Home eBooks Download › 45 wissenschaftlicher kongress

45 Wissenschaftlicher Kongress

Download 45 Wissenschaftlicher Kongress PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get 45 Wissenschaftlicher Kongress book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page

45 Wissenschaftlicher Kongress

DOWNLOAD
Author : Bundesverband der Zahnarzte des Offentlichen Gesundheitsdienstes eV.
language : de
Publisher:
Release Date : 1995

45 Wissenschaftlicher Kongress written by Bundesverband der Zahnarzte des Offentlichen Gesundheitsdienstes eV. and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with categories.

Iron As Environmental Factor In The Pathogenesis Of Crohn S Disease Like Ileitis

DOWNLOAD
Author : Tanja Werner
language : en
Publisher: Logos Verlag Berlin GmbH
Release Date : 2011

Iron As Environmental Factor In The Pathogenesis Of Crohn S Disease Like Ileitis written by Tanja Werner and has been published by Logos Verlag Berlin GmbH this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Medical categories.

Inflammatory bowel diseases (IBD) including ulcerative colitis and Crohn's disease (CD) are chronic disorders of the gastrointestinal tract. Iron replacement therapy is a common treatment in anemic CD patients, but oral iron supplements seem to be less tolerated. Pathogenesis of CD has been attributed to intestinal bacteria and environmental factors including dietary components like iron that trigger disease in a genetically predisposed host. The aim of this study was to characterize the interrelationship between iron, the gut microbiota and the development of chronic ileitis in a murine model of CD. Experimental results indicate that luminal iron sulfate deprivation in combination with systemic iron repletion inhibits the development of inflammation in TNF^{ Delta ARE/WTmice. The mechanisms imply changes in the gut microbiota as well as inhibition of endoplasmic reticulum stress and apoptosis in the intestinal epithelium. In conclusion, luminal iron may directly affect intestinal epithelial function or generate a pathological milieu in the intestine that triggers epithelial cell stress-associated apoptosis through changes in the microbial homeostasis. These data may offer a new possibility for the treatment of chronic intestinal inflammation and anemia in CD patients through modulation of the patients? iron status. In addition, oral replacement therapy with iron sulfate may trigger inflammatory processes associated with progression of CD-like ileitis and intravenous therapy should be preferred.