Apte Zile Plus Una
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Drug Transporters In Drug Disposition Effects And Toxicity
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Author : Xiaodong Liu
language : en
Publisher: Springer Nature
Release Date : 2019-09-30
Drug Transporters In Drug Disposition Effects And Toxicity written by Xiaodong Liu and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-30 with Medical categories.
This book provides with a comprehensive overview of the role of drug transporters in drug disposition and efficacy/toxicity, as well as drug-drug interactions and recent advances in the field. Transporters are known determinants of drug disposition and efficacy/toxicity. In general, they are divided into solute carrier (SLC) and ATP binding cassette (ABC) families, and are located along cell membranes, where they mediate drug uptake into cells and export out of cells. Drug transporters are essential in maintaining cell homeostasis, and their gene mutations may cause or contribute to severe human genetic disorders, such as cystic fibrosis, neurological disease, retinal degeneration, anemia, and cholesterol and bile transport defects. Conversely, some diseases may also alter transporter functions and expressions, in turn aggravating disease process. Further, since over-expression of some ABC transporters is a potential contributor to multidrug-resistance (MDR), the book presents a number of strategies to overcome MDR, including ABC transporter inhibitors and applying epigenetic methods to modulate transporter expressions and functions. This book is useful for graduate students and professionals who are looking to refresh or expand their knowledge of this exciting field.
M N Nci Mult Sl Be Ti Mult
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Author : Haylie Pomroy
language : ro
Publisher: Editura NICULESCU
Release Date :
M N Nci Mult Sl Be Ti Mult written by Haylie Pomroy and has been published by Editura NICULESCU this book supported file pdf, txt, epub, kindle and other format this book has been release on with Cooking categories.
HAYLIE POMROY, supranumită „nutriţionista vedetelor”, este consilieră autorizată în nutriţie şi consilieră holistică si îsi desfăşoară activitatea în clinici din Beverly Hills şi Burbank. Dintre apariţiile ei la postul de televiziune NBC, putem aminti emisiunile Access Hollywood şi Extra. De asemenea, Haylie semnează articole în publicaţii precum Marie Claire, People sau Star. Concepţia fundamentală a lui Haylie este că nu trebuie să privim mâncarea ca pe un duşman, ci ca pe un prieten de care avem nevoie pentru a ne regla metabolismul, astfel încât organismul să devină capabil să ardă grăsimea. Consumul alimentar poate fi, aşadar, privit ca o experienţă biologică pozitivă. Ţinând dieta propusă de autoare, vei mânca pe săturate: trei mese pe zi şi cel puţin două gustări. Gata cu număratul caloriilor, cu înfometarea şi cu mâncărurile lipsite de savoare! Cartea cuprinde peste 50 de reţete şi un plan alimentar pentru patru săptămâni – care are inclusiv mese vegetariene, bio sau fără gluten –, recomandate celor care au ţinut până acum, fără succes, diete peste diete, dar şi acelora care se află la prima încercare de a slăbi sau care, pur şi simplu, îşi doresc un stil de viaţă sănătos şi un corp frumos. În doar patru săptămâni, nu doar că te vei bucura să vezi cum pierzi în greutate, dar vei constata, cel mai probabil, că ţi-a scăzut şi nivelul colesterolului, că nivelul zahărului din sânge s-a stabilizat şi că te simţi mai relaxat.
Mai Intunecat
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Author : E L James
language : ro
Publisher: Editura Trei
Release Date : 2023
Mai Intunecat written by E L James and has been published by Editura Trei this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023 with Fiction categories.
E L James revine în lumea celor Cincizeci de umbre cu o perspectivă mai profundă și mai misterioasă asupra poveștii de dragoste care a fascinat milioane de cititori din întreaga lume. AVENTURA LOR MISTUITOARE S,I SENZUALA˘ s-a sfârșit cu inimi zdrobite și vinovăţie, dar Christian Grey n-o poate uita pe Anastasia Steele. Hotărât s-o recâștige, încearcă să-și înăbușe cele mai întunecate dorinţe și nevoia de control total și s-o iubească pe Ana așa cum își dorește ea. Dar lucrurile îngrozitoare din copilărie încă îl bântuie, iar șeful intrigant al Anei, Jack Hyde, o vrea pe aceasta pentru el. Oare dr. Flynn, confidentul și terapeutul lui Christian, îl poate ajuta să-și învingă demonii? Sau firea posesivă a Elenei, fosta lui dominatoare, și devotamentul obsesiv al Leilei, fosta sa supusă, îl pot trage pe Christian înapoi în trecut? Dacă totuși Christian o va recâștiga pe Ana, poate oare un bărbat atât de distrus și întunecat s-o păstreze alături de el?
Handbook Of Evidence Based Critical Care
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Author : Paul Ellis Marik
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-06-14
Handbook Of Evidence Based Critical Care written by Paul Ellis Marik and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-06-14 with Medical categories.
This updated and revised edition of the classic bedside pocket reference remains the gold standard in critical care medicine. The new edition maintains Dr. Marik's trademark humor and engaging writing style, while adding numerous references.
Stem Cell Research And Therapeutics
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Author : Yanhong Shi
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-07-15
Stem Cell Research And Therapeutics written by Yanhong Shi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-07-15 with Medical categories.
This book is an updated reference for one of the most exciting field of biomedical researches- Stem Cell Research and its therapeutic applications. Stem cell research holds great promise for the treatment of many human diseases that currently lack effective therapies. The set of chapters in this book provide insights into both basic stem cell biology and clinical applications of stem cell-based cell replacement therapies for a variety of human diseases, including cardiovascular diseases, neurological disorders, and li ver degeneration. It also covers novel technologies for the culture and differentiation of both human embryonic stem cells and adult tissue stem cells. This book summarizes our current state of knowledge in stem cell research and integrates basic stem cell biology with regenerative medicine in an overall context. It is an essential reference for students, postdoctoral fellows, academic and industrial scientists, and clinicians. v Acknowledgements The editors would like to thank Ms. Jill Brantley, Rose Chavarin, Alina Haas, and Emily Sun for their administrative assistance and proof-reading of this book. We would also like to thank all the authors for their contributions. vii The editors wish to dedicate this book to our mentors Ron Evans, Fred Gage, and, in memory of Daniel E. Koshland, Jr. Contents Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v Acknowledgements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . vii Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xi 1 Retinal Pigment Epithelial Cells: Development In Vivo and Derivation from Human Embryonic Stem Cells In Vitro for Treatment of Age-Related Macular Degeneration . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Dennis O. Clegg, David Buchholz, Sherry Hikita, Teisha Rowland, Qirui Hu, and Lincoln V.
Italic And Romance
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Author : Herbert J. Izzo
language : en
Publisher: John Benjamins Publishing
Release Date : 1980-01-01
Italic And Romance written by Herbert J. Izzo and has been published by John Benjamins Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 1980-01-01 with Language Arts & Disciplines categories.
The papers in this volume deal with the languages of ancient Italy and the Romance dialects that grew from them. The arrangement of papers in the volume is topical, starting with ancient Italy and moving upward in time and outward in space through general Romance to Italian, French and Provençal, Spanish, Romanian and Sardinian.
Sensuyt Lordonnance Des Royaulmes Duchez Marq Satz Pr Cipaultez Contez C Appten S A La Ma Imperiale Charles Etc G L
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Author :
language : un
Publisher:
Release Date : 1520
Sensuyt Lordonnance Des Royaulmes Duchez Marq Satz Pr Cipaultez Contez C Appten S A La Ma Imperiale Charles Etc G L written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1520 with categories.
Revista De Cre Terea Animalelor
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Author :
language : ro
Publisher:
Release Date : 1981
Revista De Cre Terea Animalelor written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1981 with Animal industry categories.
Treaty Series Recueil Des Traites
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Author : United Nations
language : en
Publisher: UN
Release Date : 2007-11-02
Treaty Series Recueil Des Traites written by United Nations and has been published by UN this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-02 with Political Science categories.
Evidence Based Critical Care
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Author : Paul Ellis Marik
language : en
Publisher: Springer
Release Date : 2014-12-08
Evidence Based Critical Care written by Paul Ellis Marik and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-12-08 with Medical categories.
This is the premier evidence-based textbook in critical care medicine. The Third Edition features updated and revised chapters, numerous new references, streamlined content, and new chapters on key topics such as the new paradigm in critical care medicine, cardiac output monitoring, surgical optimization, vital signs, and arterial blood gas analysis. The book maintains the author’s trademark humor and engaging writing style and is suitable for a broad and diverse audience of medical students, residents, fellows, physicians, nurses, and respiratory therapists who seek the latest and best evidence in critical care. From reviews of previous editions: “This is an excellent introduction to the concept of evidence-based medicine...The writing is clear, logical, and highly organized, which makes for fast and enjoyable reading. I believe this book will get daily use in most intensive care units, by a wide range of readers.” –Respiratory Care “This is one of the most comprehensive handbooks on critical care medicine with a strong emphasis on evidence base...Overall, this book should be useful for junior doctors or intensive care trainees who are starting their term in an intensive care unit.” –Anaesthesia and Intensive Care