The Em Discoveries
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The Em Discoveries
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Author : Robert Gibbons
language : en
Publisher:
Release Date : 1974
The Em Discoveries written by Robert Gibbons and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1974 with Science fiction, American categories.
Ion Channel Structure And Drug Discovery Accelerated By Cryo Em
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Author : Shujia Zhu
language : en
Publisher: Frontiers Media SA
Release Date : 2022-11-30
Ion Channel Structure And Drug Discovery Accelerated By Cryo Em written by Shujia Zhu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-30 with Science categories.
The Resolution Revolution Recent Advances In Cryoem
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Author :
language : en
Publisher: Academic Press
Release Date : 2016-08-26
The Resolution Revolution Recent Advances In Cryoem written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-26 with Science categories.
cryoEM, a new volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods and new developments in recording images, the creation, evaluation and validation of 3D maps from the images, model building into maps and refinement of the resulting atomic structures, and applications of essentially single particle methods to helical structures and to sub-tomogram averaging. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers research methods that determine the structures of biological molecules, a vital step for understanding their function Contains the technical developments underpinning the advances of cryoEM and captures the exciting insights that have resulted
Visualizing Biological Complexity
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Author : Anke M. Mulder
language : en
Publisher:
Release Date : 2011-09-09
Visualizing Biological Complexity written by Anke M. Mulder and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-09 with Electron microscopy categories.
The advent of an information age in which cutting edge technologies and important scientific discoveries are accessible to a global audience at an instant's notice has drastically changed the landscape of scientific investigation. The era of advancing scientific knowledge painstakingly and one hypothesis at a time has given way to high-throughput, large scale, discovery based approaches. Discovery-based efforts in genomics, proteomics, and metabolomics have exchanged the old view of single genes that encode single proteins to act in isolation, for an understanding of life as an intricate web of networks of interactions between proteins, RNA, DNA, and small molecules with complex, interrelated feedback loops of information flow. High-throughput efforts in structural genomics are increasingly establishing a role for structural biology in systems level investigations and an understanding of the structural dimension of biological complexity is emerging. Recent advances in automation and computation in single particle electron microscopy (EM), are rapidly pushing this field into the realm of high-throughput structural biology. This thesis strives to illustrate the unique contribution that discovery-based, high-throughput single-particle EM can make toward resolving complex biological interaction networks. First, the design of a discovery-based experiment is illustrated via the discovery-based metabolite profiling (DMP) investigation of the endocannabinoid signaling pathway. Next, the unique ability of single-particle EM data analysis to resolve heterogeneous biological information into homogenous sub-sets is demonstrated via single-particle EM analysis of Kinesin-13 binding to bent microtubule (MT) protofilaments. Finally, a novel discovery-based single particle profiling (DSP) method is developed and used to construct a mechanism for 30S ribosome subunit assembly, thereby illustrating the potential of single particle EM to deconvolute complex biological interaction networks. Future application of DSP to other complex biological networks promises to open exciting new avenues of research, and will establish single particle EM as a formidable contender in the omics-centered nature of the modern scientific landscape.
Cryoem
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Author : Tamir Gonen
language : en
Publisher: Humana
Release Date : 2021-12-28
Cryoem written by Tamir Gonen and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-28 with Science categories.
This volume details the most up-to-date cryo-EM techniques from leading researchers. Chapters are organized into four parts with emphasis on electron cryotomography, single particle analysis, and the crystal based cryo-EM methods of 2D electron crystallography, and MicroED for the study of 3D crystals. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, application details for both the expert and non-expert reader, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, CryoEM: Methods and Protocols aims to serve as an excellent resource on cryo-EM and can serve as the foundation for new researchers to this growing field in structural biology.
Ethnomedicine And Drug Discovery
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Author : M.M. Iwu
language : en
Publisher: Elsevier
Release Date : 2002-03-01
Ethnomedicine And Drug Discovery written by M.M. Iwu and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-03-01 with Science categories.
Approx.344 pages
Phenotypic Drug Discovery
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Author : Beverley Isherwood
language : en
Publisher: Royal Society of Chemistry
Release Date : 2020-12-09
Phenotypic Drug Discovery written by Beverley Isherwood and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-09 with Medical categories.
Phenotypic drug discovery has been highlighted in the past decade as an important strategy in the discovery of new medical entities. How many marketed drugs are derived from phenotypic screens? From the most recent examples, what were the factors enabling target identification and validation? This book answers these questions by elaborating on fundamental capabilities required for phenotypic drug discovery and using case studies to illustrate approaches and key success factors. Written and edited by experienced practitioners from both industry and academia, this publication will equip researchers with a thought-provoking guide to the application and future development of contemporary phenotypic drug discovery for clinical success.
Single Particle Cryo Electron Microscopy
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Author : Joachim Frank
language : en
Publisher: World Scientific Publishing Company
Release Date : 2017-12-31
Single Particle Cryo Electron Microscopy written by Joachim Frank and has been published by World Scientific Publishing Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-31 with Electron microscopy categories.
The book reproduces 55 of more than 300 articles written by the author, representing milestones in methods development of single-particle cryo-EM as well as important results obtained by this technique in the study of biological macromolecules and their interactions. Importantly, neither symmetries nor ordered arrangements (as in two-dimensional crystals, helical assemblies, icosahedral viruses) are required. Although the biological applications are mainly in the area of ribosome structure and function, the elucidation of membrane channel structures and their activation and gating mechanisms are represented, as well. The book is introduced by a commentary that explains the original development of concepts, describes the contributions of the author's colleagues and students, and shows how challenges were overcome as the technique matured. Along the way, the ribosome served as an example for a macromolecule with intricate structure and conformational dynamics that pose challenges for three-dimensional visualization. Toward the end of the book -- bringing us to the present time -- molecular structures with near-atomic resolution are presented, and a novel type of computational analysis, manifold embedding, is introduced. Single-particle cryo-EM is currently revolutionizing structural biology, presenting a powerful alternative to X-ray crystallography as a means to solve the structure of biological macromolecules. The book presents in one place a number of articles containing key advances in mathematical and computational methods leading up to the present time. Secondly, the development of the technique over the years is reflected by ever-expanding discoveries in the field of ribosome structure and function. Thirdly, as all histories of ideas, the history of concepts pertaining to this new method of visualization is fascinating all in itself.
Motif Discovery With The Em Algorithm
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Author : Maria del Mar Vila Muñoz
language : en
Publisher:
Release Date : 2010
Motif Discovery With The Em Algorithm written by Maria del Mar Vila Muñoz and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.
Artificial Intelligence In Drug Discovery
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Author : Nathan Brown
language : en
Publisher: Royal Society of Chemistry
Release Date : 2020-11-04
Artificial Intelligence In Drug Discovery written by Nathan Brown and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-04 with Computers categories.
Following significant advances in deep learning and related areas interest in artificial intelligence (AI) has rapidly grown. In particular, the application of AI in drug discovery provides an opportunity to tackle challenges that previously have been difficult to solve, such as predicting properties, designing molecules and optimising synthetic routes. Artificial Intelligence in Drug Discovery aims to introduce the reader to AI and machine learning tools and techniques, and to outline specific challenges including designing new molecular structures, synthesis planning and simulation. Providing a wealth of information from leading experts in the field this book is ideal for students, postgraduates and established researchers in both industry and academia.
