Gua Gaia Fogo E Ar

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Translational Medicine

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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26

Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.

Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.

Volcanoes Of The Azores

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Author : Ulrich Kueppers
language : en
Publisher: Springer
Release Date : 2018-02-22

Volcanoes Of The Azores written by Ulrich Kueppers and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02-22 with Science categories.

The Azores archipelago consists of nine islands that emerge from the Azores Plateau in the Central Northern Atlantic, situated within the triple junction of the American, Eurasian and African lithosphere plates. Subaerial volcanic activity has been well known since the Pliocene and continues today, with several well-documented eruptions since the settlement of the islands in the fifteenth century. The origin of the Azores Plateau has been a matter of scientific debate and thus this book provides the first comprehensive overview of geological features in the Azores from volcanological, geochemical, petrological, paleontological, structural and hydrological perspectives

A History Of Greek Philosophy Volume 2 The Presocratic Tradition From Parmenides To Democritus

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Author : William Keith Chambers Guthrie
language : en
Publisher: Cambridge University Press
Release Date : 1962

A History Of Greek Philosophy Volume 2 The Presocratic Tradition From Parmenides To Democritus written by William Keith Chambers Guthrie and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1962 with Philosophy categories.

The most striking merits of Guthrie's work are his mastery of a tremendous range of ancient literature and modern scholarship.

Preclinical Safety Evaluation Of Biopharmaceuticals

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Author : Joy A. Cavagnaro
language : en
Publisher: John Wiley & Sons
Release Date : 2013-03-07

Preclinical Safety Evaluation Of Biopharmaceuticals written by Joy A. Cavagnaro and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-07 with Medical categories.

"The goal is to provide a comprehensive reference book for the preclinicaldiscovery and development scientist whose responsibilities span target identification, lead candidate selection, pharmacokinetics, pharmacology, and toxicology, and for regulatory scientists whose responsibilities include the evaluation of novel therapies." —From the Afterword by Anthony D. Dayan Proper preclinical safety evaluation can improve the predictive value, lessen the time and cost of launching new biopharmaceuticals, and speed potentially lifesaving drugs to market. This guide covers topics ranging from lead candidate selection to establishing proof of concept and toxicity testing to the selection of the first human doses. With chapters contributed by experts in their specific areas, Preclinical Safety Evaluation of Biopharmaceuticals: A Science-Based Approach to Facilitating Clinical Trials: Includes an overview of biopharmaceuticals with information on regulation and methods of production Discusses the principles of ICH S6 and their implementation in the U.S., Europe, and Japan Covers current practices in preclinical development and includes a comparison of safety assessments for small molecules with those for biopharmaceuticals Addresses all aspects of the preclinical evaluation process, including: the selection of relevant species; safety/toxicity endpoints; specific considerations based upon class; and practical considerations in the design, implementation, and analysis of biopharmaceuticals Covers transitioning from preclinical development to clinical trials This is a hands-on, straightforward reference for professionals involved in preclinical drug development, including scientists, toxicologists, project managers, consultants, and regulatory personnel.

Journey Into Healing

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Author : Deepak Chopra
language : en
Publisher: Random House
Release Date : 2010-10-31

Journey Into Healing written by Deepak Chopra and has been published by Random House this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-10-31 with Body, Mind & Spirit categories.

'Perfect health, pure and invincible, is the state we have lost. Regain it, and we regain a world.' In Journey Into Healing essential ideas from the work of Deepak Chopra are arranged to create a transcendent experience for the reader, a journey into healing. Along the path, we discover that what we think and feel can actually change our biology. We learn to go beyond self-imposed limitations that create disease, and to seek that place inside ourselves that is at one with the infinite intelligence of the universe, the source of life. By the end of this book, our consciousness will have been altered by the experience of the journey itself. Such change has the power to transform our lives, to grace us with gifts of lasting peace and perfect health. The final pages contain techniques for Mindfulness Mediation, which can access the silent space between our thoughts and tap into the inner wisdom that will make all our dreams come true.

Historia Serafica Da Ordem Dos Frades Menores De S Francisco Na Provincia De Portugal Por Frei Manoel Da Esperan A

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Author :
language : pt-BR
Publisher:
Release Date : 1656

Historia Serafica Da Ordem Dos Frades Menores De S Francisco Na Provincia De Portugal Por Frei Manoel Da Esperan A written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1656 with categories.

Management Guidelines For Iucn Category V Protected Areas

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Author : Adrian Phillips
language : en
Publisher: World Conservation Union
Release Date : 2002

Management Guidelines For Iucn Category V Protected Areas written by Adrian Phillips and has been published by World Conservation Union this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Business & Economics categories.

Protected Landscapes (IUCN Protected Area Category V) are lived-in working landscapes. In the past, there has been a tendency to see them as a rather Eurocentric approach to protected areas but increasingly the category is being designated in other parts of the world, including in a number of developing countries. The Guidelines include sections on the background and on the planning of such areas, and chapters on the principles, policies, process and the means for their management. The text includes more than twenty case studies from ore than fifteen countries in every region of the world.

New International Atlas Of The World

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Author : Lloyd Edwin Smith
language : en
Publisher:
Release Date : 1942

New International Atlas Of The World written by Lloyd Edwin Smith and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1942 with Atlases categories.

Women Business And The Law 2020

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Author : World Bank Group
language : en
Publisher: World Bank Publications
Release Date : 2020-04-24

Women Business And The Law 2020 written by World Bank Group and has been published by World Bank Publications this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-24 with Law categories.

The World Bank Group’s Women, Business and the Law examines laws and regulations affecting women’s prospects as entrepreneurs and employees across 190 economies. Its goal is to inform policy discussions on how to remove legal restrictions on women and promote research on how to improve women’s economic inclusion.

Imaginary Futures

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Author : Richard Barbrook
language : en
Publisher: Pluto Press (UK)
Release Date : 2007-04-20

Imaginary Futures written by Richard Barbrook and has been published by Pluto Press (UK) this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-04-20 with Computers categories.

Leading scholars discuss ideology and hotly contested post-structuralist theory.