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Translational Medicine

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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26

Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.

Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.

Princess Isabel Of Brazil

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Author : Roderick J. Barman
language : en
Publisher: Rowman & Littlefield
Release Date : 2002

Princess Isabel Of Brazil written by Roderick J. Barman and has been published by Rowman & Littlefield this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Biography & Autobiography categories.

Having specialized in the South American country for most of his academic career, Barman (history, U. of British Columbia) here integrates gender studies into his concerns. He extracts copiously from Isabel's (1846-1921) letters and recollections within the framework of a female life cycle. In addition to showing how women have been shaped by and have lived within cultural, social, and economic structures created by men and predicated on female subordination and exploitation, he uses the princess' life to illuminate the interplay of gender and power in the 19th century. Annotation copyrighted by Book News, Inc., Portland, OR.

Di Logos Inesperados Sobre Dificuldades Domadas

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Author : Elenilson Nascimento & Anna Carvalho
language : pt-BR
Publisher: Clube de Autores
Release Date : 2015-06-07

Di Logos Inesperados Sobre Dificuldades Domadas written by Elenilson Nascimento & Anna Carvalho and has been published by Clube de Autores this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-06-07 with Philosophy categories.

Os textos que compõem esses Diálogos Inesperados... foram concebidos por acreditar que ser escritor no Brasil está se tornando algo muito mais complicado que nos tempos do Álvares de Azevedo, quando a expectativa de vida não passava dos 30 anos. Contos e crônicas que fazem parte de uma ousadia e de uma parceira que se aglomeram por todas as 26 histórias que compõem essas ficções letais, por uma lente de literatura de gênero meio ressentida com essa realidade que reduz a verve humana em legenda de um filme Classe B, e nada mais. Textos rigorosos como A Decadência das Máscaras ; afiados como Por Dentro da Perfeição ; feministas em Memórias Póstumas de um Matrimônio ; panfletários em A Pasta Quebrada ; eróticos em A Mulher do Melhor Amigo ; intimistas em Amar Sozinho é o Pior dos Pecados e de lógica interna muito bem elaborada, como é o caso de Interrupções . É drama, comédia, verdade e farsa. Chulo e erudito, dependendo da página, do parágrafo, da frase, da palavra que se leia. E, nessa aptidão em escrever o escárnio dos seres (humanos), temos nossos neurônios incompatíveis aos refrões monossilábicos do pagode pós-moderno, e foi decisiva e efetiva na busca pela inspiração que pairou sobre diversos olhares, e sobre esse admirável objeto de sedução que é o ato solitário de escrever.

George Washington S False Teeth

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Author : Robert Darnton
language : en
Publisher: W. W. Norton & Company
Release Date : 2003

George Washington S False Teeth written by Robert Darnton and has been published by W. W. Norton & Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with History categories.

A collection of articles concentrated on the Enlightenment in France argues for a scaled-down interpretation of the significance of the movement.

Grande E Nov Ssimo Dicion Rio Da L Ngua Portuguesa

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Author : Laudelino Freire
language : pt-BR
Publisher:
Release Date : 1939

Grande E Nov Ssimo Dicion Rio Da L Ngua Portuguesa written by Laudelino Freire and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1939 with Portuguese language categories.

Bill Bryson S African Diary

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Author : Bill Bryson
language : en
Publisher: Random House
Release Date : 2010-03-02

Bill Bryson S African Diary written by Bill Bryson and has been published by Random House this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-03-02 with Travel categories.

Bill Bryson goes to Kenya at the invitation of CARE International, the charity dedicated to working with local communities to eradicate poverty around the world. Kenya, generally regarded as the cradle of humankind, is a land of stunning landscapes, famous game reserves, and a vibrant culture, but it also has many serious problems, including refugees, AIDS, drought and grinding poverty. It also provides plenty to worry a nervous traveller like Bill Bryson: hair-raising rides in light aircraft, tropical diseases, snakes, insects and large predators. Bryson casts his inimitable eye on a continent new to him, and the resultant diary, though short in length, contains all his trademark laugh-out-loud wit, wry observation and curious insight. All the author’s royalties from this book, as well as all profits, will go to CARE International.

Vida Simples Ed 235 Abra Se Para O Novo

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Author : VS EDITORA E CONTEUDO
language : pt-BR
Publisher: VS EDITORA E CONTEUDO
Release Date : 2021-10-26

Vida Simples Ed 235 Abra Se Para O Novo written by VS EDITORA E CONTEUDO and has been published by VS EDITORA E CONTEUDO this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-26 with Social Science categories.

Mudanças são oportunidades valiosas para encontrar novos jeitos de viver. Saiba como criar espaço para as transformações acontecerem