relationship between ideas of nation, national cinema, and national identity. Many of the essays identify similar themes or motifs adapted from neorealism, and several essays address a politicized national film tradition that developed in opposition to a monolithic Western aesthetic. In all, Italian Neorealism and Global Cinema provides a novel critical understanding of the wide-ranging international impact of a short period in Italian cultural history. Film scholars and students of film history will appreciate this insightful text.