Voc Consegue Mudar
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Translational Medicine
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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26
Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.
Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.
Sapiens
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Author : Yuval Noah Harari
language : en
Publisher: Random House
Release Date : 2014-09-04
Sapiens written by Yuval Noah Harari and has been published by Random House this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-04 with History categories.
'Interesting and provocative... It gives you a sense of how briefly we've been on this Earth' Barack Obama What makes us brilliant? What makes us deadly? What makes us Sapiens? One of the world's preeminent historians and thinkers, Yuval Noah Harari challenges everything we know about being human. Earth is 4.5 billion years old. In just a fraction of that time, one species among countless others has conquered it: us. In this bold and provocative book, Yuval Noah Harari explores who we are, how we got here and where we're going. **ONE OF THE GUARDIAN'S 100 BEST BOOKS OF THE 21st CENTURY** PRAISE FOR SAPIENS: 'Jaw-dropping from the first word to the last... It may be the best book I've ever read' Chris Evans 'Startling... It changes the way you look at the world' Simon Mayo 'I would recommend Sapiens to anyone who's interested in the history and future of our species' Bill Gates
The Jesuit Makasar Documents
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Author : Hubert Jacobs
language : en
Publisher: Institutum Historicum S. I.
Release Date : 1988
The Jesuit Makasar Documents written by Hubert Jacobs and has been published by Institutum Historicum S. I. this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988 with History categories.
The Tb12 Method
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Author : Tom Brady
language : en
Publisher: Simon and Schuster
Release Date : 2017-09-19
The Tb12 Method written by Tom Brady and has been published by Simon and Schuster this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-19 with Biography & Autobiography categories.
The first book by New England Patriots quarterback Tom Brady--the five-time Super Bowl champion.
4000 Essential English Words
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Author : Paul Nation
language : en
Publisher:
Release Date : 2009
4000 Essential English Words written by Paul Nation and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with English language categories.
Alicia
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Author : Solange Borkovski
language : pt-BR
Publisher: Clube de Autores
Release Date : 2011-02-04
Alicia written by Solange Borkovski and has been published by Clube de Autores this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-02-04 with Juvenile Fiction categories.
Depois de perder a mãe em um acidente de carro, quando Alicia, tinha apenas oito anos de idade, a menina foi encaminhada a um orfanato religioso, já que sua unica parente viva, uma tia que mora em Toronto, não quis se responsabilizar pela mesma. Alicia passa a ter um ensinamento diferente, levando em consideração todos os conceitos da religião. Agora com 16 anos ela recebe uma proposta de sua tia, ir morar com ela, mas por que a tia demorara tanto para finalmente aceita-la? Sua vida ira mudar de cabeça para baixo, a partir do momento que ela aceitar, e então conhecer Caled Ferhell, um rapaz estranho e misterioso, mas isso não é tudo, coisas bizarras começam a acontecer. Caled é diferente e cada vez mais Alicia se vê presa ele, ela precisa descobrir quem ele é, antes que mais coisas comecem a acontecer.
Asylums
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Author : Erving Goffman
language : en
Publisher: Routledge
Release Date : 2017-09-08
Asylums written by Erving Goffman and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-08 with Social Science categories.
A total institution is defined by Goffman as a place of residence and work where a large number of like-situated, individuals, cut off from the wider society for an appreciable period of time, together lead an enclosed, formally administered round of life. Prisons serve as a clear example, providing we appreciate that what is prison-like about prisons is found in institutions whose members have broken no laws. This volume deals with total institutions in general and, mental hospitals, in particular. The main focus is, on the world of the inmate, not the world of the staff. A chief concern is to develop a sociological version of the structure of the self. Each of the essays in this book were intended to focus on the same issue--the inmate's situation in an institutional context. Each chapter approaches the central issue from a different vantage point, each introduction drawing upon a different source in sociology and having little direct relation to the other chapters. This method of presenting material may be irksome, but it allows the reader to pursue the main theme of each paper analytically and comparatively past the point that would be allowable in chapters of an integrated book. If sociological concepts are to be treated with affection, each must be traced back to where it best applies, followed from there wherever it seems to lead, and pressed to disclose the rest of its family.
The Mamba Mentality
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Author : Kobe Bryant
language : en
Publisher: MCD
Release Date : 2018-10-23
The Mamba Mentality written by Kobe Bryant and has been published by MCD this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-23 with Sports & Recreation categories.
The Mamba Mentality: How I Play is Kobe Bryant’s personal perspective of his life and career on the basketball court and his exceptional, insightful style of playing the game—a fitting legacy from the late Los Angeles Laker superstar. In the wake of his retirement from professional basketball, Kobe “The Black Mamba” Bryant decided to share his vast knowledge and understanding of the game to take readers on an unprecedented journey to the core of the legendary “Mamba mentality.” Citing an obligation and an opportunity to teach young players, hardcore fans, and devoted students of the game how to play it “the right way,” The Mamba Mentality takes us inside the mind of one of the most intelligent, analytical, and creative basketball players ever. In his own words, Bryant reveals his famously detailed approach and the steps he took to prepare mentally and physically to not just succeed at the game, but to excel. Readers will learn how Bryant studied an opponent, how he channeled his passion for the game, how he played through injuries. They’ll also get fascinating granular detail as he breaks down specific plays and match-ups from throughout his career. Bryant’s detailed accounts are paired with stunning photographs by the Hall of Fame photographer Andrew D. Bernstein. Bernstein, long the Lakers and NBA official photographer, captured Bryant’s very first NBA photo in 1996 and his last in 2016—and hundreds of thousands in between, the record of a unique, twenty-year relationship between one athlete and one photographer. The combination of Bryant’s narrative and Bernstein’s photos make The Mamba Mentality an unprecedented look behind the curtain at the career of one of the world’s most celebrated and fascinating athletes.
Still Me
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Author : Jojo Moyes
language : en
Publisher: Penguin
Release Date : 2018-01-30
Still Me written by Jojo Moyes and has been published by Penguin this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-30 with Fiction categories.
From the New York Times bestselling author of The Giver of Stars, discover the love story that captured over 20 million hearts in Me Before You, After You, and Still Me. Louisa Clark arrives in New York ready to start a new life, confident that she can embrace this new adventure and keep her relationship with Ambulance Sam alive across several thousand miles. She steps into the world of the superrich, working for Leonard Gopnik and his much younger second wife, Agnes. Lou is determined to get the most out of the experience and throws herself into her new job and New York life. As she begins to mix in New York high society, Lou meets Joshua Ryan, a man who brings with him a whisper of her past. Before long, Lou finds herself torn between Fifth Avenue where she works and the treasure-filled vintage clothing store where she actually feels at home. And when matters come to a head, she has to ask herself: Who is Louisa Clark? And how do you find the courage to follow your heart—wherever that may lead? Funny, romantic, and poignant, Still Me follows Lou as she discovers who she is and who she was always meant to be—and learns to live boldly in her brave new world.
Bright Futures
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Author : American Academy of Pediatrics
language : en
Publisher:
Release Date : 2017
Bright Futures written by American Academy of Pediatrics and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with Medical categories.
"This essential resource provides key background information and recommendations for 12 health promotion themes, including 3 brand-new topics : promoting lifelong health for families and communities, promoting health for children and youth with special health care needs, and promoting the healthy and safe use of social media. Also included in this essential resource are well-child supervision standards for 31 age-based visits, from newborn through 21 years. The result : more efficient visits, stronger partnerships with children and families, and enhanced ability to keep up with changes in family, communities, and society that affect a child's health."--Page 4 de la couverture.