A D Cima Segunda Noite Nova Edi O
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Translational Medicine
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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26
Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.
Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.
The Book Of Disquiet
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Author : Fernando Pessoa
language : en
Publisher: Serpent's Tail
Release Date : 2017-08-17
The Book Of Disquiet written by Fernando Pessoa and has been published by Serpent's Tail this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-17 with Fiction categories.
The Book of Disquiet is one of the great literary works of the twentieth century. Written over the course of Fernando Pessoa's life, it was first published in 1982, pieced together from the thousands of individual manuscript pages left behind by Pessoa after his death in 1935. Now this fragmentary modernist masterpiece appears in a major new edition that unites Margaret Jull Costa's celebrated translation with the most complete version of the text ever produced. It is presented here, for the first time in English, by order of original composition, and accompanied by facsimiles of the original manuscript. Narrated principally by an assistant bookkeeper named Bernardo Soares - an alias of sorts for Pessoa himself - The Book of Disquiet is 'the autobiobraphy of someone who never existed', a mosaic of dreams, of hope and despair; a hymn to the streets and cafs of 1930s Lisbon, and an extraordinary record of the inner life of one of the century's most important writers. This new edition represents the most complete vision of Pessoa's genius.
Materia Medica Physico Historico Mechanica Reyno Mineral Parte I Edi Am Nova A Que Se Accrescentam Por Continua Am Desta Obra Reynos Vegetavel E Animal Parte Ii With A Portrait
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Author : Jacob de Castro Sarmento
language : en
Publisher:
Release Date : 1758
Materia Medica Physico Historico Mechanica Reyno Mineral Parte I Edi Am Nova A Que Se Accrescentam Por Continua Am Desta Obra Reynos Vegetavel E Animal Parte Ii With A Portrait written by Jacob de Castro Sarmento and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1758 with categories.
My Sweet Orange Tree
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Author : José Mauro de Vasconcelos
language : en
Publisher: Pushkin Press
Release Date : 2018-01-04
My Sweet Orange Tree written by José Mauro de Vasconcelos and has been published by Pushkin Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-04 with Juvenile Fiction categories.
A worldwide classic of children's literature - a moving, life-affirming childhood story, finally available in English again Meet Zezé - Brazil's naughtiest and most loveable boy, his talent for mischief matched only by his great kindness. When he grows up he wants to be a 'poet with a bow-tie' but for now he entertains himself playing pranks on the residents of his family's poor Rio de Janeiro neighbourhood and inventing friends to play with. That is, until he meets a real friend, and his life begins to change... My Sweet Orange Tree is a worldwide classic of children's literature – never out of print in Brazil since it was first published in 1968, it has also been translated into an astonishing number of languages and won the hearts of millions of young readers from Korea to turkey, Poland to Thailand and in many other countries too. José Mauro de Vasconcelos (1920-84) was a Brazilian writer who worked as a sparring partner for boxers, a labourer on a banana farm, and a fisherman before he started writing at the age of 22. He is most famous for his autobiographical novel My Sweet Orange Tree, which tells the story of his own childhood in Rio de Janeiro.
Discipline And Punish
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Author : Michel Foucault
language : en
Publisher: Vintage
Release Date : 2012-04-18
Discipline And Punish written by Michel Foucault and has been published by Vintage this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-04-18 with Social Science categories.
A brilliant work from the most influential philosopher since Sartre. In this indispensable work, a brilliant thinker suggests that such vaunted reforms as the abolition of torture and the emergence of the modern penitentiary have merely shifted the focus of punishment from the prisoner's body to his soul.
O Panorama
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Author :
language : en
Publisher:
Release Date : 1839
O Panorama written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1839 with categories.
Mean Baby
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Author : Selma Blair
language : en
Publisher: Vintage
Release Date : 2022-05-17
Mean Baby written by Selma Blair and has been published by Vintage this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-17 with Biography & Autobiography categories.
NEW YORK TIMES BEST SELLER • Selma Blair has played many roles: Ingenue in Cruel Intentions. Preppy ice queen in Legally Blonde. Muse to Karl Lagerfeld. Advocate for the multiple sclerosis community. But before all of that, Selma was known best as … a mean baby. In a memoir that is as wildly funny as it is emotionally shattering, Blair tells the captivating story of growing up and finding her truth. "Blair is a rebel, an artist, and it turns out: a writer." —Glennon Doyle, Author of the #1 New York Times Bestseller Untamed and Founder of Together Rising The first story Selma Blair Beitner ever heard about herself is that she was a mean, mean baby. With her mouth pulled in a perpetual snarl and a head so furry it had to be rubbed to make way for her forehead, Selma spent years living up to her terrible reputation: biting her sisters, lying spontaneously, getting drunk from Passover wine at the age of seven, and behaving dramatically so that she would be the center of attention. Although Selma went on to become a celebrated Hollywood actress and model, she could never quite shake the periods of darkness that overtook her, the certainty that there was a great mystery at the heart of her life. She often felt like her arms might be on fire, a sensation not unlike electric shocks, and she secretly drank to escape. Over the course of this beautiful and, at times, devasting memoir, Selma lays bare her addiction to alcohol, her devotion to her brilliant and complicated mother, and the moments she flirted with death. There is brutal violence, passionate love, true friendship, the gift of motherhood, and, finally, the surprising salvation of a multiple sclerosis diagnosis. In a voice that is powerfully original, fiercely intelligent, and full of hard-won wisdom, Selma Blair’s Mean Baby is a deeply human memoir and a true literary achievement.
7 Ways
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Author : Jamie Oliver
language : en
Publisher: Penguin UK
Release Date : 2020-08-20
7 Ways written by Jamie Oliver and has been published by Penguin UK this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-20 with Cooking categories.
INCLUDING RECIPES FROM JAMIE'S HIT CHANNEL 4 TV SHOW KEEP COOKING FAMILY FAVOURITES Make everyday meals more exciting with the No. 1 bestselling cookbook, featuring 120 exciting and tasty new recipes _______ Jamie has done his research to find out exactly what we, as a nation, love to eat. He's taken 18 of our favourite ingredients and created 7 new, easy and delicious ways to cook them. We're talking about those meal staples we pick up without thinking - chicken breast, salmon fillet, mince, eggs, potatoes, broccoli, mushrooms, to name but a few. Jamie will share 7 achievable, exciting and tasty ways to cook each of these hero foods, requiring minimal time, effort and a maximum of only 8 ingredients. Jamie's fun, delicious and nutritious recipes include: · Crispy Salmon Tacos · Prosciutto Pork Fillet · Pepper & Chicken Jalfrezi · Mushroom Cannelloni · Beef & Guinness Hotpot · Broccoli & Cheese Pierogi With everything from fakeaways and traybakes to family and freezer favourites, you'll find bags of inspiration to help you mix things up in the kitchen. Discover 7 Ways, the most straight-forward cookbook Jamie has ever written. _______ Readers can't stop cooking from Jamie's brilliant 7 Ways: 'The new 5 Ingredients!' · 'By far the best cook book I have ever bought' 'Might just be the best Jamie book ever' · 'The best book ever' 'One of Jamie's best ideas' · 'The best cook book I've owned' 'Best Jamie book ever' · 'My favourite Jamie Oliver book' _______ 'Easy, achievable and delicious; Oliver has created another fail-safe cookbook for families and those of us who are stretched for time' Daily Telegraph 'This is perfect for anyone stuck in a cookery rut and in need of some inspiration' Daily Mail 'Simple, affordable and delicious food designed for all the family' i 'Cooking dinner just got easier (and tastier) with Jamie's brilliant new book 7 Ways' Mail on Sunday
Communicating Science
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Author : Toss Gascoigne
language : en
Publisher: ANU Press
Release Date : 2020-09-14
Communicating Science written by Toss Gascoigne and has been published by ANU Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-14 with Science categories.
Modern science communication has emerged in the twentieth century as a field of study, a body of practice and a profession—and it is a practice with deep historical roots. We have seen the birth of interactive science centres, the first university actions in teaching and conducting research, and a sharp growth in employment of science communicators. This collection charts the emergence of modern science communication across the world. This is the first volume to map investment around the globe in science centres, university courses and research, publications and conferences as well as tell the national stories of science communication. How did it all begin? How has development varied from one country to another? What motivated governments, institutions and people to see science communication as an answer to questions of the social place of science? Communicating Science describes the pathways followed by 39 different countries. All continents and many cultures are represented. For some countries, this is the first time that their science communication story has been told.
A Comparative History Of Literatures In The Iberian Peninsula
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Author : Fernando Cabo Aseguinolaza
language : en
Publisher: John Benjamins Publishing
Release Date : 2010-05-26
A Comparative History Of Literatures In The Iberian Peninsula written by Fernando Cabo Aseguinolaza and has been published by John Benjamins Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-05-26 with Literary Criticism categories.
A Comparative History of Literatures in the Iberian Peninsula is the second comparative history of a new subseries with a regional focus, published by the Coordinating Committee of the International Comparative Literature Association. As its predecessor for East-Central Europe, this two-volume history distances itself from traditional histories built around periods and movements, and explores, from a comparative viewpoint, a space considered to be a powerful symbol of inter-literary relations. Both the geographical pertinence and its symbolic condition are obviously discussed, when not even contested. Written by an international team of researchers who are specialists in the field, this history is the first attempt at applying a comparative approach to the plurilingual and multicultural literatures in the Iberian Peninsula. The aim of comprehensiveness is abandoned in favor of a diverse and extensive array of key issues for a comparative agenda. A Comparative History of Literatures in the Iberian Peninsula undermines the primacy claimed for national and linguistic boundaries, and provides a geo-cultural account of literary inter-systems which cannot otherwise be explained.