Rdw

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Red Cell Distribution Width Rdw Predicts Both Mortality And Organ Failure In Critically Ill Patients

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Author : Isabelle Van Ussel
language : en
Publisher:
Release Date : 2013

Red Cell Distribution Width Rdw Predicts Both Mortality And Organ Failure In Critically Ill Patients written by Isabelle Van Ussel and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with categories.

ObjectivesRed cell distribution width (RDW), a measure of erythrocytes size variability, is routinely measured in every blood count. Recently, RDW has been shown to be a prognostic marker for mortality particularly in cardiovascular disorders and recently in the critically ill. The aim of this study was to investigate if RDW has the potential to predict not only mortality but also organ failure in an independent, large and unselected population of intensive care unit (ICU) patients. The exposure of interest was RDW as a predictor of mortality and organ failure in the critical care population. Design: One center observational study.Setting: Intensive care unit of the University Hospital of Antwerp, Belgium.Patients: We retrospectively studied a large population of 11957 adult patients who received critical care between 2007 and 2013.Interventions: None.Materials and Methods:A series of hematological markers of the first day of admission (RDW, HDW, MPV, MCV, MCH, MCHC), demographic data, validated scores for pathological severity (SAPS-3) and nurse workload (TISS), markers of inflammation as well as a large number of variables for multiple and single organ failure: the SOFA score, markers of renal function, respiratory insufficiency, liver function and global hypoperfusion. Results: There was a stepwise increase with increasing quintile of RDW for the SAPS-3 score, the length of stay in the ICU, and the mortality rate both in the ICU and in the hospital. An increasing gradient across RDW quintiles was also observed for the parameters for renal function. Moreover patients with a higher RDW quintile had a higher change of achieving a higher SOFA-max during their stay in the ICU. This statistically significant increase was also seen for each individual SOFA category which describes single organ failure. Moreover a higher RDW quintile was associated with a longer duration of mechanical ventilation, a higher maximal lactate level and a lower arterial pH value. This stepwise association was robust, but not unique for RDW. Comparable trends were seen by analyzing quintiles for another marker of cell width variability i.e. the mean platelet volume (MPV). Elevated RDW during the first day of admission was associated with a significant increase in mortality rates irrespective to hemoglobin levels. Univariate logistic regression suggests that elevations of RDW on admission are associated with a higher risk of mortality with an Odds ratio of 1.564 (CI 1.484-1.648, P

A Manual Of Laboratory And Diagnostic Tests

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Author : Frances Talaska Fischbach
language : en
Publisher: Lippincott Williams & Wilkins
Release Date : 2009

A Manual Of Laboratory And Diagnostic Tests written by Frances Talaska Fischbach and has been published by Lippincott Williams & Wilkins this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Medical categories.

Now in its Eighth Edition, this leading comprehensive manual helps nurses deliver safe, effective, and informed care for patients undergoing diagnostic tests and procedures. The book covers a broad range of laboratory and diagnostic tests and studies that are delivered to varied patient populations in varied settings. Tests are grouped according to specimen and function/test type (e.g. blood, urine, stool, cerebrospinal fluid, etc.). Each test is described in detail, with step-by-step guidance on correct procedure, tips for accurate interpretation, and instructions for patient preparation and aftercare. Clinical Alerts highlight critical safety information.

The Relationship Between Red Blood Cell Distribution Width And All Cause And Cause Specific Mortality In A General Population

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Author : Yan Bornu00e9
language : en
Publisher:
Release Date : 2017

The Relationship Between Red Blood Cell Distribution Width And All Cause And Cause Specific Mortality In A General Population written by Yan Bornu00e9 and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.

BackgroundRed Cell Distribution Width (RDW) could be a risk factor for developing various chronic diseases, and seems to be a prognostic marker in patients with cardiovascular disease (CVD) or cancer. Our aim was to explore the association between RDW and all-cause and cause-specific mortality in a general population.MethodsRDW was measured in 27,063 participants (aged 45-73 years) from the population-based Malmu00f6 Diet and Cancer cohort. After a follow-up of 19.8u00b15.5 years, Cox proportional hazards regression analysis was used to study the relationship between RDW and all-cause and cause-specific mortality, with adjustment for potential confounders.ResultsA total of 9388 individuals (4715 men and 4673 women) died during the follow up. Subjects with higher RDW had a significant higher risk for mortality, which remained significant after adjustment for potential confounders (HR, 4th vs. 1st of sex-specific quartile: 1.34, 95%CI:1.24-1.45). RDW was significantly associated with cancer mortality (HR, 4th vs. 1st: 1.27, 95%CI:1.12-1.44), CVD mortality (HR:1.39, 95%CI:1.21-1.59), and respiratory disease mortality (HR:1.47, 95%CI:1.06-2.03).ConclusionsHigh RDW is associated with increased all-cause and cause-specific mortality. We propose that high RDW is a significant, but non-specific marker of mortality risk in the general population.

Diagnostic Hematology

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Author : Norman Beck
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-12-19

Diagnostic Hematology written by Norman Beck and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-12-19 with Medical categories.

The approach described in this book is different from that in most student texts, and has been very successful in practice, starting almost from scratch, but omitting many of the ‘basics’ such as the details of hematopoiesis, laboratory technology, and so on, which are hardly relevant to the practising clinician and student in the wards, and are primarily of interest to the hematologist and sometimes to the clinical specialist. Considerable emphasis is given to the clinical history and examination, and the interpretation of the clinical patterns thus exposed. Hopefully it will overcome many of the traditional problems experienced in practical diagnostic haematology.

Interaction Between Redox Chaperones And Rdw Mutant Thyroglobulin

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Author :
language : en
Publisher:
Release Date : 2004

Interaction Between Redox Chaperones And Rdw Mutant Thyroglobulin written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with categories.

Inherited as an autosomal recessive, the WIC-rdw rat exhibits congenital dwarfism (rdw). Genetic linkage analysis revealed that the rdw gene locus was identical to the thyroglobulin (Tg) gene locus. Complete sequencing of both wild type and the WIC-rdw rat Tg cDNA2s revealed a single missense mutation G6958C, causing a G2320R amino acid substitution at a position that is highly conserved. Further, transient expression of intact Tg cDNA containing the rdw mutation in COS-7 cells showed no detectable Tg in the secreted media confirming a defect in the export of rdw Tg. Despite the many similar features to other animal models for congenital hypothyroidism, the one major difference was that the rdw rat thyroid glands displayed marked hypoplasia. To examine the role of multiple ER chaperones in the processing of both wild type and rdw Tg, we followed their interactions by co-immunoprecipitation after pulse-chase. In COS-7 cells transfected with wild type Tg, the kinetics of dissociation of the chaperone BiP from Tg closely followed the kinetics of folding and ER exit of Tg, whereas, BiP association with the mutant Tg2s did not diminish over the same early chase periods. The oxidoreductases ERp72 and PDI but not ERp57 displayed little or no interaction with wild type Tg but did display significant stable binding to the mutant Tg. At long chase times up to 24 hrs, it was observed that majority of intracellularly retained mutant Tg was associated with BiP, ERp72 and PDI. These interactions were found to be both covalent and non-covalent. The classic non-covalent Tg 6 chaperone interaction diminished in parallel with the intracellular degradation of the rdw-mutant Tg but the covalent interaction with the redox chaperones remained constant throughout the chase period. During extended periods of chase, the covalently linked fraction remained unchanged. Investigations of both wild type and rdw rat thyroid tissue sections revealed the presence of foci that were positive for apoptosis. Thus, it is possible that the loss-of-function rdw mutation that results in accumulation of mutant Tg in the thryocyte ER may also be responsible for cellular toxicity leading to apoptosis, accounting for the observed thyroid gland hypoplasia.

Relation Between Red Cell Distribution Width Rdw And Lung Function In A Sample Of The U S Population

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Author : Pankaj A. Patel
language : en
Publisher:
Release Date : 2002

Relation Between Red Cell Distribution Width Rdw And Lung Function In A Sample Of The U S Population written by Pankaj A. Patel and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with categories.

Rdw Co Since 1803

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Author : R. D. Wood Company
language : en
Publisher:
Release Date : 1950

Rdw Co Since 1803 written by R. D. Wood Company and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1950 with categories.

Utility Of Red Cell Distribution Width As A Prognostic Factor In Young Breast Cancer Patients

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Author :
language : en
Publisher:
Release Date : 2016

Utility Of Red Cell Distribution Width As A Prognostic Factor In Young Breast Cancer Patients written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.

Abstract : Abstract: The prognosis of breast cancer occurs in young women is usually poor. Red cell distribution width (RDW), 1 of many routinely examined parameters, has recently been proposed as a prognostic marker in solid tumors. The aim of our study was to assess the predictive value of RDW for survival in young women with breast cancer. We reviewed 203 consecutive young female patients (under 40) with invasive breast cancer diagnosed at the First Affiliated Hospital of Wenzhou Medical University between January 2008 and December 2012. Preoperational RDW, clinicopathological information, and prognostic data were collected. RDW levels were divided into 2 groups: 161 patients with low RDW (≤13.75%) and 42 patients with high RDW (>13.75%). Clinicopathological differences between the 2 groups were calculated by chi-squared test and Wilcoxon rank-sum test. Kaplan–Meier survival analysis and Cox proportional hazard regression analyses were used to examine the effect of RDW on survival. We found that high RDW was significantly associated with larger tumor size ( P = 0.002), positive lymph node metastases ( P = 0.011), and advanced stages ( P = 0.004). Patients with high RDW showed significantly lower disease-free survival (DFS; P

Hematology Oncology Secrets

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Author : Marie E. Wood
language : en
Publisher: Elsevier Health Sciences
Release Date : 2003

Hematology Oncology Secrets written by Marie E. Wood and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Blood categories.

You asked for a new edition. Here it is, better than ever! Not only have many of the same experts in hematology and oncology returned to update their chapters, but new specialists have joined the team, rounding out this edition's detailed coverage of cancer treatment, palliative care, blood disorders, genetic counseling, and more. New to this edition are: skeletal complications of malignancy, fatigue in the cancer patient, and targeted molecular therapy. Freshen your knowledge base, study for the boards, or read for the challenge of testing yourself. - Back cover.

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